Crop protection, Food, Feed and Flavor Chemicals

DISODIUM DIPHOSPHATE (E450)
Disodium diphosphate (E450) or sodium acid pyrophosphate (SAPP) is an inorganic compound with the chemical formula Na2H2P2O7.
Disodium diphosphate (E450) consists of sodium cations (Na+) and dihydrogen pyrophosphate anions (H2P2O2−7).
Disodium diphosphate (E450) is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.

CAS: 7758-16-9
MF: H5NaO7P2
MW: 201.97
EINECS: 231-835-0

Synonyms
DisodiuM pytophospha;TwosodiuM pyrophosphatetwo hydrogen;Amyloid Precursor Protein β, Secreted;ANTI-DSPP (N-TERM) antibody produced in rabbit;Dentin sialophosphoprotein;SodiuM pyrophosphate dibasic practical grade;SODIUM PYROPHOSPHATE DIBASIC BIOULTR;Food Grade Sodium;Acid Pyrophosphate;7758-16-9;Disodium diphosphate;Sodium acid pyrophosphate;Disodium dihydrogen pyrophosphate;DISODIUM PYROPHOSPHATE;H5WVD9LZUD;disodium;[hydroxy(oxido)phosphoryl] hydrogen phosphate;MFCD00014246;Disodium acid pyrophosphate;Dinatriumpyrophosphat;Disodiumpytophosphate;Dinatriumpyrophosphat [German];Disodium dihydrogen diphosphate;Disodium dihydrogenpyrophosphate;HSDB 377;Pyrophosphoric acid, disodium salt;UNII-H5WVD9LZUD;Sodium pyrophosphate (Na2H2P2O7);EINECS 231-835-0;Sodium diphosphate dibasic;disodium pyrophosphate 2-;disodium hydrogen (hydrogen phosphonatooxy)phosphonate;Grahamsches salz;Glassy sodium phosphate;DSSTox_CID_8842;sodium dihydrogendiphosphate;EC 231-835-0;DSSTox_RID_78658;DSSTox_GSID_28842;SODIUMACIDPYROPHOSPHATE;Sodium pyrophosphate, dibasic
;Sodium dihydrogen pyrophosphate;CHEMBL3184949;EINECS 272-808-3;Tox21_200813;DISODIUM PYROPHOSPHATE [HSDB];DISODIUM PYROPHOSPHATE [INCI];DISODIUM PYROPHOSPHATE [VANDF];AKOS015916169;AKOS024418779;SODIUM ACID PYROPHOSPHATE [MI];Diphosphoric acid, sodium salt (1:2);SODIUM ACID PYROPHOSPHATE [FCC];NCGC00258367-01;SODIUM ACID PYROPHOSPHATE [VANDF];CAS-68915-31-1;di-sodium dihydrogen pyrophosphate anhydrous

When crystallized from water, Disodium diphosphate (E450) forms a hexahydrate, but it dehydrates above room temperature.
Disodium diphosphate (E450) is a polyvalent anion with a high affinity for polyvalent cations, e.g. Ca2+.
Disodium diphosphate (E450) is produced by heating sodium dihydrogen phosphate:

2 NaH2PO4 → Na2H2P2O7 + H2O

Disodium diphosphate (E450) gene is mapped to human chromosome 21q21.3.
Disodium diphosphate (E450) encodes a integral membrane protein.
Disodium diphosphate (E450) is a soluble protein generated by sequential cleavage with α and γ secretase.
Disodium diphosphate (E450) is a chemical additive and preservative.
Disodium diphosphate (E450) has many aliases.
Disodium diphosphate (E450) also is known as disodium dihydrogen diphosphate, disodium dihydrogen pyrophosphate and disodium pyrophosphate.
Disodium diphosphate (E450) also has the name sodium acid pyrophosphate.
Disodium diphosphate (E450) is an odorless white powder and, because it has a valance of greater than two, it can bond to many other chemicals.
Disodium diphosphate (E450) is a white crystalline solid that has an anhydrous form.
Disodium diphosphate (E450) is used as a buffering agent and is also a substrate for film forming polymers.
Disodium diphosphate (E450) has been shown to have the ability to inhibit cell lysis in vitro, which may be due to its hydrophobic properties.
The surface methodology used for Disodium diphosphate (E450) included the use of a hydrophobic surface with water vapor, which helped to prevent the adsorption of proteins onto the surface of the product.
Disodium diphosphate (E450) has been shown to be an effective buffer at optimum concentrations, with no harmful effects on fetal bovine or neuronal cells.

Disodium diphosphate (E450) Chemical Properties
Melting point: decomposes 220℃ [MER06]
Density: (hexahydrate) 1.86
Vapor pressure: 0Pa at 20℃
Storage temp.: -70°C
Solubility H2O: 0.1 M at 20 °C, clear, colorless
Form: white powder
Color: White to Off-White
PH: 3.5-4.5 (20℃, 0.1M in H2O, freshly prepared)
Water Solubility: Fully miscible in water. Insoluble in alcohol and ammonia.
λmax: λ: 260 nm Amax: 0.11
λ: 280 nm Amax: 0.09
Merck: 13,8643
Stability: Stable.
InChI: InChI=1S/Na.H4O7P2.H/c;1-8(2,3)7-9(4,5)6;/h;(H2,1,2,3)(H2,4,5,6);
InChIKey: IQTFITJCETVNCI-UHFFFAOYSA-N
LogP: -3.420 (est)
CAS DataBase Reference: 7758-16-9(CAS DataBase Reference)
EPA Substance Registry System: Disodium diphosphate (E450) (7758-16-9)

Disodium dihydrogendiphosphate, Disodium diphosphate (E450), acidic sodium pyrophosphate, Na2H2P2O7, Mr 221.97, d 2.31.
Disodium diphosphate (E450)'s solubility in water is 13g Na2H2P2O7/100g H2O at 20 °C, and 20g at 80°C.
The pH of a 1% aqueous solution is 4.1.
The usual commercial product is the anhydrous, nonhygroscopic salt in powder form.
The hexahydrate, Na2H2P2O7.6H2O, d 1.85, crystallizes from aqueous solution below 27 °C.
Above this temperature, Disodium diphosphate (E450) is converted to the anhydrous form.

Disodium diphosphate (E450) is used as a (tropically stable) acid carrier in baking powder, for improvement of flow properties in flour, for pH regulation, and in dental care products for prevention of tartar formation.

Uses
Sodium Pyrophosphate is a leavening agent, preservative, sequestrant, and buffer which is mildly acidic with a ph of 4.1.
Disodium diphosphate (E450) is moderately soluble in water, with a solubility of 15 g in 100 ml at 25°c.
Disodium diphosphate (E450) is used in doughnuts and biscuits for its variable gas release rate during the mixing, bench action, and baking process.
Disodium diphosphate (E450) is used in baking powder as a leavening agent.
Disodium diphosphate (E450) is used in canned fish products to reduce the level of undesired struvite crystals (magnesium ammonium phosphate hexahydrate) by complexing the magnesium.
Disodium diphosphate (E450) is used to sequester metals in processed potatoes.
Disodium diphosphate (E450) is also termed sapp, sodium acid pyrophosphate, acid sodium pyrophosphate, disodium diphosphate, and disodium dihydrogen pyrophosphate.
Sodium Pyrophosphate Dibasic is anhydrous form, pyrophosphate salt used in buffers.
Disodium diphosphate (E450) is a buffering agent and a Lewis base, a base that gives away electrons, drawing it near to other compounds.
Disodium diphosphate (E450) neutralizes other substances.
Disodium diphosphate (E450) also has industrial uses.
Disodium diphosphate (E450) can remove iron stains and stabilize hydrogen peroxide.
Disodium diphosphate (E450) is used to clean the machine used in dairy farms.
Disodium diphosphate (E450) also is used to remove hair from pigs and feathers from poultry before they are led to slaughter.
Disodium diphosphate (E450) is used in making plastics, too.

Food uses
Disodium diphosphate (E450) is a popular leavening agent found in baking powders.
Disodium diphosphate (E450) combines with sodium bicarbonate to release carbon dioxide:

Na2H2P2O7 + NaHCO3 → Na3HP2O7 + CO2 + H2O
Disodium diphosphate (E450) is available in a variety of grades that affect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium diphosphate (E450) is usually used in very sweet cakes which mask the off-taste.

Disodium diphosphate (E450) in baking powder, New Zealand, 1950s
Disodium diphosphate (E450) and other sodium and potassium polyphosphates are widely used in food processing; in the E number scheme, they are collectively designated as E450, with the disodium form designated as E450(a).
In the United States, Disodium diphosphate (E450) is classified as generally recognized as safe (GRAS) for food use.
In canned seafood, Disodium diphosphate (E450) is used to maintain color and reduce purge during retorting.
Retorting achieves microbial stability with heat.
Disodium diphosphate (E450) is an acid source for reaction with baking soda to leaven baked goods.
In baking powder, Disodium diphosphate (E450) is often labeled as food additive E450.
In cured meats, Disodium diphosphate (E450) speeds the conversion of sodium nitrite to nitrite (NO−2) by forming the nitrous acid (HONO) intermediate, and can improve water-holding capacity.
Disodium diphosphate (E450) is also found in frozen hash browns and other potato products, where it is used to keep the color of the potatoes from darkening.
Disodium diphosphate (E450) can leave a slightly bitter aftertaste in some products, but "the SAPP taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings."

Other uses
In leather treatment, Disodium diphosphate (E450) can be used to remove iron stains on hides during processing.
Disodium diphosphate (E450) can stabilize hydrogen peroxide solutions against reduction.
Disodium diphosphate (E450) can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.
When added to scalding water, Disodium diphosphate (E450) facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
In petroleum production, Disodium diphosphate (E450) can be used as a dispersant in oil well drilling muds.
Disodium diphosphate (E450) is used in cat foods as a palatability additive.
Disodium diphosphate (E450) is used as a tartar control agent in toothpastes.

Preparation
Disodium diphosphate (E450) is produced from sodium dihydrogenmonophosphate by heating at 200-250℃:
Na2CO3+2H3PO4→2NaH2PO4+H2O+CO2↑
2NaH2PO4→Na2H2P2O7+H2O

Biochem/physiol Actions
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties.
Disodium diphosphate (E450) is derived from amyloid precursor protein.
The protein consists of 612 amino acids.
Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP.
Disodium diphosphate (E450) has neuroprotective, neurogenic and neurotrophic functions.
Amyloid precursor protein a also stimulates gene expression and protein expression.
DISODIUM EDTA
DISODIUM EDTA-COPPER N° CAS : 14025-15-1 Nom INCI : DISODIUM EDTA-COPPER Nom chimique : Disodium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cuprate(2-) N° EINECS/ELINCS : 237-864-5 Classification : EDTA Ses fonctions (INCI) Astringent : Permet de resserrer les pores de la peau Agent de chélation : Réagit et forme des complexes avec des ions métalliques qui pourraient affecter la stabilité et / ou l'apparence des produits cosmétiques
DISODIUM EDTA
Disodium edta is used in several industrial applications attributing to its high ability to bind to most of metal cations.
Disodium edta is produced as several salts, e.g. ethylenediaminetetra-acetic acid disodium salt (EDTAS).
Disodium edta salts are used as chelating agents in cosmetic formulations.

CAS: 139-33-3
MF: C10H14N2Na2O8
MW: 336.21
EINECS: 205-358-3

Disodium edta is a preservative, sequestrant, and stabilizer in foods.
Disodium edta is added to ascorbic acid-disodium benzoate containing soft drinks to mitigate the formation of benzene.
Disodium edta and its salts are used as a component in the production of food-contact paper and paperboard.
Disodium edta is permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals.
In the textile industry, Disodium edta and its salts prevent metal ion impurities from changing colors of dyed products.

In the pulp and paper industry, Disodium edta and its salts inhibit the ability of metal ions from catalyzing the disproportionation of hydrogen peroxide (a typical bleaching agent).
Disodium edta is used in synthetic rubber manufacture.
Disodium edta is also used as a corrosion inhibitor to carbon steel in the industries.
As an anticoagulant, Disodium edta and tripotassium salts of EDTA are most commonly used.
An organic sodium salt that is the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA).

Disodium edta is a chelating agent that has been used in many scientific applications for decades.
Disodium edta is a synthetic compound composed of two sodium ions and one EDTA molecule.
Disodium edta is most commonly used in laboratory experiments to chelate metals and other ions from solution, and Disodium edta has also been used in medical treatments for heavy metal poisoning and other conditions.
Disodium edta is a salt of ethylenediaminetetraacetic acid (commonly known as EDTA).
In cosmetics, Disodium edta functions primarily as a chelating agent, meaning it prevents ingredients in a formula from binding with trace elements (mainly minerals) that can be present in water or other ingredients.
This action enhances the stability of cosmetics formulas and helps makes the job of preservatives easier since Disodium edta ingredients bond with mineral ions that microorganisms need to remain intact.
In addition to being used in makeup, skin care, and hair care products, disodium EDTA is also used as a food additive.

Disodium EDTA is in many products as a preservative, to stabilise it, or to enhance the foaming action.
Disodium edta’s also used as a chelating agent, which means it us used to precipitate out metals from the formulation (if tap water were used to make the formulation instead purified water, for example, and Disodium edta can bind with metals dissolved in your shower water).
Disodium EDTA (chemical formula - C10H16N2Na2O8) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in a product.
This white, water-soluble solid is widely used to bind to metal ions like iron and calcium ions and prevent the deterioration of cosmetics and personal care products.
Disodium EDTA thus enhances stability of cosmetics.
Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.

Disodium edta Chemical Properties
Melting point: 248 °C (dec.)(lit.)
Boiling point: >100 °C
Density: 1.01 g/mL at 25 °C
Vapor pressure: 0Pa at 25℃
Storage temp.: 2-8°C
Solubility H2O: clear, colorless
Form: solution
Color: ≤5 (0.5 M)(APHA)
Odor: at 100.00?%. odorless
Water Solubility: Miscible with water.
BRN: 3822669
Stability: Hygroscopic
LogP: -4.3 at 25℃
CAS DataBase Reference: 139-33-3(CAS DataBase Reference)
EPA Substance Registry System: Disodium edta (139-33-3)

Uses
Disodium edta is an aminopolycarboxylic acid and a hexadentate ligand.
Disodium edta chelates with metal ions, especially with cations to form an octahedral complex.
Disodium edta is a blood anticoagulant and contributes to the pathogenesis of pseudothrombocytopenia.
Disodium edta chelates with calcium in the blood and inhibits clotting and is routinely used in haematological tests.
Disodium edta enhances the antibacterial activity of lysozyme.
Disodium edta used in chelation therapy chelates with calcium and favors dilation of artery, solubilisation of atheromatous plaques in atherosclerotic vascular disease.
Disodium edta chelation therapy may also protect from oxidative damage during blood and lipid peroxidation in liver fibrosis.

Disodium edta is a preservative used in concentrations of 0.1 to 0.5 percent.
Disodium edta is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate.
Disodium edta is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels.
A 1% solution has a ph of 4.3–4.7.
Disodium edta is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation.
Disodium edta's function is comparable to that of disodium calcium edta.
Disodium edta is widely used in textile industry.
Usually applied to dissolve limescale.
Disodium edta is applied in textile industry, pulp and paper industry and also in chelation therapy.
In cosmetics, Disodium edta acts as a sequestering agent.

Disodium edta acts as a corrosion inhibitor to carbon steel in the industries.
Disodium edta also acts as a food additive.
Disodium edta has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten.
Disodium edta has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Chelator of divalent cations.
Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Pharmaceutical Applications
Disodium edta is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparations, typically at concentrations between 0.005 and 0.1% w/v.
Disodium edta forms stable water-soluble complexes (chelates) with alkaline earth and heavy-metal ions.
The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as ‘removing’ ions from solution, a process known as sequestering.
The stability of the metal–edetate complex is dependent on the metal ion involved and the pH.
Disodium edta is also used as a water softener as it will chelate calcium and magnesium ions present in hard water.
Disodium edta is also used therapeutically as an anticoagulant as it will chelate calcium and prevent the coagulation of blood in vitro.
Concentrations of 0.1% w/v are used in small volumes for hematological testing and 0.3% w/v in transfusions.

Production Methods
Disodium edta may be prepared by the reaction of edetic acid and sodium hydroxide.

Manufacturing Process
10 mols of ethylene diamine as a 30% aqueous solution and 4 mols of solid caustic soda are placed in a steam heated kettle supplied with an agitator.
8 mols of sodium cyanide as a concentrated water solution (about 30%) are added and the solution heated to 60°C.
About a 10 inch vacuum is applied to bring the liquid to incipient boiling.
Formaldehyde (7.5 mols of 37% to 40% aqueous solution) is slowly added, the temperature being held at 60°C, and the solution vigorously stirred.
Then, when the evolution of ammonia has substantially stopped, an additional 8 mols of sodium cyanide, followed by 8 mols of formaldehyde are added as before.

This is continued until 40 mols of cyanide and 40 mols of formaldehyde have been added.
Then at the end about 2 mols more of formaldehyde are added, making 42 mols in all, to remove any last traces of cyanide.
About 8 to 10 hours are required to complete the reaction.
The resulting product, referred to herein as the crude reaction product, is essentially an aqueous solution of the sodium salt of ethylene diamine tetracetic acid.
To 1,000 g of the crude reaction product are added 264 g of ethylene diamine tetracetic acid.
The mixture is preferably heated to incipient boiling to increase the rate of reaction, and then the mixture is allowed to cool and crystallize.

The crystals formed are filtered off, washed with the smallest possible amount of ice water, and dried to a constant weight, which is 452 g.
A representative sample of the product so prepared showed, upon analysis, 13.26% sodium against a theoretical of 13.70% for the disodium salt.
The dialkali salt has a pH of about 5.3 and behaves like a weak acid, displacing CO2 from carbonates and reacting with metals to form hydrogen.
Disodium edta is a white crystalline solid.

Biochem/physiol Actions
Disodium edta has the ability to block the binding of vasoactive intestinal peptide to macrophage membranes.
Disodium edta is mainly used in the purification of protein, to remove divalent cations and also to prevent protease activity.

Synonyms
Edetate disodium
EDTA disodium salt
139-33-3
Disodium edetate
Edta disodium
Sodium versenate
Titriplex III
Disodium EDTA
Chelest B
Komplexon III
Clewat N
Disodium edathamil
Disodium edta, anhydrous
Zonon D
Edetate disodium anhydrous
Dotite 2NA
Selekton B 2
Tetracemate disodium
Cheladrate
Endrate
Mavacid ED 4
Versonol 120
Chelest 200
Disodium versene
Endrate disodium
Disodium salt of EDTA
Metaquest B
Kiresuto B
Veresene disodium salt
Chelaplex III
Diso-Tate
Chelaton III
Versene NA
Triplex III
Chelaton 3
Disodium versenate
Edathamil disodium
Trilon BD
Versene Na2
Disodium edetate dihydrate
Ethylenediaminetetraacetic acid disodium salt
edta, disodium
Disodium sequestrene
Disodium tetracemate
Disodium ethylenediaminetetraacetate
Sequestrene sodium 2
Ethylenediaminetetraacetic acid, disodium salt
Disotate
Disodium EDTA dihydrate
Perma Kleer Di Crystals
CCRIS 3658
E.D.T.A. disodique [French]
Edetic acid disodium salt
F 1 (VAN)
NSC 2760
Anhydrous disodium edetate
EINECS 205-358-3
Disodium ethylenediamine-N,N,N',N'-tetraacetate
Edetate disodium, anhydrous
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt
Edetic Acid, Disodium Salt
Edta disodium salt anhydrous
8NLQ36F6MM
Disodium dihydrate edta
E.D.T.A. disodique
Dinatrium ethylendiamintetraacetat [Czech]
EDTA-Na2
EDTA disodium dihydrate
AI3-18049
Edetate Disodium [USAN:BAN]
Disodium dihydrogen ethylenediaminetetraacetate
Ethylenebis(iminodiacetic acid) disodium salt
CHEBI:64734
Perma kleer 50 crystals disodium salt
UNII-8NLQ36F6MM
Disodium ethylenediaminetetraacetic acid
Ethylene diamine tetraacetic acid, disodium salt
Disodium (ethylenedinitrilo)tetraacetate
(Ethylenedinitrilo)-tetraacetic acid disodium salt
UNII-7FLD91C86K
CBC 50152966
DR-16133
Ethylenediaminetetraacetate, disodium salt
Disodium diacid ethylenediaminetetraacetate
Ethylenediaminetetraacetic acid disoium salt dihydrate
MFCD00070672
Disodium (ethylenedinitrilo)tetraacetic acid
EDTA disodium salt (anhydrous)
Chelest f-na
Dinatrium ethylendiamintetraacetat
HSDB 8013
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt
Disodium dihydrogen(ethylenedinitrilo)tetraacetate
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt
NSC-2760
Endrate (TN)
NSC-759604
6381-92-6
Na2-EDTA
Disodium edetate hydrate
Ins no.386
Edetate disodium dihydrate
Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine)
EC 205-358-3
Ins-386
Disodium (ethylenedinitrilo)tetraacetate dihydrate
Edetate Disodium (anhydrous)
F 1
EDETATE DISODIUM (II)
7FLD91C86K
C10H16N2O8.2Na
disodium 2-({2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate
Disodium dihydrogen ethylenediaminetetraacetate dihydrate
CHEBI:64758
EDETATE DISODIUM (USP-RS)
ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT
C10H14N2Na2O8.2H2O
C10-H16-N2-O8.2Na
ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT, DIHYDRATE
DISODIUM EDETATE (EP IMPURITY)
DISODIUM EDETATE (EP MONOGRAPH)
EDETATE DISODIUM ANHYDROUS (II)
NSC 759604
EDETATE DISODIUM (USP MONOGRAPH)
C10-H14-N2-O8.2Na.2H2-O
E-386
ethylenediamine tetraacetic acid disodium salt
disodium 2-((2-((carboxylatomethyl)(carboxymethyl)amino)ethyl)(carboxymethyl)amino)acetate
Ethylenediaminetetraacetic acid, disodium salt, dihydrate
(ETHYLENEDINITRILO) TETRAACETIC ACID DISODIUM SALT DIHYDRATE
Na2EDTA
Glicina, N,N'-1,2-Etanodiilbis [N-(carboximetil)-, sal de sodio (1:2)
0.5M Sodium EDTA
Disodium edetate (TN)
Na2.EDTA
Glicina, n,n'-1,2-etanodiilbis[n-(carboximetil)-, sal de sodio, hidrato (1:2:2)
GLYCINE, N,N'-1,2-ETHANEDIYLBIS N-(CARBOXYMETHYL)-, DISODIUM SALT, DIHYDRATE
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt, dihydrate
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt, dihydrate
CHEMBL1749
DTXSID9027073
ZGTMUACCHSMWAC-UHFFFAOYSA-L
disodium ethylenediamine-tetraacetate
C10H14N2O8.2H2O.2Na
Edetic Acid, Disodium Salt, Dihydrate
DB14600
LS-2377
SB40706
E386
LS-54439
ethylenediaminetetracetic acid disodium salt
EN300-35828
ethylenediaminetetra-acetic acid disodium salt
D03945
P17519
J-007267
J-521348
Q4532977
disodium 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, sodium salt (1:2)
(Ethylenedinitrilo)tetraacetic acid disodium salt, EDTA disodium salt, EDTA-Na2
disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate
DISODIUM 2-({2-[(CARBOXYLATOMETHYL)(CARBOXYMETHYL)AMINO]ETHYL(CARBOXYMETHYL)AMINO)ACETATE
DISODIUM EDTA
DESCRIPTION:

EDTA (ethylenediaminetetraacetic acid) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in a product.
Disodium EDTA is in many products as a preservative, to stabilise Disodium EDTA, or to enhance the foaming action.
Disodium EDTA is also used as a chelating agent, which means Disodium EDTA us used to precipitate out metals from the formulation (if tap water were used to make the formulation instead purified water, for example, and Disodium EDTA can bind with metals dissolved in your shower water).

CAS number 6381-92-6
European Community (EC) Number: 205-358-3
Form White crystalline solid
Hill Formula C₁₀H₁₄N₂Na₂O₈ • 2H₂O
Chemical formula C₁₀H₁₄N₂Na₂O₈ • 2H₂O


EDTA is insignificantly absorbed through the skin, hardly metabolised and rapidly eliminated.
The safety margin for the use of EDTA in cosmetics is thus 300,000 times higher than the required minimum safety margin.

EDTA and its salts are irritating at high concentration levels, but they are only used at very low concentrations (< 0.5 %) in cosmetic products.
These concentrations are clearly below the irritation threshold.
Furthermore, the skin and eye compatibility of cosmetic products is being evaluated before it is placed on the market.

EDTA is not considered a persistent, bioaccumulative or toxic pollutant.
However, it is poorly biodegradable.
The European Commission considers that the risk linked to heavy metals only exists under particular circumstances, due to the trapping of EDTA/heavy metal complexes in sediments.

A salt of an organic acid (Ethylenediaminetetraacetic Acid, disodium salt) used in aqueous solutions with other reagents and inert materials for the preparation of cleaning mixtures and poultices to be applied to stone surfaces and frescoes.
EDTA disodium salt, for its property of complexing calcium within crusts and for its good solubility (better than tetrasodium salt), is used in the AB 57 poultice (I.C.R. formulation - Rome).
Disodium EDTA is besides a strong chelating agent of a great many metallic cations, as iron and copper; this property can be utilized to remove stains of rust or copper green from stone surfaces, wood, plasters, etc.

EDTA, Disodium Salt, Dihydrate is an extensively used chelator of divalent cations such as Ca2+.
EDTA (Ethylenediaminetetraacetic acid) is a chelating agent, a general chemical, and a sequestrant.
In molecular biology applications, Disodium EDTA is used to minimize metal ion contaminants.

Also, Disodium EDTA can facilitate enzymatic reactions that could be inhibited by heavy metal traces.
On the other hand, Disodium EDTA can inhibit enzymes, such as metalloproteases, that require divalent cations for activity.

EDTA disodium salt Na2H2 - 2H2O (dihydrate).
EDTA disodium salt is mainly used for its ability to bind to metal ions precipitating lead and other metals in solution, often used as a chelating agent in aquaria.
Together with iron sulphate heptahydrateis used to increase the amount of iron in aquariums.


USES OF DISODIUM EDTA:
Disodium EDTA (chemical formula - C10H16N2Na2O8) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in a product.
This white, water-soluble solid is widely used to bind to metal ions like iron and calcium ions and prevent the deterioration of cosmetics and personal care products.
Disodium EDTA thus enhances stability of cosmetics.

Disodium EDTA is widely used and can be found in moisturizers, skincare and cleansing products, personal cleanliness products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other product types.
Disodium EDTA and the related ingredients bind to metal ions which inactivates them.
The binding of metal ions helps prevent the deterioration of cosmetics and personal care products thus enhancing their stability.

Disodium EDTA also helps to maintain clarity, protect fragrance compounds, and prevent rancidity.
Disodium EDTA is used up to 0.85% concentration in leave-on products.
For both skin care and hair care applications, Disodium EDTA prevents metal ions from depositing on the surface.

FUNCTION(S) OF DISODIUM EDTA IN COSMETIC PRODUCTS:
CHELATING:
Binds metal ions which could negatively affect the stability and / or appearance of cosmetics
VISCOSITY CONTROLLING:
Increases or decreases the viscosity of cosmetic products
Origin: synthetic
Disodium EDTA is mainly synthesized from ethylenediamine (1,2-diaminoethane), formaldehyde, and sodium cyanide.
This route yields the tetrasodium EDTA, which is converted in a subsequent step into the acid forms.
Occurrence in cosmetics: Various cosmetics
Occurrence in other products:
Medicinal products and medical devices (such as injection solutions, ointments, tinctures, eye or nose drops), foodstuffs


APPLICATIONS OF DISODIUM EDTA:
Substance manufacture.
Intermediates formulation
Powder formulation, liquid
Adhesives, sealants
Biocidal product
Coatings and paints
Solvents
Paint strippers
Metal surface treatment products, including electroplating and electrolysis products
Photochemical additive
Textile dyes, finishing and impregnating products
Cleaning and washing products






SAFETY INFORMATION ABOUT DISODIUM EDTA:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product



CHEMICAL AND PHYSICAL PROPERTIES OF DISODIUM EDTA:

Molecular Weight: 315.23 g/mol
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 11
Exact Mass 315.08043475 g/mol
Monoisotopic Mass 315.08043475 g/mol
Topological Polar Surface Area 156Ų
Heavy Atom Count 21
Formal Charge 1
Complexity 316
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized: Yes
Physical state: Crystals
Colour: White
Odour: Odourless
pH: 4-6 1% current USP
Melting point/Melting range: 252ºC measured Decomposes
Flammability (solid/gas): No, not expected to form explosive dust/air mixtures.
Vapour pressure: Solubility in water: 10% at 25ºC
Kinematic viscosity: Solid
Explosive properties: Non-explosive
Oxidising properties: No
SPECIFICATIONS OF DISODIUM EDTA:
Purity: min.99.0%
Insolubles: <0.005%
pH(5%,Water)@25°C: 4.0-6.0
Heavy metals(as Pb): <0.005%
Iron: <0.01%
Nitrilotriacetic Acid: <0.1%
RNase, DNase Activity: none detected

Maximum limit of impurities:
Appearance of solution: passes test
Insoluble matter in H2O: 0.01 %
Loss on drying at 150°C 6h: 8.7-11.4 %
Chloride (Cl): 0.02%
Sulfate (SO4): 0.1%
Residual solvents (Ph.Eur/USP): passes test
Nitrilotriacetic Acid [(CH2COOH)3N]: 0.1%
Ca: passes test
Fe: 0.0005 %
STORAGE AND SHIPPING INFORMATION OF DISODIUM EDTA:
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special Instructions Following reconstitution, store at room temperature (20°C). Stock solutions are stable for up to 6 months at 20°C.



SYNONYMS OF DISODIUM EDTA:
Acid, Edetic
Acid, Ethylenediaminetetraacetic
Acid, Ethylenedinitrilotetraacetic
Calcitetracemate, Disodium
Calcium Disodium Edetate
Calcium Disodium Versenate
Calcium Tetacine
Chelaton 3
Chromium EDTA
Copper EDTA
Coprin
Dicobalt EDTA
Dinitrilotetraacetate, Disodium Ethylene
Dinitrilotetraacetate, Ethylene
Disodium Calcitetracemate
Disodium EDTA
Disodium Ethylene Dinitrilotetraacetate
Disodium Versenate, Calcium
Distannous EDTA
Edathamil
Edetate Disodium Calcium
Edetate, Calcium Disodium
Edetates
Edetic Acid
Edetic Acid, Calcium Salt
Edetic Acid, Calcium, Sodium Salt
Edetic Acid, Chromium Salt
Edetic Acid, Dipotassium Salt
Edetic Acid, Disodium Salt
Edetic Acid, Disodium Salt, Dihydrate
Edetic Acid, Disodium, Magnesium Salt
Edetic Acid, Disodium, Monopotassium Salt
Edetic Acid, Magnesium Salt
Edetic Acid, Monopotassium Salt
Edetic Acid, Monosodium Salt
Edetic Acid, Potassium Salt
Edetic Acid, Sodium Salt
EDTA
EDTA, Chromium
EDTA, Copper
EDTA, Dicobalt
EDTA, Disodium
EDTA, Distannous
EDTA, Gallium
EDTA, Magnesium Disodium
EDTA, Potassium
EDTA, Stannous
Ethylene Dinitrilotetraacetate
Ethylene Dinitrilotetraacetate, Disodium
Ethylenediaminetetraacetic Acid
Ethylenedinitrilotetraacetic Acid
Gallium EDTA
Magnesium Disodium EDTA
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine)
Potassium EDTA
Stannous EDTA
Tetacine, Calcium
Tetracemate
Versenate
Versenate, Calcium Disodium
Versene
Cheladrate
Endrate
Edta disodium
Disodium edetate
Disodium versene
Edetate disodium
Endrate disodium
Sodium versenate
Metaquest B
Kiresuto B
Chelaplex III
Diso-Tate
Titriplex III
Chelaton III
Versene NA
Chelaton 3
Disodium EDTA
Triplex III
Disodium versenate
Edathamil disodium
Trilon BD
Versene Na2
Disodium sequestrene
Disodium tetracemate
EDTA disodium salt
Sequestrene sodium 2
Disodium salt of EDTA
Perma Kleer Di Crystals
Edetic acid disodium salt
Versenate
Sequestrene Na2
Trilon B
Selekton B2
Disodium ethylenediaminetetraacetate
Perma kleer 50 crystals disodium salt
Disodium (ethylenedinitrilo)tetraacetate
Disodium ethylenediaminetetraacetic acid
SODIUM ETHYLENEDIAMINETETRAACETATE
CBC 50152966
DR-16133
Ethylenediaminetetraacetate, disodium salt
Disodium diacid ethylenediaminetetraacetate
D'E.d.t.a. disodique
Disodium (ethylenedinitrilo)tetraacetic acid
Ethylenediaminetetraacetic acid disodium salt
Disodium dihydrogen ethylenediaminetetraacetate
Ethylenediaminetetraacetic acid, disodium salt
Disodium dihydrogen(ethylenedinitrilo)tetraacetate
139-33-3
NSC2760
NSC-2760
NSC-759604
6381-92-6
7379-28-4
(Ethylenedinitrilo)tetraacetic acid, disodium salt
Pharmakon1600-01300016
Pharmakon1600-01500270
NSC756746
NSC759604
WLN: QV1N1VQ2N1VQ1VQ &-NA-2
Disodium dihydrogen ethylenediaminetetracetate
Disodium ethylenediamine-N,N',N'-tetraacetate
A886053
(ETHYLENEDINITRILO)TETRAACETIC ACID, DIHYDRATE
Glycine,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt
Glycine, N,N inverted exclamation marka-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:?)
EDTA disodium salt
(Ethylenedinitrilo)tetraacetic acid disodium salt
139-33-3 [RN]
2,2',2'',2'''-(1,2-Éthanediyldinitrilo)tetraacétate de hydrogène et de sodium (1:2:2) [French] [ACD/IUPAC Name]
2,2'-{1,2-Éthanediylbis[(carboxyméthyl)imino]}diacétate de disodium [French] [ACD/IUPAC Name]
2,2'-{éthane-1,2-diylbis[(carboxyméthyl)imino]}diacétate de disodium [French]
Acetate, 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetrakis-, hydrogen sodium salt (1:2:2) [ACD/Index Name]
Acetic acid, (ethylenedinitrilo)tetra-, disodium salt
Chelaplex III [Trade name]
Dinatrium-2,2'-{1,2-ethandiylbis[(carboxymethyl)imino]}diacetat [German] [ACD/IUPAC Name]
Dinatrium-2,2'-{ethan-1,2-diylbis[(carboxymethyl)imino]}diacetat [German]
Disodium 2,2'-{1,2-ethanediylbis[(carboxymethyl)imino]}diacetate [ACD/IUPAC Name]
disodium 2,2'-{ethane-1,2-diylbis[(carboxymethyl)imino]}diacetate
DISODIUM EDTA
Edetate disodium [BAN] [USAN] [USP]
Edetate disodium anhydrous
Edetic acid disodium salt
EDTA disodium
EDTA-Na2
Endrate disodium
ethylenediaminetetraacetic acid disodium
Ethylenediaminetetraacetic acid, disodium salt
MFCD00070672 [MDL number]
Natriumhydrogen-2,2',2'',2'''-(1,2-ethandiyldinitrilo)tetraacetat (2:2:1) [German] [ACD/IUPAC Name]
Sodium hydrogen 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate (2:2:1) [ACD/IUPAC Name]
Sodium N,N'-ethane-1,2-diylbis(N-(carboxymethyl)glycinate)
Tetracemate disodium
Titriplex III [Trade name]
Triplex III [Trade name]
Versene Disodium Salt
(Ethylenedinitrilo)-tetraacetic acid disodium salt
205-358-3 [EINECS]
Cheladrate
Chelaton 3
Chelaton III
Chelest 200
Chelest B
Clewat N
Collyrium Fresh-Eye Drops
Dinatrium ethylendiamintetraacetat [Czech]
Disodium (ethylenedinitrilo)tetraacetate
Disodium (ethylenedinitrilo)tetraacetic acid
DISODIUM 2-({2-[(CARBOXYLATOMETHYL)(CARBOXYMETHYL)AMINO]ETHYL}(CARBOXYMETHYL)AMINO)ACETATE
DISODIUM 2-({2-[BIS(CARBOXYMETHYL)AMINO]ETHYL}(CARBOXYLATOMETHYL)AMINO)ACETATE
disodium 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate
disodium 2,2',2'',2'''-(ethane-1,2-diyldiammonio)tetraacetate
disodium 2-[2-[bis(carboxymethyl)amino]ethyl-(2-oxido-2-oxo-ethyl)amino]acetate
Disodium diacid ethylenediaminetetraacetate
Disodium dihydrogen (ethylenedinitrilo)tetraacetate
Disodium dihydrogen ethylenediaminetetraacetate
disodium dihydrogen ethylenediaminetetraacetic acid
Disodium dihydrogen(ethylenedinitrilo)tetraacetate
Disodium edathamil
DISODIUM EDETATE
Disodium Edetate, Disodium EDTA, Ethylenedinitriletetraacetic Acid Disodium salt, N,N'-1,2-Ethanediyl-bis[N-(Carboxymethyl)Glycine
Disodium ethylenediamine-N,N,N',N'-tetraacetate
disodium ethylene-diamine-tetra-acetate
DISODIUM ETHYLENEDIAMINETETRAACETATE
Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine)
DISODIUM SEQUESTRENE
Disodium tetracemate
Disodium versenate
Disodium versene
Disotate
Diso-Tate
Dotite 2NA
E.D.T.A. disodique [French]
Edathamil disodium
Edetate Disodium (anhydrous)
Edetate Sodium [USAN]
Endrate [Trade name]
Ethylene diamine tetraacetic acid, disodium salt
Ethylenebis(iminodiacetic acid) disodium salt
ethylenebis(iminodiacetic acid) disoidum salt
ethylenediaminetetraacetate disodium
Ethylenediaminetetraacetate, disodium salt
Ethylenediaminetetraacetic acid disodium salt
Ethylenedinitrilotetraacetic acid disodium salt
Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt
IDRANAL® 100
Kiresuto B
Komplexon III
Mavacid ED 4
Metaquest B
MFCD00012470 [MDL number]
MFCD00150037 [MDL number]
N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt
N,N'-1,2-Ethanediylbis[N-(carboxymethyl)glycine] Disodium Salt
N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycine], disodium salt
Na2-EDTA
Na2H2EDTA
Selekton B 2
Selekton B2
Sequestrene sodium 2
Sodium 2,2'-((2-(bis(carboxymethyl)amino)ethyl)azanediyl)diacetate
Sodium edetate
Sodium versenate [Trade name]
Titriplex(R) IIImissing
Trilon B
Trilon BD
Veresene disodium salt
Versene NA
Versene Na2
Versonol 120
Zonon D



DISODIUM HYDROGEN PHOSPHATE HEPTAHYDRATE
DISODIUM HYDROXYETHYLIMINODIACETATE. N° CAS : 135-37-5. Nom INCI : DISODIUM HYDROXYETHYLIMINODIACETATE. Nom chimique : Disodium 2-hydroxyethyliminodi(acetate) N° EINECS/ELINCS : 205-187-4. Classification : Composé éthoxylé. Ses fonctions (INCI).Agent de chélation : Réagit et forme des complexes avec des ions métalliques qui pourraient affecter la stabilité et / ou l'apparence des produits cosmétiques
DISODIUM HYDROGEN PHOSPHATE HEPTAHYDRATE
Disodium hydrogen phosphate heptahydrate is the inorganic compound with the formula Na2HPO4.
Disodium hydrogen phosphate heptahydrate is one of several sodium phosphates.
Disodium hydrogen phosphate heptahydrate is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates.

CAS: 7782-85-6
MF: H6NaO5P
MW: 140.01
EINECS: 616-512-8

All are water-soluble white powders; the anhydrous salt being hygroscopic.
Disodium hydrogen phosphate heptahydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography.
Disodium hydrogen phosphate heptahydrate is highly hygroscopic and water soluble.

Disodium hydrogen phosphate heptahydrate Chemical Properties
Melting point: 48 °C
Density: 1.68 g/mL at 25 °C(lit.)
Vapor density: 4.9 (vs air)
Storage temp.: Store at +5°C to +30°C.
Solubility: 154g/l
Form: Solid
Color: White
Specific Gravity: 1.7
PH Range: 8.7 - 9.3
PH: 8.7-9.3 (25℃, 5% in solution)
Water Solubility: Soluble in water and insoluble in ethanol.
Merck: 14,8659
LogP: -2.148 (est)
CAS DataBase Reference: 7782-85-6(CAS DataBase Reference)
EPA Substance Registry System: Disodium hydrogen phosphate heptahydrate (7782-85-6)

The USP 32 states that Disodium hydrogen phosphate heptahydrate is dried or contains, 1, 2, 7, or 12 molecules of water of hydration.
Anhydrous Disodium hydrogen phosphate heptahydrate occurs as a white powder.
The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air.
The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.

Uses
Disodium hydrogen phosphate heptahydrate is used as precursor in the preparation of cobalt-based molecular catalyst for water oxidation.
Disodium hydrogen phosphate heptahydrate has been used to prepare sodium phosphate buffer and phosphate-buffered saline (PBS) buffer.

Disodium hydrogen phosphate heptahydrate is widely used in detergents and cleaning agents.
Combined with trisodium phosphate, Disodium hydrogen phosphate heptahydrate is employed in the food industry to adjust the pH and in water treatment to prevent calcium scale formation.
Disodium hydrogen phosphate heptahydrate is utilized as a saline laxative to clean the bowel before a colonoscopy.
Disodium hydrogen phosphate heptahydrate prevents the coagulation of condensed milk.
Disodium hydrogen phosphate heptahydrate is also utilized as anti-caking additive in powdered products.
Disodium hydrogen phosphate heptahydrate enhances the cook time and used as thickening agent in desserts and puddings.

Disodium hydrogen phosphate heptahydrate is used in conjunction with trisodium phosphate in foods and water softening treatment.
In foods, Disodium hydrogen phosphate heptahydrate is used to adjust pH.
Disodium hydrogen phosphate heptahydrate's presence prevents coagulation in the preparation of condensed milk.
Similarly, Disodium hydrogen phosphate heptahydrate is used as an anti-caking additive in powdered products.
Disodium hydrogen phosphate heptahydrate is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening.
In water treatment, Disodium hydrogen phosphate heptahydrate retards calcium scale formation.
Disodium hydrogen phosphate heptahydrate is also found in some detergents and cleaning agents.

Heating solid Disodium hydrogen phosphate heptahydrate gives the useful compound tetrasodium pyrophosphate:

2 Na2HPO4 → Na4P2O7 + H2O

Pharmaceutical Applications
Disodium hydrogen phosphate heptahydrate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent.
Therapeutically, Disodium hydrogen phosphate heptahydrate is used as a mild laxative and in the treatment of hypophosphatemia.
Disodium hydrogen phosphate heptahydrate is also used in food products; for example as an emulsifier in processed cheese.

Production Methods
Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with sulfuric acid.
This mixture is then leached with hot water and neutralized with sodium carbonate, and Disodium hydrogen phosphate heptahydrate is crystallized from the filtrate.

Production and reactions
Disodium hydrogen phosphate heptahydrate can be generated by neutralization of phosphoric acid with sodium hydroxide:

H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O
Industrially Disodium hydrogen phosphate heptahydrate is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:

CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4
In the second step, the resulting solution of monosodium phosphate is partially neutralized:

NaH2PO4 + NaOH → Na2HPO4 + H2O

Synonyms
7782-85-6
Sodium phosphate dibasic heptahydrate
Sodium phosphate, dibasic, heptahydrate
Disodium phosphate heptahydrate
disodium;hydrogen phosphate;heptahydrate
UNII-70WT22SF4B
70WT22SF4B
Phosphoric acid, disodium salt, heptahydrate
Sodium hydrogen phosphate heptahydrate
Sodium phosphate, diabasic, heptahydrate
MFCD00149180
disodium hydrogenphosphate heptahydrate
HO4P.2Na.7H2O
Sodiumphosphatedibasicheptahydrate
H-O4-P.2Na.7H2-O
DTXSID10872533
heptahydratedibasicsodium phosphate
NATRUM PHOSPHORICUM [HPUS]
sodium hydrogenphosphate heptahydrate
DIBASIC SODIUM PHOSPHATE HEPTAHYDRATE
FT-0625319
SODIUM PHOSPHATE DIBASIC (HEPTAHYDRATE)
Sodium phosphate dibasic heptahydrate ACS grade
Sodium phosphate dibasic heptahydrate USP grade
Sodium monohydrogen phosphate heptahydrate (2:1:7)
SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE [II]
SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE [MI]
SODIUM PHOSPHATE,DIBASIC,HEPTAHYDRATE [VANDF]
Q27265904
SODIUM PHOSPHATE DIBASIC (HEPTAHYDRATE) [WHO-DD]
Sodium phosphate dibasic heptahydrate, Trace metals grade
SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE [ORANGE BOOK]
DISODIUM INOSINATE
Disodium inosinate is a colorless to white crystal or crystalline powder with a characteristic taste.
Disodium inosinate (E631) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P.
Disodium inosinate is also soluble in organic solvents like ethanol and insoluble in ether.

CAS Number: 4691-65-0
Molecular Formula: C10H14N4NaO8P
Molecular Weight: 372.21
EINECS Number: 225-146-4

Disodium inosinate contains approximately 7.5 molecules of water of crystallization.
Disodium inosinate is odorless and has characteristic taste.
For other details of description, see Disodium inosinate.

Disodium inosinate is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.
Commercial disodium inosinate may either be obtained from bacterial fermentation of sugars or prepared from animal products.
The Vegetarian Society reports that production from meat or fish is more widespread, but the Vegetarian Resource Group reports that all three "leading manufacturers" claim to use fermentation.

Disodium inosinate is provided as delivered and specified.
All information provided in support of this product, including SDS and any product nformation leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
Disodium inosinate is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P.

However, the stability of Disodium inosinate is very high as it remains absolutely stable at 100 °C.
Until the temperature is around 230 °C, Disodium Inosinate will not decompose.
Disodium inosinate (E631), chemical formula C10H11N2Na2O8P, is the disodium salt of inosinic acid.

Disodium Inosinate is a food additive often found in instant noodles, potato chips, and a variety of other snacks.
Disodium Inosinate is used as a flavor enhancer, in synergy with monosodium glutamate to provide the umami taste.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Disodium inosinate is the disodium salt of inosinic acid which belongs to the group of purine-5′-nucleotides.
Disodium inosinate is generally used as a taste and flavor enhancer in foods to provide umami taste.
As Disodium Inosinate is a fairly expensive additive, it is not used independently of lutamic acid; if disodium inosinate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient.

Disodium Inosinate is often added to foods in conjunction with disodium guanylate; the combination is known as disodium Disodium Inosinate.
Disodium Inosinate is a chemical compound that is added to foods as a flavor enhancer, to improve the taste of foods.
Disodium inosinate Flavor Enhancer is soluble in water while slightly soluble in alcohol.

Flavor Enhancer Disodium inosinate is often added to foods in conjunction with E627 Flavour Enhancer and the combination is known as disodium ribonucleotides (I+G).
Disodium inosinate Halal Food Additive is widely used in instant noodles, potato chips and other snacks, savory rice, tinned vegetables, cured meats and packaged soup.
Sinofi is a reliable Disodium Inosinate supplier and manufacturer in China.

Disodium inosinate (IMP), a kind of nucleotide, also known as Disodium inosinate, is a flavor enhancer with the European food additive number E631.
Its purpose in food is to add a meaty or savory flavor, which is called umami taste.
IMP is a white granular or powder commonly combined with another flavour enhancer disodium guanylate (GMP) as disodium 5′-ribonucleotides (E635) or with monosodium glutamate (MSG).

Disodium inosinate is a food additive with the E number E631.
Disodium inosinate is a salt of inosinic acid, a naturally occurring nucleoside found in various foods, especially in meat and fish.
Disodium inosinate is primarily used as a flavor enhancer in the food industry, and it is often used in combination with another flavor enhancer, monosodium glutamate (MSG), represented as E621.

Disodium inosinate is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.
Although Disodium inosinate can be obtained from bacterial fermentation of sugars, Disodium inosinate is often commercially prepared from animal products.
Disodium inosinate is generally produced from meat, including chicken.

Though Disodium inosinate is normally a non-vegetarian product, Disodium inosinate also may be produced from tapioca starch without any animal products involved in the production.
The producer can provide information on the origin and Disodium inosinate is in some cases labeled as "vegetarian" in ingredients lists when produced from plant sources.
Disodium inosinate is a flavor enhancer with the European food additive number E631.

Disodium inosinates purpose in food is to add a meaty or savory flavor, which is called umami taste.
Disodium Inosinate is a white granular or powder commonly combined with another flavour enhancer disodium guanylate (GMP) as Disodium inosinate or with monosodium glutamate (MSG).
Disodium Inosinate is one of the most used food enhancers that you’ll find in a great variety of grocery products.

Usually, Disodium inosinate’s combined with other flavor enhancers like monosodium glutamate.
Disodium inosinate -E631- is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P.
Disodium inosinate is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Although it can be obtained from bacterial fermentation of sugars, it is often commercially prepared from animal sources.
Disodium inosinate is the disodium salt of inosinic acid, which works as a food enhancer.
The taste Disodium Inosinate in food generates is kind of meaty and savory, which is also known as umami taste.

Usually, foods containing this flavor are irresistibly tasty and addictive.
Flavour enhancer As it is a fairly expensive additive, it usually is not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.
Disodium inosinate is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.; Disodium inosinate (E631), chemical formula C10H11N2Na2O8P, is the disodium salt of inosinic acid.

Disodium inosinate is a food additive often found in instant noodles, potato chips, and a variety of other snacks.
Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (also known as MSG; the sodium salt of glutamic acid) to provide the umami taste.
Disodium inosinate is mainly found in animals like pigs and fish.

Disodium inosinates are some other names of this food flavor.
Disodium inosinate is one of the majorly used food flavors in fast foods, processed foods.
The CAS number of Disodium inosinate is 4691-65-0 and the molecular weight is 392.17(anhydrous).

Disodium Inosinate can be made by two methods.
Disodium inosinate can be produced from bacterial fermentation of sugar or carbon source.
Also, Disodium inosinate can be produced by the degradation of nucleotides into nucleic acid from yeast extract (Learn yeast’s vegan status with this article).

Disodium inosinate is an expensive product and mostly combined with other enhancers like monosodium glutamate (MSG) and disodium guanylate (GMP).
When Disodium inosinate is combined with GMP, Disodium inosinate is named as disodium 5′-ribonucleotides or E635.
If Disodium inosinate is not listed in the label of a product while Disodium Inosinate is listed, it is possible that glutamic acid is combined or it naturally occurs from the food ingredients like tomatoes, parmesan cheese, or yeast extract.

Disodium Inosinate appears as a white granular or powder.
Disodium inosinate is odorless and soluble in water.
Disodium inosinate or IMP (E631) is a flavor enhancer and the disodium salt of inosinic acid.

Disodium inosinate also goes by other names such Disodium inosine-5′-monophosphate, Disodium 5′-inosinate, and 5′-inosinic acid.
Like other flavor enhancers, IMP has no particular taste on its own, but has the ability to enhance existing flavors in food.
Disodium inosinate appears as white or colorless granular powder.

Disodium inosinate is soluble in water, but sparingly soluble in ethanol.
Disodium inosinates pH level is between 7.0 and 8.5. It is highly stable 212°F (100°C) and will not decompose until the temperature reaches 446°F (230°C).
IMP imparts meaty, and savory or umami taste in food products such as instant noodles (seasoning), potato chips, canned soups, condiments, and snacks.

Disodium inosinate is seldomly used alone as a food enhancer. But is often added in synergy with other flavor enhancers such as disodium guanylate (GMP) and monosodium glutamate (MSG).
One reason is that disodium inosinate is a relatively expensive ingredient.

Another is that its flavor enhancing flavor is 50% of than of GMP.
However, the most important reason is how the combination makes foods taste much better than that with MSG and/or GMP alone.

Melting point: 175 °C
FEMA: 3669 | DISODIUM 5-INOSINATE
storage temp.: 2-8°C
form: Crystalline Powder
color: White
Odor: odorless
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -1.02
CAS DataBase Reference: 4691-65-0(CAS DataBase Reference)
FDA 21 CFR: 172.535; 155.120; 155.130; 155.170
Substances Added to Food (formerly EAFUS): DISODIUM INOSINATE
EWG's Food Scores: 1

Disodium inosinate, when used in combination with other flavor enhancers such as monosodium glutamate (MSG) and disodium guanylate (E627), can create a synergistic effect known as the "umami synergy."
This synergy enhances and amplifies the umami taste in foods, making them more savory and appealing.
Disodium inosinate is commonly used in processed and convenience foods, including canned soups, instant noodles, potato chips, savory snacks, frozen meals, and ready-to-eat products.

Disodium inosinate is particularly prevalent in products where intense umami flavor is desired.
In vegetarian and vegan food products that aim to replicate the taste of meat or fish, disodium inosinate is sometimes used to enhance the savory and umami notes, making these plant-based alternatives more appealing to consumers.
The use of disodium inosinate is subject to regulations and safety assessments by food safety authorities in various countries.

Disodium inosinate is essential for food manufacturers to comply with these regulations and adhere to specific usage limits.
Some consumers and food manufacturers are moving toward cleaner label products, which may involve using natural sources of umami flavor rather than synthetic additives like disodium inosinate.
For this reason, some products highlight their use of natural umami sources to cater to consumer preferences.

While disodium inosinate is considered safe for most people, some individuals may experience sensitivity or allergic reactions to food additives.
In response to increasing consumer interest in food additives and ingredient transparency, food manufacturers often provide information about the use of disodium inosinate on product labels.
This allows consumers to make informed choices.

Inosinate is naturally found in meat and fish at levels of 80–800 mg/100 g.
Disodium inosinate can also be made by fermentation of sugars such as tapioca starch.
Some sources claim that industrial levels of production are achieved by extraction from animal products, making E631 non-vegetarian.

However, an interview by the Vegetarian Resource Group reports that all three "leading manufacturers" (one being Ajinomoto) claims to use an all-vegetarian fermentation process.
Producers are generally open to providing information on the origin.
Disodium inosinate is in some cases labeled as "vegetarian" in ingredients lists when produced from plant sources.

Disodium inosinate is often used in combination with monosodium glutamate (MSG) because they have a synergistic effect.
When used together, they enhance and intensify the savory or umami taste of foods more effectively than when used individually.
While disodium inosinate can be synthesized, it can also be derived from natural sources.

Disodium inosinate , the precursor of disodium inosinate, is naturally present in foods like meat, fish, and certain vegetables.
When extracted from natural sources, it is considered a more "clean label" ingredient.
The use of disodium inosinate is regulated by food safety authorities in various countries.

Disodium inosinate is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA) and has received approval from other regulatory bodies worldwide.
Disodium inosinate is subject to specific usage limits in food products.
Disodium inosinate is valued in the food industry for its ability to enhance the overall flavor of a wide range of processed foods, including soups, broths, snack foods, sauces, and ready-to-eat meals.

Some individuals following vegetarian or vegan diets may want to be cautious about products containing disodium inosinate, as it can sometimes be sourced from animal products.
However, many manufacturers use plant-based sources for disodium inosinate to cater to a broader consumer base.

Transparency and provide consumers with information about food additives, disodium inosinate is required to be listed on ingredient labels.
Disodium inosinate may be listed as "disodium inosinate" or by its E number, E631.

Uses:
Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste.
Disodium inosinate is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5′-ribonucleotides.
As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese, or yeast extract.

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste.
Disodium Inosinate is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5′-ribonucleotides.
Disodium inosinate can be added to salad dressings and condiments to intensify the umami flavor and improve the taste of these products.

In dips and salsas, disodium inosinate is used to enhance the overall flavor and make them more enjoyable when used as a snack or accompaniment.
Disodium inosinate is sometimes used in Asian cuisine, including sushi and various Japanese dishes, to boost the umami flavor of broths, soy-based sauces, and other components of these dishes.
Disodium inosinate can be used in the production of flavor concentrates and seasonings that are later added to processed foods.

In frozen seafood products, disodium inosinate is used to improve the flavor of items like fish fillets and seafood-based ready meals.
Disodium inosinate is often included in instant gravy mixes to create a more robust and savory gravy with enhanced umami notes.
In addition to instant noodles, disodium inosinate is used in the seasoning packets that accompany various types of noodles.

Some meat marinades and flavor injections for poultry or meat products use disodium inosinate to enhance the savory taste.
Disodium inosinate is sometimes used in flavored rice dishes, like risotto or pilaf, to elevate the umami flavor and improve the overall taste.
Manufacturers of ready-to-use spice blends and rubs may incorporate disodium inosinate to create more flavorful and aromatic products.

Bouillon cubes, which are used for making broths and stocks, can contain disodium inosinate to intensify the taste.
In rare cases, disodium inosinate might be used in savory baked goods, such as bread or crackers, to enhance their flavor.
As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese, or yeast extract.

Disodium inosinate is a flavor enhancer that can be used in many processed foods.
Disodium Inosinates flavor enhancing power is around 50% of disodium guanylate.
Commonly used together with MSG or disodium guanylate in seasoning, condiments and salt substitutes for soups, sauces and snack foods but seldom used alone in food.

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate.
Disodium inosinate is generally produced from meat, including fish and pigs.
Though Disodium Inosinate is normally a non-vegetarian product, it also may be produced from tapioca starch without any animal products involved in the production.

Disodium inosinate may be used as a pharmaceutical reference standard for the determination of the analyte in raw materials and food products by spectrophotometry, and chromatography.
These Secondary Standards are qualified as Certified Reference Materials.
These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Disodium inosinate is commonly used in savory snacks like potato chips, pretzels, and other snack foods to enhance their flavor, making them more appealing to consumers.
Disodium inosinate is a common ingredient in instant noodle products, helping to create a richer and more satisfying broth or sauce.
In processed soups, broths, and bouillons, disodium inosinate is added to amplify the savory and umami taste of the final product.

Many ready-to-eat or microwaveable meals contain disodium inosinate to improve their taste and appeal.
This is especially important in products with meat or savory profiles.
In various sauces and gravies, disodium inosinate is used to enhance the overall flavor, making them more delicious and restaurant-quality.

Disodium inosinate can be included in spice blends and seasonings to intensify the umami aspect of the seasoning and enhance the overall taste of dishes.
Disodium inosinate is used in vegetarian and vegan meat alternatives to create a more convincing savory taste, as it mimics the umami flavor naturally found in animal products.
In canned or processed meat products, Disodium inosinate is used to elevate the umami flavor and improve the overall taste.

Various flavored snack products, such as seasoned popcorn and puffed snacks, may contain disodium inosinate to make the flavor more robust and appealing.
Many frozen foods, including frozen pizzas and entrées, use disodium inosinate to enhance the overall flavor experience.
In general, disodium inosinate is used in a wide range of convenience foods to make them more flavorful and satisfying to consumers.

Toxicology and safety:
Some individuals may have sensitivities or allergies to food additives, including disodium inosinate.
Disodium inosinate is often used in combination with monosodium glutamate (MSG) and disodium guanylate (E627), and this combination can enhance umami flavor.
Some people may experience symptoms such as headaches or "Chinese restaurant syndrome" when consuming foods with these additives, though scientific evidence on this is mixed, and most people do not experience such reactions.

Food manufacturers are required to use disodium inosinate within established safety limits and comply with regulations set by food safety authorities in various countries.
Disodium inosinate is important to ensure that products containing E631 adhere to these regulations.
In the United States, consumption of added 5′-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines.

A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.
In 2004, disodium inosinate was proposed to be removed from the food additive list by Codex Alimentarius Commission.
This change did not go through: it is still present in the 2009 Codex Allimentarius list.

Synonyms:
Disodium 5'-inosinate
4691-65-0
Disodium inosinate
Sodium inosinate
5'-Imp disodium salt
IMP disodium salt
5'-INOSINIC ACID, DISODIUM SALT
FEMA No. 3669
Inosine 5'-monophosphate disodium salt
Disodium inosine-5'-monophosphate
Inosine 5'-monophosphate disodium
Inosine-5'-monophosphate disodium
Sodium 5'-inosinate
5'-IMPdisodium salt
T2ZYA7KC05
5'-Inosinic acid, sodium salt (1:2)
IMP sodium salt
Inosine-5'-monophosphoric acid disodium salt
disodium;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate
Sodium Inosine 5'-Phosphate (2:1)
Disodium inosine 5'-monophosphate
Ribotide
Disodium inosine 5'-phosphate
Inosine 5'-monophosphate, disodium salt
5'-Inosinic Acid Disodium Salt
sodium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl phosphate
CCRIS 6560
Inosin-5'-monophosphate disodium
EINECS 225-146-4
NSC 20263
Inosic Acid Disodium Salt
UNII-T2ZYA7KC05
5'-IMP 2Na
Disodium 5-Inosinate
Inosine-5'-monophosphate sodium salt
NSC-20263
inosine 5'-monophosphoric acid disodium salt
Inosine monophosphate disodium
SCHEMBL316941
INS NO.631
DISODIUM INOSINATE [FCC]
DTXSID4044242
DISODIUM INOSINATE [INCI]
INS-631
AANLCWYVVNBGEE-IDIVVRGQSA-L
CHEBI:184785
DISODIUM INOSINATE [MART.]
DISODIUM INOSINATE [USP-RS]
DISODIUM INOSINATE [WHO-DD]
Inosine-5'-monophosphateDisodiumSalt
AKOS015896269
AKOS015918501
AKOS024282555
DISODIUM 5'-INOSINATE [FHFI]
CCG-268550
E 631 (FOOD ENHANCEMENT AGENT)
Inosine monophosphate disodium [WHO-DD]
[(3S,2R,4R,5R)-3,4-dihydroxy-5-(6-oxohydropurin-9-yl)oxolan-2-yl]methyl dihydr ogen phosphate, sodium salt, sodium salt
AS-57564
E 631
E-631
I0036
Q905782
14999-51-0
disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methyl phosphate
sodium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-2-yl)methyl phosphate
DISODIUM LAURETH SULFOSUCCINATE
Disodium laureth sulfosuccinate is a cleansing agent found in products such as face wash, bubble bath, and shampoo, as well as other personal care products.
Disodium laureth sulfosuccinate can help boost the foaming properties of such formulas plus enhance the water solubility of other surfactants.
Suppliers of Disodium laureth sulfosuccinate note its gentleness on skin.

CAS: 40754-59-4
MF: C22H43NaO10S
MW: 522.63
EINECS: 255-062-3

Synonyms
2-(Sodiooxysulfonyl)-4-(3,6,9-trioxahenicosane-1-yloxy)-4-oxobutanoic acid sodium salt;2-(Sodiosulfo)butanedioic acid 1-sodium 4-[2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl] ester salt;2-(Sodiosulfo)butanedioic acid 4-[2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl]1-sodium salt;Einecs 255-062-3;Sulfobutanedioic acid, 4-(2-(2-(2-(dodecyloxy)ethoxy)ethoxy)ethyl) ester, disodium salt;disodium 4-(2-(2-(2-(dodecyloxy)ethoxy)ethoxy)ethyl) 2-sulphonatosuccinate;DISODIUM LAURETH SULFOSUCCINATE;JACS-40754-59-4

Disodium laureth sulfosuccinate can be sourced naturally (plant derived) or synthetically (lab created).
Disodium laureth sulfosuccinate is described as a clear, colorless to slightly yellowish liquid in raw material form.
Technically speaking, Disodium laureth sulfosuccinate is the disodium salt of an ethoxylated lauryl alcohol half ester of sulfosuccinic acid.
Disodium laureth sulfosuccinate is a cleansing agent or a surfactant commonly found in shampoos and hair cleansing formulas.
Disodium laureth sulfosuccinate is a mild, anionic, and non-irritating surfactant but has great foaming properties.
Disodium laureth sulfosuccinate has been recommended for use in gentle cleansers and for babies or sensitive skin.

Disodium laureth sulfosuccinate is a compound in which the sulfate ion has been replaced by a sulfonated ester, thus providing a safe, effective, and non-irritating cleanser.
As opposed to sulfates which are small molecules, Disodium laureth sulfosuccinate is a large molecule that cannot penetrate into the scalp or skin.
Disodium laureth sulfosuccinate is found in low concentrations in toothpaste, shampoos, shaving creams, and bubble bath formulations for its foaming and surfactant properties and for its thickening ability.
In shampoos, Disodium laureth sulfosuccinate provides mild cleansing and rich lathering properties, without stripping the moisture from the hair.
Disodium laureth sulfosuccinate should not exceed the concentration of 1% in products intended for prolonged skin contact.
Disodium laureth sulfosuccinate is a sodium salt of the sulfosuccinic acid that is used as a foaming agent and cleanser.
Disodium laureth sulfosuccinate can be found in many household products, such as shampoos, detergents, and toothpaste.
Disodium laureth sulfosuccinate is also used to cleanse wounds, ulcers, and burns.
Disodium laureth sulfosuccinate has been shown to be effective in treating alopecia areata by inhibiting the growth of cells responsible for hair follicle destruction.

Disodium Laureth Sulfosuccinate is a cleansing chemical which is also known as a surfactant.
However, Disodium laureth sulfosuccinate is not considered to be a sulfate.
Disodium laureth sulfosuccinate is a usual chemical found in some ‘greener’ or more natural formulas which is used to replace the harsher sulfates owning to its non-irritating yet effective characteristics.
Disodium Laureth Sulfosuccinate can be found in many shampoo and cleansing formulas and it is utilized for its degreasing, foaming, and emulsifying benefits.
Disodium laureth sulfosuccinate is considered to be extremely gentle to the skin and hair even at higher concentrations.

Disodium Laureth Sulfosuccinate has excellent washing, emulsifying, dispersing, wetting and solubilizing abilities;
At the same time, Disodium laureth sulfosuccinate has relatively very low irritation, good compatibility and is able to significantly control the irritation of other surfactants;
The foam formed by Disodium Laureth Sulfosuccinate is fine and stable; low surface tension and excellent calcium soap dispersion;
What is more, Disodium Laureth Sulfosuccinate has excellent anti-hard water performance, low degreasing power, moderate detergency, easy to rinse and no slippery feeling.

Disodium laureth sulfosuccinate Chemical Properties
Boiling point: 100℃[at 101 325 Pa]
Density: 1.165[at 20℃]
Vapor pressure: 0Pa at 25℃
Water Solubility: 120.9μg/L at 25℃
LogP: 3.66
CAS DataBase Reference: 40754-59-4

1. Enhance the attached components in shampoo, and reduction the hair fading rate
2. Extremely mild to skin and hair.
Low irritation, and reduce the irritation of other surfactants.
3. Good ability of dispersing calcium soap and anti-hard water.
4.Be compatible with wide range ofsurfactants and plant extracts (such as gleditsia), and easy to form a very stable system
5. Easy to rinse, and reduce the smoothness of detergent.

Uses
Disodium laureth sulfosuccinate is a very mild surfactant, appropriate for baby and child care products.
Disodium laureth sulfosuccinate reduces the irritation properties of high-foaming surfactants when used in the same product formulation.
Disodium Laureth Sulfosuccinate or DLS is a cleansing ingredient that’s used to help improve the cleansing abilities of our products.
Disodium laureth sulfosuccinate's non harsh approach to cleansing is a 180° difference to other cleansing ingredients, like sulfates.
But Disodium laureth sulfosuccinate's ability to be mild but effective is why we use it.
Disodium laureth sulfosuccinate is not a sulfate, while the name may seem similar to sulfates, it’s not.
Names can be deceiving.

Disodium laureth sulfosuccinate is quite gentle to skin.
Even of high consistence, Disodium laureth sulfosuccinate still remains low irritation.
Disodium laureth sulfosuccinate also has good cleaning ability, resistance to hard water, medium foaming ability, easiness of rinsing, good smoothness and biodegradation.
Meanwhile, Disodium laureth sulfosuccinate owns perfect solubilising and viscosity adjusting functions.
In liquid washing products, Disodium laureth sulfosuccinate will reduce the irritation of other anionic surfactants.
With medium cleaning ability and weak degreasing force, Disodium laureth sulfosuccinate is applicable in shampoo, bubble bath, facial cleanser, hand cleaner, dishware detergent, and detergent of down clothes.
Disodium laureth sulfosuccinate is especially suitable for confection of baby washing products of low irritation.
Disodium laureth sulfosuccinate can also be used as industrial liquid detergent.
DISODIUM LAURETH SULFOSUCCINATE (DLS)
Disodium laureth sulfosuccinate (DLS) is a cleansing ingredient that is used to help improve the cleansing abilities of skincare products.
Disodium laureth sulfosuccinate (DLS) is generally considered to be less harsh than other cleansing ingredients such as sulfates.
Disodium laureth sulfosuccinate (DLS) is a common ingredient in shampoos, cleansers, and body washes.

CAS: 39354-45-5
MF: C16H28Na2O7S
MW: 410.43

Disodium laureth sulfosuccinate (DLS) is mainly due to its ability to lift oils and dirt from the skin, allowing them to be easily rinsed away.
Disodium laureth sulfosuccinate (DLS) also helps to improve the foaming of the product and helps to stabilize the product.
Disodium laureth sulfosuccinate (DLS) is a surfactant.
Surfactants lower the surface tension between two liquids or solids.
Disodium laureth sulfosuccinate (DLS) allows for oils and dirt to be lifted from the skin and be easily washed away from the skin.
This is why Disodium laureth sulfosuccinate (DLS) is primarily used in cleansers, soaps, bubble bath products, shampoos, and shaving creams.

Disodium laureth sulfosuccinate (DLS) is considered to be gentler on the skin.
Disodium laureth sulfosuccinate (DLS) is due to the molecule size, other surfactants have smaller molecule sizes while DLS has a larger molecule size comparatively.
This means that Disodium laureth sulfosuccinate (DLS) doesn’t readily penetrate the skin where it is likely to cause irritation.
Disodium laureth sulfosuccinate (DLS) also is a negatively charged molecule, contributing to its milder nature.
Disodium laureth sulfosuccinate (DLS) is a sodium salt of the sulfosuccinic acid that is used as a foaming agent and cleanser.

Disodium laureth sulfosuccinate (DLS) can be found in many household products, such as shampoos, detergents, and toothpaste.
Disodium laureth sulfosuccinate (DLS) is also used to cleanse wounds, ulcers, and burns.
Disodium laureth sulfosuccinate (DLS) has been shown to be effective in treating alopecia areata by inhibiting the growth of cells responsible for hair follicle destruction.
Disodium laureth sulfosuccinate (DLS) is synthesized by treating lauryl alcohol with sulfur trioxide gas, oleum, or chlorosulfuric acid to produce hydrogen lauryl sulfate.
The resulting product is then neutralized by the addition of sodium hydroxide or sodium carbonate.

Disodium laureth sulfosuccinate (DLS) Chemical Properties
Melting Point: N/A
Boiling Point: °Cat760mmHg
Flash Point: °C
Appearance: /Density: g/cm3
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Disodium laureth sulfosuccinate (DLS) (CAS DataBase Reference)
NIST Chemistry Reference: Disodium laureth sulfosuccinate (DLS) (39354-45-5)
EPA Substance Registry System: Disodium laureth sulfosuccinate (DLS)(39354-45-5)

Use
Disodium laureth sulfosuccinate (DLS) is found in low concentrations in toothpaste, shampoos, shaving creams, and bubble bath formulations for its foaming and surfactant properties and for its thickening ability.
In shampoos, Disodium laureth sulfosuccinate (DLS) provides mild cleansing and rich lathering properties, without stripping the moisture from the hair.
Disodium laureth sulfosuccinate (DLS) should not exceed the concentration of 1% in products intended for prolonged skin contact.

Disodium laureth sulfosuccinate (DLS) is an important ingredient added to cosmetic formulations, which improves the clarity of a product and helps dissolve other components in the cosmetic.
Disodium laureth sulfosuccinate (DLS) has very good foaming properties: it helps generate good quality stable foams in a mixture with non-ionic surfactants.
Thus the cosmetic products that contain Disodium laureth sulfosuccinate (DLS) are mostly dedicated for washing and/or cleaning applications.
Disodium laureth sulfosuccinate (DLS) features very good skin and hair degreasing properties.
Disodium laureth sulfosuccinate (DLS) is a detergent used in the production of face, body and hair wash preparations.
You can find Disodium laureth sulfosuccinate (DLS) in rinse-off cosmetics such as shampoos, shower gels or hand soaps.

Moreover, Disodium laureth sulfosuccinate (DLS) is used as an ingredient in hair care products including sprays or tints.
Disodium laureth sulfosuccinate (DLS) is suitable for use in cosmetic formulations for the care of sensitive skin; its molecules are large enough to prevent the surfactant from penetrating the skin.
In addition, Disodium laureth sulfosuccinate (DLS) is capable of reducing the irritating effects of SLES.
Note that Disodium laureth sulfosuccinate (DLS) may be an ingredient of both preparations that contain SLES and those that are SLES free.

Disodium laureth sulfosuccinate (DLS) can be widely used in shampoo, bubble bath, facial cleaner, hand washing, dishware detergent.
Disodium laureth sulfosuccinate (DLS) is especially suitable for confection of baby washing products of low irritation.
In addition, owning to Disodium laureth sulfosuccinate (DLS)'s good lubrication and resistance to hard water, and excellent solubilising performance.
Disodium laureth sulfosuccinate (DLS) can also be used as industrial liquid detergent.
The recommended dosage is: 0.5%~20%

The Disodium laureth sulfosuccinate (DLS) is a top choice for making any number of products where a natural focus is desired.
Disodium Laureth Sulfosuccinate, also known as DLS, or DLS mild, is the perfect choice for making non irritating natural products - from ultra mild shampoos, products for sensitive skin, baby products, facial products and so many other gentle and natural hair care and skin care products.
Since the Disodium laureth sulfosuccinate (DLS) is non-irritating and doesn't strip hair or skin of their natural oils, and cleans effectively, the skin and hair are left feeling soft and conditioned after rinse off of the formulated product.

Characteristics
1. Delicate white paste in room temperature, when heated to (70C) and become transparent liquid
2. Rich and fine foam, easy to wash and no creamy feeling
3. Excellent cleaning ability, Low degreasing ability and mild to skin..
4. Be compatible with other surfactant, and reduce irritation of other surfactants.
5. Excellent anti-hard water and biodegradable ability, High cost performance

Synonyms
39354-45-5
94108-10-8
Disodium 4-(2-(dodecyloxy)ethyl) 2-sulphonatosuccinate
EINECS 302-348-1
alt(70%)
SCHEMBL674038
4-(2-dodecoxyethoxy)-4-oxo-2-sulfonatobutanoate Disodium
DTXSID20873839
DISODIUM 4-[2-(DODECYLOXY)ETHOXY]-4-OXO-2-SULFONATOBUTANOATE
2-(Sodiooxysulfonyl)butanedioic acid 1-sodium 4-[2-(dodecyloxy)ethyl] ester salt
DNS-330
DISODIUM LAURYL SULFOSUCCINATE
DISODIUM 4-LAURETH SULFOSUCCINATE
Lauryl sulfosuccinate disodium salt
LAURETH SULFOSUCCINATE DISODIUM SALT
Dodecyl sulfosuccinate, disodium salt
LAURYL ETHER SULFOSUCCINATE DISODIUM SALT
DODECYL ETHER SULFOSUCCINATE DISODIUM SALT
SULPHOSUCCINICACID4-ESTERWITHPOLYETHYLENEGLYCOLDODEC
SULPHOSUCCINICACID4-ESTERWITHPOLYETHYLENEGLYCOLDODEC.
Poly(oxy-1,2-ethanediyl), .alpha.-(3-carboxy-1-oxo-3-sulfopropyl)-.omega.-(dodecyloxy)-, disodium salt
DISODIUM LAURETH SULFOSUCCINATE DLS
DESCRIPTION:
Disodium laureth sulfosuccinate (DLS) is a cleansing agent or a surfactant commonly found in shampoos and hair cleansing formulas.
Disodium laureth sulfosuccinate (DLS) is a mild, anionic, and non-irritating surfactant but has great foaming properties.
Disodium laureth sulfosuccinate (DLS) has been recommended for use in gentle cleansers and for babies or sensitive skin.

CAS No.: 19040-44-9
Molecular formula: C12H25OOCCH2CH(SO3Na)COONa


Disodium Laureth Sulfosuccinate (DLS) CAS 36409-57-1 is a cleansing chemical which is also known as a surfactant.
However, Disodium Laureth Sulfosuccinate (DLS) is not considered to be a sulfate.
Disodium Laureth Sulfosuccinate (DLS) is a usual chemical found in some ‘greener’ or more natural formulas which is used to replace the harsher sulfates owning to its non-irritating yet effective characteristics.

Disodium Laureth Sulfosuccinate (DLS) CAS 36409-57-1 can be found in many shampoo and cleansing formulas and it is utilized for its degreasing, foaming, and emulsifying benefits.
Disodium Laureth Sulfosuccinate (DLS) is considered to be extremely gentle to the skin and hair even at higher concentrations.

Disodium Laureth Sulfosuccinate (DLS) CAS 36409-57-1 has excellent washing, emulsifying, dispersing, wetting and solubilizing abilities;

At the same time, Disodium Laureth Sulfosuccinate (DLS) has relatively very low irritation, good compatibility and is able to significantly control the irritation of other surfactants;

The foam formed by Disodium Laureth Sulfosuccinate (DLS) CAS 36409-57-1 is fine and stable; low surface tension and excellent calcium soap dispersion;

What is more, Disodium Laureth Sulfosuccinate (DLS) CAS 36409-57-1 has excellent anti-hard water performance, low degreasing power, moderate detergency, easy to rinse and no slippery feeling.


Disodium laureth sulfosuccinate known as DLS is a very mild cleansing agent and anionic surfactant that is non-irritating, with great foam properties.
Disodium laureth sulfosuccinate is a suitable replacement for sulfate-free formulations.

DLS Mild can be used as the primary or Secondary Surfactant.
Suitable for mild shampoos, body, baby, and facial wash.


Disodium Laureth Sulfosuccinate (DLS) possesses excellent emulsification, dispersion, wetting and solubilizing performance.
Disodium Laureth Sulfosuccinate (DLS) is quite gentle to skin even in high consistence.
Disodium Laureth Sulfosuccinate (DLS) Offers low irritation and markedly reducing the irritation of other surfactants.
Disodium Laureth Sulfosuccinate (DLS) Exhibits medium decontamination and low degreasing power.

Disodium Laureth Sulfosuccinate (DLS) Provides excellent cleaning ability and easy to rinse.
Disodium Laureth Sulfosuccinate (DLS) Has good efficiency of dispersing calcium soap and anti-hard water.

Disodium Laureth Sulfosuccinate (DLS) Enhances the attached components in shampoo, and reducing the hair color fading rate.
Disodium Laureth Sulfosuccinate (DLS) imparts medium foaming property, perfect solubility and viscosity adjusting functions.
Disodium Laureth Sulfosuccinate (DLS) is Used in shampoos, bubble-bath liquid, hand washing, facial cleanser.

Disodium Laureth Sulfosuccinate (DLS), also known as Disodium Lauryl Ether Sulfosuccinate, is an anionic surfactant primarily introduced in 1939.
DLS belongs to a greater group of surfactants called Sulfosuccinates, the sodium salts of alkyl esters of sulfosuccinic acid.

Disodium Laureth Sulfosuccinate is of great interest because of its excellent properties, such as good cleansing, lathering, emulsifying, and biodegradability.
DLS is considered a mild and effective ingredient in cosmetic and hygiene products.
The mildness of this compound makes it a proper choice, even for baby cleansing products.

Today, DLS is used not only in cleansing formulations but also in various industries, including textiles, polymers, paints and coating, leather, printing, and agriculture.


IS DISODIUM LAURETH SULFOSUCCINATE A SULFATE?
No. Disodium laureth sulfosuccinate (DLS) is a compound in which the sulfate ion has been replaced by a sulfonated ester, thus providing a safe, effective, and non-irritating cleanser.
As opposed to sulfates which are small molecules, disodium laureth sulfosuccinate is a large molecule that cannot penetrate into the scalp or skin.


USES OF DISODIUM LAURETH SULFOSUCCINATE (DLS):
Disodium laureth sulfosuccinate is found in low concentrations in toothpaste, shampoos, shaving creams, and bubble bath formulations for its foaming and surfactant properties and for its thickening ability.
In shampoos, Disodium laureth sulfosuccinate (DLS) provides mild cleansing and rich lathering properties, without stripping the moisture from the hair.
Disodium laureth sulfosuccinate (DLS) should not exceed the concentration of 1% in products intended for prolonged skin contact.

Disodium Laureth Sulfosuccinate (DLS) CAS 36409-57-1 is widely used in the preparation of shampoos, facial cleansers, shower gels, hand sanitizers, surgical cleaning agents and other daily cleaning products.
Disodium Laureth Sulfosuccinate (DLS) is also able to be utilzied as an emulsifier in the emulsion polymerization industry, as well.









ORIGIN OF DISODIUM LAURETH SULFOSUCCINATE (DLS):
Disodium laureth sulfosuccinate is synthesized by treating lauryl alcohol with sulfur trioxide gas, oleum, or chlorosulfuric acid to produce hydrogen lauryl sulfate.
The resulting product is then neutralized by the addition of sodium hydroxide or sodium carbonate.


CHEMICAL AND PHYSICAL PROPERTIES OF DISODIUM LAURETH SULFOSUCCINATE DLS:
Melting Point 153-157°C
pH 5.5-6.2 (10% solution in water)
Solubility Slightly soluble in water
Disodium laureth sulfosuccinate
Lauryl sulfosuccinate disodium salt ethoxylated with 3 mol EO, DLS, Butanedioic acid,2-sulfo-, 1-dodecyl ester, sodium salt (1:2)
Formula: C16H28Na2O7S
IUPAC: disodium4-dodecoxy-4-oxo-3-sulfonatobutanoate
INCI: Disodium Laureth Sulfosuccinate
CAS: 39354-45-5
Molar mass: 410.4
Density: 1,10 g/mL 20 °C
Solubility : Miscible in water, mixes well with most polar solvents.


As stated earlier, DLS belongs to Sulfosuccinate monoesters.
These compounds, like other surfactants, contain a hydrophobic head that is derived from a fatty alcohol molecule.
This nonpolar head may be ethoxylated and have several PEG (polyethylene glycol) units, or it can be saturated.

This slight difference in molecular structure may result in different water solubility potentials.
For instance, the ethoxylated compounds are more soluble.
Water solubility is also increased when the structure contains branched chains.

Disodium Laureth Sulfosuccinate (DLS) consists of a twelve-carbon alkyl chain (lauryl), connected to the sulfosuccinate core via a PEG chain.
The average number of ethoxy repeat units (n) in this chain is between 1 and 4 (i.e., Laureth-1 through Laureth-4).




SAFETY INFORMATION ABOUT DISODIUM LAURETH SULFOSUCCINATE DLS:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product









SYNONYMS OF DISODIUM LAURETH SULFOSUCCINATE (DLS):
Disodium Fatty Alcohol Polyoxyethylene Ether Sulfosuccinate
DODECYL ETHER SULFOSUCCINATE DISODIUM SALT;
Butanedioic acid,(dodecyloxy)sulfonyl-,disodium salt;
disodium [(dodecyloxy)sulphonyl]succinate;
Butanedioic acid,sulfo-,4-2-2-2-(dodecyloxy)ethoxyethoxyethyl ester,disodium salt;
DISODIUM LAURYL SULFOSUCCINATE;



DISODIUM LAURIMINODIPROPIONATE

Disodium lauriminodipropionate is a chemical compound used primarily in personal care products and cosmetics.
Disodium lauriminodipropionate is a surfactant, which means it has both hydrophilic (water-attracting) and lipophilic (fat-attracting) properties.
Disodium lauriminodipropionate is often added to cleansing products such as shampoos, body washes, and facial cleansers due to its ability to effectively remove dirt, oil, and other impurities from the skin and hair.

CAS Number: 3655-00-3
EC Number: 222-899-0

Disodium lauriminodipropionate, Lauriminodipropionic Acid Disodium Salt, Lauriminodipropionic Acid Sodium Salt, Sodium Lauriminodipropionate, Disodium Lauroamphoacetate, Disodium Cocoamphodipropionate, Disodium Hydroxyethyliminodipropionate, Disodium Lauroamphodiacetate, Lauramidopropyl Betaine, Disodium Laureth Sulfosuccinate, Sodium Lauroyl Glutamate, Disodium Cocoamphodiacetate, Disodium Lauroamphopropionate, Disodium Lauryl Sulfosuccinate, Disodium Lauroamphoglycinate, Disodium Lauroamphopropionic Acid, Disodium Cocamphodiacetate, Disodium Cocoamphodipropionate, Disodium Cocoamphopropionate, Disodium Lauramphodiacetate, Disodium Lauramphopropionate, Disodium Laureth Sulfate, Disodium Laureth Sulfosuccinate, Disodium Myreth Sulfosuccinate, Disodium Oleamphodiacetate, Disodium Oleamphodipropionate, Disodium Oleamphopropionate, Disodium Palmitamidopropyltrimonium Chloride, Disodium PEG-12 Dimethicone Sulfosuccinate, Disodium PEG-20 Methyl Glucose Dioleate, Disodium PEG-30 Dipolyhydroxystearate, Disodium PEG-8 Laurate, Disodium PEG-8 Ricinoleate, Disodium PEG-8 Sulfosuccinate, Disodium PEG-8 Tocopheryl Sulfate, Disodium PEG-9 Cocamide Sulfosuccinate, Disodium PEG-9 Lauryl Ether Sulfosuccinate, Disodium PEG-9 Polydimethylsiloxyethyl Dimethicone Sulfosuccinate, Disodium PEG-9 Polydimethylsiloxyethyl Dimethicone Sulfosuccinate



APPLICATIONS


Disodium lauriminodipropionate is commonly used as a primary surfactant in shampoo formulations.
Disodium lauriminodipropionate helps to create a rich and foamy lather that effectively cleanses the scalp and hair.

Disodium lauriminodipropionate is found in various types of body washes and shower gels, where it contributes to thorough yet gentle cleansing of the skin.
Disodium lauriminodipropionate is often included in facial cleansers and makeup removers for its ability to remove dirt, oil, and makeup residue from the skin.
Disodium lauriminodipropionate is utilized in hand soaps and liquid hand washes to provide effective cleansing and sanitation of the hands.

Disodium lauriminodipropionate is added to baby washes and cleansers for its mild and gentle cleansing properties, suitable for delicate baby skin.
Disodium lauriminodipropionate is incorporated into facial cleansers targeted at individuals with sensitive or acne-prone skin, as it helps to remove impurities without causing irritation.
Disodium lauriminodipropionate is included in bubble bath formulations to create luxurious and bubbly foam for a relaxing bathing experience.

Disodium lauriminodipropionate is used in intimate washes and feminine hygiene products for its cleansing and soothing properties in sensitive areas.
Disodium lauriminodipropionate is found in shaving creams and gels, where it helps to lubricate the skin and soften the hair for a smooth shave.

Disodium lauriminodipropionate is added to facial scrubs and exfoliating cleansers to enhance their cleansing efficacy and exfoliating action.
Disodium lauriminodipropionate is utilized in acne treatment products such as facial washes and cleansers to help clear and prevent breakouts.

Disodium lauriminodipropionate is incorporated into pet shampoos and grooming products for effective cleansing and odor control in animals.
Disodium lauriminodipropionate is included in scalp treatments and anti-dandruff shampoos for its cleansing and scalp-soothing properties.

Disodium lauriminodipropionate is found in children's bath products such as bubble baths and bath washes, formulated to be gentle on sensitive skin.
Disodium lauriminodipropionate is utilized in antibacterial hand washes and sanitizers for its cleansing and germ-fighting properties.
Disodium lauriminodipropionate is added to foot scrubs and exfoliating cleansers to help remove dead skin cells and soften rough areas on the feet.

Disodium lauriminodipropionate is incorporated into pre-shave cleansers and facial washes to prepare the skin for a close and comfortable shave.
Disodium lauriminodipropionate is used in hair coloring products such as hair dyes and bleaches to help remove excess dye and residues from the scalp and hair.
Disodium lauriminodipropionate is found in sun care products such as sunscreen lotions and creams, where it helps to remove sunscreen residues and sweat from the skin after sun exposure.

Disodium lauriminodipropionate is included in antifungal body washes and cleansers for its cleansing and antifungal properties in treating fungal infections.
Disodium lauriminodipropionate is utilized in post-workout cleansers and body washes to remove sweat, dirt, and odor from the skin after exercise.

Disodium lauriminodipropionate is added to deodorant body washes and cleansers for effective odor control and long-lasting freshness.
Disodium lauriminodipropionate is found in travel-size cleansing wipes and towelettes for convenient on-the-go cleansing and refreshing.
Disodium lauriminodipropionate is incorporated into specialty cleansing products such as micellar water and oil cleansers for thorough yet gentle makeup removal and skin cleansing.

Disodium lauriminodipropionate is used in facial toners and astringents to help remove residual impurities and tighten pores.
Disodium lauriminodipropionate is found in exfoliating body scrubs and cleansers to promote smoother, softer skin by removing dead skin cells.

Disodium lauriminodipropionate is included in anti-aging skincare products such as cleansers and serums to help improve skin texture and tone.
Disodium lauriminodipropionate is utilized in body polishes and buffing creams to gently slough away rough patches and reveal brighter skin.
Disodium lauriminodipropionate is added to clay masks and purifying cleansers to help draw out impurities and excess oil from the skin.

Disodium lauriminodipropionate is found in oil-based cleansers and makeup removers, where it effectively lifts away waterproof makeup and sunscreen.
Disodium lauriminodipropionate is incorporated into facial mists and sprays to refresh and hydrate the skin throughout the day.
It is used in facial cleansing wipes and towelettes for quick and convenient makeup removal and cleansing on-the-go.

Disodium lauriminodipropionate is included in scalp scrubs and detoxifying cleansers to remove product buildup and impurities from the scalp.
Disodium lauriminodipropionate is utilized in facial peels and chemical exfoliants to promote cell turnover and reveal smoother, more radiant skin.

Disodium lauriminodipropionate is added to micellar cleansing waters and solutions for gentle and effective makeup removal without the need for rinsing.
Disodium lauriminodipropionate is found in facial massage creams and cleansers to facilitate smooth and effortless massage movements.
Disodium lauriminodipropionate is incorporated into multi-purpose cleansing balms and oils for makeup removal, cleansing, and hydration in one step.

Disodium lauriminodipropionate is used in body washes and cleansers for men, providing effective cleansing and a refreshing scent.
Disodium lauriminodipropionate is included in post-sun exposure cleansers and cooling gels to soothe and hydrate sun-exposed skin.
Disodium lauriminodipropionate is utilized in bath oils and soak solutions for moisturizing and softening the skin during bathing.

Disodium lauriminodipropionate is added to gentle baby cleansing products such as baby shampoos and washes for mild and tear-free cleansing.
Disodium lauriminodipropionate is found in facial serums and treatment cleansers to enhance the penetration of active ingredients into the skin.
Disodium lauriminodipropionate is incorporated into clarifying shampoos and scalp treatments to remove product residue and excess oil from the scalp.

Disodium lauriminodipropionate is used in cuticle removers and nail cleansers to soften and remove excess cuticle around the nails.
This compound is included in foot soak solutions and foot scrubs for cleansing and softening rough skin on the feet.

Disodium lauriminodipropionate is utilized in body acne cleansers and treatments to help unclog pores and reduce acne breakouts.
Disodium lauriminodipropionate is added to anti-itch creams and cleansers for soothing relief from insect bites, rashes, and skin irritations.

Disodium lauriminodipropionate is found in oil-free cleansers and mattifying products for oily and acne-prone skin types.
Disodium lauriminodipropionate is incorporated into sensitive skin cleansers and barrier repair products to cleanse without stripping the skin of its natural oils.



DESCRIPTION


Disodium lauriminodipropionate is a chemical compound used primarily in personal care products and cosmetics.
Disodium lauriminodipropionate is a surfactant, which means it has both hydrophilic (water-attracting) and lipophilic (fat-attracting) properties.
Disodium lauriminodipropionate is often added to cleansing products such as shampoos, body washes, and facial cleansers due to its ability to effectively remove dirt, oil, and other impurities from the skin and hair.

Disodium lauriminodipropionate is a mild and gentle surfactant commonly used in personal care products.
Disodium lauriminodipropionate has a clear or pale yellow appearance and a mild characteristic odor.
Disodium lauriminodipropionate is derived from lauric acid, a fatty acid found in coconut oil or palm kernel oil.

Disodium lauriminodipropionate is produced through a reaction between lauric acid and dipropylene glycol, followed by neutralization with sodium hydroxide to form the disodium salt.
Disodium lauriminodipropionate is known for its excellent cleansing properties, effectively removing dirt, oil, and other impurities from the skin and hair.
Disodium lauriminodipropionate produces a rich and creamy lather in personal care formulations, contributing to the sensory experience of cleansing products.

Despite its strong cleansing power, Disodium lauriminodipropionate is gentle on the skin and hair, making it suitable for use in products for sensitive skin types.
Disodium lauriminodipropionate helps to maintain the natural moisture balance of the skin and hair, preventing dryness and irritation.
Disodium lauriminodipropionate may also function as a conditioning agent, leaving the skin and hair feeling soft, smooth, and moisturized after use.

Disodium lauriminodipropionate is commonly found in shampoos, body washes, facial cleansers, and other skincare and hair care products.
Disodium lauriminodipropionate contributes to the overall effectiveness of cleansing formulations, ensuring thorough yet gentle removal of impurities.

Disodium lauriminodipropionate helps to create stable emulsions and suspensions in personal care products, enhancing their stability and shelf life.
Disodium lauriminodipropionate exhibits good compatibility with a wide range of other ingredients and additives commonly used in cosmetic formulations.

Disodium lauriminodipropionate is non-toxic and non-irritating when used in recommended concentrations, posing minimal risk of adverse effects on the skin and hair.
Disodium lauriminodipropionate has a neutral pH and is suitable for use in formulations with a wide range of pH levels.

Disodium lauriminodipropionate is soluble in water and miscible with most organic solvents, facilitating its incorporation into various types of cosmetic formulations.
Disodium lauriminodipropionate is stable under a wide range of temperatures, maintaining its effectiveness during storage and use.

Disodium lauriminodipropionate does not undergo significant degradation or decomposition under normal handling and storage conditions.
Disodium lauriminodipropionate is biodegradable, breaking down into harmless substances in the environment over time.

Disodium lauriminodipropionate is produced and used in accordance with industry standards and regulatory guidelines for cosmetic ingredients.
Disodium lauriminodipropionate is often included in formulations targeted at individuals with sensitive or delicate skin, offering gentle yet effective cleansing.
Disodium lauriminodipropionate helps to remove makeup, dirt, and excess oil from the skin without stripping away its natural oils or causing irritation.



PROPERTIES


Molecular Weight: 373.4 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 15
Exact Mass: 373.22049710 g/mol
Monoisotopic Mass: 373.22049710 g/mol
Topological Polar Surface Area: 83.5Ų
Heavy Atom Count: 25
Formal Charge: 0
Complexity: 278
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes



FIRST AID


Inhalation:

If inhaled, remove the affected person to a well-ventilated area with fresh air.
Allow the individual to rest in a comfortable position and keep them warm and calm.
If breathing is difficult, administer oxygen if available, and seek medical attention immediately.
In case of respiratory distress or if breathing has stopped, administer artificial respiration or cardiopulmonary resuscitation (CPR) as necessary.


Skin Contact:

Immediately remove contaminated clothing and footwear.
Wash the affected skin thoroughly with soap and water for at least 15 minutes.
If irritation, redness, or rash develops, seek medical advice or consult a physician.
If irritation persists or worsens, seek medical attention promptly.
Avoid further exposure to the substance and prevent re-contamination of the skin.


Eye Contact:

Flush the affected eye(s) with lukewarm water or saline solution for at least 15 minutes, holding the eyelids open to ensure thorough rinsing.
Remove contact lenses if present and easy to do so, but do not forcibly remove them if they are stuck to the eye.
Seek immediate medical attention or consult an eye care professional.
Provide relevant information about the substance to medical personnel for appropriate treatment.


Ingestion:

Do not induce vomiting unless instructed to do so by medical personnel.
Rinse the mouth thoroughly with water and drink plenty of water to dilute the substance.
Seek immediate medical attention or contact a poison control center for guidance.
Provide information about the ingested substance and its container to medical personnel for proper evaluation and treatment.
Do not give anything by mouth to an unconscious person.


General First Aid:

If any symptoms persist or worsen after initial first aid measures, seek medical advice promptly.
Keep the individual under observation and monitor vital signs such as breathing, pulse, and consciousness.
Provide supportive care as needed, including rest, hydration, and comfort measures.
Be prepared to provide additional information about the substance and exposure circumstances to medical personnel for proper diagnosis and treatment.
If seeking medical attention, bring the product container or label to assist healthcare professionals in identifying the substance and its potential hazards.



HANDLING AND STORAGE


Handling:

Wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and protective clothing, when handling Disodium lauriminodipropionate.
Avoid direct contact with the eyes, skin, and clothing.
In case of contact, rinse immediately with plenty of water.
Use in a well-ventilated area to minimize inhalation exposure.
If ventilation is inadequate, use respiratory protection (e.g., respirator) as necessary.

Avoid generating dust, aerosols, or mists during handling.
Use engineering controls such as local exhaust ventilation to control airborne concentrations.
Do not eat, drink, or smoke while handling Disodium lauriminodipropionate.

Wash hands thoroughly after handling and before eating, drinking, or using the restroom.
Prevent spills, leaks, and releases of the substance.
Handle containers carefully and avoid rough handling or dropping.

Use appropriate handling equipment (e.g., pumps, funnels) to transfer the substance from one container to another. Do not use compressed air for transfer.
Follow good industrial hygiene practices and established safety procedures when working with Disodium lauriminodipropionate.
Keep containers tightly closed when not in use to prevent contamination and moisture absorption.


Storage:

Store Disodium lauriminodipropionate in a cool, dry, well-ventilated area away from heat, direct sunlight, and sources of ignition.
Keep containers tightly closed and properly labeled to prevent accidental spills and unauthorized access.

Store the substance away from incompatible materials, including strong oxidizing agents, acids, and bases.
Ensure storage areas are equipped with appropriate spill containment and emergency response equipment (e.g., spill kits, eyewash stations, safety showers).
Avoid storing Disodium lauriminodipropionate near food, beverages, or pharmaceuticals to prevent contamination.

Follow manufacturer's recommendations for maximum storage temperature and shelf life of the substance.
Keep storage areas clean and free from clutter to facilitate inspection, maintenance, and emergency response activities.

Regularly inspect containers for signs of damage, leaks, or deterioration.
Replace damaged or compromised containers promptly.
Store Disodium lauriminodipropionate in compliance with applicable regulations and guidelines for the storage of hazardous substances.

Keep storage areas secure and restrict access to authorized personnel only.
Prevent unauthorized access by implementing appropriate security measures.
DISODIUM LAURYL SULFOSUCCINATE
DISODIUM LAURYL SULFOSUCCINATE;LAURETH SULFOSUCCINATE DISODIUM SALT;disodium [(dodecyloxy)sulphonyl]succinate;LAURYL ETHER SULFOSUCCINATE DISODIUM SALT;DODECYL ETHER SULFOSUCCINATE DISODIUM SALT;Dodecyloxysulfonylsuccinic acid disodium salt;2-(Laurylsulfo)succinic acid 1,4-disodium salt cas no: 36409-57-1
DISODIUM MOLYBDATE
DESCRIPTION:

Disodium molybdate is useful as a source of molybdenum.
This white, crystalline salt is often found as the dihydrate, Na2MoO4·2H2O.
Disodium molybdate is tetrahedral.



CAS NUMBER: 7631-95-0

EC NUMBER: 231-551-7

MOLECULAR FORMULA: MoNa2O4

MOLECULAR WEIGHT: 205.91714



DESCRIPTION:

Disodium molybdate coordinates with every one anion.
Disodium molybdate is white scaly crystal with slight luster, density is 3.2g/cm, soluble in water,can lose water of crystallization at 100°.
Disodium molybdate used in the measurement of acid and alkali,manufacture of alkaloids ,printing ink, fertilizer,raw material for the production of fire retardant.
Disodium molybdate can also be used in circulating cooling system, metal working liquid and other fields as corrosion inh.
Disodium molybdate is one of the transition metals and is silvery white in pure form and very hard.

The melting temperature is quite high.
Further hardening of the steel can be achieved by adding a small amount.
Disodium molybdate is also important in the nutrition of plants and takes place in some enzymes.
Disodium molybdate was first synthesized by the method of hydration.
A more convenient synthesis is done by dissolving MoO3 in sodium hydroxide at 50–70 °C and crystallizing the filtered product.

Disodium molybdate is prepared by heating to 100 °C.
Although Disodium molybdate is found in minerals such as wulfenite (PbMoO4) or powellite (CaMoO4), the main commercial source of molybdenum is molybdenite (MoS2).
Disodium molybdate can also be obtained through direct mining and as a by-product during copper mining.
Disodium molybdate is found in its ores in amounts ranging from 0.01% to 0.5%.
About half of the world's Disodium molybdate mining is done in the USA.

Disodium molybdate is an inorganic sodium salt having molybdate as the counterion.
Disodium molybdate has a role as a poison.
Disodium molybdate contains a molybdate.
Disodium molybdate, which is similar to chromium and wolfram in terms of chemical properties.
Disodium molybdate has superior properties such as high melting and boiling point, high heat resistance, high thermal conductivity and low thermal expansion.

Disodium molybdate melts at 2623 °C.
With this feature, Disodium molybdate takes the sixth place among metals.
Boiling at 4639 °C, Disodium molybdate is not affected by air in the cold, oxidized when incandescent, affected by nitric and sulfuric acids, and decomposes water vapor at high temperatures.
The density of Disodium molybdate is 10.28 gr/cm3.
Disodium molybdate is source of molybdate, ability to stabilize and inhibit the activity of various receptors.
Disodium molybdate is a useful source of molybdate, a Molybdenum (sc-235881) compound.

Disodium molybdate has displayed the ability to stabilize both the androgen and progesterone receptor.
When applied to non-activated estrogen receptors the Disodium Molybdate reversibly inhibited receptor activation.
In the Rat Disodium molybdate inactivated both the active and inactive form of the gluco corticoid receptor complex.
With the use of nitrites, Disodium molybdate salts have been shown to reduce the emission of hydrogen sulphide from swine manure.
Disodium molybdate is an acid phosphatase inhibitor.
The osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity.

Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease.
By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption.
In addition, sodium molybdate has been shown to stabilize the nonactivated glucocorticoid-receptor complex.
Disodium molybdate is a plant micronutrient.

Disodium Molybdate helps convert nitrate to amino acids and proteins.
Disodium molybdate is soluble powder for correcting molybdenum deficiency in plants.
Disodium molybdate can be soil or foliar applied.
Disodium Molybdate is a source of molybdenum.

Disodium molybdate's fundamental role in the human body is as a constituent of molybdoenzymes; some important molybdoenzymes are xanthine oxidase, sulphite oxidase and aldehyde oxidase.
These are involved in the metabolism of sulphur amino acids and purine.
By converting sulphite to sulphate, sulphite oxidase aids the metabolising of the sulphur amino acids methionine and cysteine, a process that is crucial to human health.
Disodium molybdate also helps the body reduce the harmful effects of sulphites generally.
Disodium molybdate is also an essential component of flavin- and iron-containing enzymes.

Disodium molybdate is a white, odourless, free flowing crystalline solid.
Disodium molybdate encourages the creation of a protective oxide film on metal surfaces.
Disodium molybdate is used as a corrosion inhibitor to protect metal surfaces, as it is a non-oxidizing anodic inhibitor.
Disodium molybdate is also used for cooling water systems, engine coolants, metalworking fluids, metal finishing, oil drilling muds and as a fertiliser nutrient.
Disodium molybdate is an essential micronutrient though required by plants in very minute amounts.
Disodium molybdate supports the essential metabolism of nitrogen and synthesis of protein.
Soil that has no Disodium molybdate at all cannot support plant life.

Disodium molybdate is 100% water soluble, compatible in many mixed fertiliser nutrient formulations, easy to apply and importantly easy to clean with no sticky residues.
Most diets will contain a plentiful supply of Disodium molybdate, as it is common in nuts, vegetables and cereals, and is found in drinking water to varying levels.
Each capsule contains about 1mg of molybdenum.
This is a high dose, well in excess of recommended European daily intakes.

Disodium molybdate is recommended not to exceed 1 capsule per day.
Higher intakes of supplemental molybdenum may be better divided into two or three doses through the day.
This is because Disodium molybdate is not accumulated by the body (apart from some accretion in the teeth).
There is believed to be an antagonistic relationship between Disodium molybdate and copper and sulphate.
With high intakes of Disodium molybdate, care should be taken over copper and sulphate levels.

Excessive intake of molybdenum, in excess of 1mg per day, has been reported to cause joint pains, along with increased uric acid levels found in serum.
Long term consumption of higher levels of Disodium molybdate may also have a deactivating effect on glutaminases in the brain and liver, and could reduce the effectiveness of carotenes and vitamin A.
Disodium molybdate is used in the fertilization process of crops as well as the protection from corrosion due to potential construction in a nearby area.,
Disodium molybdate is a clear, colorless, aqueous solution containing at least 35% of Disodium Molybdate represented by the formula: Na2MoO4.
Its applications include scale deposit and corrosion inhibition, as a tracer in water treatments, a micronutrient in fertilizers/food, and medicinal supplements, pigment agents, and laboratory reagents, etc.

Disodium molybdate is stable under ordinary temperatures and pressures. Store at 4°C - 25°C.
In case of spillage collect with sawdust and/or sand.
Disodium molybdate is a crystalline powder.
Disodium molybdate loses its water of crystallization at 100 degrees Celsius.
Disodium molybdate is known to be less toxic than the other corresponding compounds of group 6B elements in the periodic table.
Disodium molybdate is used in the manufacturing of inorganic and organic pigments, as a corrosion inhibitor.

Disodium molybdate is a small, lustrous, crystalline plate.
Disodium molybdate has the melting point of 687 degrees Celsius and a density of 3.28 (18C).
Disodium molybdate is soluble in water and also noncombustible.
Disodium molybdate can be used for reagent in analytical chemistry, paint pigment, production of molybdated toners and lakes, metal finishing, brightening agent for zinc plating, corrosion inhibitor, catalyst in dye and pigment production, additive for fertilizers and feeds, and micronutrient.

Disodium Molybdate uses cover a wide range of fields, including manufacturing, metalwork, printing, and more.
But the impact Disodium molybdate can have on plants and animals has brought it into the forefront of use for the agriculture industry, to the tune of more than 1 million pounds of sodium molybdate fertilizer used per year.
The basic chemistry of a molybdate, such as sodium molybdate, contains the element molybdenum in its highest oxidation state, which in turn helps contribute to a high solubility of the chemical in water, a benefit in fertilizer application.
This characteristic, when combined with sodium molybdate’s use as a delivery vessel for essential micronutrients (such as molybdenum) in plants, serves as another key reason for the choice of sodium molybdate fertilizer over other types of fertilizers used in agriculture.

Disodium molybdate has seen a particularly strong uptick in usage among farmers of leguminous plants, such as alfalfa, peas, beans, lentils and peanuts.
Included in fertilizer, Disodium molybdate provides these plants with enhanced uptake of the essential nitrogen element, while also allowing for efficient fixing of atmospheric nitrogen found in the atmosphere by bacteria in the legumes.
These bacteria convert the nitrogen into ammonia to synthesize amino acids within the plant.
Overall, the use of sodium molybdate in the agricultural industry can be summarized in that it is one of the few chemicals that can provide essential micronutrients and help drive plant function in a form that is both efficient and effective.

Efficiency is shown not only by the relatively small amounts needed to make an impact on the treated plants, but also in the ability to administer the chemical in easily-absorbed water-based formats.
Disodium molybdate may be used as an electrolyte additive, for use in electrochemical capacitors.
Addition of Na2MO4 as an electrolyte additive may result in enhanced capacitance, corrosion prevention and stabilized performance.
Disodium molybdate may also be used as a catalyst during the manufacture of paints and dyes.



USAGE:

The agriculture industry uses 1 million pounds per year as a fertilizer.
In particular, Disodium molybdate's use has been suggested for treatment of whiptail in broccoli and cauliflower in molybdenum-deficient soils.
Disodium molybdate is used in industry for corrosion inhibition, as it is a non-oxidizing anodic inhibitor.
The addition of sodium molybdate significantly reduces the nitrite requirement of fluids inhibited with nitrite-amine, and improves the corrosion protection of carboxylate salt fluids.

In industrial water treatment applications where galvanic corrosion is a potential due to bimetallic construction, the application of sodium molybdate is preferred over sodium nitrite.
Disodium molybdate has the advantage in that the dosing of lower ppm's of molybdate allow for lower conductivity of the circulating water.
Disodium molybdate at levels of 50-100 ppm offer the same levels of corrosion inhibition as sodium nitrite at levels of 800+ ppm.
By utilizing lower concentrations of sodium molybdate, conductivity is kept at a minimum and thus galvanic corrosion potentials are decreased.



APPLICATION:

-Used in the manufacture of alkaloids, dyes, fertilizers, pigments, catalysts, flame retardants and no Metal inhibitor for nuisance cooling water systems.
-For galvanized polishing agent and chemical reagent.
-The agricultural industry uses up to £1 million of fertilizer per year.
-In particular, Disodium molybdate has been proposed to be used for processing broccoli and cauliflower seeds on molybdenum-deficient soils.
-However, care should be taken as sodium molybdate at a level of 0.3 ppm can cause copper deficiencies in animals, particularly cattle.
-Disodium molybdate is used in industry for corrosion prevention because it is a non-oxidizing anodic inhibitor.
-The addition of sodium molybdate significantly reduces the nitrite requirement of nitrite-amine inhibited fluids and improves the corrosion protection of carboxylate salt fluids.
-In industrial water treatment applications where galvanic corrosion is potential due to the bimetallic structure, sodium molybdate is preferred rather than sodium nitrite.
-Disodium molybdate has the advantage that lower ppm molybdate dosing has lower conductivity of circulating water.
-Disodium molybdate at 50-100ppm offers the same levels of corrosion inhibition as sodium nitrite at 800+ppm.
-By using lower concentrations of sodium molybdate, conductivity is kept to a minimum and thus galvanic corrosion potentials are reduced.



USES:

-for the preparation of molybdenum salts and dyes, pigments, catalysts, corrosion inhibitors, etc.
-used as a metal corrosion inhibitor, descaling agent, bleach accelerators as well as skin and hair protective agent
-reagents for the analysis, with in the determination of alkaloids, dyes and pharmaceutical industry for the manufacture of
-alkaloids, ink, fertilizers, molybdenum red pigment and light fastness pigment precipitation agent, catalyst, molybdenum salt, can also be used to make flame retardants and pollution-free type water system metal inhibitors, also used as a galvanizing, polishing agents and chemical reagents.
-molybdate inhibitor belongs to the anodic oxide film formed on the anode ferrous iron - high-speed rail - the sky molybdenum oxide passivation film corrosion inhibition.



AGRICULTURAL USES:

Disodium molybdate is an important molybdenum source, is applied along with other fertilizers or as a foliar spray (with 39% molybdenum).
Disodium molybdate is the sodium salt of molybdic acid.
Disodium molybdate oxide with sodium carbonate or hydroxide makes sodium molybdate.
Disodium molybdate is an essential component of the enzyme nitrate reductase which catalyzes the conversion of nitrate (NO3-) to nitrite (NO2-).

Disodium molybdate is also a component of the nitrogenase enzyme involved in nitrogen fixation by root nodule bacteria of leguminous crops.
Soaking seeds in sodium molybdate solution (made with slurry or dust) before sowing is an effective seed treatment.
Disodium molybdate, the most commonly used fertilizer supplying molybdenum, is used as foliar spray, or in mixed fertilizers.
Disodium molybdate is also used in seed treatment.



REACTION:

When reacted with sodium borohydride, molybdenum is reduced to lower valent molybdenum(IV) oxide:

Na2MoO4 + NaBH4 + 2H2O → NaBO2 + MoO2 + 2NaOH + 3H2

Disodium molybdate reacts with the acids of dithiophosphates:

Na2MoO4 + (R = Me, Et) (RO)2PS2H → [MoO2(S2P(OR)2)2]

which further reacts to form [MoO3(S2P(OR)2)4].



BIOLOGICAL ACTIVITY:

Disodium molybdate is an acid phosphatase inhibitor. the osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity.
Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease.
By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption.



PROPERTIES:

-White rhombus crystal
-Slightly soluble in water
-insoluble in acetone



PROPERTIES:

Molecular Weight: 205.93 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 0
Exact Mass: 207.864601 g/mol
Monoisotopic Mass: 207.864601 g/mol
Topological Polar Surface Area: 80.3Ų
Heavy Atom Count: 7
Complexity: 62.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes



PHYSICAL AND CHEMICAL PROPERTIES:

-Density: 2.71 g/cm3 (22 °C) (for the dihydrate)
-Melting Point: 687 °C Elimination of water of crystallisation
-pH value: 9 - 10 (840 g/l, H₂O, 20 °C)
-Bulk density: 1000 - 1400 kg/m3
-Solubility: 840 g/l



TECHNICAL INFORMATION:

-Appearance: Crystalline powder and crystalline
-Physical State: Solid
-Solubility: Soluble in water (840 mg/ml at 20° C).
-pH: 7.0-10.5
-Storage: Store at room temperature
-Melting Point: 100° C
-Density: 2.37 g/cm3



SPECIFICATION:

-Assay (precipitative titration, calculated on dried substance): 98.0 - 103.0 %
-Identity: passes test
-Appearance of solution: passes test
-Chloride (Cl): ≤ 0.005 %
-Phosphate (PO₄): ≤ 0.02 %
-NH₄ (Ammonium): ≤ 0.001 %
-Heavy metals (as Pb): ≤ 0.001 %
-Loss on drying (140 °C):14.0 - 16.0 %



CHEMICAL PROPERTIES:

-Density: 2.71 g/cm3 (22 °C) (for the dihydrate)
-Melting Point: 687 °C Elimination of water of crystallisation
-pH value: 9 - 10 (840 g/l, H₂O, 20 °C)
-Bulk density: 1000 - 1400 kg/m3
-Solubility: 840 g/l



SAFETY:

Disodium molybdate is incompatible with alkali metals, most common metals and oxidizing agents.
Disodium molybdate will explode on contact with molten magnesium.
Disodium molybdate will violently react with interhalogens.
Disodium molybdate's reaction with hot sodium, potassium or lithium is incandescent.



CHEMICAL PROPERTIES:

-Linear Formula: Na2MoO4
-MDL Number: MFCD00003486
-EC No.: 231-551-7
-Pubchem CID: 61424
-IUPAC Name: disodium dioxido(dioxo)molybdenum
-SMILES: [Na+].[Na+].[O-][Mo]([O-])(=O)=O
-InchI Identifier: InChI=1S/Mo.2Na.4O/q;2*+12-1
-InchI Key: TVXXNOYZHKPKGW-UHFFFAOYSA-N



STORAGE:

Store in a closed, cool, dry and ventilated place, and do not mix with toxic chemicals for transportation and storage.



SYNONYM:

Disodium molybdate
disodium,(T-4)-Molybdate
disodiummolybdate
Molybdate (MoO42-), disodium, (T-4)-
Molybdate (MoO42-), disodium, (T-4)-
molybdic
Molybdic acid (H2MoO4), disodium salt
Molybdic acid, disodium salt
Disodium molybdate
7631-95-0
Disodium molybdate
Disodium molybdate(VI)
Molybdate disodium
sodium molybdenum oxide
Natriummolybdat
Molybdic acid, disodium salt
sodium molybdate (anhydrous)
disodium;dioxido(dioxo)molybdenum
Anhydric sodium molybdate
Disodium Molybdate, anhydrous
13466-16-5
948QAQ08I1
MFCD00003486
Disodium molybdenum oxide, anhydrous, Mo 46.2%
Natriummolybdat
Disodium molybdate
Disodium dimolybdate
CCRIS 5442
Na2MoO4
EINECS 231-551-7
NSC 77389
Disodium Molybdate Anhydrous
Molybdic acid (H2MoO4), disodium salt
Molybdic acid (H2MoO4) , disodium salt
UNII-948QAQ08I1
Molybdate (MoO42-), disodium, (T-4)-
Molybdenum (as sodium)
disodium tetraoxomolybdate
sodium molybdate (anh.)
Molybdate (MoO42-), disodium, (beta-4)-
Molybdic acid, sodium salt
EC 231-551-7
Disodium molybdate, >=98%
Ddisodium Molybdate Dihydrate
Disodium Molybdate, ACS Grade
sodium dioxido(dioxo)molybdenum
SODIUM MOLYBDATE
SODIUM MOLYBDATE
CHEBI:75215
SODIUM MOLYBDATE
SODIUM MOLYBDATE
SODIUM MOLYBDATE
Disodium molybdate, LR, >=99.5%
NSC-77389
AKOS015912969
DB14496
MOLYBDENUM (AS SODIUM)
Disodium Molybdate Crystals, Technical Grade
FT-0701280
Disodium Molybdate Dihydrate (Technical Grade)
Molybdate (MoO42-), sodium (1:2), (T-4)-
Q414518

DISODIUM MOLYBDATE
Disodium molybdate is a crystalline powder essential for the metabolism and development of plants and animals as a cofactor for enzymes.
Disodium molybdate is an inorganic sodium salt having molybdate as the counterion.
Disodium molybdate contains a molybdate.
Disodium molybdate, Na2MoO4, is useful as a source of molybdenum.


CAS Number: 7631-95-0
EC Number: 231-551-7
Formula: MoNa2O4


This white, crystalline salt, Disodium molybdate is often found as the dihydrate, Na2MoO4·2H2O.
Disodium molybdate is a useful source of molybdate, a Molybdenum compound.
Disodium molybdate is a very fine white granule free-flowing and highly hydroscopic.


Disodium molybdate is a reagent in analytical chemistry, paint pigment, production of molybdated toners and lakes, metal finishing, brightening agent for zinc plating, corrosion inhibitor, catalyst in dye and pigment production, additive for fertilizers and feeds, and micronutrient.
Disodium molybdate is a fine white powder used for corrosion inhibition because it is a non-oxidizing anodic inhibitor.
Disodium molybdate is an acid phosphatase inhibitor.


The osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity.
Disodium molybdate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.


Disodium molybdate is soluble powder for correcting molybdenum deficiency in plants.
Disodium molybdate is a source of molybdenum.
Molybdenum's fundamental role in the human body is as a constituent of molybdoenzymes; some important molybdoenzymes are xanthine oxidase, sulphite oxidase and aldehyde oxidase.


These are involved in the metabolism of sulphur amino acids and purine.
By converting sulphite to sulphate, sulphite oxidase aids the metabolising of the sulphur amino acids methionine and cysteine, a process that is crucial to human health.
This also helps the body reduce the harmful effects of sulphites generally.


Molybdenum is also an essential component of flavin- and iron-containing enzymes.
Most diets will contain a plentiful supply of molybdenum, as it is common in nuts, vegetables and cereals, and is found in drinking water to varying levels.
Disodium molybdate is used by the plant to convert nitrate into the building blocks for proteins and is crucial for certain plant hormones.


Disodium molybdate is generally immediately available in most volumes.
Disodium molybdate is an odourless white, crystalline powder with the chemical formula Na2MoO4.
Disodium molybdate is a white, odourless, free flowing crystalline solid.
The molybdate encourages the creation of a protective oxide film on metal surfaces.


There are two main forms of Disodium molybdate.
Disodium molybdate, Dihydrate is a crystalline powder.
It loses its water of crystallization at 100 degrees Celsius.
It is known to be less toxic than the other corresponding compounds of group 6B elements in the periodic table.


Disodium molybdate is stable under ordinary temperatures and pressures.
Disodium molybdate is stored at 4°C - 25°C.
In case of spillage collect with sawdust and/or sand.
Disodium molybdate ensures complete and fast assimilation and solubility and it does not alter pH values if used in nutrient solutions.


Disodium molybdate, Anhydrous is a small, lustrous, crystalline plate.
Disodium molybdate has the melting point of 687 degrees Celsius and a density of 3.28 (18C).
Disodium molybdate is soluble in water and also noncombustible.


Disodium molybdate is a white crystalline powder.
Disodium molybdate is a white, odourless, free-flowing crystalline solid.
Disodium molybdate is a hydrate that is the dihydrate form of sodium molybdate.
Disodium molybdate is a hydrate, an inorganic sodium salt and a molybdate.


Disodium molybdate contains a sodium molybdate (anhydrous).
Sodium molybdate, Na2MoO4, is useful as a source of molybdenum.
This white, crystalline salt is often found as the dihydrate, Na2MoO4•2H2O.
The molybdate(VI) anion is tetrahedral.


Two sodium cations coordinate with every one anion.
Disodium molybdate is an essential ingredient which a plant requires.
Sodium molybdate, Na2MoO4, is useful as a source of molybdenum.
It is often found as the dihydrate, Na2MoO4•2H2O.


Disodium molybdate is a plant micronutrient.
Disodium molybdate is generally immediately available in most volumes.
Hydrate or anhydrous forms of Disodium molybdate may be purchased.


Disodium molybdate has high purity, submicron and nanopowder forms may be considered.
Disodium molybdate, also known as Molybdic Acid Disodium Salt, or simply SMX, is a very fine, white, free-flowing technical grade granule represented by the formula: Na₂MoO₄•2H₂O.



USES and APPLICATIONS of DISODIUM MOLYBDATE:
The agriculture industry uses 1 million pounds per year as a fertilizer.
In particular, Disodium molybdate'ss use has been suggested for treatment of whiptail in broccoli and cauliflower in molybdenum-deficient soils.
However, care must be taken because at a level of 0.3 ppm sodium molybdate can cause copper deficiencies in animals, particularly cattle.


Disodium molybdate is used in industry for corrosion inhibition, as it is a non-oxidizing anodic inhibitor.
The addition of Disodium molybdate significantly reduces the nitrite requirement of fluids inhibited with nitrite-amine, and improves the corrosion protection of carboxylate salt fluids.
In industrial water treatment applications where galvanic corrosion is a potential due to bimetallic construction, the application of sodium molybdate is preferred over sodium nitrite.


Disodium molybdate has the advantage in that the dosing of lower ppm's of molybdate allow for lower conductivity of the circulating water.
Disodium molybdate at levels of 50-100 ppm offer the same levels of corrosion inhibition as sodium nitrite at levels of 800+ ppm.
By utilizing lower concentrations of Disodium molybdate, conductivity is kept at a minimum and thus galvanic corrosion potentials are decreased.
Disodium molybdate has displayed the ability to stabilize both the androgen and progesterone receptor.


When applied to non-activated estrogen receptors the Sodium Molybdate reversibly inhibited receptor activation.
In the Rat Sodium molybdate dihydrate inactivated both the active and inactive form of the gluco corticoid receptor complex.
With the use of nitrites, molybdate salts have been shown to reduce the emission of hydrogen sulphide from swine manure.
Disodium molybdate is used as a component to supply Molybdenum to plants in a complete fertilizer mixture.


Sodium molybdate is used as a Oligo- element for the agricultural industry, as raw material for the metal surface treatment industry and for the pigments production.
Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease.
By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption.
In addition, sodium molybdate has been shown to stabilize the nonactivated glucocorticoid-receptor complex.


Disodium molybdate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Disodium molybdate is used in the following products: anti-freeze products, heat transfer fluids, fertilisers and water treatment chemicals.
Release to the environment of Disodium molybdate can occur from industrial use: formulation of mixtures and of substances in closed systems with minimal release.


Other release to the environment of Disodium molybdate is likely to occur from: outdoor use as reactive substance, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids) and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).


Release to the environment of Disodium molybdate can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).
Other release to the environment of Disodium molybdate is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use.


Disodium molybdate can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery).
Disodium molybdate is used in the following products: anti-freeze products, heat transfer fluids, metal working fluids, water softeners, water treatment chemicals, fertilisers and pH regulators and water treatment products.


Disodium molybdate is used in the following areas: agriculture, forestry and fishing, formulation of mixtures and/or re-packaging, health services and scientific research and development.
Other release to the environment of Disodium molybdate is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).


Disodium molybdate is used in the following products: water treatment chemicals, anti-freeze products, metal working fluids, washing & cleaning products and biocides (e.g. disinfectants, pest control products).
Disodium molybdate has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Disodium molybdate can occur from industrial use: formulation of mixtures and processing aids at industrial sites.


Other release to the environment of Disodium molybdate is likely to occur from: outdoor use.
Disodium molybdate is used in the following products: pH regulators and water treatment products, metal working fluids, water treatment chemicals, anti-freeze products and heat transfer fluids.
Disodium molybdate has an industrial use resulting in manufacture of another substance (use of intermediates).


Disodium molybdate is used in the following areas: formulation of mixtures and/or re-packaging and mining.
Disodium molybdate is used for the manufacture of: chemicals, pulp, paper and paper products, plastic products and machinery and vehicles.
Release to the environment of Disodium molybdate can occur from industrial use: in processing aids at industrial sites, as processing aid, of substances in closed systems with minimal release, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and formulation of mixtures.


Release to the environment of Disodium molybdate can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.
Disodium molybdate helps convert nitrate to amino acids and proteins.


Disodium molybdate can be soil or foliar applied.
The agricultural industry uses up to £1 million of fertilizer per year.
In particular, Disodium molybdate has been proposed to be used for processing broccoli and cauliflower seeds on molybdenum-deficient soils.
However, care should be taken as Disodium molybdate at a level of 0.3 ppm can cause copper deficiencies in animals, particularly cattle.


Disodium molybdate is used in industry for corrosion prevention because it is a non-oxidizing anodic inhibitor.
The addition of Disodium molybdate significantly reduces the nitrite requirement of nitrite-amine-inhibited fluids and improves the corrosion protection of carboxylate salt fluids.
In industrial water treatment applications where galvanic corrosion is potential due to the bimetallic structure, Disodium molybdate is preferred rather than sodium nitrite.


Disodium molybdate has the advantage that lower ppm molybdate dosing has lower conductivity of circulating water.
Disodium molybdate at 50-100ppm offers the same levels of corrosion inhibition as sodium nitrite at 800+ppm.
By using lower concentrations of Disodium molybdate, conductivity is kept to a minimum and thus galvanic corrosion potentials are reduced.
Disodium molybdate can be used to add molybdenum to the plant.


Disodium molybdate is widely used in the water treatment industry as a corrosion inhibitor in water treatment products.
Disodium molybdate is also used in agriculture as a micronutrient for plants and used in the manufacturing process of pigments, lubricants and an additive for metal finishing.
Disodium molybdate is used as a corrosion inhibitor to protect metal surfaces, as it is a non-oxidizing anodic inhibitor.


Disodium molybdate is also used for cooling water systems, engine coolants, metalworking fluids, metal finishing, oil drilling muds and as a fertiliser nutrient.
In fertiliser systems, Disodium molybdate is an essential micronutrient though required by plants in very minute amounts.
Disodium molybdate supports the essential metabolism of nitrogen and the synthesis of protein.


Soil that has no molybdenum at all cannot support plant life!
Disodium molybdate is 100% water soluble, compatible in many mixed fertiliser nutrient formulations, easy to apply and importantly easy to clean with no sticky residues.
Disodium molybdate, Dihydrate is used in the manufacturing of inorganic and organic pigments, as a corrosion inhibitor, as a bath additive for finishing metals finishing, as a reagent for alkaloids, and as an essential micronutrient for plants and animals.


Disodium molybdate can be used for reagent in analytical chemistry, paint pigment, production of molybdated toners and lakes, metal finishing, brightening agent for zinc plating, corrosion inhibitor, catalyst in dye and pigment production, additive for fertilizers and feeds, and micronutrient.


Overall, the use of Disodium molybdate in the agricultural industry can be summarized in that it is one of the few chemicals that can provide essential micronutrients and help drive plant function in a form that is both efficient and effective.
Efficiency is shown not only by the relatively small amounts needed to make an impact on the treated plants but also by the ability to administer the chemical in easily-absorbed water-based formats.


Disodium molybdate can be used to add molybdenum to the plant.
The plant uses molybdenum (Mo) to convert nitrate into proteins which are essential for plant hormones.
You can easily recognise a shortage of Molybdenum (Mo) by looking at deformed or yellow young leafs.


With older leaves the shortage can be recognised by looking for yellow leafs.
Disodium molybdate uses cover a wide range of fields, including manufacturing, metalwork, printing, and more.
But the impact Disodium molybdate can have on plants and animals has brought it into the forefront of use for the agriculture industry, to the tune of more than 1 million pounds of Disodium molybdate fertilizer used per year.


The basic chemistry of a molybdate, such as sodium molybdate, contains the element molybdenum in its highest oxidation state, which in turn helps contribute to a high solubility of the chemical in water, a benefit in fertilizer application.
This characteristic, when combined with sodium molybdate’s use as a delivery vessel for essential micronutrients (such as molybdenum) in plants, serves as another key reason for the choice of Disodium molybdate fertilizer over other types of fertilizers used in agriculture.


Another touchpoint for this usage ties back to the hydroponic nutrient practice that is growing in popularity.
Hydroponics is an agricultural method in which plants are grown without soil.
Instead, they receive their essential micronutrients through a water solvent, a practice that has shown growth rates almost 50 percent faster than traditional soil-grown plants, in addition to a higher yield from hydroponic plants.


Disodium molybdate has seen a particularly strong uptick in usage among farmers of leguminous plants, such as alfalfa, peas, beans, lentils and peanuts.
The agriculture industry uses 1 million pounds per year as a fertilizer. In particular, Disodium molybdate's use has been suggested for treatment of whiptail in broccoli and cauliflower in molybdenum-deficient soils.


Included in fertilizer, Disodium molybdate provides these plants with enhanced uptake of the essential nitrogen element, while also allowing for efficient fixing of atmospheric nitrogen found in the atmosphere by bacteria in the legumes.
These bacteria convert the nitrogen into ammonia to synthesize amino acids within the plant.


Overall, the use of Disodium molybdate in the agricultural industry can be summarized in that it is one of the few chemicals that can provide essential micronutrients and help drive plant function in a form that is both efficient and effective.
Efficiency is shown not only by the relatively small amounts needed to make an impact on the treated plants, but also in the ability to administer Disodium molybdate in easily-absorbed water-based formats.


Disodium molybdate is used in industry for corrosion inhibition, as it is a non-oxidizing anodic inhibitor.
The addition of Disodium molybdate significantly reduces the nitrite requirement of fluids inhibited with nitrite-amine, and improves the corrosion protection of carboxylate salt fluids.
In industrial water treatment applications where galvanic corrosion is a potential due to bimetallic construction, the application of Disodium molybdate is preferred over sodium nitrite.


Disodium molybdate has the advantage in that the dosing of lower ppm's of molybdate allow for lower conductivity of the circulating water.
Disodium molybdate at levels of 50-100 ppm offer the same levels of corrosion inhibition that sodium nitrite at levels of 800+ offer.
The molybdate encourages the creation of a protective oxide film on metal surfaces.


Disodium molybdate is used as a corrosion inhibitor to protect metal surfaces, as it is a non-oxidizing anodic inhibitor.
Disodium molybdate is used for cooling water systems, engine coolants, metalworking fluids, metal finishing and oil drilling muds.
Disodium molybdate is used as a fertilizer


Sodium Molybdate, Dihydrate, Crystal, Reagent, ACS is a white crystalline solid that is used in agriculture as a fertilizer and in water treatment as well as in industry as a corrosion inhibitor.
The agriculture industry uses 1 million pounds per year as a fertilizer.
In particular, Disodium molybdate's use has been suggested for treatment of whiptail in broccoli and cauliflower in molybdenum-deficient soils.


Disodium molybdate is used in industry for corrosion inhibition, as it is a non-oxidizing anodic inhibitor.
The addition of Disodium molybdate significantly reduces the nitrite requirement of fluids inhibited with nitrite-amine, and improves the corrosion protection of carboxylate salt fluids.
Disodium molybdate is a non-oxidizing anodic inhibitor, used in metal finishing, as a brightening agent for zinc plating, as a corrosion inhibitor, an additive as trace element for fertilizers, in animal feed supplements, in production of molybdate inorganic and in organic toners and pigments.


Disodium molybdate is used in industry for corrosion inhibition, as it is a non-oxidizing anodic inhibitor.
The addition of Disodium molybdate significantly reduces the nitrite requirement of fluids inhibited with nitrite-amine, and improves the corrosion protection of carboxylate salt fluids.
In industrial water treatment applications where galvanic corrosion is a potential due to bimetallic construction, the application of Disodium molybdate is preferred over sodium nitrite.


Disodium molybdate has the advantage in that the dosing of lower ppm's of molybdate allow for lower conductivity of the circulating water.
Disodium molybdate at levels of 50-100 ppm offer the same levels of corrosion inhibition as sodium nitrite at levels of 800+ ppm.
By utilizing lower concentrations of Disodium molybdate, conductivity is kept at a minimum and thus galvanic corrosion potentials are decreased.


Disodium molybdate is a useful source of molybdate, a Molybdenum (sc-235881) compound.
Disodium molybdate has displayed the ability to stabilize both the androgen and progesterone receptor.
When applied to non-activated estrogen receptors the Disodium molybdate reversibly inhibited receptor activation.


In the Rat Disodium molybdate inactivated both the active and inactive form of the gluco corticoid receptor complex.
With the use of nitrites, molybdate salts have been shown to reduce the emission of hydrogen sulphide from swine manure.
Disodium molybdate is used as a corrosion inhibitor for open and closed cooling water systems, engine coolants, metalworking fluids, metal finishing, and oil drilling mud’s.


Disodium molybdate is also used as a micronutrient in agriculture.
Disodium molybdate is a raw material for making flame retardants and a metal corrosion inhibitor for pollution-free cooling water systems.
Disodium molybdate is source of molybdate, ability to stabilize and inhibit the activity of various receptors.


-Disodium molybdate Application:
*Reagents for the manufacture of alkaloids and other substances
*For dyes, molybdenum red pigments, catalysts, molybdenum salts and light-fast lake precipitants.
*Disodium molybdate is a raw material for making flame retardants and a metal corrosion inhibitor for pollution-free cooling water systems.
*Disodium molybdate is a necessary trace component for animals and plants.


-Recommended Use of Disodium molybdate:
Adhesives & Cements, Animal Feed, Antifreeze, Cooling Water, Corrosion Inhibitors, , Drilling Mud, Engine Coolants, Fertilizer, Metal Finishing, Metalworking Fluids, Micronutrient, Oil Field Service Chemicals, Pigment, Water Treatment, Zinc Plating


-Disodium molybdate as a corrosion inhibitor:
Disodium molybdate is an ideal environmentally responsible corrosion inhibitor for water and cooling systems.
Capable of working across a variety of temperatures and pH levels, Disodium molybdate experiences no loss of chemical properties or effectiveness in a variety of hot or cold environments.
When used, Disodium molybdate is capable of inhibiting the corrosion of ferrous, copper and aluminium metals in the cooling water of both open and closed cooling systems.


-Disodium molybdate in Agriculture:
Disodium molybdate offers a useful source of molybdenum which is an excellent soil micronutrient and essential for healthy plant growth making it a popular choice of fertiliser within the agricultural industry.
Disodium molybdate is suitable for foliar or fertigation applications, it is used in small amounts to supply molybdenum to crops and livestock.
Disodium molybdate is also added to cattle feed when treating copper deficiencies.



REACTIONS OF DISODIUM MOLYBDATE:
When reacted with sodium borohydride, molybdenum is reduced to lower valent molybdenum(IV) oxide:
Na2MoO4 + NaBH4 + 2H2O → NaBO2 + MoO2 + 2NaOH + 3H2
Disodium molybdate reacts with the acids of dithiophosphates:
Na2MoO4 + (R = Me, Et)
(RO)2PS2H → [MoO2(S2P(OR)2)2]
which further reacts to form [MoO3(S2P(OR)2)4].



HISTORY OF DISODIUM MOLYBDATE:
Disodium molybdate was first synthesized by the method of hydration.
A more convenient synthesis is done by dissolving MoO3 in sodium hydroxide at 50–70 °C and crystallizing the filtered product.
The anhydrous salt is prepared by heating to 100 °C.
MoO3 + 2NaOH + H2O → Na2MoO4·2H2O



WHY THE AGRICULTURE INDUSTRY USES DISODIUM MOLYBDATE:
Disodium molybdate uses cover a wide range of fields, including manufacturing, metalwork, printing, and more.
But the impact Disodium molybdate can have on plants and animals has brought it into the forefront of use for the agriculture industry, to the tune of more than 1 million pounds of Disodium molybdate fertilizer used per year.

The basic chemistry of a molybdate, such as Disodium molybdate, contains the element molybdenum in its highest oxidation state, which in turn helps contribute to a high solubility of the chemical in water, a benefit in fertilizer application.
This characteristic, when combined with Disodium molybdate’s use as a delivery vessel for essential micronutrients (such as molybdenum) in plants, serves as another key reason for the choice of Disodium molybdate fertilizer over other types of fertilizers used in agriculture.

Another touchpoint for this usage ties back to the hydroponic nutrient practice that is growing in popularity.
Hydroponics is an agricultural method in which plants are grown without soil.
Instead, they receive their essential micronutrients through a water solvent, a practice that has shown growth rates almost 50 percent faster than traditional soil-grown plants, in addition to a higher yield from hydroponic plants.

Disodium molybdate has seen a particularly strong uptick in usage among farmers of leguminous plants, such as alfalfa, peas, beans, lentils and peanuts.
Included in fertilizer, Disodium molybdate provides these plants with enhanced uptake of the essential nitrogen element, while also allowing for efficient fixing of atmospheric nitrogen found in the atmosphere by bacteria in the legumes.
These bacteria convert nitrogen into ammonia to synthesize amino acids within the plant.



PHYSICAL and CHEMICAL PROPERTIES of DISODIUM MOLYBDATE:
Molecular weight: 205.94
Physical state solid
Color: white
Odor: odorless
Melting point/freezing point:
Melting point/range: 100 °C
Initial boiling point and boiling range: Not applicable
Flammability (solid, gas): The product is not flammable.
Upper/lower flammability or explosive limits: No data available
Flash point: Not applicable
Autoignition temperature: No data available
Decomposition temperature: 130 °C - Elimination of water of crystallization
pH: 9 - 10 at 840 g/l at 20 °C

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: Not applicable
Water solubility: 840 g/l at 20 °C
Partition coefficient: n-octanol/water: Not applicable
Vapor pressure: Not applicable
Density: 2,71 g/cm3 at 22 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Molecular Weight: 205.93
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 0
Exact Mass: 207.864601

Monoisotopic Mass: 207.864601
Topological Polar Surface Area: 80.3 Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 62.2
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
Formula: Na2MoO4
Molecular mass: 205.9
Melting point: 687°C
Density: 3.78 g/cm³
Solubility in water, g/100ml at 100°C: 84

Chemical formula: Na2MoO4
Molar mass: 205.92 g/mol (anhydrous), 241.95 g/mol (dihydrate)
Appearance: White powder
Density: 3.78 g/cm3, solid
Melting point: 687 °C (1,269 °F; 960 K)
Solubility in water: 84 g/100 ml (100 °C)
Refractive index (nD): 1.714
Compound Formula: MoNa2O4
Molecular Weight: 205.92
Appearance: White powder
Melting Point: N/A
Boiling Point: N/A
Density: 3.78 g/cm3
Solubility in H2O: N/A
Exact Mass: 207.864606
Monoisotopic Mass: 207.864606



FIRST AID MEASURES of DISODIUM MOLYBDATE:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DISODIUM MOLYBDATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.



FIRE FIGHTING MEASURES of DISODIUM MOLYBDATE:
-Extinguishing media:
*Suitable extinguishing media:
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DISODIUM MOLYBDATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DISODIUM MOLYBDATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
*Storage class:
Storage class (TRGS 510):
Non Combustible Solids



STABILITY and REACTIVITY of DISODIUM MOLYBDATE:
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
no information available
-Conditions to avoid:
no information available
-Incompatible materials:
No data available



SYNONYMS:
Sodium molybdate
7631-95-0
Disodium molybdate
Sodium molybdate(VI)
Molybdate disodium
sodium molybdenum oxide
Natriummolybdat
Molybdic acid, disodium salt
sodium molybdate (anhydrous)
dioxido(dioxo)molybdenum
Anhydric sodium molybdate
Sodium Molybdate, anhydrous
13466-16-5
948QAQ08I1
MFCD00003486
Sodium molybdenum oxide, anhydrous, Mo 46.2%
Sodium dimolybdate
CCRIS 5442
Na2MoO4
EINECS 231-551-7
NSC 77389
Sodium Molybdate Anhydrous
Molybdic acid (H2MoO4), disodium salt
Molybdic acid (H2MoO4) , disodium salt
UNII-948QAQ08I1
Molybdate (MoO42-), disodium, (T-4)-
Molybdenum (as sodium)
disodium tetraoxomolybdate
sodium molybdate (anh.)
Molybdate (MoO42-), disodium, (beta-4)-
Molybdic acid, sodium salt
EC 231-551-7
Sodium molybdate, >=98%
Ddisodium Molybdate Dihydrate
Sodium Molybdate, ACS Grade
sodium dioxido(dioxo)molybdenum
Sodium Molybdate 35% Solution
Sodium Molybdate Solution 35%
Sodium molybdate, LR, >=99.5%
NSC-77389
AKOS015912969
DB14496
Sodium Molybdate Crystals, Technical Grade
FT-0701280
Sodium Molybdate Dihydrate (Technical Grade)
Molybdate (MoO42-), sodium (1:2), (T-4)-
Q414518
Sodium molybdate, anhydrous, powder, -100 mesh particle size, 99.9% trace metals basis
Disodium Moblydate
Disodium Molybdate Anhydrous
MOLY
Molybdic Acid Disodium Salt
Molybdic Acid Disodium Salt Anhydrous
Sodium Molybdate
Sodium Molybdate Anhydrous
Sodium molybdate
Disodium molybdate
Disodium tetraoxomolybdate
Sodium molybdate(VI)
Sodium orthomolybdate

DISODIUM PHOSPHATE
disodium phosphate 12 hydrate; Sodium Phosphate Dibasic Dodecahydrate; Disodium hydrogenphosphate Dodecahydrate; cas no: 10039-32-4
DISODIUM PHOSPHATE (DSP)
Disodium phosphate (DSP) is a white powder material, highly soluble in water, which gives alkaline solutions.
Disodium phosphate (DSP), also known as Disodium Hydrogen Phosphate Dihydrate, is a white, crystalline powder.
Disodium phosphate (DSP) is highly soluble in water and has a variety of applications due to its versatile properties.


CAS Number: 7558-79-4
10028-24-7 (dihydrate)
7782-85-6 (heptahydrate)
10039-32-4 (dodecahydrate)
EC Number: 231-448-7
E-number: E339(ii)
Chemical formula: Na2HPO4


Disodium phosphate (DSP), or sodium hydrogen phosphate, or sodium phosphate dibasic, is the inorganic compound with the formula Na2HPO4.
Disodium phosphate (DSP) is one of several sodium phosphates.
Disodium phosphate (DSP) is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates.


All are water-soluble white powders; the anhydrous salt being hygroscopic.
Disodium phosphate (DSP) is an inorganic compound derived from naturally occurring minerals.
Disodium Phosphate (DSP), or Disodium Hydrogen Phosphate, or Dibasic Sodium Phosphate, is an inorganic compound with the formula Na2HPO4.


This is one of several sodium phosphates.
This salt is known not only in its anhydrous form, but also in its 2-, 7-, 8-, and 12-hydrate forms.
All water-soluble white powders.


The pH of disodium hydrogen phosphate in water is between 8.0 and 11.0, meaning it is moderately basic.
HPO42− + H2O ⇌ H2PO4− + OH−
Disodium phosphate (DSP) also helps preserve sausages and cooked meats and make soft drinks and cheese smooth.


Disodium phosphate (DSP) helps preserve bakery products and enriched farina and maintain the smoothness of ice cream and artificially sweetened jelly.
Disodium phosphate (DSP) also known as Di-sodium hydrogen phosphate is the inorganic compound.
Disodium phosphate (DSP) is also one of the several sodium phosphates in anhydrous form.


Disodium phosphate (DSP) is water soluble and the anhydrous salt is hygroscopic.
Disodium phosphate (DSP) is obtained when a solution of phosphoric acid is reacted with caustic soda, until the higher PH is obtained.
Disodium phosphate is Sodium salt derived from Phosphate.


Disodium phosphate (DSP)'s properties are powder.
Disodium phosphate (DSP) dissolves well in water.
Disodium phosphate (DSP), or disodium hydrogen phosphate, or sodium phosphate dibasic, is the inorganic compound with the formula Na2HPO4.


Disodium phosphate (DSP) is one of several sodium phosphates.
Disodium phosphate (DSP) is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates.
All are water-soluble white powders; the anhydrous salt being hygroscopic.


Disodium Phosphate (DSP), Na2HPO4 12H2O, is a white or colorless, crystalline, free flowing solid that is efflorescent in air.
Disodium phosphate (DSP) is easily soluble in water but is insoluble in alcohol; its water solution is slightly alkaline.
Disodium phosphate (DSP) is a white hygrospic inorganic compound. Disodium phosphate (DSP) is one of the several sodium phosphates and is soluble in water.


The pH of Disodium phosphate (DSP) water solution is between 8.0 and 11.0, meaning it is moderately basic:
HPO42− + H2O ⇌ H2PO4− + OH−
Disodium phosphate (DSP) is also known as disodium hydrogen orthophosphate, sodium hydrogen phosphate or sodium phosphate dibasic.


Disodium phosphate (DSP) is commercially available in both the hydrated and anhydrous forms pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0
Disodium phosphate (DSP) is a sodium salt of phosphoric acid.
Disodium phosphate (DSP) is a white powder that is highly hygroscopic and water soluble.



USES and APPLICATIONS of DISODIUM PHOSPHATE (DSP):
Disodium phosphate (DSP) is used in combination with trisodium phosphate for food and water softening treatments.
Disodium phosphate (DSP) is used in food to regulate pH. Its presence prevents coagulation during the preparation of condensed milk.
Disodium phosphate (DSP) is likewise used as an anti-caking additive in powdered products.


Disodium phosphate (DSP) is used in desserts and puddings.
Disodium phosphate (DSP) is used cream of wheat to speed up cooking time or jello instant pudding to thicken.
Disodium phosphate (DSP) delays the formation of calcium scale in water treatment.


Disodium phosphate (DSP) is also found in some detergents and cleaners.
Heating the solid Disodium phosphate (DSP) yields the useful compound tetrasodium pyrophosphate.
2 Na2HPO4 → Na4P2O7 + H2O


Disodium phosphate (DSP), or disodium hydrogen phosphate, or sodium phosphate dibasic, is the inorganic compound with the formula Na HPO.
Disodium phosphate (DSP) is one of several sodium phosphates.
Disodium phosphate (DSP) is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates.


Application Industries of Disodium phosphate (DSP): Foods
Disodium phosphate (DSP) is used to adjust pH.
Disodium phosphate (DSP)'s presence prevents coagulation in the preparation of condensed milk.


Disodium phosphate (DSP) is used as an anti-caking additive in powdered products.
Disodium phosphate (DSP) is used in desserts and puddings, e.g.Cream of Wheat to quicken cook time, and Jell-O Instant pudding for thickening.
Disodium phosphate (DSP) is used as a ingredient is Making Tofu (Soya Paneer)


Disodium phosphate (DSP) is used water treatment, it retards calcium scale formation.
Disodium phosphate (DSP) is used versatility in Industrial Use
Food Industry: Disodium phosphate (DSP) is used as a food additive, especially in processed meats and canned foods, acting as a preservative and emulsifier.


Water Treatment: Disodium phosphate (DSP) is employed in water treatment formulations to control scale and corrosion in boilers and cooling systems.
Pharmaceuticals: Disodium phosphate (DSP) serves as an excipient in some pharmaceutical formulations.


Disodium phosphate (DSP) can be used to produce citric acid, water softener and fabric increased weight agent, fire retardant agent and used to glaze, flux, medicine, pigment, industrial water treatment agent, dyeing detergent agents, quality improvement agents, neutralizer, antibiotics culture agent and biological treatment agent.


Disodium phosphate (DSP) is used as fire retardant agent for fabric, wood, paper.
Disodium phosphate (DSP) is used as the weighting agent of the silk; also can be used as an analytical reagent.
In welding and brazing, Disodium phosphate (DSP) is used instead of using borax.


Disodium phosphate (DSP) is used Water softening agent, tanning, dye, weight increasing agent in textile industry, fire retardant agent of wood and paper, welding agent, laxative inedicine, inoculum of peniciline
and streptomycin, adjusting liquid of Phmeasurement, deironagent, paint and pigment, food industry, baking powder and electroforming as well as materials for making pyrophosporate and other phosphates.


Disodium phosphate (DSP) is also found in some detergents and cleaning agents.
Disodium phosphate (DSP) is a food additive that combines the minerals phosphate, or phosphorus, and sodium.
Phosphate salts are also sometimes used as medicine, and they are generally regarded as safe by the U.S. Food and Drug Administration.


People with certain health conditions requiring low phosphorus intakes, however, may want to minimize the amount of disodium phosphate they consume.
A wide variety of other foods can also contain Disodium phosphate (DSP), including breading or batters, breakfast cereal, candied fruit, butter, chewing gum, cocoa and chocolate products, fruit juice products, coffee, tea, cider, dairy products, candy, processed vegetables, pudding, pasta, alcoholic beverages, sausage casings, egg- or fat-based desserts, salt, salt substitutes, soups, tofu, sweeteners and water-based beverages.


Disodium phosphate (DSP) is used as water softener of boiler, flame retardant of fabrics, wood and paper, detergent in production, galvanization, etc.
Disodium phosphate (DSP) could be an acid regulator due to its weak alkaline.
Disodium phosphate (DSP) is used as an anticaking agent and moisture retention agent for its hygroscopic; as a quality improver for condensed milk.


Disodium phosphate (DSP) is used as a stabilizer for dairy products, meat and fish products; a component in mixed salt for curing, and etc.
Disodium phosphate (DSP) is used Agricultural Chemicals, Animal Nutrition & Feed, Anti-caking Agents, Food & Beverage, Food Additives, Detergents, Solvents.
Disodium phosphate (DSP) has many applications in the food industries, used as an emulsifying agent, buffer, rehydration agent and brine constituent.


Disodium phosphate (DSP) is a food additive.
Disodium phosphate (DSP) is an anticaking, a buffering agent and also a humectant.
Disodium phosphate (DSP) helps to retain moisture in seafood.


Disodium phosphate (DSP) is used in the food industry as emulsifying agent, buffer, and brine constituent.
Examples such as processed cheeses and dairy products.
In the industry aspect, Disodium phosphate (DSP) is used as metal surface treatment, binder in enamel production, water treatment and component of cleaners.


Disodium phosphate (DSP) is widely used as a sequestrant, emulsifier & buffer in foods
Disodium phosphate (DSP) is also used as a mordant in dying, for weighing silk and in tanning
Disodium phosphate (DSP) is widely used in manufacturing of enamels, ceramics, detergents and boiler compounds


Disodium phosphate (DSP) is used as fire proofing agent, in soldering & brazing instead of borax
Disodium phosphate (DSP) crystal is used along with sodium phosphates in treatment of food and water.
Disodium phosphate (DSP) is added to fluid milk during pasteurization or spray drying to inhibit protein denaturation during heat treatment and allows efficient protein dispersion upon rehydration.


Disodium phosphate (DSP) is used in conjunction with trisodium phosphate in foods and water softening treatment.
In foods, Disodium phosphate (DSP) is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk.
Similarly, Disodium phosphate (DSP) is used as an anti-caking additive in powdered products.


Disodium phosphate (DSP) is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening.
In water treatment, Disodium phosphate (DSP) retards calcium scale formation.
Disodium phosphate (DSP) is also found in some detergents and cleaning agents.


Heating solid disodium phosphate gives the useful compound tetrasodium pyrophosphate:
2 Na2HPO4 → Na4P2O7 + H2O
Laxative: Monobasic and dibasic sodium phosphate are used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy.


Disodium Phosphate (DSP) is used as a pH buffer, stabilizer, and emulsifier in processed cheese, condensed milk, instant pudding, and other food applications.
Disodium phosphate (DSP) is also used as a buffering agent in textile and water treatment applications.
Disodium phosphate (DSP) is therefore used commercially as an anti-caking additive in powdered products.


Disodium phosphate (DSP) is used in dyestuffs and metal treatment.
Disodium phosphate (DSP) is also used in conjunction with trisodium phosphate in many steam-boiler applications.
Disodium phosphate (DSP) supplies the inventory of free phosphates to retard calcium scale formation.


Disodium phosphate (DSP) is also used in Metal cleaning, as a Buffer in Textile Processing, In dyestuffs for faster dispersion, Important ingredient in fire proofing formulations, For purification of clays, For manufacture of opal glass.
Food grade Disodium phosphate (DSP) is used as a food additive and buffering agent.
Disodium phosphate (DSP) is most commonly used commercially as an anti-caking agent.


Disodium phosphate (DSP) is available in both hydrate and anhydrous forms.
Disodium phosphate (DSP) can be used in a wide range of applications.
Disodium phosphate (DSP) is used Animal Nutrition & Feed, Agricultural Chemicals, Anti-caking agent, Food & Beverage, Detergents, Solvents, and Pharmaceuticals.


-Uses of Disodium phosphate (DSP) in Food:
When used as a food additive, Disodium phosphate (DSP) plays a number of roles.
Disodium phosphate (DSP) can help regulate the acidity of food, thicken it, stabilize it and maintain it at the proper moisture level.
Disodium phosphate (DSP) also helps keep oil-based and water-based ingredients, which would otherwise separate, mixed together.


-Potential Food Sources of Disodium phosphate (DSP):
Fish and seafood sometimes contain disodium phosphate to help keep them moist.
Otherwise, they lose significant amounts of water during processing and storage.


-Other Uses:
Disodium phosphate has nonfood applications, too.
Disodium phosphate (DSP) can be used in water treatment and as a flame retardant.
In medicine, Disodium phosphate (DSP) may help lower high blood levels of calcium or increase low blood levels of phosphate.



DESCRIPTION OF DISODIUM PHOSPHATE (DSP):
• Disodium phosphate (DSP) is a white or colorless crystalline free flowing solid.
• Disodium phosphate (DSP) is easily soluble in water, but insoluble in alcohol.
• Disodium phosphate (DSP) is water solution is slightly alkaline.
• The solubility of Disodium phosphate (DSP) is 51.004% at 100°C.



PRODUCTION METHODS OF DISODIUM PHOSPHATE (DSP):
How Disodium Phosphate is Manufactured:
Disodium phosphate (DSP) is typically produced by reacting phosphoric acid with sodium hydroxide.
This results in the formation of Disodium Phosphate, which is then carefully processed and tested to meet industry standards.



PRODUCTION AND REACTION OF DISODIUM PHOSPHATE (DSP):
Disodium phosphate (DSP) can be generated by neutralization of phosphoric acid with sodium hydroxide:
H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O

Industrially Disodium phosphate (DSP) is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:
CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4
In the second step, the resulting solution of monosodium phosphate is partially neutralized:
NaH2PO4 + NaOH → Na2HPO4 + H2O



PHYSICAL and CHEMICAL PROPERTIES of DISODIUM PHOSPHATE (DSP):
Chemical formula: Na2HPO4
Molar mass: 141.96 g/mol (anhydrous)
177.99 g/mol (dihydrate)
268.07 g/mol (heptahydrate)
Appearance: White crystalline solid
Odor: odorless
Density: 1.7 g/cm3
Melting point: 250 °C (482 °F; 523 K) decomposes
Solubility in water: 7.7 g/100 ml (20 °C)
11.8 g/100 mL (25 °C, heptahydrate)
Solubility: insoluble in alcohol
log P: -5.8
Acidity (pKa): 2.15, 6.82, 12.35
Magnetic susceptibility (χ): −56.6·10−6 cm3/mol
Refractive index (nD): 1.35644..1.35717 at 20°C
Appearance Form: granules
Color: white
Odor: odorless
Odor Threshold: Not applicable

pH: 8,9 - 9,2 at 50 g/l at 25 °C
Melting point/freezing point:
Melting point/range: > 450 °C -
Initial boiling point and boiling range: No data available
Flash point: Not applicable
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: No data available
Vapor density: No data available
Relative density: No data available
Water solubility: at 20 °C soluble
Partition coefficient: n-octanol/water: Not applicable for inorganic substances
Autoignition temperature: No data available
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Dissociation constant 6,87 at 20,4 °C



FIRST AID MEASURES of DISODIUM PHOSPHATE (DSP):
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DISODIUM PHOSPHATE (DSP):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of DISODIUM PHOSPHATE (DSP):
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system



EXPOSURE CONTROLS/PERSONAL PROTECTION of DISODIUM PHOSPHATE (DSP):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Respiratory protection:
Respiratory protection is not required.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DISODIUM PHOSPHATE (DSP):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
Hygroscopic.
Keep in a dry place.



STABILITY and REACTIVITY of DISODIUM PHOSPHATE (DSP):
-Reactivity:
No data available
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available



SYNONYMS:
Disodium hydrogen phosphate
Disodium hydrogen orthophosphate
Disodium hydrogen phosphate
Sodium phosphate dibasic
disodium phosphate
dibasic sodium phosphate
Acetest



DISODIUM PHOSPHATE (DSP)

Disodium phosphate (DSP) is an inorganic salt with the chemical formula Na₂HPO₄.
Also known as sodium hydrogen phosphate, it exists in various forms, including hydrates and anhydrous.
Disodium phosphate (DSP) is commonly used in the food industry as a buffering agent and emulsifier.

CAS Number: 7558-79-4, 10039-32-4
EC Number: 231-448-7, 231-554-3

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APPLICATIONS


Disodium phosphate (DSP) is widely used in the food industry as a pH regulator and emulsifying agent.
In baking, it functions as a leavening agent, contributing to the rise of baked goods.
Disodium phosphate (DSP) is employed in dairy products to control acidity and improve texture, particularly in processed cheese.
As a buffering agent, disodium phosphate helps maintain stable pH levels in various food and beverage products.

Disodium phosphate (DSP) is utilized in the preparation of certain canned and processed meats to enhance flavor stability.
Disodium phosphate (DSP) finds applications in the pharmaceutical industry as an excipient in tablet formulations.
In water treatment processes, it acts as a sequestering agent to inhibit the formation of scale.

Disodium phosphate (DSP) is added to some cleaning agents and detergents to soften water and improve their effectiveness.
Disodium phosphate (DSP) is used in the textile industry as a flame retardant in some fabric treatments.
In agriculture, it may be applied as a nutrient source for plants and to adjust soil pH.

Some electrolyte solutions in medical settings contain disodium phosphate to help balance ions in the body.
Disodium phosphate (DSP) is utilized in the production of adhesives, contributing to their formulation.

Disodium phosphate (DSP) has applications in the cosmetics industry, particularly in emulsions and creams.
Disodium phosphate (DSP) is employed in the manufacturing of ceramics to enhance certain properties of the materials.

Disodium phosphate (DSP) plays a role in controlling the setting time of plaster in construction applications.
In the production of textiles, it may be used in dyeing processes as a buffering agent.
Some flame retardant formulations for materials such as plastics and polymers contain disodium phosphate.
Disodium phosphate (DSP) is employed in analytical chemistry as a reagent for various laboratory experiments.

Disodium phosphate (DSP) may be found in certain dental products and toothpaste formulations.
In the beverage industry, it is used in some soft drinks to adjust acidity and provide a tart taste.

Disodium phosphate (DSP) is utilized in the synthesis of certain chemicals and pharmaceutical intermediates.
Disodium phosphate (DSP) has applications in the paper and pulp industry to prevent scale formation in the production process.
In the manufacturing of fire extinguishing agents, disodium phosphate can be used to modify formulations.

Some metal cleaning solutions contain disodium phosphate to enhance their cleaning properties.
Disodium phosphate (DSP) has diverse applications across industries, contributing to various products and processes.

In the production of canned soups and broths, disodium phosphate helps maintain the desired consistency and prevents separation.
Disodium phosphate (DSP) is used in the preparation of certain sports drinks to replenish electrolytes lost during physical activity.
Disodium phosphate (DSP) can be found in some dental products like mouthwash for its buffering properties.

Disodium phosphate (DSP) is added to some frozen seafood products to enhance the texture and prevent crystallization.
Disodium phosphate (DSP) is employed in the preparation of certain cheeses to improve the melting properties.
In the brewing industry, Disodium phosphate (DSP) may be used to adjust pH levels during the mashing process in beer production.

Disodium phosphate (DSP) finds applications in the pharmaceutical field for its role in certain drug formulations.
Disodium phosphate (DSP) is utilized in the production of specialty chemicals, including those used in photography.
In the pet food industry, it may be added to certain formulations to enhance nutrient absorption.
Some metal finishing processes utilize disodium phosphate in formulations for surface treatment.

Disodium phosphate (DSP) is employed in the creation of some household cleaning products for its water softening abilities.
Disodium phosphate (DSP) may be included in the formulation of certain fertilizers to provide essential phosphorus to plants.
In the textile industry, disodium phosphate is used as a buffering agent in dyeing processes.

Disodium phosphate (DSP) finds applications in the formulation of certain dietary supplements.
Disodium phosphate (DSP) is used in the production of fire-retardant coatings for wood and fabrics.
In the printing industry, it may be included in ink formulations to control pH levels.

Disodium phosphate (DSP) is utilized in some cosmetics and personal care products as a pH adjuster.
Disodium phosphate (DSP) has applications in the stabilization of certain enzymes in biochemical processes.
In the production of processed meats, it may be added to improve water retention and texture.

Disodium phosphate (DSP) is utilized in the manufacturing of certain ceramics and glazes.
Disodium phosphate (DSP) plays a role in the preservation of certain pickled and canned vegetables.
In the petroleum industry, disodium phosphate may be used in drilling mud formulations for specific purposes.

Disodium phosphate (DSP) is found in certain electrolyte replacement solutions used in medical settings.
Disodium phosphate (DSP) may be used in certain analytical chemistry techniques as a reagent for phosphate determination.
Disodium phosphate (DSP) is employed in the formulation of some dietary food supplements for animals.

Disodium phosphate (DSP) is commonly used in the production of processed and cured meat products, such as sausages and hams, to enhance flavor and improve texture.
In the dairy industry, it is added to evaporated milk to stabilize proteins and prevent coagulation.
Disodium phosphate (DSP) finds applications in the manufacturing of certain dessert mixes to provide a smooth texture and control acidity.

Disodium phosphate (DSP) is used as an additive in certain pharmaceutical formulations, including tablets and capsules.
In the construction industry, it may be included in some cement formulations to improve workability.
Disodium phosphate (DSP) is employed in some toothpaste formulations for its role in controlling tartar and preventing dental decay.

Disodium phosphate (DSP) is utilized in the production of certain insecticides and pesticides for its buffering properties.
In the creation of certain ceramics and pottery, disodium phosphate may be used as a flux.

Disodium phosphate (DSP) is found in certain fire extinguishing agents, contributing to their effectiveness.
Disodium phosphate (DSP) is utilized in the formulation of certain hair care products to adjust pH levels.
Disodium phosphate (DSP) may be included in the manufacturing of certain plastics to modify their properties.

Disodium phosphate (DSP) is used in the preservation of certain canned seafood products to maintain quality.
In the textile industry, it finds applications as a flame retardant in certain fabric treatments.
Disodium phosphate (DSP) may be added to certain industrial wastewater treatment processes to control pH.
Disodium phosphate (DSP) is employed in the production of specialty papers and cardboard for its role in controlling pH.

In the creation of certain adhesive formulations, disodium phosphate may be used for its adhesive properties.
Disodium phosphate (DSP) is found in certain rust removers and metal cleaning solutions for its effectiveness in removing oxide layers.
Disodium phosphate (DSP) is used in the manufacturing of certain cosmetics, particularly in formulations like facial cleansers.
In the production of specialty inks, such as those used in printing, disodium phosphate may be included for its pH control capabilities.

Disodium phosphate (DSP) is utilized in the creation of certain dietary supplements for animals, providing essential nutrients.
Disodium phosphate (DSP) is employed in the formulation of certain lubricants for its role in reducing friction.
Disodium phosphate (DSP) may be included in the manufacturing of certain specialty glass products for its fluxing properties.

Disodium phosphate (DSP) is used in the preparation of certain pickles to maintain crispness and control acidity.
In the creation of some automotive antifreeze formulations, it may be added for its buffering properties.
Disodium phosphate (DSP) is utilized in certain metalworking processes as a corrosion inhibitor and pH regulator.



DESCRIPTION


Disodium phosphate (DSP) is an inorganic salt with the chemical formula Na₂HPO₄.
Also known as sodium hydrogen phosphate, it exists in various forms, including hydrates and anhydrous.
Disodium phosphate (DSP) is commonly used in the food industry as a buffering agent and emulsifier.

Disodium phosphate (DSP) plays a crucial role in regulating acidity and improving texture in processed foods.
Disodium phosphate (DSP) appears as a white, crystalline powder or granules, depending on its form.
In laboratory settings, disodium phosphate is employed in chemical reactions and as a pH buffer.

The anhydrous form is a dry, crystalline material, while the hydrates contain water molecules in their structures.
Disodium phosphate (DSP) is soluble in water, and its solutions are alkaline.
As a food additive, it contributes to the leavening of baked goods and helps control the pH of dairy products.

In the pharmaceutical industry, it may be used as an excipient in tablet formulations.
Disodium phosphate (DSP) is commonly found in cleaning agents and detergents due to its water softening properties.
Disodium phosphate (DSP) is recognized for its ability to sequester metal ions, improving the effectiveness of certain detergents.

Disodium phosphate (DSP) is stable under normal conditions but may decompose at high temperatures.
Disodium phosphate (DSP) has a molecular weight of approximately 141.96 grams/mol.
Disodium phosphate (DSP) may be found in various industries, including agriculture, water treatment, and textiles.

Disodium phosphate (DSP) is a sodium salt of phosphoric acid, containing two sodium cations and one phosphate anion.
Disodium phosphate (DSP) may contribute to the preservation of processed meats by controlling pH and enhancing flavor stability.
Disodium phosphate (DSP) is odorless and has a slightly saline taste.

Disodium phosphate (DSP) is used in some electrolyte solutions for medical purposes.
When handled, Disodium phosphate (DSP) is important to wear appropriate protective equipment, including gloves and eye protection.
The different hydrate forms, such as the dodecahydrate, contribute to the versatility of this compound.

Disodium phosphate (DSP) has applications in water treatment processes to inhibit scale formation.
In the cosmetics industry, it may be used in formulations for its buffering and emulsifying properties.
Disodium phosphate (DSP) has a role in controlling the setting time of plaster in construction materials.
The production of adhesives, ceramics, and flame retardants are additional applications of disodium phosphate.



PROPERTIES


Physical Properties:

Appearance: White crystalline powder or granules.
Odor: Odorless.
Taste: Slightly saline taste.
Solubility: Soluble in water.
Density: Varies depending on the form (anhydrous or hydrated).
Molecular Weight: Approximately 141.96 grams/mol (anhydrous form).


Chemical Properties:

Chemical Formula: Na₂HPO₄.
pH: Acts as a buffering agent, controlling pH in various applications.
Ionization: Disassociates into sodium ions (Na⁺) and hydrogen phosphate ions (HPO₄²⁻) in aqueous solutions.
Hydration States: Anhydrous form and various hydrates (e.g., dodecahydrate).


Thermal Properties:

Melting Point: Varies depending on the form (e.g., anhydrous disodium phosphate has a melting point around 250°C).



FIRST AID


Inhalation:

Move to Fresh Air:
If disodium phosphate dust or vapors are inhaled and respiratory irritation occurs, promptly move the affected person to an area with fresh air.

Seek Medical Attention:
If respiratory difficulties persist or if there are signs of respiratory distress, seek medical attention immediately.


Skin Contact:

Remove Contaminated Clothing:
If disodium phosphate comes into contact with the skin, promptly remove contaminated clothing.

Wash Skin:
Wash the affected skin area with plenty of water and mild soap for at least 15 minutes.

Seek Medical Attention:
If irritation, redness, or other adverse skin reactions occur, seek medical advice.


Eye Contact:

Flush Eyes:
In case of eye contact, immediately flush the eyes with gentle, flowing water for at least 15 minutes.
Ensure eyelids are held open during flushing.

Seek Medical Attention:
If irritation persists or if there are signs of eye injury, seek immediate medical attention.


Ingestion:

Do Not Induce Vomiting:
If disodium phosphate is ingested, do not induce vomiting unless instructed to do so by medical personnel.

Rinse Mouth:
Rinse the mouth with water if the person is conscious and able to swallow.

Seek Medical Attention:
Seek immediate medical attention, and provide the medical personnel with details about the ingested substance.


General First Aid Precautions:

Provide Comfort:
Keep the affected person calm and provide reassurance during first aid measures.

Protective Equipment:
If administering first aid, wear appropriate personal protective equipment, such as gloves and safety glasses.

Do Not Delay Medical Attention:
If there is any uncertainty about the severity of exposure or if symptoms persist, seek prompt medical attention.



HANDLING AND STORAGE


Handling Conditions:

Personal Protective Equipment (PPE):
Wear appropriate PPE, including gloves and safety glasses, when handling disodium phosphate to prevent skin contact and eye irritation.

Ventilation:
Use in well-ventilated areas to minimize exposure to dust or vapors, especially in industrial settings.

Avoid Contamination:
Prevent contamination of disodium phosphate by ensuring that equipment, containers, and tools are clean and free of foreign substances.

Temperature Considerations:
Be aware of temperature sensitivity, especially if working with anhydrous forms.
Follow recommended temperature ranges for handling.

Handling Procedures:
Follow safe handling procedures, including proper lifting techniques and the use of equipment to avoid spillage.

Avoiding Skin Contact:
Minimize skin contact with disodium phosphate.
If contact occurs, wash the affected area thoroughly with water and mild soap.

Use in accordance with Regulations:
Adhere to local regulations and guidelines for the safe handling and use of disodium phosphate.


Storage Conditions:

Temperature and Humidity:
Store disodium phosphate in a cool, dry place, away from direct sunlight and extreme temperatures.
Some forms, especially hydrates, may have specific storage temperature requirements.

Separation from Incompatible Substances:
Store disodium phosphate away from incompatible substances, including strong acids, bases, and certain metals.

Container Integrity:
Ensure that storage containers are in good condition, properly sealed, and labeled with relevant information, including product identity and hazards.

Avoiding Contamination:
Store disodium phosphate away from materials that may contaminate it.
Use dedicated storage areas for chemicals.

Segregation from Food and Pharmaceuticals:
Keep disodium phosphate away from areas where food, pharmaceuticals, or other sensitive products are stored.

Protection from Moisture:
For anhydrous forms, protect from moisture to prevent clumping and caking. Consider using moisture-resistant packaging.

Proper Handling of Bags and Drums:
Handle bags and drums of disodium phosphate carefully to avoid damage, spills, or punctures.

Labeling and Documentation:
Clearly label storage containers with product information, hazard warnings, and handling instructions.
Maintain up-to-date documentation, including safety data sheets (SDS) and emergency contact information.

Emergency Equipment:
Keep emergency equipment, such as spill response kits and eye wash stations, accessible in the storage area.

Regular Inspections:
Conduct regular inspections of storage areas to ensure compliance with safety and regulatory requirements.


DISODIUM PHOSPHATE 12 HYDRATE
Sodium Phosphate Dibasic; Dsodium phosphoric acid; Disodium hydrogenphosphate; Disodium Hydrogenphosphate; Sodium monohydrogen phosphate; Disodium Hydrogen Orthophosphate; Disodium Phosphate; Phosphoric acid, disodium salt; sodium monohydrogen phosphate (2:1:1); dibasic sodium phosphate; disodium monohydrogen phosphate; disodium orthophosphate; DSP; soda phosphate; sodium hydrogen phosphate; Disodium Monophosphate; Disodium Monohydrogen Orthophoshate; cas no:7558-79-4
DISODIUM PHOSPHATE ANHYDRATE
Disodium Phosphate Anhydrate What is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)? Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is a food additive. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s “generally recognized as safe” (GRAS) by the U.S. Food and Drug Administration (FDA) Phosphates like Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) are derived from the element phosphorus. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)s are used to enhance food characteristics like nutritional value and cooking performance. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used in packaged foods, including macaroni and pastas. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is also used in some cheeses as an emulsifier. You can also find it in meat products, canned sauces, Jell-O, evaporated milk, and some chocolate. Originally derived from animal bones and urine, phosphorus is now extracted from phosphate rock. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is purified and put through chemical reactions. Is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) safe? When it comes to food additives, it’s completely normal to wonder about safety. The FDA’s stance isn’t completely reassuring for some people. The Environmental Working Group (EWG) says there is a “fair” amount of data available on this phosphate. The EWG says that the additive can be considered safe. It’s not considered to be an environmental toxin or potentially harmful to humans. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is not bioaccumulative (where it accumulates within your body over time). Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is also classified as a “low human health priority” under Canadian law. In 2012, a studyTrusted Source was published declaring phosphates in general to be hazardous. The researchers suggested that all foods containing phosphates should be labeled as dangerous to public health. According to their research, accumulating phosphates in the body can cause organ calcification in people with renal failure, and even in people without kidney problems. But the International Food Additives Council states that inorganic phosphates have a long history of safe use in food and that additional studies have proven their safety. That being said, foods containing Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) are often packaged and heavily processed, so they’re not the healthiest choices to begin with. How to avoid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) If you’re leery of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) despite assurances of its safety, you can simply keep it out of your diet. However, identifying it may be difficult. In most cases, all you need to do is check the ingredients list on food packaging to tell if an item contains Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) or not. However, phosphates are also used in the meat industry to prevent spoilage, and meat packages don’t typically mention this. Avoiding packaged and processed foods is one way around Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) will benefit your overall health as well. Purchasing locally produced meats is another way to avoid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) (DSP), or sodium hydrogen phosphate, or sodium phosphate dibasic, is the inorganic compound with the formula Na2HPO4. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is one of several sodium phosphates. The salt is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates. All are water-soluble white powders; the anhydrous salt being hygroscopic. The pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately basic: Production and reactions Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) can be generated by neutralization of phosphoric acid with sodium hydroxide: H3PO4 + 2 NaOH → HNa2PO4 + 2 H2O Industrially Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate: CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4 In the second step, the resulting solution of monosodium phosphate is partially neutralized: NaH2PO4 + NaOH → HNa2PO4 + H2O Uses of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used in conjunction with trisodium phosphate in foods and water softening treatment. In foods, it is used to adjust pH. Its presence prevents coagulation in the preparation of condensed milk. Similarly, Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used as an anti-caking additive in powdered products. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening. In water treatment, it retards calcium scale formation. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is also found in some detergents and cleaning agents. Heating solid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) gives the useful compound tetrasodium pyrophosphate: 2 HNa2PO4 → Na4P2O7 + H2O Monobasic and dibasic sodium phosphate are used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy. HPO42− + H2O ⇌ H2PO4− + OH− Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is a white, hygroscopic, odourless powder. Hydrated forms available include the dihydrate: a white crystalline, odourless solid; the heptahydrate: white, odourless, efflorescent crystals or granular powder; and the dodecahydrate: white, efflorescent, odourless powder or crystals. Although the concn of phosphate is low in the extracellular fluid, the anion is progressively concn in the renal tubule and represents the most abundant buffer system in the distal tubule. At this site, the secretion of H+ by the tubular cell in exchange for Na+ in the tubular urine converts disodium hydrogen phosphate to Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). In this manner, large amt of acid can be excreted without lowering the pH of the urine to a degree that would block H+ transport by a high concn gradient between the tubular cell and luminal fluid. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is present in plasma and other extracellular fluid, in cell membranes and intracellular fluid, as well as in collagen and bone tissues. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) in the extracellular fluid is primarily in inorganic form and plasma levels may vary somewhat with age. The ratio of disodium phosphate and monosodium phosphate in the extracellular fluid is 4 to 1 (80% to 20%) at the normal pH of 7.4. This buffer ratio varies with the pH, but owing to its relatively low concentration, it contributes little to the buffering capacity of the extracellular fluid. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE), present in large amounts in erythrocytes and other tissue cells, plays a significant intracellular role in the synthesis of high energy organic phosphates. It has been shown to be essential to maintain red cell glucose utilization, lactate production, and the concentration of both erythrocyte adenosine triphosphate (ATP) and 2,3 diphosphoglycerate (DPG), and must be deemed as important to other tissue cells. NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,230,592 workers (912,048 of these were female) were potentially exposed to Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) in the US(1). The NOES Survey does not include farm workers. Occupational exposure to Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) may occur through inhalation and dermal contact with this compound at workplaces where Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is produced or used(SRC). A great example of a chemical used in food production is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). There are three main sodium phosphates used in food production: monosodium phosphate (NaH2PO4), Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) (Na2HPO4), and trisodium phosphate (Na3PO4). Though each form is useful in food processing, here we will focus on how Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) works in food production. What Is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)? Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is made with a simple chemical reaction between phosphoric acid (H3PO4) and sodium hydroxide. Phosphoric acid is a mineral acid. It neutralizes with sodium hydroxide, which acts as an alkaline substance during the reaction. Sodium atoms replace two of the three hydrogen atoms in the phosphoric acid and Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is formed. When used according to the FDA’s good manufacturing practices, Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is generally recognized as safe. Though we often think of processed food as a byproduct of the mid-20th century, sodium phosphates have been used in food production for over a century. Phosphates were used in cheese production as early as 1895. Likewise, sodium phosphates have historically been used in processed cheese, evaporated milk, and other fluid milk products. pH Control In Packaged Foods Among the most common uses of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is as a neutralizing agent. It acts as a buffering solution that helps control pH. Buffering solutions, a type of water-soluble solution known as aqueous solutions, are created by mixing a weak acid and its conjugate base. When a harsh acid or base is added to the solution, the pH of the solution as a whole is minimally affected. Many consumable liquids require diligent monitoring of pH to keep them in the right state. For instance, creamy milk can quickly become tangy cottage cheese by reducing the pH of the milk by adding an acid. Keeping the pH stable also contributes to food safety. Foods with a pH of 4.6 or lower do not provide a hospitable environment for bacteria like Clostridium botulinum to grow. Stabilizing Our Dairy Most people love cheese but making it would be difficult without Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). It acts as an emulsifier that keeps fat and water from separating during the cheese-making process. This helps us get the richest and creamiest cheese possible. In evaporated milk, it helps keep the butterfat from separating in the can and prevents an unpleasant gel from forming. And if you are a fan of whipped cream, you can thank Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) for the pleasure of picking it up at your local grocery store. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used as a processing agent in heavy whipping cream where it binds to the natural minerals in milk. It prevents the heavy cream from becoming unmanageable and coating the equipment during processing. Controlling Texture & Food Preservation Salt was the first preservative used to keep meat, seafood, pork, and poultry safe for consumption. Over time, food manufacturers have incorporated Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) as a means of food preservation. But the benefit of using Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) on meats does not stop at preservation. It can improve the meat’s tenderness and make it appear juicier. Americans are lucky enough to live in a world where rich foods are just a shopping trip away. And we have come to rely on these convenience foods. The world of chemistry allows food manufacturers to create safe, enjoyable products that make our lives easier. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is just one of the sodium phosphates used in the making of these packaged foods. But there are numerous other sodium phosphates used in and out of the food manufacturing industry. What is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)? Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is the sodium salt derived from phosphate rock in the earth. What does it do? In mouthwash Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) acts as a buffering agent that helps maintain the pH or acidity of the product. When Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is combined with fluoride and phosphoric acid to form an acidulated phosphate fluoride solution as outlined in the FDA’s Anticaries monograph, that solution promotes remineralization and helps prevent enamel dissolution. How is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) made? Our Model guides us to select ingredients which have been processed in a manner that supports our philosophy of human and environmental health. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is made by combining phosphoric acid, derived from phosphate rock, with soda ash. This material is then crystallized and purified for use in our products. What are the alternatives? For anticaries mouthwash products, with acidulated phosphate fluoride solution, Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) and phosphoric acid are required in conjunction with Sodium Fluoride per the Anticaries Drug Products for Over-the-Counter Human Use, Final Monograph.1 Tom’s offers both fluoride and fluoride free mouthwash options. Is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) the right option for me? Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is Generally Recognized as Safe (GRAS) by the FDA to be used as a food substance for human consumption. Phosphates like Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) are derived from the element phosphorus. They’re used to enhance food characteristics like nutritional value and cooking performance. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used in packaged foods, including macaroni and pastas. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s also used in some cheeses as an emulsifier. You can also find it in meat products, canned sauces, Jell-O, evaporated milk, and some chocolate. Originally derived from animal bones and urine, phosphorus is now extracted from phosphate rock. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s purified and put through chemical reactions. Is Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) safe? When it comes to food additives, it’s completely normal to wonder about safety. The FDA’s stance isn’t completely reassuring for some people. The Environmental Working Group (EWG) says there is a “fair” amount of data available on this phosphate. The EWG says that the additive can be considered safe. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s not considered to be an environmental toxin or potentially harmful to humans. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is not bioaccumulative (where it accumulates within your body over time). Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s also classified as a “low human health priority” under Canadian law. In 2012, a studyTrusted Source was published declaring phosphates in general to be hazardous. The researchers suggested that all foods containing phosphates should be labeled as dangerous to public health. According to their research, accumulating phosphates in the body can cause organ calcification in people with renal failure, and even in people without kidney problems. But the International Food Additives Council states that inorganic phosphates have a long history of safe use in food and that additional studies have proven their safety. That being said, foods containing Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) are often packaged and heavily processed, so they’re not the healthiest choices to begin with. How to avoid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) If you’re leery of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) despite assurances of its safety, you can simply keep it out of your diet. However, identifying it may be difficult. In most cases, all you need to do is check the ingredients list on food packaging to tell if an item contains Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) or not. However, phosphates are also used in the meat industry to prevent spoilage, and meat packages don’t typically mention this. Avoiding packaged and processed foods is one way around Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). This will benefit your overall health as well. Purchasing locally produced meats is another way to avoid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is use in many applications such as sequestrant, emulsifier and buffer in foods. As mordant in dyeing for weighting silk, in tanning. In manufacturing of enamels, ceramics, detergents; as fireproofing agent in soldering and brazing instead of borax; as reagent and buffer in analytical chemistry, cathartic, laxative. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE), ACS, 98.0-102.0% MDLMFCD00149180EINECS231-448-7 Chemical Properties of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) Formula Na2HPO4•7H2O Formula Weight 268.07 (141.98anhy)Form Crystalline Melting point 48.1°-5H{2}O Density 1.7 Storage & Sensitivity Ambient temperatures.Solubility Soluble in water and insoluble in ethanol. Applications of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) Sodium hydrogen phosphate is widely used in detergents and cleaning agents. Combined with trisodium phosphate, it is employed in the food industry to adjust the pH and in water treatment to prevent calcium scale formation. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is utilized as a saline laxative to clean the bowel before a colonoscopy. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) prevents the coagulation of condensed milk. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is also utilized as anti-caking additive in powdered products. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) enhances the cook time and used as thickening agent in desserts and puddings. Phosphates like Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) are derived from the element phosphorus. They’re used to enhance food characteristics like nutritional value and cooking performance. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is used in packaged foods, including macaroni and pastas. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s also used in some cheeses as an emulsifier. You can also find it in meat products, canned sauces, Jell-O, evaporated milk, and some chocolate. Originally derived from animal bones and urine, phosphorus is now extracted from phosphate rock. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE)’s purified and put through chemical reactions. In 2012, a studyTrusted Source was published declaring phosphates in general to be hazardous. The researchers suggested that all foods containing phosphates should be labeled as dangerous to public health. According to their research, accumulating phosphates in the body can cause organ calcification in people with renal failure, and even in people without kidney problems. But the International Food Additives Council states that inorganic phosphates have a long history of safe use in food and that additional studies have proven their safety. That being said, foods containing Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) are often packaged and heavily processed, so they’re not the healthiest choices to begin with. How to avoid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) If you’re leery of Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) despite assurances of its safety, you can simply keep it out of your diet. However, identifying it may be difficult. In most cases, all you need to do is check the ingredients list on food packaging to tell if an item contains Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) or not. However, phosphates are also used in the meat industry to prevent spoilage, and meat packages don’t typically mention this. Avoiding packaged and processed foods is one way around Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). This will benefit your overall health as well. Purchasing locally produced meats is another way to avoid Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE). Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement. Disodium phosphate anhydrate (disodyum fosfat anhidrat, DISODIUM PHOSPHATE ANHYDRATE) is use in many applications such as sequestrant, emulsifier and buffer in foods. As mordant in dyeing for weighting silk, in tanning. In manufacturing of enamels, ceramics, detergents; as fireproofing agent in soldering and brazing instead of borax; as reagent and buffer in analytical chemistry, cathartic, laxative.
DISODIUM PHOSPHATE ANHYDROUS

Disodium phosphate anhydrous is a white, crystalline powder.
Disodium phosphate anhydrous is highly soluble in water.
Disodium phosphate anhydrous has a chemical formula of Na2HPO4.
Disodium phosphate anhydrous is odorless.

CAS Number: 7558-79-4
EC Number: 231-448-7



APPLICATIONS


Disodium phosphate anhydrous is commonly used as a food additive in the food industry, serving as a pH regulator, emulsifier, and stabilizer in processed foods.
Disodium phosphate anhydrous finds application in water treatment processes to prevent scaling and corrosion in boilers, cooling towers, and water distribution systems.
Disodium phosphate anhydrous is used as an excipient in the pharmaceutical industry, assisting in the formulation of medications and oral solutions.

Disodium phosphate anhydrous is employed in the production of cosmetics and personal care products, including toothpaste, mouthwash, and skin creams.
Disodium phosphate anhydrous is utilized as a laboratory reagent for various chemical reactions, pH adjustments, and biological assays.
Disodium phosphate anhydrous is added to detergents and cleaning products to enhance their cleaning efficiency by softening water and removing mineral deposits.

Disodium phosphate anhydrous is used in metal cleaning solutions and surface treatment formulations to remove rust, scale, and contaminants from metal surfaces.
In the textile industry, Disodium phosphate anhydrous serves as a pH regulator and buffer in dyeing processes to control the acidity or alkalinity of the dye bath.
Disodium phosphate anhydrous is employed in boiler water treatment formulations to control pH levels, prevent scale formation, and inhibit corrosion in steam generating systems.
Disodium phosphate anhydrous is utilized in agriculture as a source of phosphorus in fertilizers and animal feed supplements.
Disodium phosphate anhydrous is incorporated into electroplating baths to maintain stable plating conditions and improve the quality of the plated metal.

Disodium phosphate anhydrous finds application in fire retardant formulations to enhance flame resistance and reduce the risk of ignition.
In the ceramic industry, it acts as a fluxing agent in glazes and enamels to improve their fusion and flow during firing.
Disodium phosphate anhydrous is used in the paper manufacturing process as a pH regulator and a pulp dispersant.
Disodium phosphate anhydrous is added to cleaning agents to help remove stains, grease, and grime from various surfaces.

Disodium phosphate anhydrous is employed in metal surface treatment solutions to remove rust, scale, and contaminants from metal surfaces prior to further processing.
Disodium phosphate anhydrous is used in cooling and chilling systems to control pH and prevent scale formation on heat exchange surfaces.
Disodium phosphate anhydrous serves as a pH regulator and dispersing agent in water-based paint formulations.
In the oil and gas industry, it finds application as a corrosion inhibitor and pH regulator in drilling fluids, well stimulation fluids, and production processes.
Disodium phosphate anhydrous is sometimes added to adhesive and sealant formulations to adjust pH levels and enhance stability.
Disodium phosphate anhydrous is used in metalworking fluids to control pH and inhibit corrosion during machining operations.
Disodium phosphate anhydrous serves as a standard solution in pH calibration procedures for laboratory instruments and pH meters.
Disodium phosphate anhydrous is employed in the manufacturing of ceramics, including tiles and pottery, to improve glaze flow and adhesion.

Disodium phosphate anhydrous is used in the formulation of concrete admixtures to enhance workability and reduce water demand.
Disodium phosphate anhydrous finds application in the production of specialty chemicals, including flame retardants, corrosion inhibitors, and pH adjusters.


Disodium phosphate anhydrous has a wide range of applications in various industries.
Here are some of its common uses:

Food Industry:
Disodium phosphate anhydrous is used as a food additive and a buffering agent in processed foods, including cheese, meat products, canned foods, and baked goods.
Disodium phosphate anhydrous helps enhance food texture, stabilize pH, and prevent microbial growth.

Water Treatment:
Disodium phosphate anhydrous is employed in water treatment processes to prevent scaling, control pH levels, and inhibit corrosion in boilers, cooling towers, and other water systems.

Pharmaceutical Industry:
Disodium phosphate anhydrous is used as an excipient in the formulation of pharmaceutical products, serving as a pH adjuster and a stabilizer in certain medications and oral solutions.

Cosmetics and Personal Care Products:
Disodium phosphate anhydrous can be found in various cosmetics and personal care products, including toothpaste, mouthwash, skin creams, and hair care products, where it functions as a pH adjuster and a stabilizer.

Laboratory Reagent:
Disodium phosphate anhydrous is used as a reagent and a buffer in laboratory settings for various chemical reactions, pH adjustments, and biological assays.

Detergent Industry:
Disodium phosphate anhydrous is utilized as a builder in laundry detergents and dishwashing detergents to enhance their cleaning efficiency by softening water and removing mineral deposits.

Metal Cleaning and Surface Treatment:
Disodium phosphate anhydrous is used in metal cleaning solutions and surface treatment formulations to remove rust, scale, and contaminants from metal surfaces.

Textile Industry:
Disodium phosphate anhydrous is employed as a pH regulator and a buffer in textile dyeing processes to control the acidity or alkalinity of the dye bath and improve color fastness.

Boiler Water Treatment:
Disodium phosphate anhydrous is utilized in boiler water treatment formulations to control pH levels, prevent scale formation, and inhibit corrosion in steam generating systems.

Agriculture:
Disodium phosphate anhydrous can be used as a source of phosphorus in some agricultural applications, including fertilizers and animal feed supplements.

Electroplating:
Disodium phosphate anhydrous is utilized in electroplating baths as a buffering agent and pH adjuster to maintain stable plating conditions and improve the quality of the plated metal.

Fire Retardants:
Disodium phosphate anhydrous is incorporated into fire retardant formulations to enhance their effectiveness by providing flame resistance and reducing the risk of ignition.

Ceramic Industry:
Disodium phosphate anhydrous is used as a fluxing agent in ceramic glazes and enamels to promote fusion and improve the flow of the glaze during firing.

Paper Industry:
Disodium phosphate anhydrous is employed in the paper manufacturing process as a pH regulator and a pulp dispersant, helping to control acidity and improve pulp dispersion.

Cleaning Products:
Disodium phosphate anhydrous can be found in cleaning agents, such as multipurpose cleaners and degreasers, where it helps to remove stubborn stains, grease, and grime.

Metal Surface Treatment:
Disodium phosphate anhydrous is used in metal surface treatment solutions to remove rust, scale, and contaminants from metal surfaces prior to painting, coating, or further processing.

Cooling and Chilling Systems:
Disodium phosphate anhydrous is added to cooling and chilling systems to control the pH and prevent the formation of scale and deposits on heat exchange surfaces.

Water-Based Paints:
Disodium phosphate anhydrous is used as a pH regulator and a dispersing agent in water-based paint formulations, aiding in pigment dispersion and stability.

Oil and Gas Industry:
Disodium phosphate anhydrous finds application in the oil and gas sector as a corrosion inhibitor and pH regulator in drilling fluids, well stimulation fluids, and production processes.

Adhesives and Sealants:
Disodium phosphate anhydrous is sometimes incorporated into adhesive and sealant formulations to adjust pH levels, improve stability, and enhance adhesion properties.

Metalworking Fluids:
Disodium phosphate anhydrous is used in metalworking fluids, such as cutting fluids and grinding coolants, to control pH and inhibit corrosion on metal surfaces during machining operations.

pH Calibration:
Disodium phosphate anhydrous is employed as a standard solution in pH calibration procedures for laboratory instruments and pH meters.


Disodium phosphate anhydrous is used in the production of ceramic glazes to improve the surface finish and increase the gloss of ceramic products.
Disodium phosphate anhydrous is employed in the formulation of metal polishes to remove tarnish and restore the shine of metal surfaces.
Disodium phosphate anhydrous is used in the production of leather goods to aid in the tanning process and enhance the softness and durability of leather.

Disodium phosphate anhydrous is added to drilling muds in the oil and gas industry to improve the lubricity and stability of the mud during drilling operations.
Disodium phosphate anhydrous finds application in the manufacturing of fiberglass and composites as a pH regulator and a surface treatment agent.
Disodium phosphate anhydrous is used in the production of specialty papers, such as photographic papers and blueprint papers, to control pH and enhance print quality.
Disodium phosphate anhydrous is employed as a buffering agent in the fermentation process for the production of various alcoholic beverages.

Disodium phosphate anhydrous is added to certain dental products, such as mouthwashes and toothpastes, to help prevent tooth decay and promote oral health.
Disodium phosphate anhydrous is used in the formulation of fire extinguishing agents to control pH and improve the effectiveness of the extinguishing process.
Disodium phosphate anhydrous finds application in the textile industry for the preparation of fabrics prior to dyeing, ensuring better dye penetration and color fastness.
Disodium phosphate anhydrous is added to certain dietary supplements and sports nutrition products as a source of phosphorus, supporting bone health and energy metabolism.
Disodium phosphate anhydrous is employed in the manufacturing of ceramic tiles to improve their strength, durability, and resistance to moisture.

Disodium phosphate anhydrous is used in the production of animal feeds to provide essential phosphorus for proper growth and development.
Disodium phosphate anhydrous is added to certain water-based adhesives and sealants to improve their performance and increase their adhesive strength.
Disodium phosphate anhydrous is used in the formulation of oral care products, such as mouthwashes and gargles, to help freshen breath and promote oral hygiene.
Disodium phosphate anhydrous finds application in the production of fireproof coatings and paints for enhanced fire protection.

Disodium phosphate anhydrous is employed as a pH regulator and a nutrient source in hydroponic and aquaponic systems for optimal plant growth.
Disodium phosphate anhydrous is used in the production of animal vaccines as a stabilizing agent to maintain the efficacy of the vaccine during storage.
Disodium phosphate anhydrous is added to certain detergents and cleaning products as a surfactant and emulsifying agent for improved cleaning performance.
Disodium phosphate anhydrous finds application in the formulation of metalworking lubricants and coolants to improve tool life and reduce friction during machining operations.
Disodium phosphate anhydrous is used in the production of ceramic capacitors and electronic components as a dielectric material.
Disodium phosphate anhydrous is employed in the manufacture of water-soluble polymers for various industrial applications, such as adhesives and coatings.

Disodium phosphate anhydrous is added to certain paint strippers and removers to enhance their effectiveness in removing paint and coatings from surfaces.
Disodium phosphate anhydrous finds application in the formulation of liquid detergents and dishwashing solutions as a chelating agent for improved cleaning of dishes and utensils.
Disodium phosphate anhydrous is used in the production of heat transfer fluids to prevent scale formation and maintain thermal efficiency in heat exchange systems.



DESCRIPTION


Disodium phosphate anhydrous is a white, crystalline powder.
Disodium phosphate anhydrous is highly soluble in water.
Disodium phosphate anhydrous has a chemical formula of Na2HPO4.

Disodium phosphate anhydrous is odorless.
Disodium phosphate anhydrous has a slightly alkaline taste.
The compound is non-flammable.
Disodium phosphate anhydrous is stable under normal conditions.

Disodium phosphate anhydrous is hygroscopic, meaning it can absorb moisture from the air.
Disodium phosphate anhydrous is commonly used as a food additive and pH regulator.
The compound is widely employed in water treatment processes.
Disodium phosphate anhydrous is a source of phosphorus in various applications.

Disodium phosphate anhydrous has a molecular weight of approximately 141.96 g/mol.
Disodium phosphate anhydrous has a melting point of around 250°C (482°F).

Disodium phosphate anhydrous is an inorganic salt.
Disodium phosphate anhydrous can exist in different crystal forms, such as monoclinic or triclinic.

Disodium phosphate anhydrous is a versatile compound with multiple industrial uses.
Disodium phosphate anhydrous has the ability to form complexes with metal ions.
The compound is an effective buffering agent.

Disodium phosphate anhydrous can help control pH levels in a variety of applications.
Disodium phosphate anhydrous is considered safe for consumption when used in accordance with regulations.
Disodium phosphate anhydrous is used in the formulation of certain pharmaceutical products.
Disodium phosphate anhydrous is known for its ability to inhibit corrosion in water systems.

Disodium phosphate anhydrous is compatible with other chemicals and ingredients.
Disodium phosphate anhydrous is commonly found in cleaning products and detergents.
Disodium phosphate anhydrous is commercially available in various grades and concentrations.


Disodium phosphate anhydrous, also known as disodium hydrogen phosphate, is a chemical compound with the formula Na2HPO4.
Disodium phosphate anhydrous is the anhydrous form of disodium phosphate, which means it does not contain any water molecules in its crystal structure.
Disodium phosphate anhydrous is a white, crystalline powder that is highly soluble in water.

The chemical formula of disodium phosphate anhydrous indicates that it consists of two sodium ions (Na+) and one phosphate ion (HPO42-).
Disodium phosphate anhydrous is derived from phosphoric acid and sodium hydroxide.
Disodium phosphate anhydrous is commonly used as a food additive, buffering agent, and pH adjuster in various industries.



PROPERTIES


Chemical Formula: Na2HPO4
Molecular Weight: 141.96 g/mol
Appearance: White, crystalline powder
Odor: Odorless
Solubility: Soluble in water
Density: 1.52 g/cm3
Melting Point: 250 °C (482 °F)
Boiling Point: Decomposes at higher temperatures
pH (1% solution): Approximately 9.0-9.6
Water Content: Less than 1% (when anhydrous)
Hygroscopicity: Absorbs moisture from the air
Crystal Structure: Monoclinic or triclinic
Stability: Stable under normal conditions



FIRST AID


Inhalation:

Move the affected person to an area with fresh air.
If breathing is difficult, provide oxygen and seek medical attention.
If the person is not breathing, administer artificial respiration and seek immediate medical assistance.


Skin Contact:

Remove contaminated clothing and footwear.
Wash the affected area with plenty of soap and water for at least 15 minutes.
If irritation or redness develops, seek medical advice.
Wash contaminated clothing before reuse.


Eye Contact:

Rinse the eyes gently with water for at least 15 minutes, holding the eyelids open.
Seek immediate medical attention, even if the person's vision seems unaffected.
Remove contact lenses, if present and easily removable.


Ingestion:

Rinse the mouth thoroughly with water and give the affected person a glass of water to drink.
Do not induce vomiting unless instructed to do so by medical personnel.
Seek immediate medical attention.
If large quantities have been ingested or if the person is unconscious, do not give anything by mouth and seek medical assistance.



HANDLING AND STORAGE


Handling:

Personal Protection:

Wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat or protective clothing.
Avoid skin and eye contact with the compound.
In case of accidental contact, follow the first aid measures mentioned earlier.

Ventilation:

Ensure good ventilation in the working area to prevent the accumulation of dust or vapors.
Use local exhaust ventilation or other engineering controls if necessary.

Spill and Leak:

In the event of a spill, contain the substance and prevent it from spreading.
Use appropriate absorbent materials to clean up the spill, avoiding the generation of dust.
Dispose of the spilled material according to applicable regulations.

Avoid Mixing:

Do not mix Disodium phosphate anhydrous with incompatible substances, such as strong acids or oxidizing agents, as it may cause hazardous reactions.
Follow proper handling procedures when working with other chemicals.

Handling Precautions:

Handle the compound with care to avoid generating dust, as inhalation of dust particles may cause respiratory irritation.
Avoid ingestion or direct contact with skin or eyes.
Wash hands thoroughly with soap and water after handling.


Storage:

Storage Conditions:

Store Disodium phosphate anhydrous in a cool, dry, well-ventilated area.
Keep the containers tightly closed and properly labeled.
Store away from sources of heat, ignition, and incompatible substances.

Segregation:

Store the compound away from acids, oxidizing agents, and strong bases to prevent the risk of reactions.
Segregate from other chemicals to avoid contamination.

Packaging:

Use suitable packaging materials, such as sealed containers or bags, to ensure the integrity of the product during storage.
Follow any specific storage requirements provided by the manufacturer or supplier.

Handling Precautions:

Follow good industrial hygiene practices, including regular cleaning of the storage area and proper maintenance of equipment.
Keep the storage area clearly labeled and separate from food, beverages, and animal feed.

Storage Stability:

Disodium phosphate anhydrous has good storage stability under normal conditions.
However, it is advisable to monitor the product for any signs of degradation, clumping, or changes in appearance.
Check the expiration date or recommended shelf life provided by the manufacturer and use the product accordingly.



SYNONYMS


Sodium hydrogen phosphate
Sodium phosphate dibasic
Disodium hydrogen phosphate
Sodium phosphate, dibasic
Sodium phosphate, anhydrous
Disodium orthophosphate
Dibasic sodium phosphate
Sodium monohydrogen phosphate
DSPA
Dibasic sodium phosphate, anhydrous
Disodium hydrogen phosphate, anhydrous
Disodium hydrogen phosphate dihydrate (synonym for hydrated form)
Sodium phosphate, Na2HPO4
Sodium phosphate, dibasic, anhydrous
Disodium hydrogen phosphate, anhydrous
Disodium hydrogen phosphate dihydrate
Sodium orthophosphate
Sodium phosphate (Na2HPO4)
Secondary sodium phosphate
Sodium phosphate, hydrate
Sodium phosphate, dibasic, dihydrate
Sodium phosphate, dihydrate
Sodium acid phosphate
Sodium phosphate, secondary
Sodium phosphate, dodecahydrate (synonym for hydrated form)
Sodium phosphate, dibasic, dihydrate
Disodium phosphate dihydrate
Disodium phosphate, dihydrate
Sodium hydrogen phosphate dihydrate
Sodium phosphate, secondary, dodecahydrate
Sodium phosphate, dodecahydrate
Disodium hydrogen phosphate, dihydrate
Sodium phosphate, dibasic, dodecahydrate
Sodium phosphate, dodecahydrate, dihydrate
Disodium hydrogen phosphate dodecahydrate
Sodium hydrogen phosphate dodecahydrate
Sodium phosphate, secondary, dihydrate
Sodium phosphate, dibasic, hydrate
Sodium phosphate, hydrate, dihydrate
Disodium phosphate hydrate
Disodium phosphate, dodecahydrate
Sodium hydrogen phosphate hydrate
Sodium phosphate, dibasic, dodecahydrate, dihydrate
Sodium phosphate, dodecahydrate, hydrate
Disodium hydrogen phosphate, dodecahydrate
Sodium hydrogen phosphate dodecahydrate, dihydrate
Sodium phosphate, secondary, hydrate
Sodium phosphate, dibasic, anhydrous, hydrate
Sodium phosphate, hydrate, dodecahydrate
Disodium phosphate, anhydrous, hydrate
DISODIUM PHOSPHATE ANHYDROUS


Disodium phosphate anhydrous, also known by its chemical formula Na2HPO4, is a salt of sodium and phosphate.
Disodium phosphate anhydrous is one of the inorganic compounds derived from phosphoric acid and is the anhydrous (water-free) form of disodium phosphate.
Disodium phosphate anhydrous consists of two sodium ions (Na+) and one phosphate ion (HPO4^2-) for every molecule.
Disodium phosphate anhydrous is a white, crystalline powder that is highly soluble in water.

CAS Number: 7558-79-4
EC Number: 231-448-7



APPLICATIONS


Disodium phosphate anhydrous is commonly used as a food additive to control the acidity and improve the texture of processed foods.
In the food industry, it functions as a buffering agent, helping to maintain the pH of various food products.
Disodium phosphate anhydrous is often found in processed cheeses, where it enhances the melting properties and texture, contributing to the creaminess of cheese sauces and spreads.
Disodium phosphate anhydrous plays a crucial role in baking, as it acts as a leavening agent in some baked goods, helping them rise and become light and fluffy.

In the dairy industry, it is utilized in the production of evaporated milk and condensed milk to stabilize the product and maintain its consistency.
Disodium phosphate anhydrous is used in the manufacturing of breakfast cereals to fortify them with essential minerals like phosphorus and sodium.

In the meat and seafood industry, it serves as a sequestrant, helping to improve the water-holding capacity of processed meats and prevent undesirable texture changes during cooking.
Disodium phosphate anhydrous is employed in some beverages, such as powdered drink mixes, as a pH regulator and to enhance the solubility of certain ingredients.
Disodium phosphate anhydrous is used in the preparation of canned soups and broths to maintain their flavor and quality during storage.

In the pharmaceutical industry, it is included in the formulation of certain medications to serve as a buffering agent, helping to stabilize the pH of the medication.
Disodium phosphate anhydrous is used in the preparation of oral rehydration solutions to help restore electrolyte balance in cases of dehydration.
Disodium phosphate anhydrous is a common ingredient in certain electrolyte beverages used to rehydrate after physical activity or illness.

In the cosmetic industry, it is utilized in skincare products to adjust the pH of formulations, ensuring they are gentle on the skin.
In the agricultural sector, it can be used in some plant fertilizers to provide essential nutrients to crops.

Disodium phosphate anhydrous is a water-softening agent in water treatment processes, helping to reduce the levels of hardness-causing ions in water.
Disodium phosphate anhydrous is found in some household cleaning products, particularly those used for dishwashing and dishwasher detergents.

In industrial applications, this compound is used as a corrosion inhibitor to protect equipment and pipes from rust and corrosion.
Disodium phosphate anhydrous is employed in some laboratory experiments and research as a buffering agent to control and maintain a constant pH level.

Disodium phosphate anhydrous is sometimes used in the production of fire-retardant coatings for wood and textiles.
Disodium phosphate anhydrous is utilized in the creation of emulsions and gels, enhancing their stability and shelf life.

In the brewing industry, it can be added to certain beer styles to adjust the pH of the brewing water and affect the beer's flavor profile.
Disodium phosphate anhydrous is used in the manufacture of detergents and cleaning agents, contributing to their cleaning efficiency.
In the textile industry, it is used as a sizing agent to improve the quality and durability of fabrics.

Disodium phosphate anhydrous is a versatile compound with applications in the development of ceramics, especially in the glazing and clay body formulation.
Disodium phosphate anhydrous is employed in certain analytical chemistry procedures and experiments to help maintain the desired pH conditions for accurate measurements.

Disodium phosphate anhydrous is used in the dairy industry to control the pH of dairy products such as yogurt, ensuring they maintain their desired texture and flavor.
Disodium phosphate anhydrous is a common ingredient in powdered desserts and dessert mixes, contributing to their smooth consistency and preventing separation.
In the pet food industry, this compound is used to adjust the pH of pet food formulations and maintain product stability.

Disodium phosphate anhydrous is added to certain toothpaste formulations as a pH adjuster and stabilizer to ensure product efficacy.
Disodium phosphate anhydrous plays a role in the production of synthetic detergents and cleaning products, enhancing their cleaning power.

In the production of non-alcoholic beverages, it can be used as an emulsifier and stabilizer to improve product quality.
Disodium phosphate anhydrous is found in some dietary supplements and nutritional products, providing a source of essential minerals.
Disodium phosphate anhydrous is used in the pulp and paper industry to adjust the pH of paper pulps during the papermaking process.
In the construction industry, it is employed in cement formulations as a retardant to control the setting time of cement-based products.

Disodium phosphate anhydrous is utilized in the creation of adhesives to improve their bonding properties and consistency.
Disodium phosphate anhydrous is added to some frozen desserts to maintain their texture and prevent crystallization.

In the textile industry, it can be used as a dye-leveling agent to ensure uniform color distribution in fabrics.
Disodium phosphate anhydrous is found in certain hair care products, helping to adjust the pH of shampoos and conditioners.
In the petroleum industry, it is used as a drilling mud additive to improve the stability and viscosity of drilling fluids.

Disodium phosphate anhydrous is included in some fire extinguishing agents to enhance their fire-suppressing properties.
Disodium phosphate anhydrous is employed in the production of synthetic resins, contributing to their adhesive properties and consistency.

In the formulation of some pharmaceutical tablets, it acts as a disintegrant, aiding in the breakdown of the tablet for effective drug release.
Disodium phosphate anhydrous is used in the manufacturing of ceramic glazes and engobes, contributing to their texture and appearance.
Disodium phosphate anhydrous is a key ingredient in the creation of printing inks, enhancing their viscosity and printability.

In the agriculture industry, it can be used as a pH regulator in irrigation water to optimize soil pH for crop growth.
Disodium phosphate anhydrous is included in some fireproofing products to enhance their fire-resistant properties.
Disodium phosphate anhydrous is found in some heating and cooling systems as a corrosion inhibitor to protect equipment and pipes.

In the cosmetics industry, it is used in hair coloring products to maintain the stability of the product.
Disodium phosphate anhydrous is employed in certain explosives formulations, where it serves as a stabilizer.

In the manufacture of ceramic tiles, it can be used in glaze formulations to improve the adherence and appearance of the glaze.
Disodium phosphate anhydrous is a crucial component in the preparation of certain medical contrast agents used in diagnostic imaging procedures, enhancing their solubility and stability.
In the textile printing industry, it is used as a dye thickener to improve the consistency and control of color application.
Disodium phosphate anhydrous is added to powdered spices and seasonings to prevent caking and maintain their free-flowing nature.

In the manufacture of drilling and fracking fluids in the oil and gas industry, it helps control the viscosity of these fluids for efficient well drilling and completion.
Disodium phosphate anhydrous is utilized in the production of certain ceramics, particularly in the formulation of engobes, which are used for decorative coatings on ceramic products.
Disodium phosphate anhydrous is incorporated into the creation of certain abrasive cleaners to enhance their scrubbing efficiency.

In the brewing and beverage industry, it is used in water treatment to adjust the pH of brewing water and influence the flavor and quality of the final product.
Disodium phosphate anhydrous can be employed in cooling water treatment to prevent scale and corrosion in cooling systems.
Disodium phosphate anhydrous is utilized in the formulation of some dishwashing detergents to improve their cleaning and grease-cutting properties.

In the manufacture of plasterboard, it is used as a setting regulator to control the setting time of the plaster.
Disodium phosphate anhydrous is added to some hair care products, contributing to the stability and pH balance of shampoos and conditioners.
Disodium phosphate anhydrous plays a role in the preservation of canned fruits and vegetables, helping to maintain their color, texture, and overall quality.

In the laboratory, it is used in the preparation of buffer solutions for various experiments and analytical procedures.
Disodium phosphate anhydrous is found in the production of certain antifreeze solutions, improving their performance in cold weather conditions.

In the manufacture of rubber products, it is used as a dispersing agent to evenly distribute rubber components.
Disodium phosphate anhydrous is included in some specialty welding fluxes used in metalworking to protect welds from contamination and ensure high-quality joints.

Disodium phosphate anhydrous can be employed in the formulation of certain heat treatment baths used to harden metal parts.
In the leather tanning industry, it is used as an auxiliary agent in the tanning process, assisting in the penetration of tanning agents.
Disodium phosphate anhydrous is used as a pH regulator in the production of wastewater treatment chemicals to optimize treatment processes.

In the printing industry, it is utilized as a buffering agent in fountain solutions for offset printing, ensuring stable pH levels during printing.
Disodium phosphate anhydrous can be added to some automotive and industrial cleaning products, improving their performance in removing grease and grime.
Disodium phosphate anhydrous is used in some fireproofing materials to enhance their fire-resistant properties, providing protection in case of fire.

In the production of certain pesticides and herbicides, it serves as a pH regulator in the formulation process.
Disodium phosphate anhydrous can be utilized in the creation of certain insect baits, enhancing their attractiveness to target pests.
Disodium phosphate anhydrous is employed in the construction industry as a setting regulator in cement-based products to control the hardening time of mortars and concretes.
In the textile industry, it is used as a sizing agent to improve the quality and durability of fabrics, particularly in weaving and textile finishing.

Disodium phosphate anhydrous finds application in the formulation of ceramic glazes, where it contributes to glaze adherence, smoothness, and gloss.
Disodium phosphate anhydrous is used in certain oral care products, such as mouthwash, to adjust the pH of the product and enhance its effectiveness.

In the construction industry, this compound is included in the preparation of plaster to regulate the setting time, allowing for proper workability.
Disodium phosphate anhydrous serves as a corrosion inhibitor in cooling water systems, protecting equipment and pipelines from rust and scale.
Disodium phosphate anhydrous is used in the creation of adhesive products to enhance bonding properties and product consistency.

In the brewing industry, it is added to specific beer styles to adjust brewing water pH, affecting the beer's flavor and character.
Disodium phosphate anhydrous plays a role in the pulp and paper industry, where it is utilized as a pH regulator in paper pulps for papermaking.
Disodium phosphate anhydrous is incorporated into certain drilling fluids in the oil and gas industry, aiding in the control of fluid viscosity during drilling operations.
Disodium phosphate anhydrous is used as a sequestrant in the meat processing industry, helping to improve water retention in processed meats and prevent textural changes during cooking.

Disodium phosphate anhydrous is employed in the production of fire-extinguishing agents, enhancing their firefighting properties.
Disodium phosphate anhydrous can be found in certain fireproofing materials used in the construction industry to improve fire resistance.

In the cosmetics industry, it is used in hair color products to maintain the stability and pH balance of the product.
Disodium phosphate anhydrous plays a crucial role in the formulation of oral rehydration solutions, helping to restore electrolyte balance in cases of dehydration.

In the manufacture of synthetic detergents, it contributes to their cleaning efficiency and grease-cutting properties.
Disodium phosphate anhydrous is utilized in the preparation of powdered drink mixes and beverages to adjust pH levels and enhance solubility.
In the pharmaceutical industry, it is included in the formulation of tablets as a disintegrant to facilitate drug release upon ingestion.

Disodium phosphate anhydrous can be added to pet food to maintain pH levels and product stability.
Disodium phosphate anhydrous is used in the creation of synthetic resins, contributing to adhesive properties and product consistency.

In the agriculture sector, it can be employed to adjust the pH of irrigation water and optimize soil pH for crop growth.
Disodium phosphate anhydrous is a common ingredient in non-alcoholic beverages, contributing to product stability and flavor enhancement.
Disodium phosphate anhydrousis utilized in the production of synthetic rubber products to ensure uniform distribution of rubber components.
Disodium phosphate anhydrous is employed in the manufacture of ceramic tiles to improve glaze adherence and overall appearance.

In the automotive industry, it can be found in some specialty welding fluxes, protecting welds from contamination and ensuring high-quality joints.
Disodium phosphate anhydrous is used as a buffering agent in the formulation of dental products such as toothpaste to stabilize pH levels and improve product efficacy.



DESCRIPTION


Disodium phosphate anhydrous, also known by its chemical formula Na2HPO4, is a salt of sodium and phosphate.
Disodium phosphate anhydrous is one of the inorganic compounds derived from phosphoric acid and is the anhydrous (water-free) form of disodium phosphate.
Disodium phosphate anhydrous consists of two sodium ions (Na+) and one phosphate ion (HPO4^2-) for every molecule.
Disodium phosphate anhydrous is a white, crystalline powder that is highly soluble in water.

Disodium phosphate anhydrous is commonly used in various applications, including as a food additive (E339) to regulate acidity and improve food texture.
Disodium phosphate anhydrous is also employed in water treatment processes, as a buffering agent in chemistry, and in some pharmaceutical preparations.
Additionally, it has applications in the manufacture of detergents and cleaning products.

Disodium phosphate anhydrous is a white, crystalline powder with a fine texture.
Disodium phosphate anhydrous is highly soluble in water, forming clear and colorless solutions.
Disodium phosphate anhydrous is derived from phosphoric acid and contains two sodium ions (Na+) and one phosphate ion (HPO4^2-) in each molecule.

Disodium phosphate anhydrous is often used as a pH regulator in various applications.
Disodium phosphate anhydrous is sometimes referred to as disodium hydrogen phosphate.

In the food industry, it serves as a food additive with the E number E339, commonly used to adjust the acidity of processed foods.
Disodium phosphate anhydrous is odorless and has a slightly salty taste.

Disodium phosphate anhydrous is known for its water-softening properties and is used in water treatment processes.
Disodium phosphate anhydrous plays a crucial role in the production of processed cheese products, where it helps improve the texture and melting properties.
In pharmaceutical formulations, it can be used as a buffering agent to stabilize the pH of medications.

Disodium phosphate anhydrous is employed in the preparation of emulsions and gels, enhancing their stability.
Disodium phosphate anhydrous is a key ingredient in certain electrolyte solutions used for medical and hydration purposes.

In laboratory settings, it is used as a buffering agent in chemical reactions to maintain a constant pH level.
Disodium phosphate anhydrous is sometimes used in combination with other chemicals to create effective cleaning agents.
Disodium phosphate anhydrous can serve as a corrosion inhibitor in cooling water systems and industrial applications.

Disodium phosphate anhydrous is a hygroscopic compound, meaning it can absorb moisture from the air.
Disodium phosphate anhydrous has the chemical formula Na2HPO4 and is classified as a sodium salt of phosphoric acid.

In the agriculture industry, it is used as a nutrient source in some plant fertilizers.
Disodium phosphate anhydrous is non-flammable and does not pose significant fire hazards.
Disodium phosphate anhydrous is considered safe for consumption in the quantities typically used in food products.

Disodium phosphate anhydrous is used as a component in some oral care products, such as toothpaste and mouthwash.
Disodium phosphate anhydrous can be found in certain food items, including processed meats, baked goods, and canned soups.

In the cosmetic industry, Disodium phosphate anhydrous is sometimes used in skincare products to adjust pH levels.
Disodium phosphate anhydrous is available in various grades, each suited for specific applications.



PROPERTIES


Chemical Formula: Na2HPO4
Molecular Weight: 141.96 g/mol
Appearance: White, crystalline powder
Odor: Odorless
Taste: Slightly salty
Solubility: Highly soluble in water, forming clear and colorless solutions.
pH (1% solution): Alkaline, typically around 8.0 - 9.0
Density: 2.45 g/cm³
Melting Point: Approximately 250°C (482°F)
Boiling Point: Decomposes before reaching a boiling point.
Hygroscopicity: Exhibits hygroscopic properties, absorbing moisture from the air.
Water Softening: Used as a water-softening agent to reduce water hardness by binding to calcium and magnesium ions.
Ionization: Forms sodium ions (Na+) and phosphate ions (HPO4^2-) in solution.
Non-Flammable: Does not pose significant fire hazards.
Corrosion Inhibitor: Acts as a corrosion inhibitor in cooling water systems and industrial applications.
Buffering Agent: Used as a buffering agent to stabilize pH levels in various applications.
Dispersing Agent: Serves as a dispersing agent to evenly distribute components in rubber products.
Sequestrant: Functions as a sequestrant in the meat industry to improve water retention in processed meats.



FIRST AID


Inhalation:

If Disodium phosphate anhydrous dust or mist is inhaled, move the affected person to an area with fresh air.
Allow the person to rest in a comfortable position.
If breathing difficulties persist or if symptoms worsen, seek immediate medical attention.


Skin Contact:

In case of skin contact with Disodium phosphate anhydrous, immediately remove contaminated clothing and jewelry.
Wash the affected skin area thoroughly with plenty of water for at least 15 minutes.
Use mild soap to aid in cleaning, and ensure that the chemical is completely removed from the skin.
Seek medical attention if skin irritation, redness, or other adverse reactions occur.


Eye Contact:

If Disodium phosphate anhydrous comes into contact with the eyes, immediately flush the eyes with gently flowing lukewarm water for at least 15 minutes.
Keep the affected person's eyes open to ensure thorough rinsing.
Remove contact lenses, if applicable, after the initial flush.
Seek immediate medical attention, especially if eye irritation, redness, or pain persists.


Ingestion:

If Disodium phosphate anhydrous is accidentally ingested, do not induce vomiting unless instructed to do so by a medical professional.
Rinse the mouth with water and provide the affected person with small sips of water.
Do not give anything by mouth if the person is unconscious, convulsing, or displaying symptoms of severe distress.
Seek immediate medical attention or contact a poison control center for guidance.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
When working with Disodium phosphate anhydrous, wear appropriate PPE, including safety goggles, gloves, and a lab coat or protective clothing to minimize the risk of skin and eye contact.
Respiratory protection may be necessary if there is a potential for inhalation exposure.

Ventilation:
Use adequate ventilation, such as local exhaust or mechanical ventilation, to control airborne dust and maintain air quality within recommended exposure limits.
Ensure the workplace has proper airflow.

Avoiding Contact:
Minimize skin and eye contact by exercising caution when handling the chemical.
Do not touch your face, eyes, or mouth while working with Disodium phosphate anhydrous, and wash hands thoroughly after handling.

Spill Management:
Implement spill control measures to prevent the spread of Disodium phosphate anhydrous in case of accidental spills. Use appropriate absorbents and follow established spill response procedures.
Avoid creating dust during cleanup.

Avoid Ingestion:
Do not eat, drink, or smoke while working with the chemical.
Always wash hands and face before eating, drinking, or using tobacco products.

Labeling and Storage:
Ensure containers of Disodium phosphate anhydrous are clearly labeled with the product name, hazard information, and appropriate safety labels.
Store the chemical in its original container or an approved container, and keep it tightly closed when not in use.

Segregation:
Store Disodium phosphate anhydrous away from incompatible substances, such as strong acids, bases, and reducing agents.
Maintain separation to prevent chemical reactions.

Handling Equipment:
Use dedicated equipment (e.g., scoops, containers) when handling the chemical to prevent contamination of equipment used for other substances.

Safe Working Practices:
Follow safe laboratory or workplace practices and adhere to established safety protocols, including emergency response procedures.


Storage:

Location:
Store Disodium phosphate anhydrous in a cool, dry, and well-ventilated area, away from direct sunlight and heat sources.
Ensure the storage area is designed to minimize temperature fluctuations.

Separation:
Keep the chemical away from incompatible materials to prevent potential chemical reactions or hazards.

Containment:
Store the chemical in approved containers that are properly labeled and sealed.
Ensure containers are in good condition without leaks or damage.

Accessibility:
Store containers of Disodium phosphate anhydrous in a way that allows easy access and minimizes the risk of spills during retrieval.

Incompatibility:
Be aware of the chemical's incompatibility with certain substances, and do not store it near these incompatible materials.

Temperature Control:
Maintain storage temperatures within recommended limits to prevent exposure to extreme heat or cold, as well as temperature-related changes in the chemical's properties.

Security:
Ensure that access to storage areas is restricted to authorized personnel only to prevent unauthorized handling or tampering with the chemical.

Inventory Control:
Keep an inventory of Disodium phosphate anhydrous, including tracking the quantity on hand, monitoring expiration dates, and conducting regular inspections for signs of damage or degradation.

Emergency Preparedness:
Maintain appropriate spill response equipment and supplies in the storage area.
Ensure that spill containment measures are readily available.



SYNONYMS


Sodium phosphate dibasic anhydrous
Disodium hydrogen phosphate anhydrous
Sodium hydrogen phosphate
Sodium phosphate, dibasic
Sodium phosphate, secondary
Sodium hydrogen orthophosphate
Disodium hydrogen orthophosphate
Sodium phosphate, Na2HPO4
DSPA
Sodium phosphate, heptahydrate-free
Disodium hydrogen orthophosphate anhydrous
Sodium phosphate, dibasic, anhydrous
Dodecasodium triphosphate
Disodium phosphate, anhydrous
Secondary sodium phosphate
Disodium orthophosphate anhydrous
Sodium orthophosphate, dibasic
Sodium hydrogen orthophosphate, anhydrous
Sodium phosphate, secondary, heptahydrate-free
Disodium hydrogen orthophosphate, heptahydrate-free
Sodium hydrogen phosphate, anhydrous
Sodium phosphate, dibasic, heptahydrate-free
Disodium orthophosphate, heptahydrate-free
Secondary sodium phosphate, anhydrous
Sodium hydrogen orthophosphate, dodecahydrate-free
Sodium phosphate, anhydrous
Sodium phosphate, dibasic, anhydrous
Disodium hydrogen phosphate, anhydrous
Disodium orthophosphate
Sodium orthophosphate, secondary
Sodium phosphate secondary, anhydrous
Sodium phosphate dibasic, heptahydrate-free
Sodium phosphate, dodecahydrate-free
Sodium phosphate, dibasic, heptahydrate-deprived
DSPA, anhydrous
Secondary sodium phosphate, heptahydrate-free
Disodium phosphate, heptahydrate-deprived
Disodium hydrogen orthophosphate, dodecahydrate-free
Sodium hydrogen phosphate, anhydrous
Sodium phosphate, dibasic, heptahydrate-restricted
Disodium orthophosphate, dodecahydrate-free
Sodium hydrogen orthophosphate, heptahydrate-free
Sodium phosphate, secondary, heptahydrate-deprived
Disodium phosphate, anhydrous and heptahydrate-deprived
Secondary sodium phosphate, anhydrous and heptahydrate-free
Sodium hydrogen orthophosphate, dodecahydrate-restricted
Sodium phosphate, dibasic, anhydrous and heptahydrate-free
DSPA, anhydrous and heptahydrate-deprived
Disodium hydrogen orthophosphate, heptahydrate-free and dodecahydrate-restricted
Disodium phosphate, heptahydrate-deprived and dodecahydrate-free
DISODIUM PHOSPHATE ANHYDROUS (FOOD)
DESCRIPTION:

Disodium phosphate anhydrous (Food), or disodium hydrogen phosphate, or sodium phosphate dibasic, is the inorganic compound with the formula Na2HPO4.
Disodium phosphate anhydrous (Food) is one of several sodium phosphates.
The salt is known in anhydrous form as well as forms with 2, 7, 8, and 12 hydrates.
All are water-soluble white powders, the anhydrous salt being hygroscopic.


CAS Number, 7558-79-4
EC Number, 231-448-7


Disodium phosphate anhydrous (Food), Dibasic, Anhydrous, FCC is an additive used as an antioxidant, sequestrant and a pH regulator with very high buffering capacity widely used in foods.
The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications.

Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.


Sodium phosphate, dibasic appears as a colorless to white crystalline solid.
Disodium phosphate anhydrous (Food) is Soluble in water.
The primary hazard is the threat to the environment.

Immediate steps should be taken to limit spread to the environment.
Disodium phosphate anhydrous (Food) is Used as a fertilizer, in pharmaceuticals, in food processing, and for many other uses.


Also known as disodium hydrogen orthophosphate dodecahydrate, disodium phosphate dodecahydrate, sodium hydrogene dibasic.
Disodium phosphate anhydrous (Food) is a white powder that is highly hygroscopic and water soluble.
Disodium phosphate anhydrous (Food) is therefore used commercially as an anti-caking additive in powdered products.


Disodium phosphate anhydrous (Food) is Used as a pH buffer, stabilizer and emulsifier in processed cheese, condensed milk, instant pudding and other food applications.
The pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately basic:
HPO42− + H2O ⇌ H2PO4− + OH−

Disodium phosphate anhydrous (Food) is a white, powdered, non-aggressive and non-flammable substance.

Disodium phosphate anhydrous (Food) is often used as an emulsifier and a buffering agent for the production of processed cheese, as well as an additive to prevent the gelation of milk.
And addition of Disodium Phosphate Anhydrous can shorten the cooking time of pasta.


Disodium Phosphate, Anhydrous (DSPa) Granular & Powder is a white, odorless, free flowing powder.
This product is known for its alkalinity and is used as a buffering agent, protein modifier, stabilizer, and emulsifying agent.
DSP is commonly used during production of spray dried cheese and nonfat milk powders.

DSP protects the milk proteins from heat dehydration allowing the proteins to remain dispersed during the spray drying process, which assists in the solubility of the powders upon reconstitution with water.
DSP also stabilizes the emulsion to enhance flavor, body, and appearance of the final product.


Disodium phosphate anhydrous (Food) is made with a simple chemical reaction between phosphoric acid (H3PO4) and sodium hydroxide.
Phosphoric acid is a mineral acid.
Disodium phosphate anhydrous (Food) neutralizes with sodium hydroxide, which acts as an alkaline substance during the reaction.

Sodium atoms replace two of the three hydrogen atoms in the phosphoric acid and disodium phosphate is formed.
When used according to the FDA’s good manufacturing practices, disodium phosphate is generally recognized as safe.
Though we often think of processed food as a byproduct of the mid-20th century, sodium phosphates have been used in food production for over a century.

Phosphates were used in cheese production as early as 1895.
Likewise, sodium phosphates have historically been used in processed cheese, evaporated milk, and other fluid milk products.



pH Control In Packaged Foods:
Among the most common uses of disodium phosphate is as a neutralizing agent.
Disodium phosphate anhydrous (Food) acts as a buffering solution that helps control pH.
Buffering solutions, a type of water-soluble solution known as aqueous solutions, are created by mixing a weak acid and its conjugate base.

When a harsh acid or base is added to the solution, the pH of the solution as a whole is minimally affected.
Many consumable liquids require diligent monitoring of pH to keep them in the right state.
For instance, creamy milk can quickly become tangy cottage cheese by reducing the pH of the milk by adding an acid.

Keeping the pH stable also contributes to food safety.
Foods with a pH of 4.6 or lower do not provide a hospitable environment for bacteria like Clostridium botulinum to grow.


Stabilizing Our Dairy:
Most people love cheese but making it would be difficult without disodium phosphate.
Disodium phosphate anhydrous (Food) acts as an emulsifier that keeps fat and water from separating during the cheese-making process.
This helps us get the richest and creamiest cheese possible.


In evaporated milk, Disodium phosphate anhydrous (Food) helps keep the butterfat from separating in the can and prevents an unpleasant gel from forming.
And if you are a fan of whipped cream, you can thank disodium phosphate for the pleasure of picking it up at your local grocery store.
Disodium phosphate is used as a processing agent in heavy whipping cream where it binds to the natural minerals in milk.

Disodium phosphate anhydrous (Food) prevents the heavy cream from becoming unmanageable and coating the equipment during processing.


Controlling Texture & Food Preservation:
Salt was the first preservative used to keep meat, seafood, pork, and poultry safe for consumption.
Over time, food manufacturers have incorporated disodium phosphate as a means of food preservation.

But the benefit of using disodium phosphate on meats does not stop at preservation.
Disodium phosphate anhydrous (Food) can improve the meat’s tenderness and make it appear juicier.

Americans are lucky enough to live in a world where rich foods are just a shopping trip away.
And we have come to rely on these convenience foods.
The world of chemistry allows food manufacturers to create safe, enjoyable products that make our lives easier.

Disodium phosphate anhydrous (Food) is just one of the sodium phosphates used in the making of these packaged foods.
But there are numerous other sodium phosphates used in and out of the food manufacturing industry.


PRODUCTION AND REACTIONS OF DISODIUM PHOSPHATE ANHYDROUS (FOOD):
Disodium phosphate anhydrous (Food) can be generated by neutralization of phosphoric acid with sodium hydroxide:
H3PO4 + 2 NaOH → Na2HPO4 + 2 H2O

Industrially It is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:
CaHPO4 + NaHSO4 → NaH2PO4 + CaSO4

In the second step, the resulting solution of monosodium phosphate is partially neutralized:
NaH2PO4 + NaOH → Na2HPO4 + H2O



USES OF DISODIUM PHOSPHATE ANHYDROUS (FOOD):
It is used in conjunction with trisodium phosphate in foods and water softening treatment.
In foods, it is used to adjust pH.
Its presence prevents coagulation in the preparation of condensed milk.

Similarly, Disodium phosphate anhydrous (Food) is used as an anti-caking additive in powdered products.
Disodium phosphate anhydrous (Food) is used in desserts and puddings, e.g. Cream of Wheat to quicken cook time, and Jell-O Instant Pudding for thickening.
In water treatment, it retards calcium scale formation.

Disodium phosphate anhydrous (Food) is also found in some detergents and cleaning agents.
Heating solid disodium phosphate gives the useful compound tetrasodium pyrophosphate:[citation needed]
2 Na2HPO4 → Na4P2O7 + H2O


Laxative:
Monobasic and dibasic sodium phosphate are used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy

DISODIUM PHOSPHATE IN FOOD:
It’s very common in processed and packaged foods.
Some of the purposes Disodium phosphate anhydrous (Food) serves in the manufacturing process are:
Disodium phosphate anhydrous (Food) is an Emulsifier.

Disodium phosphate anhydrous (Food) is a chemical that helps to bind fats and water together.
Fats don’t mix with many other liquids without help.

Emulsifiers have a chemical structure that helps them mix.
Disodium phosphate is a helpful emulsifier for dairy products and other foods.
Cheese, whipped cream, milk, and other dairy products have unique textures and consistencies because of disodium phosphate.


SAFETY INFORMATION ABOUT DISODIUM PHOSPHATE ANHYDROUS (FOOD):
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product





CHEMICAL AND PHYSICAL PROPERTIES OF DISODIUM PHOSPHATE ANHYDROUS (FOOD):
Chemical formula, Na2HPO4
Molar mass, 141.96 g/mol (anhydrous)
177.99 g/mol (dihydrate)
268.07 g/mol (heptahydrate)
Appearance, White crystalline solid
Odor, odorless
Density, 1.7 g/cm3
Melting point, 250 °C (482 °F; 523 K) decomposes
Solubility in water, 7.7 g/100 ml (20 °C)
11.8 g/100 mL (25 °C, heptahydrate)
Solubility, insoluble in alcohol
log P, -5.8
Acidity (pKa), 2.15, 6.82, 12.35
Magnetic susceptibility (χ), −56.6•10−6 cm3/mol
Refractive index (nD), 1.35644..1.35717 at 20°C
Minimum Assay: >98.5%
Molecular Formula: HNa2O4P
Molecular Weight: 141.96
Appearance Form: White Crystalline powder
pH: 8.9 – 9.2 at 50 g/l at 25 °C
PO2 Content: 49.7%
Vapour density: 4.90 – (Air = 1.0)
Relative density: 1.520 g/cm3
Water solubility: soluble
Relative vapour density 4.90 – (Air = 1.0)
Arsenic (As): <1ppm
Fluoride (F): <10ppm
Lead (Pb): <1ppm
Cadmium (Cd): <1ppm
Mercury (Hg): <0.5ppm
Insoluble Matter: <0.02%
Loss on Drying: <0.1%
Molecular Weight
141.959 g/mol
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
141.94078407 g/mol
Monoisotopic Mass
141.94078407 g/mol
Topological Polar Surface Area
83.4Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
46.5
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
3
Compound Is Canonicalized
Yes
PSA:
95.4
XLogP3:
-0.82380
Appearance:
White Crystals
Density:
1,52 g/cm3
Melting Point:
35 °C
Boiling Point:
158ºC at 760 mmHg
Refractive Index:
1.429
Water Solubility:
H2O: 218 g/L (20 ºC)
Storage Conditions:
Store at +15°C to +25°C.
Taste:
Saline taste



SYNONYMS OF DISODIUM PHOSPHATE ANHYDROUS (FOOD):
Dibasic sodium phosphate
Disodium acid phosphate
Disodium phosphate
Secondary sodium phosphate
Disodium hydrogen monophosphate
Disodium hydrogen orthophosphate
Disodium hydrogen phosphate
dibasic sodium phosphate, anhydrous
disodium acid phosphate
disodium hydrogen phosphate
disodium hydrogen phosphate anhydrous
monosodium dihydrogen phosphate
neutral sodium hydrogen phosphate
phosphoric acid, disodium salt
phosphoric acid, disodium salt, 32P-labeled
phosphoric acid, disodium salt, anhydrous
phosphoric acid, disodium salt, dodecahydrate
phosphoric acid, disodium salt, heptahydrate
phosphoric acid, monosodium salt
phosphoric acid, monosodium salt, anhydrous
phosphoric acid, sodium (2:3) salt
phosphoric acid, sodium salt
phosphoric acid, trisodium salt
phosphoric acid, trisodium salt , 32P-labeled
phosphoric acid, trisodium salt , dodecahydrate
sodium biphosphate
sodium dihydrogen orthophosphate
sodium dihydrogen phosphate
sodium hydrophosphate
sodium phosphate
sodium phosphate monobasic anhydrous
sodium phosphate, dibasic
sodium phosphate, dibasic (anhydrous)
sodium phosphate, disodium salt
sodium phosphate, monobasic
sodium phosphate, monobasic anhydrous
sodium phosphate, tribasic
sodium phosphate, tribasic, dodecahydrate
trisodium phosphate
trisodium phosphate dodecahydrate
7558-79-4
Disodium hydrogen phosphate
Sodium phosphate dibasic
DISODIUM PHOSPHATE
Disodium hydrogenorthophosphate
Sodium phosphate, dibasic
Acetest
Dibasic sodium phosphate
disodium hydrogenphosphate
Disodium acid phosphate
Soda phosphate
Phosphoric acid, disodium salt
Exsiccated sodium phosphate
Disodium orthophosphate
Sodium hydrogenphosphate
Sodium hydrogen phosphate
Sodium monohydrogen phosphate
FEMA No. 2398
secondary Sodium phosphate
disodium;hydrogen phosphate
Disodium acid orthophosphate
sec-Sodium phosphate
Disodium phosphate, anhydrous
Disodium monohydrogen phosphate
Disodium hydrogen phosphate, anhydrous
Hydrogen disodium phosphate
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS
Sodium phosphate, dibasic (anhydrous)
SODIUM PHOSPHATE, DIBASIC ANHYDROUS
Na2HPO4
Phosphoric acid, sodium salt (1:2)
Disodium hydrogen monophosphate
22ADO53M6F
INS NO.339(II)
DSP
CHEBI:34683
INS-339(II)
Dibasic sodium phosphate anhydrous
dibasic sodium phosphate, anhydrous
E-339(II)
MFCD00003496
phosphoric acid, disodium salt, anhydrous
Phosphate of soda
Caswell No. 778
Disodium hydrophosphate
Disodium phosphoric acid
FEMA Number 2398
Fleet enema
Natriumphosphat [German]
Sodium phosphate (NaHPO4)
Sodium phosphate, exsiccated
CCRIS 5931
HSDB 376
Sodium orthophosphate, secondary
Sodium acid phosphate, anhydrous
Sodium Phosphate dibasic anhydrous
EINECS 231-448-7
EPA Pesticide Chemical Code 076403
Sodium monohydrogen phosphate (2:1:1)
UNII-22ADO53M6F
Disodium hydrogen orthophosphate
Disodium phospahte
Sodiumphosphatedibasic
Disodiumhydrogenphosphate
sodium hydrogen-phosphate
disodium hydrogen-phosphate
Disodium phosphate anhydrous
EC 231-448-7
Sorensen's sodium phosphate
di-sodium hydrogen phosphate
phosphoric acid disodium salt
sodium hydrogen orthophosphate
SODIUM PHOSPHATE [FHFI]
DTXSID1026039
DISODIUM PHOSPHATE [HSDB]
DISODIUM PHOSPHATE [INCI]
BNIILDVGGAEEIG-UHFFFAOYSA-L
Sodium phosphate,dibasic,anhydrous
BCP13559
Sodium hydrogen phosphate, anhydrous
Sodium phosphate dibasic, ACS grade
Disodium Hydrogen Phosphate Submicron
AKOS015902440
AKOS015950661
CCG-266159
DB14502
SODIUM PHOSPHATE, DIBASIC [MI]
DISODIUM PHOSPHATE [EP MONOGRAPH]
SODIUM PHOSPHATE DIBASIC [WHO-DD]
Sodium phosphate dibasic, ACS/HPLC grade
Sodium phosphate dibasic, biochemical grade
FT-0625321
Sodium phosphate dibasic, Trace metals grade
A937532
Q418448
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS [II]
SODIUM PHOSPHATE,DIBASIC,ANHYDROUS [VANDF]
Water Supply QC Check Sample: o-Phosphate Nutrients
Disodium hydrogen orthophosphate;Sodium hydrogen phosphate
SODIUM PHOSPHATE, DIBASIC ANHYDROUS [ORANGE BOOK]
SODIUM PHOSPHATE, DIBASIC, ANHYDROUS [ORANGE BOOK]
VISICOL COMPONENT SODIUM PHOSPHATE, DIBASIC ANHYDROUS
OSMOPREP COMPONENT SODIUM PHOSPHATE, DIBASIC ANHYDROUS
SODIUM PHOSPHATE, DIBASIC ANHYDROUS COMPONENT OF VISICOL
SODIUM PHOSPHATE, DIBASIC ANHYDROUS COMPONENT OF OSMOPREP





DISODIUM PHOSPHATE DIHYDRATE

Disodium phosphate dihydrate, often represented as Na2HPO4 • 2H2O, is a chemical compound.
Disodium phosphate dihydrate is a hydrated form of disodium phosphate, meaning it contains two molecules of water (H2O) in its crystalline structure.
Disodium phosphate dihydrate is commonly used in various industrial applications, including as a food additive, a buffering agent, and a component in cleaning and detergents.
Its chemical structure consists of two sodium (Na) ions, one hydrogen phosphate (HPO4^2-) ion, and two water molecules (H2O).

CAS Number: 10028-24-7
EC Number: 231-448-7



APPLICATIONS


Disodium phosphate dihydrate is commonly used as a food additive and pH regulator in the food industry, where it helps maintain the stability and texture of processed foods.
Disodium phosphate dihydrate serves as an emulsifying agent in food products, improving the mixing of water and fats.

In the dairy industry, it is used in the production of processed cheeses, preventing them from becoming too oily.
Disodium phosphate dihydrate is added to canned soups and broths to control pH and enhance their flavor.
Disodium phosphate dihydrate is used as a leavening agent in baked goods, such as bread and cakes, to help them rise during baking.

Disodium phosphate dihydrate can be found in breakfast cereals to improve texture and crispness.
In the beverage industry, it is used as a stabilizer and buffering agent in powdered drink mixes.

The pharmaceutical industry uses it as a disintegrant in tablet formulations, aiding in the rapid breakdown of tablets upon ingestion.
In the water treatment sector, it acts as a water softener, reducing water hardness by binding to calcium and magnesium ions.

Dental products like toothpaste incorporate it to maintain the pH balance and improve product stability.
In the cleaning industry, it enhances the cleaning efficiency of detergents and cleaning agents.

Disodium phosphate dihydrate is employed in some fire-extinguishing agents to enhance their firefighting properties.
Disodium phosphate dihydrate plays a crucial role in the formulation of synthetic detergents and soaps, improving their foaming properties.
Disodium phosphate dihydrate is used in construction materials like cement, where it helps control the setting time.
Disodium phosphate dihydrate can be found in certain fireproofing materials, enhancing fire resistance in building materials.
In the cosmetics and personal care industry, it is used in hair coloring products to maintain product stability and pH balance.

Disodium phosphate dihydrate is added to oral rehydration solutions, helping restore electrolyte balance in cases of dehydration.
Disodium phosphate dihydrate contributes to the creation of adhesive products, improving bonding properties and consistency.

In the agriculture sector, it is employed to adjust the pH of irrigation water and optimize soil pH for crop growth.
The automotive industry uses it in some specialty welding fluxes to protect welds from contamination and ensure high-quality joints.

Certain laboratory and research processes rely on it as a buffering agent and pH regulator.
Disodium phosphate dihydrate is used in the preparation of ceramics, glazes, and clay bodies to enhance plasticity and green strength.

Disodium phosphate dihydrate is found in some drilling fluids used in the oil and gas industry, aiding in viscosity control during drilling operations.
Disodium phosphate dihydrate is a common component in non-alcoholic beverages, enhancing product stability and flavor.

In the textile industry, Disodium phosphate dihydrate is used as a sizing agent to improve the quality and durability of fabrics, particularly in weaving and textile finishing.
In the paper and pulp industry, Disodium phosphate dihydrate is used as a pulping agent to extract cellulose fibers from wood, improving the papermaking process.
Disodium phosphate dihydrate finds application in the textile industry as a flame retardant and finishing agent for fabrics, enhancing their resistance to fire.

In the brewing industry, it can be used to adjust the pH of brewing water, leading to improved beer quality.
Disodium phosphate dihydrate is employed in the manufacture of ceramics, where it enhances glazes and slip casting formulations.
Disodium phosphate dihydrate is used in the production of air fresheners and deodorizers, helping to neutralize odors effectively.
Disodium phosphate dihydrate is added to shampoos and hair conditioners to adjust their pH and improve hair texture.

In the paint and coating industry, it serves as a pH buffer, contributing to the stability of paint formulations.
Disodium phosphate dihydrate can be found in metal cleaning and plating solutions to enhance cleaning efficiency and prevent corrosion.
Disodium phosphate dihydrate is used as a stabilizing agent in some medical diagnostic reagents to ensure accurate test results.

In the petroleum industry, it plays a role in drilling mud formulations, aiding in viscosity control during drilling operations.
Disodium phosphate dihydrate is used in the manufacturing of detergents and laundry products to improve their cleaning performance.

Disodium phosphate dihydrate is employed in the construction of fire-resistant drywall to enhance its fireproofing properties.
Disodium phosphate dihydrate is used as a pH regulator in the production of soap bars and liquid soaps, ensuring their mildness and effectiveness.
In the leather industry, it is added to tanning solutions to improve the tanning process and leather quality.

Disodium phosphate dihydrate finds application in the creation of specialty adhesives for various industrial and consumer uses.
Disodium phosphate dihydrate can be found in cooling water systems as a corrosion inhibitor, protecting industrial equipment from damage.
Disodium phosphate dihydrate is used in the formulation of industrial floor cleaners to remove stubborn stains and dirt.
Disodium phosphate dihydrate is employed in the construction industry as a setting regulator for cement-based products, controlling setting times.

In the dairy industry, it contributes to the production of evaporated milk by enhancing the milk's stability and texture.
Disodium phosphate dihydrate is utilized in oil well stimulation to control pH and improve the efficiency of stimulation fluids.
Disodium phosphate dihydrate can be found in corrosion protection coatings to enhance their durability and resistance to environmental factors.
Disodium phosphate dihydrate is used in the production of synthetic rubber, improving the dispersion of rubber components.
In the photography industry, it can be found in the formulation of photographic developers.

Disodium phosphate dihydrate is a valuable component in fire extinguishing powders, enhancing their firefighting properties.
Disodium phosphate dihydrate plays a role in the creation of adhesive formulations for various applications, including woodworking and laminates.

In the agricultural industry, Disodium phosphate dihydrate is used as a component in fertilizer formulations to provide essential phosphorus and adjust soil pH.
Disodium phosphate dihydrate is employed in the manufacturing of fire-resistant textiles and fabrics for applications such as firefighter gear and industrial safety clothing.
In the cosmetics industry, it is used as a buffering agent in skincare products to control and maintain the pH levels of creams, lotions, and serums.

Disodium phosphate dihydrate plays a role in the production of household cleaning products, such as bathroom cleaners, where it assists in removing stubborn stains.
Disodium phosphate dihydrate is used in the formulation of specialized lubricants and cutting fluids for metalworking, improving the performance and efficiency of machining processes.

In the production of dry mixes for soups, sauces, and gravies, it acts as a thickening and stabilizing agent, ensuring consistent texture and flavor.
Disodium phosphate dihydrate is utilized in water-based drilling fluids in the oil and gas industry to enhance viscosity and control fluid properties during drilling operations.

Disodium phosphate dihydrate is added to boiler water treatment chemicals to prevent scale buildup and corrosion in industrial boiler systems.
Disodium phosphate dihydrate finds application in the formulation of electrolyte solutions for use in batteries and fuel cells, helping maintain efficient ion transport.
Disodium phosphate dihydrate is used in the production of dental products such as toothpaste and mouthwash to help control pH and maintain product stability.

In the manufacture of fire-resistant paints and coatings, it enhances the fireproofing properties of surfaces, such as building materials and steel structures.
Disodium phosphate dihydrate is employed in the creation of effervescent tablets, which release carbon dioxide upon contact with water, making them useful in various pharmaceutical and dietary supplements.
Disodium phosphate dihydrate is used as a buffering agent in laboratory and biotechnological applications, helping to maintain consistent pH levels in chemical reactions.

In the agricultural sector, it is incorporated into soil amendments to adjust soil pH and provide essential nutrients for plant growth.
Disodium phosphate dihydrate is found in some pharmaceutical preparations, including antacids, where it helps neutralize excess stomach acid.

Disodium phosphate dihydrate is used in the production of electrolyte solutions for intravenous fluids, helping to maintain electrolyte balance in medical treatments.
Disodium phosphate dihydrate serves as a pH regulator in the formulation of cosmetics, improving product stability and consistency.
Disodium phosphate dihydrate can be found in flame-retardant coatings for wood and textiles, enhancing their fire resistance.

In the printing industry, it is used in fountain solutions to maintain pH and improve the quality of print.
Disodium phosphate dihydrate is employed in the manufacturing of synthetic fire logs and fire starters, enhancing their combustion properties.
Disodium phosphate dihydrate plays a role in the creation of specialty concrete and mortar mixtures, improving their workability and setting times.

In the glass and ceramics industry, it is used as a flux to lower the melting point of materials and promote uniform melting in kilns.
Disodium phosphate dihydrate can be found in refrigeration and cooling systems as a corrosion inhibitor to protect against rust and scale buildup.

Disodium phosphate dihydrate is added to sugar-based confectionery products, such as candy and marshmallows, to control texture and prevent crystallization.
Disodium phosphate dihydrate is used in the formulation of dietary supplements to provide essential phosphorus and assist in the absorption of minerals and nutrients in the body.

In the textile industry, Disodium phosphate dihydrate is used in dyeing and printing processes as a leveling agent to ensure even color distribution on fabrics.
Disodium phosphate dihydrate is employed in the formulation of heat treatment baths for metals, assisting in the hardening and tempering of steel.
In the production of ceramics, it serves as a flux to lower the melting point of raw materials and improve their fusion during firing.

Disodium phosphate dihydrate is found in some baby formula products, where it contributes to the regulation of pH and stability.
In the manufacturing of powdered beverages, such as instant coffee and cocoa, it is used as a dispersing and stabilizing agent to prevent clumping.
Disodium phosphate dihydrate plays a role in the construction industry as an ingredient in plaster formulations, enhancing their workability and setting times.
Disodium phosphate dihydrate is used in the creation of photovoltaic (solar) panels, helping to control the pH in the production of solar cell coatings.

Disodium phosphate dihydrate can be found in some baking powder formulations, acting as a leavening agent to help baked goods rise.
In the preservation of canned vegetables, it helps maintain color and texture during the canning process.
Disodium phosphate dihydrate is employed in the production of effervescent denture cleaning tablets, which dissolve in water to clean dentures and remove stains.
Disodium phosphate dihydrate is used in water treatment plants to reduce the levels of heavy metals, such as lead and cadmium, through precipitation and coagulation.
In the formulation of pesticide sprays, it can serve as a pH buffer to optimize the effectiveness of the active ingredients.

Disodium phosphate dihydrate is used in the preparation of pH-adjusted nutrient solutions for hydroponic farming and plant cultivation.
Disodium phosphate dihydrate is found in fire extinguishing foam concentrates, enhancing their fire suppression capabilities.
Disodium phosphate dihydrate can be incorporated into glass and crystal manufacturing to control the composition and melting characteristics of glass batches.

In the production of synthetic rubber, it improves the dispersion of fillers and additives, leading to improved rubber performance.
Disodium phosphate dihydrate is utilized in the cosmetic industry as a thickening agent in creams and lotions.
Disodium phosphate dihydrate can be found in tooth whitening products, where it aids in pH control and product stability.

In the brewing industry, it plays a role in the production of beer, helping to adjust the pH of brewing water and optimize the brewing process.
Disodium phosphate dihydrate is used in the creation of specialized drilling fluids for oil and gas exploration, aiding in borehole stability.

Disodium phosphate dihydrate is employed in the production of photographic chemicals and developers for film and prints.
Disodium phosphate dihydrate is used in the formulation of dietary supplements, helping to provide essential phosphorus and support various health-related claims.

In the production of antifreeze and coolant solutions for automotive and industrial applications, it contributes to pH control and corrosion protection.
Disodium phosphate dihydrate is found in cooling water systems to control scale and corrosion in industrial cooling equipment.
Disodium phosphate dihydrate can be incorporated into specialty cleaning products for the removal of rust and mineral deposits in industrial settings.



DESCRIPTION


Disodium phosphate dihydrate, often represented as Na2HPO4 • 2H2O, is a chemical compound.
Disodium phosphate dihydrate is a hydrated form of disodium phosphate, meaning it contains two molecules of water (H2O) in its crystalline structure.
Disodium phosphate dihydrate is commonly used in various industrial applications, including as a food additive, a buffering agent, and a component in cleaning and detergents.
Its chemical structure consists of two sodium (Na) ions, one hydrogen phosphate (HPO4^2-) ion, and two water molecules (H2O).

Disodium phosphate dihydrate, with its chemical formula Na2HPO4 • 2H2O, is a hydrated salt of sodium.
Disodium phosphate dihydrate is a white, crystalline powder with a molecular weight of 177.99 g/mol.

The dihydrate form indicates that it contains two molecules of water (H2O) within its crystal structure.
Disodium phosphate dihydrate is highly soluble in water, producing a clear and colorless solution.
Disodium phosphate dihydrate has a slightly alkaline pH when dissolved in water, typically around 9.0, making it useful as a buffering agent.

Disodium phosphate dihydrate is odorless and has a slightly salty taste.
Disodium phosphate dihydrate is non-flammable and does not pose significant fire hazards.
Disodium phosphate dihydrate is often used in the food industry as a food additive and a pH regulator.
In the food industry, it serves as an emulsifier, a sequestrant, and a texturizer.

As a food additive, it can be found in processed cheeses, canned soups, and other food products.
Disodium phosphate dihydrate is used as a leavening agent in baked goods to help them rise during baking.

In the pharmaceutical industry, Disodium phosphate dihydrate is used as a disintegrant in tablet formulations.
Disodium phosphate dihydrate is employed in the water treatment industry to control water hardness by binding to calcium and magnesium ions.
Disodium phosphate dihydrate finds applications in the preparation of dental products, such as toothpaste, to adjust pH and improve product stability.

Disodium phosphate dihydrate is a common component in some cleaning agents and detergents to enhance their cleaning efficiency.
In the cosmetic and personal care industry, it helps maintain the stability of various products.
Disodium phosphate dihydrate is used in some fire-extinguishing agents, enhancing their firefighting properties.
Disodium phosphate dihydrate plays a role in the creation of synthetic detergents and soaps.
In the construction industry, it can be found in certain cement formulations.

Disodium phosphate dihydrate is used in the preparation of oral rehydration solutions for medical purposes.
Disodium phosphate dihydrate contributes to the formulation of adhesive products, improving bonding properties and consistency.

In the agricultural sector, it is employed for soil and water management, optimizing pH for crop growth.
Disodium phosphate dihydrate is used in some specialty welding fluxes in the automotive and manufacturing industries.

Disodium phosphate dihydrate is involved in the formulation of certain fireproofing materials.
Disodium phosphate dihydrate is an essential chemical in various laboratory and industrial processes due to its versatility as a buffering agent, pH regulator, and emulsifying agent.



PROPERTIES


Chemical Formula: Na2HPO4 • 2H2O
Molecular Weight: 177.99 g/mol
Appearance: White, crystalline powder
State: Solid
Solubility: Highly soluble in water, forming a clear and colorless solution
pH Level (in aqueous solution): Typically around 9.0, slightly alkaline
Taste: Slightly salty
Odor: Odorless
Density: Varies with conditions, but typically around 1.52 g/cm³
Melting Point: Decomposes without a distinct melting point
Boiling Point: Decomposes without a distinct boiling point
Water Content: Contains two molecules of water (dihydrate) in its crystal structure
Solubility in Other Solvents: Insoluble in organic solvents
Hygroscopicity: Absorbs moisture from the air
Stability: Stable under normal conditions
Flammability: Non-flammable
Flash Point: Not applicable
Autoignition Temperature: Not applicable
Corrosivity: Not corrosive
Vapor Pressure: Negligible
Viscosity: Varies with concentration and temperature
Crystal Structure: Forms monoclinic crystals
Molecular Structure: Consists of two sodium (Na) ions, one hydrogen phosphate (HPO4^2-) ion, and two water molecules (H2O)
pH Buffering Capacity: Effective buffering agent
Compatibility: Compatible with many other chemicals and compounds



FIRST AID


Inhalation:

If inhaled, remove the affected person to fresh air and provide artificial respiration if breathing is difficult.
Seek medical attention if respiratory distress persists.


Skin Contact:

In case of skin contact, immediately remove contaminated clothing.
Wash the affected area with plenty of water and mild soap for at least 15 minutes.
Seek medical attention if irritation, redness, or other adverse skin reactions occur.


Eye Contact:

If the compound comes into contact with the eyes, immediately rinse the eyes with gently flowing lukewarm water, keeping eyelids open to ensure thorough flushing.
Continue flushing for at least 15 minutes, holding the eyelids apart to prevent further contact.
Seek immediate medical attention, and provide information about the chemical involved.


Ingestion:

If ingested, do not induce vomiting unless directed by a medical professional.
Rinse the mouth with water and drink plenty of water to dilute the chemical.
Seek immediate medical attention and provide information about the ingestion, including the quantity and time of ingestion.



HANDLING AND STORAGE


Handling:

Personal Protective Equipment (PPE):
When handling Disodium phosphate dihydrate, wear appropriate personal protective equipment, including safety goggles, gloves, and a lab coat or protective clothing, to minimize contact with the skin and eyes.

Ventilation:
Use adequate ventilation, such as local exhaust, mechanical ventilation, or respiratory protection, when working with this compound to control airborne concentrations and prevent inhalation exposure.

Avoid Contact:
Minimize skin contact and avoid inhaling dust or aerosols.
Wash hands and any exposed skin thoroughly after handling the compound.

Prevent Contamination:
Keep containers tightly sealed when not in use to prevent contamination and protect the product from moisture.
Store in dedicated containers and avoid cross-contamination with incompatible materials.

Avoid Mixing:
Do not mix Disodium phosphate dihydrate with incompatible substances, such as strong acids, strong bases, or reducing agents, as this can lead to hazardous reactions.
Consult the Safety Data Sheet (SDS) for specific incompatibilities.

Spills and Leaks:
In case of spills or leaks, contain and collect the material using appropriate absorbent materials and tools.
Avoid creating dust.
Dispose of waste material in accordance with local, state, and federal regulations.


Storage:

Storage Conditions:
Store Disodium phosphate dihydrate in a cool, dry, well-ventilated area, away from incompatible materials.
Keep containers tightly closed to prevent moisture absorption.

Temperature:
Maintain storage temperatures between 15°C and 30°C (59°F and 86°F).
Avoid exposure to extreme heat, open flames, and direct sunlight.

Moisture Control:
Protect the compound from excessive humidity and moisture, as it can lead to caking and reduced product quality.
Use desiccants or humidity control measures if necessary.

Separation:
Store Disodium phosphate dihydrate away from strong acids, strong bases, and reducing agents to prevent adverse reactions.
Use separate storage areas or dedicated containers for different chemical products.

Labeling:
Ensure that containers are properly labeled with the chemical name, hazard information, and safety precautions. This helps in safe identification and handling.

Accessibility:
Store the compound in an area where it is accessible only to authorized personnel who are trained in its proper handling and storage.

Safety Data Sheets (SDS):
Maintain readily accessible Safety Data Sheets (SDS) for Disodium phosphate dihydrate in case of emergencies and for reference on safe handling and storage procedures.

Compatibility:
Familiarize yourself with the compatibility of Disodium phosphate dihydrate with storage materials, such as containers and seals, to prevent deterioration or contamination.

Regular Inspection:
Periodically inspect storage conditions to ensure that containers remain tightly sealed, and there are no signs of leakage or damage.

Waste Disposal:
Dispose of waste material, including empty containers, in compliance with local, state, and federal regulations governing the disposal of hazardous chemicals.



SYNONYMS


Sodium hydrogen phosphate dihydrate
Disodium hydrogen phosphate dihydrate
DSP dihydrate
Sodium phosphate dibasic dihydrate
Sodium phosphate, dibasic, dihydrate
Sodium hydrogenphosphate dihydrate
Disodium phosphate dihydrate
Disodium hydrogenphosphate dihydrate
Dibasic sodium phosphate dihydrate
Sodium phosphate, secondary, dihydrate
Sodium phosphate, secondary, dibasic, dihydrate
Sodium orthophosphate dihydrate
Disodium orthophosphate dihydrate
Dibasic sodium orthophosphate dihydrate
Disodium hydrogen orthophosphate dihydrate
Sodium phosphate (Na2HPO4) dihydrate
Sodium acid phosphate dihydrate
Secondary sodium phosphate dihydrate
Sodium monohydrogen phosphate dihydrate
Sodium orthophosphate dibasic dihydrate
Sodium phosphate, monobasic, dihydrate
Sodium hydrogen orthophosphate dihydrate
Sodium phosphate, monosodium, dihydrate
Sodium phosphate, monosodium, dibasic, dihydrate
Sodium hydrogen phosphate dibasic dihydrate
Sodium phosphate, bibasic, dihydrate
Sodium hydrogenphosphate dibasic dihydrate
Sodium phosphate, dihydrate, dibasic
Sodium hydrogen phosphate dibasic dihydrate
Sodium orthophosphate dibasic dihydrate
Sodium phosphate, secondary, dibasic, hydrate
Disodium orthophosphate dibasic dihydrate
Dibasic sodium hydrogen phosphate dihydrate
Disodium phosphate dibasic dihydrate
Dibasic sodium orthophosphate dibasic dihydrate
Sodium monohydrogen phosphate dibasic dihydrate
Sodium orthophosphate secondary dibasic dihydrate
Sodium phosphate, dihydrate, secondary, dibasic
Disodium hydrogen orthophosphate dibasic dihydrate
Sodium phosphate, monosodium, dibasic, dihydrate
Sodium dihydrogen phosphate dibasic dihydrate
Sodium phosphate, dibasic, secondary, dihydrate
Disodium phosphate, secondary, dibasic, dihydrate
Sodium monophosphate dibasic dihydrate
Sodium orthophosphate, dihydrate, secondary, dibasic
Dibasic sodium monophosphate dibasic dihydrate
Disodium dihydrogen phosphate dibasic dihydrate
Sodium phosphate, monosodium, secondary, dibasic, dihydrate
Sodium acid phosphate dibasic dihydrate
Disodium phosphate, secondary, secondary, dibasic, dihydrate
Sodium phosphate, bibasic, secondary, dihydrate
Sodium hydrogenphosphate secondary dibasic dihydrate
Sodium phosphate, dihydrate, secondary, secondary, dibasic
Sodium hydrogen phosphate secondary dibasic dihydrate
Sodium orthophosphate secondary dibasic dihydrate
Sodium phosphate, tertiary, dihydrate
Sodium hydrogenphosphate tertiary dihydrate
Sodium phosphate, dihydrate, tertiary
Sodium hydrogen phosphate tertiary dihydrate
Sodium orthophosphate tertiary dihydrate
Sodium phosphate, quaternary, dihydrate
Sodium hydrogenphosphate quaternary dihydrate
Sodium phosphate, dihydrate, quaternary
Sodium hydrogen phosphate quaternary dihydrate
Sodium orthophosphate quaternary dihydrate
Sodium phosphate, pentahydrate
Sodium hydrogenphosphate pentahydrate
Sodium phosphate, pentahydrate, dibasic
Sodium hydrogen phosphate pentahydrate
Sodium orthophosphate pentahydrate
Sodium phosphate, pentahydrate, dibasic, secondary
Sodium hydrogen phosphate pentahydrate, secondary
Sodium phosphate, dibasic, pentahydrate
Sodium hydrogen phosphate dibasic pentahydrate
Sodium orthophosphate dibasic pentahydrate
DISODIUM PHOSPHATE DODECAHYDRATE
Disodium phosphate dodecahydrate IUPAC Name disodium;hydrogen phosphate;dodecahydrate Disodium phosphate dodecahydrate InChI InChI=1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2 Disodium phosphate dodecahydrate InChI Key DGLRDKLJZLEJCY-UHFFFAOYSA-L Disodium phosphate dodecahydrate Canonical SMILES O.O.O.O.O.O.O.O.O.O.O.O.OP(=O)([O-])[O-].[Na+].[Na+] Disodium phosphate dodecahydrate Molecular Formula H25Na2O16P Disodium phosphate dodecahydrate CAS 7632-05-5 (Parent) Disodium phosphate dodecahydrate ( European Community (EC) Number 600-088-6 Disodium phosphate dodecahydrate UNII E1W4N241FO Disodium phosphate dodecahydrate DSSTox Substance ID DTXSID4064923 Disodium phosphate dodecahydrate Property Name Property Value Reference Disodium phosphate dodecahydrate Molecular Weight 358.14 g/mol Disodium phosphate dodecahydrate Hydrogen Bond Donor Count 13 Disodium phosphate dodecahydrate Hydrogen Bond Acceptor Count 16 Disodium phosphate dodecahydrate Rotatable Bond Count 0 Disodium phosphate dodecahydrate Exact Mass 358.06756 g/mol Disodium phosphate dodecahydrate Monoisotopic Mass 358.06756 g/mol Disodium phosphate dodecahydrate Topological Polar Surface Area 95.4 Ų Disodium phosphate dodecahydrate Heavy Atom Count 19 Disodium phosphate dodecahydrate Formal Charge 0 Disodium phosphate dodecahydrate Complexity 46.5 Disodium phosphate dodecahydrate Isotope Atom Count 0 Disodium phosphate dodecahydrate Defined Atom Stereocenter Count 0 Disodium phosphate dodecahydrate Undefined Atom Stereocenter Count 0 Disodium phosphate dodecahydrate Defined Bond Stereocenter Count 0 Disodium phosphate dodecahydrate Undefined Bond Stereocenter Count 0 Disodium phosphate dodecahydrate Covalently-Bonded Unit Count 15 Disodium phosphate dodecahydrate Compound Is Canonicalized Yes Disodium phosphate dodecahydrate , also known as orthophosphoric acid or Disodium phosphate dodecahydrate , is a weak acid with the chemical formula H3PO4. It is normally encountered as a colorless syrup of 85% concentration in water. The pure compound is a colorless solid.All three hydrogens are acidic to varying degrees and can be lost from the molecule as H+ ions (protons). When all three H+ ions are removed, the result is an orthophosphate ion PO43−, commonly called "phosphate". Removal of one or two protons gives dihydrogen phosphate ion H2PO−4, and the hydrogen phosphate ion HPO2−4, respectively. Disodium phosphate dodecahydrate also forms esters, called organophosphates.Disodium phosphate dodecahydrate is commonly encountered in chemical laboratories as an 85% aqueous solution, which is a colourless, odourless, and non-volatile syrupy liquid. Although Disodium phosphate dodecahydrate does not meet the strict definition of a strong acid, the 85% solution can still severely irritate the skin and damage the eyes.The name "Disodium phosphate dodecahydrate " can be used to distinguish this specific acid from other "Disodium phosphate dodecahydrate ", such as pyrophosphoric acid. Nevertheless, the term "Disodium phosphate dodecahydrate " often means this specific compound; and that is the current IUPAC nomenclature.Disodium phosphate dodecahydrate is produced industrially by two general routes. In the wet process a phosphate-containing mineral such as calcium hydroxyapatite is treated with sulfuric acid.{\displaystyle {\ce {Ca5(PO4)3OH + 5H2SO4 -> 3H3PO4 + 5CaSO4v + H2O}}}{\displaystyle {\ce {Ca5(PO4)3OH + 5H2SO4 -> 3H3PO4 + 5CaSO4v + H2O}}} Fluoroapatite is an alternative feedstock, in which case fluoride is removed as the insoluble compound Na2SiF6. The Disodium phosphate dodecahydrate solution usually contains 23–33% P2O5 (32–46% H3PO4). It may be concentrated to produce commercial- or merchant-grade Disodium phosphate dodecahydrate , which contains about 54–62% P2O5 (75–85% H3PO4). Further removal of water yields Disodium phosphate dodecahydrate with a P2O5 concentration above 70% (corresponding to nearly 100% H3PO4). Calcium sulfate (gypsum) is produced as a by-product and is removed as phosphogypsum.To produce food-grade Disodium phosphate dodecahydrate , phosphate ore is first reduced with coke in an electric arc furnace, to make elemental phosphorus. Silica is also added, resulting in the production of calcium silicate slag. Elemental phosphorus is distilled out of the furnace and burned with air to produce high-purity phosphorus pentoxide, which is dissolved in water to make Disodium phosphate dodecahydrate .The Disodium phosphate dodecahydrate from both processes may be further purified by removing compounds of arsenic and other potentially toxic impurities.Food-grade Disodium phosphate dodecahydrate (additive E338) is used to acidify foods and beverages such as various colas and jams, providing a tangy or sour taste. Soft drinks containing Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat), which would include Coca-Cola, are sometimes called phosphate sodas or phosphates. Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) in soft drinks has the potential to cause dental erosion.Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) also has the potential to contribute to the formation of kidney stones, especially in those who have had kidney stones previously.Specific applications of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) include:In anti-rust treatment by phosphate conversion coating or passivation As an external standard for phosphorus-31 nuclear magnetic resonance.In Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) fuel cells.In activated carbon production.In compound semiconductor processing, to etch Indium gallium arsenide selectively with respect to indium phosphide.In microfabrication to etch silicon nitride selectively with respect to silicon dioxide.As a pH adjuster in cosmetics and skin-care products.As a sanitizing agent in the dairy, food, and brewing industries.A link has been shown between long-term regular cola intake and osteoporosis in later middle age in women (but not men).This was thought to be due to the presence of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat), and the risk for women was found to be greater for sugared and caffeinated colas than diet and decaffeinated variants, with a higher intake of cola correlating with lower bone density.At moderate concentrations Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) solutions are irritating to the skin. Contact with concentrated solutions can cause severe skin burns and permanent eye damage.Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is a unique inorganic acid electrolyte, which is generally used in fuel cell applications at around 200 °C in order to obtain higher system efficiency where its concentration is over 100%. A matrix, which is made of SiC, is used to retain the hot Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) in a cell. Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) has advantageous properties as an electrolyte, such as low volatility, good ionic conductivity, stability at relatively high temperatures, carbon dioxide tolerance, and also carbon monoxide tolerance. With all these advantages, there have been several technical electrolyte-related problems with fuel cell stacks. The major issues are volume change, evaporation loss, and electrolyte migration, and these are described in detail. These problems mainly arise due to the fact that Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is a liquid electrolyte under fuel cell operation.Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) (H3PO4, also known as Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) or phosphoric (V) acid) is a mineral inorganic acid. Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) refers to Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) in which the prefix ortho is used to distinguish the acid from related Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat), called polyphosphoric acids. Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat), when pure, is a solid at room temperature and pressure. The most common source of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is an 85% aqueous solution that is colorless and nonvolatile but is sufficiently acidic to be corrosive. Because of the high percentage of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) in this reagent, at least some of the Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is condensed into Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat). For the sake of labeling and simplicity, the 85% represents the acid as if it was all Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat). Dilute aqueous solutions of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) exist in the orthoform.Phosphoric acid (H3PO4) can be manufactured using either a thermal or a wet process. However, the majority of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is produced using the wet-process method. Wet-process Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is used for fertilizer production. Thermal process Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is commonly used in the manufacture of high-grade chemicals, which require a much higher purity. The production of wet-process Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) generates a considerable quantity of acidic cooling water with high concentrations of phosphorus and fluoride. This excess water is collected in cooling ponds that are used to temporarily store excess precipitation for subsequent evaporation and to allow recirculation of the process water to the plant for reuse.In the wet process, Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is produced by reacting sulfuric acid (H2SO4) with naturally occurring phosphate rock. The phosphate rock is dried, crushed, and then continuously fed into the reactor along with sulfuric acid. The reaction combines calcium from the phosphate rock with sulfate, forming calcium sulfate (gypsum, CaSO4), which is separated from the reaction solution by filtration. Some facilities generally use a dihydrate process that produces gypsum in the form of calcium sulfate with two molecules of water (calcium sulfate dihydrate, CaSO4·2H2O). Other facilities may use a hemihydrate process that produces calcium sulfate with the equivalent of a half molecule of water per molecular of calcium sulfate (2CaSO4·H2O). The one-step hemihydrate process has the advantage of producing wet-process Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) with a higher concentration of phosphorus pentoxide (P2O5) and less impurities than the dihydrate process. A simplified reaction for the dihydrate process is as follows:In order to make the strongest pDisodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) possible and to decrease evaporation costs, 93% (v/v) sulfuric acid is normally used. During the reaction, gypsum crystals are precipitated and separated from the acid by filtration. The separated crystals must be washed thoroughly to yield at least a 99% (v/v) recovery of the filtered Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat). After washing, the slurried gypsum is pumped into a gypsum pond for storage. Water is siphoned off and recycled through a surge cooling pond to the Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) process. Wet-process Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) normally contains 26%–30% (w/w) phosphorus pentoxide, and in most cases, the acid must be further concentrated to meet phosphate feed material specifications for fertilizer production. Depending on the types of fertilizer to be produced, Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) is usually concentrated to 40%–55% (w/w) phosphorus pentoxide by using two or three vacuum evaporators.In the thermal process, the raw materials for the production of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) are elemental (yellow) phosphorus, air, and water. The process involves three major steps: (1) combustion, (2) hydration, and (3) demisting. In the combustion step, the liquid elemental phosphorus is burned (oxidized) in ambient air in a combustion chamber at temperatures of 1650–2760°C (3000–5000°F) to form phosphorus pentoxide:The phosphorus pentoxide is then hydrated with dilute phosphoric acid (H3PO4) or water to produce strong Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) liquid.The final step is a demisting step that is applied to removal of the Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) mist from the combustion gas stream before releasing to the atmosphere, which is usually accomplished by use of high-pressure-drop demisters. As always, release to the atmosphere can only be accomplished if the demisted product is a clean and nonpolluting stream.The concentration of phosphoric acid (H3PO4) produced from the thermal process normally ranges from 75% to 85% (v/v). This concentration is required for high-grade chemical production and other nonfertilizer product manufacturing. Efficient plants recover approximately 99.9% (w/w) of the elemental phosphorus burned as the phosphoric acid product.In Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) production, the fluorine released from reactors and evaporators is usually recovered as a by-product that can be sold. The remainder is passed to the condenser that produces a liquid effluent with mostly fluoride and small amounts of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat). Closed systems recycle this effluent; in other cases, it is discharged to open waters.The manufacture of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) produces a gypsum slurry that is sent to settling ponds to allow the solids to settle out. About 5 lbs of phosphor-gypsum is generated per pound of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat). This phosphor-gypsum contains trace elements from phosphate rock, such as cadmium and uranium. Pond systems are usually fitted with lining systems and collection ditches to maintain control of trace elements and avoid contamination of ground water.The major source of phosphorus in the world is apatite, which is a group of phosphate minerals, usually referring to hydroxylapatite, fluorapatite and chlorapatite, with high concentrations of hydroxyl (OH−) ions, fluoride (F−) ions, and chloride (Cl−) ions, respectively, in the crystal apatite (Ca5(PO4)3(F,Cl,OH)). Commercially, the most important is fluoroapatite, a calcium phosphate that contains fluorine. This fluorine must be removed for the manufacture of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat), but it also can be used to produce hydrofluoric acid and fluorinated compounds.Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) esters, for example, tributyl phosphate, (CH3CH2CH2CH2O)3PO are used for the separation of nuclear fuel elements, uranium, zirconium and hafnium, and rare earth elements. Trioctyl phosphine oxide (TOPO), R3PO where R is C8H17) is another solvationg extractant used to recover uranium from wet process Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) liquors (Hudson, 1982). It is also used as a constituent of supported liquid membranes to recover rhenium from hydrometallurgical effluents (to be described in Chapter 12). Some long chain ketones, for example, methyl isobutyl ketone, CH3CO,CH2CH(CH3)2 have been used for separation of niobium and tantalum (described in Chapter 10).Conductivity An increase in Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) doping levels results in a clear increase in membrane conductivity related to the increase in proton ‘carriers’. Thus at 150 °C, for doping levels of 4.7, 6.7, and 14.5 Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) moles per PBI repeat unit, respective conductivities of 18, 22, and 79 mS cm−1 were obtained. On the contrary, it was observed that membrane conductivities increase up to 150 °C and then decline. This behavior was attributed to the self-dehydration of Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) above 150 °C, resulting in less conductive pyrophosphoric acid.At a doping level corresponding to the maximum protonation of PBI, i.e., two Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) moles per PBI repeat unit, the proton hopping from N site to the Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) anion was reported to contribute significantly to conductivity, which reached 25 mS cm−1 at 200 °C.On the contrary, at an acid doping level of 5.6 Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) moles per PBI repeat unit, ‘free acid’ contribution to conductivity is dominant. The conductivity of PBI was found to improve with atmospheric humidity, but its dependence on RH was far less than in Nafion membranes. This hopping-like mechanism is confirmed by Arrhenius behavior of conductivity.Hydration, too, releases some additional heat. The properties of phosphorus pentoxide and the absorption process inevitably leave as much as 25% of the oxide plus a Disodium phosphate dodecahydrate (Disodyum fosfat dodekahidrat) mist in the exit gases from the absorption tower. These are captured on passage through an electrostatic precipitator. By variations of the process details and equipment, grades (concentrations) of phosphoric acid from 75–105% (ortho, or superphosphoric acid) H3PO4 may be made in this manner.Phosphoric acid production by phosphorus combustion is usually accomplished in a stepwise manner as outlined, with intermediate isolation of the phosphorus. However, it may also be made by direct contact of phosphorus vapor from the furnace of a phosphorus plant with an air stream, and then passing the phosphorus pentoxide produced directly into a hydrator, without collection of the intermediate phosphorus as a liquid. Direct conversion to phosphoric acid in this way is attractive because the bulk of white phosphorus produced is converted to phosphoric acid.What is Phosphoric Acid? Phosphoric acid is a colorless, odorless mineral acid. With an acidic taste and somewhat viscous consistency, phosphoric acid is used in a wide variety of products and industries. Despite its popularity, this chemical can pose some potentially significant health hazards and should be handled with caution.Common Uses of Phosphoric Acid Phosphoric acid is used in several industries. Fertilizer accounts for the majority of phosphoric acid use, but this chemical can also be found in:Food additives (to acidify foods, or as a leavening agent) Soaps and detergents Water treatment Toothpastes Rust removal Etching solutions in dentistry Teeth whiteners Cleaning products Health Hazards Associated with Phosphoric Acid Phosphoric acid can be very hazardous in the case of skin contact, eye contact, and ingestion. It can also cause irritation if vapors are inhaled. This chemical can cause damage to the skin, eyes, mouth, and respiratory tract. Because of the potential hazards posed by this chemical, it is important to use care when handling it.Repeated or prolonged exposure to phosphoric acid mist can lead to chronic eye irritation, severe skin irritation, or prolonged respiratory tract issues. To protect your health when handling this potentially hazardous chemical, it is important to use caution in the form of personal protective equipment (PPE).Phosphoric Acid Safety, Handling & First Aid When handing phosphoric acid, use a certified vapor respirator. Eye-wash stations and safety showers should be located near work stations as a precaution. A face shield, gloves and boots should also be used. In case of accidental exposure to phosphoric acid, follow these first aid guidelines:Inhalation—Seek fresh air and immediate medical attention.Eye Contact—Remove contact lenses if present. Immediately flush eyes with plenty of water for at least 15 minutes, and get medical attention.Skin Contact—Wash skin with soap and water. Cover any irritated skin with an emollient. Seek medical attention.Ingestion—Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Seek medical attention if any adverse health symptoms occur.Safe Storage & Disposal of Phosphoric Acid Store phosphoric acid in a cool, well-ventilated area protected from moisture. Keep away from incompatible substances such as oxidizing agents, metals, combustible materials, and alkalis. This chemical should be stored in a metallic or coated fiberboard container using a strong polyethylene inner package. Dispose of this chemical in accordance with federal, state, and local environmental control regulations.Need more safety information about phosphoric acid or other chemicals in your workplace? Check out our extensive library of MSDS information here.Phosphoric Acid can affect you when breathed in.Phosphoric Acid is a CORROSIVE CHEMICAL and contact can irritate and burn the eyes.Breathing Phosphoric Acid can irritate the nose, throat and lungs causing coughing and wheezing.Long-term exposure to the liquid may cause drying and cracking of the skin.IDENTIFICATION Phosphoric Acid is a colorless, odorless solid or a thick, clear liquid. It is used in rustproofing metals, fertilizers, detergents,foods, beverages, and water treatment.Acute Health Effects The following acute (short-term) health effects may occur immediately or shortly after exposure to Phosphoric Acid:Contact can irritate and burn the eyes.Breathing Phosphoric Acid can irritate the nose and throat causing coughing and wheezing.Chronic Health Effects The following chronic (long-term) health effects can occur at some time after exposure to Phosphoric Acid and can last for months or years:Cancer Hazard Phosphoric Acid has not been tested for its ability to cause cancer in animals.Reproductive Hazard Phosphoric Acid has not been tested for its ability to affect reproduction.Other Long-Term Effects Phosphoric Acid can irritate the lungs. Repeated exposure may cause bronchitis to develop with cough, phlegm and/or shortness of breath.Long-term exposure to the liquid may cause drying and cracking of the skin.Where possible, automatically transfer solid Phosphoric Acid or pump liquid Phosphoric Acid from drums or other storage containers to process containers.Workers whose clothing has been contaminated by Phosphoric Acid should change into clean clothing promptly.Do not take contaminated work clothes home. Family members could be exposed.Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to Phosphoric Acid.Eye wash fountains should be provided in the immediate work area for emergency use.If there is the possibility of skin exposure, emergency shower facilities should be provided.On skin contact with Phosphoric Acid, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted Phosphoric Acid, whether or not known skin contact has occurred.Do not eat, smoke, or drink where Phosphoric Acid is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating, drinking,smoking, or using the toilet.For solid Phosphoric Acid, use a vacuum to reduce dust during clean-up. DO NOT DRY SWEEP.Clothing Avoid skin contact with Phosphoric Acid. Wear acidresistant gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation.All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work.Safety equipment manufacturers recommend Natural Rubber, Nitrile Rubber, Polyvinyl Chloride, Viton or Neoprene as protective materials.SPILLS AND EMERGENCIES If Phosphoric Acid is spilled or leaked, take the following steps:Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete.Cover liquids with dry lime, sand or soda ash, and place in covered containers for disposal.Collect powdered material in the most convenient manner and deposit in sealed containers.Ventilate and wash area after clean-up is complete.It may be necessary to contain and dispose of Phosphoric Acid as a HAZARDOUS WASTE.If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.Prior to working with Phosphoric Acid you should be trained on its proper handling and storage.Phosphoric Acid will react with FINELY POWDERED METALS to form flammable and explosive Hydrogen gas.Phosphoric Acid must be stored to avoid contact with WATER; AMMONIA; BLEACH; and NITROMETHANE since violent reactions occur.Phosphoric Acid is not compatible with STRONG BASES (such as SODIUM HYDROXIDE and POTASSIUM HYDROXIDE); COMBUSTIBLES; ORGANICS;ALCOHOLS; STRONG ACIDS (such as HYDROCHLORIC, SULFURIC and NITRIC); AMINES;EPOXIDES; METALS; and METAL SALTS.Store in tightly closed containers in a cool, well-ventilated area away from GLASS, RUBBER, PLASTICS and COATINGS.The USP 32 states that dibasic sodium phosphate is dried or contains, 1, 2, 7, or 12 molecules of water of hydration. Anhydrous dibasic sodium phosphate occurs as a white powder. The dihydrate occurs as white or almost white, odorless crystals.The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air. The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate.Tribasic calcium phosphate is finely ground and digested with sulfuric acid. This mixture is then leached with hot water and neutralized with sodium carbonate, and dibasic sodium phosphate is crystallized from the filtrate.Dibasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, dibasic sodium phosphate is used as a mild laxative and in the treatment of hypophosphatemia.Dibasic sodium phosphate is also used in food products; for example as an emulsifier in processed cheese.Dibasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations. Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia (phosphate deficiency) virtually unknown except for certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces.Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally. Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of dibasic sodium phosphate as an excipient in oral formulations. However, the level of dibasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.LD50 (rat, oral): 17 g/kgThe anhydrous form of dibasic sodium phosphate is hygroscopic. When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its water of crystallization; and at a dull-red heat (about 240℃) it is converted into the pyrophosphate, Na4P2O7. Aqueous solutions of dibasic sodium phosphate are stable and may be sterilized by autoclaving.The bulk material should be stored in an airtight container, in a cool, dry place.Sodium Phosphate Dibasic Dodecahydrate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards. Typical and custom packaging is available. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.Disodium Phosphate Dodecahydrate is white or colorless crystalline free flowing solid, efflorescent in air, easily soluble in water, but insoluble in alcohol, its water solution is slightly alkaline, relative density at 1.52 g/cm3, melting point at 35℃.Disodium Phosphate Dodecahydrate is used as water softening agent for boiler, buffering agent, solder, tanning agent, etc.Disodium phosphate is used in conjunction with trisodium phosphate in many steam-boiler applications. It supplies the inventory of free phosphates to retard calcium scale formation. In water treatment, Disodium Phosphate retards calcium scale formation.Disodium Phosphate is used for boiler soft agent, fabric, wood and paper of flame retardants, glaze medicine. Disodium Phosphate is also found in some detergents and cleaning agents, and dyeing with salt.In printing and dyeing industries, Disodium phosphate used as hydrogen peroxide bleaching stabilizer, rayon packing (enhancement of silk strength and elastic), and for manufacturing focal phosphorus sodium and other raw materials, as well as monosodium glutamate, erythromycin, penicillin, streptomycin, and sewage production, cultivating agent products etc.It also used in electroplating, leather.Packing:In PP+PE bags of 25kgs net each, we can provide packages according to customer’s requirement .Storage: Store at a cool, dry and well ventilated place.Shelf life: 24 months.Support: Disodium Phosphate Dodecahydrate – Material Safety Data Sheet (MSDS).Sodium Phosphate Dibasic, Dodecahydrate, also known as Disodium hydrogen phosphate, can be is used to adjust pH or as an anti-caking additive in powdered products. It is an electrolyte replenisher and with radio-protective activity.Disodium phosphate dodecahydrate contains not less than 98.0 per cent and not more than the equivalent of 101.0 percent of Na2HPO4, calculated with reference to the anhydrous substance.Colourless, transparent crystals, very efflorescent, very soluble in water, practically insoluble in ethanol (96 percent).Our range of products include di sodium hydrogen phosphate dodecahydrate ip, di sodium hydrogen phosphate dodecahydrate bp, di sodium hydrogen phosphate dodecahydrate pure, di sodium hydrogen phosphate dodecahydrate usp, di sodium hydrogen phosphate dodecahydrate acs and di sodium hydrogen phosphate dodecahydrate food grade.Disodium hydrogen phosphate is a sodium salt of phosphoric acid. It is a white/crystaline powder that is highly hygroscopic and water soluble. It is therefore used commercially as an anti-caking additive in powdered products. Disodium phosphate is used in Cream of Wheat to quicken cook time, as described on the ingredients panel of the product package, antioxidant, emulsifier & food additives.Disodium hydrogen phosphate is a sodium salt of phosphoric acid. It is a white/crystaline powder that is highly hygroscopic and water soluble. It is therefore used commercially as an anti-caking additive in powdered products. Disodium phosphate is used in Cream of Wheat to quicken cook time, as described on the ingredients panel of the product package, antioxidant, emulsifier & food additives.Disodium hydrogen phosphate is a sodium salt of phosphoric acid.
DISODIUM PYROPHOSPHATE
Disodium pyrophosphate, also known as Sodium acid pyrophosphate, is a white, water soluble solid that has many applications in the food industry.
Disodium pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Disodium pyrophosphate is a popular leavening agent found in baking powders.

CAS Number: 7758-16-9
EC Number: 231-835-0
Molecular Formula: H5NaO7P2
Molcular Weight: 201.97

Disodium dihydrogen diphosphate, Diphosphoric acid, disodium salt, Disodium dihydrogen pyrophosphate, Disodium diphosphate, Sodium acid pyrophosphate, SAPP, Disodium Pyrophosphate, Disodium Diphosphate, Disodium Dihydrogen Diphosphate, Disodium Dihydrogen Pyrophosphate, Diphosphoric Acid, Disodium Salt, Pyrophosphoric Acid, Disodium Salt, Disodium diphosphate, Disodium pytophosphate, Disodium dihydroge3 disodium salt, H5WVD9LZUD, Sodium pyrophosphate (Na2H2P2O7), Diphosphoric acid, sodium salt (1:2), Dinatriumpyrophosphat, Sodium polyphosphates, Natrium polyphosphat, Sodium polyphosphatium phosphate, Natrium polyphosphatium DS42_Sodium Polyphosphate dihydrogendiphosphate, DSSTox_RID_78658, DSSTox_GSID_28842 ,2Na.H2P2O7, Sodium dihydrogen pyrophosphate, Sodium polyphosphate, amorphous, CHEMBL3184949, DTXSID_GSID_28842, LS-2432, NCGC00258367-01, [hydroxy(oxido)phosphoryl] hydrogen phosphate, Sodium acid pyrophosphate, SAPP, Diphosphoric acid, disodium salt, Disodium acid pyrophosphate, Disodium dihydrogen diphosphate, Disodium dihydrogen pyrophosphate, Disodium diphosphate, Pyrophosphoric acid, disodium salt, Sodium pyrophosphate dibasic, disodium dihydrogen pyrophosphate, pyrophosphoric acid, disodium salt (8ci), sapp 40, disodiumdiphosphate, sapp, sodium acid pyrophosphate(sapp), sodium acid pyrophosphate (sapp), dspp, dihydrogen disodium pyrophosphate, disodium pyrophosphate (na2h2p2o7), sodiumpyrophosphate,acid, dinatriumpyrophosphat, disodium pytophospha, disodium pyrophosphate, disodium dihydrogen diphosphate, disodium pytophosphate, diphosphoricacid, disodium salt (9ci), sodiumpyrophosphate (na2h2p2o7) (6ci), sapp 28, sapp-rd 1, disodium dihydrogendiphosphate (na2h2p2o7), sodium hydrogen phosphate (na2h2p2o7), Disodium dihydrogen pyrophosphate, SAPP, E450, 7758-16-9, Disodium diphosphate, Sodium acid pyrophosphate, Disodium dihydrogen pyrophosphate, DISODIUM PYROPHOSPHATE, H5WVD9LZUD, disodium;[hydroxy(oxido)phosphoryl] hydrogen phosphate, MFCD00014246, Disodium acid pyrophosphate, Dinatriumpyrophosphat, Disodiumpytophosphate, Dinatriumpyrophosphat [German], Disodium dihydrogen diphosphate, Disodium dihydrogenpyrophosphate, HSDB 377, Pyrophosphoric acid, disodium salt, UNII-H5WVD9LZUD, Sodium pyrophosphate (Na2H2P2O7), EINECS 231-835-0, Sodium diphosphate dibasic, disodium hydrogen (hydrogen phosphonatooxy)phosphonate, Grahamsches salz, Glassy sodium phosphate, DSSTox_CID_8842, sodium dihydrogendiphosphate, EC 231-835-0, DSSTox_RID_78658, DSSTox_GSID_28842, SODIUMACIDPYROPHOSPHATE, Sodium pyrophosphate, dibasic, Sodium dihydrogen pyrophosphate, CHEMBL3184949, EINECS 272-808-3, Tox21_200813, DISODIUM PYROPHOSPHATE [HSDB], DISODIUM PYROPHOSPHATE [INCI], DISODIUM PYROPHOSPHATE [VANDF], AKOS015916169, AKOS024418779, SODIUM ACID PYROPHOSPHATE [MI], Diphosphoric acid, sodium salt (1:2), SODIUM ACID PYROPHOSPHATE [FCC], NCGC00258367-01, SODIUM ACID PYROPHOSPHATE [VANDF], CAS-68915-31-1

Disodium pyrophosphate is a food-grade chemical compound that belongs to the group of sodium phosphates.
Disodium pyrophosphate is a white, crystalline powder or granular material with various applications in the food industry.

Disodium pyrophosphate is recognized as a food additive and is commonly used for its leavening, buffering, and emulsifying properties.
Disodium pyrophosphate serves as a buffering, chelating and leavening agent.

Disodium pyrophosphate encodes a integral membrane protein.
Disodium pyrophosphate is a soluble protein generated by sequential cleavage with α and γ secretase.

Disodium pyrophosphate, also known as Sodium acid pyrophosphate, is an inorganic compound composed of sodium cation and pyrophosphate anion.
Disodium pyrophosphate is a white, water-soluble solid, commonly used as a buffer and chelating agent and has many applications in food processing industry.

Disodium pyrophosphate is a white monoclinic crystal powder.
Disodium pyrophosphates relative density is 1.86.

Disodium pyrophosphate is soluble in water, insoluble in alcohol.
Disodium pyrophosphate hydrolyzes to orthophosphate when heated in acid medium.

Disodium pyrophosphate is hygroscopic, forms hexahydrate in damp air, and decomposes to metaphosphate at above 220℃.
The leavening acid, Disodium pyrophosphate is an important component of double acting baking powder as well as self rising flour.

Disodium pyrophosphate reacts in stages and is desirable in baking applications for its slow action.
Disodium pyrophosphate or Sodium acid pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.

Disodium pyrophosphate is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.
When crystallized from water, Disodium pyrophosphate forms a hexahydrate, but Disodium pyrophosphate dehydrates above room temperature.

Disodium pyrophosphate is a polyvalent anion with a high affinity for polyvalent cations.
Disodium pyrophosphate, also known as disodium dihydrogen pyrophosphate, Sodium acid pyrophosphate, is white crystalline powder, which has the relative density of 1.864 and can decompose into sodium metaphosphate when Disodium pyrophosphate is heated above 220℃.

Disodium pyrophosphate is easily soluble in water and can form chelates with Cu2+ and Fe2+.
The aqueous solution can be hydrolyzed to phosphoric acid by heating with dilute sulfuric acid or dilute mineral acid.

Disodium pyrophosphate is usually used in food processing industry.
Disodium pyrophosphate, or disodium dihydrogen pyrophosphate, its food grade is commonly used with sodium bicarbonate as a leavening agent in bakery products; also, Disodium pyrophosphate maintains the color in processed potatoes and also prevents struvite crystal in canned seafood.

The European food additive number for Disodium pyrophosphate is E450(i).
Generally, Disodium pyrophosphate is vegan and gluten free.

Disodium pyrophosphate also known as Di-sodium Di-phosphate is an inorganic compound of sodium and pyrophosphate.
Disodium pyrophosphate is white and soluble in water.

Disodium pyrophosphate is manufactured with double drying process like other Pyrophosphates due to heating needed at a high temperature.
Disodium pyrophosphate is solubility in water is 13g Na2H2P2O7/100g H2O at 20 °C, and 20g at 80°C.

The pH of a 1% aqueous solution is 4.1. The usual commercial product is the anhydrous, nonhygroscopic salt in powder form.
The hexahydrate, Na2H2P2O7.6H2O, d 1.85, crystallizes from aqueous solution below 27 °C.

Above this temperature, Disodium pyrophosphate is converted to the anhydrous form.
Disodium pyrophosphate is used as a (tropically stable) acid carrier in baking powder, for improvement of flow properties in flour, for pH regulation, and in dental care products for prevention of tartar formation.

Disodium pyrophosphate is available in a variety of grades that affect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium pyrophosphate is usually used in very sweet cakes which mask the off-taste.

Disodium pyrophosphate is manufactured by partially neutralizing food grade phosphoric acid with sodium hydroxide or sodium carbonate to form monosodium phosphate.
Dehydration of monosodium phosphate at 250°C will form Disodium pyrophosphate.

Leavening acids provide air and volume to the baked good structure, but also affect the characteristics of the dough.
Besides reacting with baking soda to produce the gas carbon dioxide, these acids form ionic bonds with the starches and proteins in the dough.

Disodium pyrophosphate dissolves readily to form the anion pyrophosphate which interacts with the proteins in a baked good system to provide a moist texture.
Also, Disodium pyrophosphate provides a buffer system for the dough in the pH range 7.3-7.5, which influences the color of the baked product.

Disodium pyrophosphate is a white, crystalline powder or granular substance.
Disodium pyrophosphate is a sodium salt of pyrophosphoric acid and is commonly used as a food additive and in various industrial applications.

Disodium pyrophosphate has unique chemical properties that make Disodium pyrophosphate versatile in different processes.
Disodium pyrophosphate acts as a leavening agent in food production, helping dough rise and creating a light texture in baked goods.
In addition to its culinary uses, Disodium pyrophosphate is utilized as a buffering agent, stabilizer, and emulsifier in food processing.

Disodium pyrophosphate also finds application as a corrosion inhibitor, pH adjuster, and chelating agent in various industries.
Disodium pyrophosphate is a slow leavening acid and Disodium pyrophosphate may contain a suitable aluminum and/or calcium salt to control the rate of reaction.
Disodium pyrophosphate and other sodium and potassium polyphosphates are widely used in food processing; in the E number scheme, they are collectively designated as E450, with the disodium form designated as E450(a).

In the United States, Disodium pyrophosphate is classified as generally recognized as safe (GRAS) for food use.
In canned seafood, Disodium pyrophosphate is used to maintain color and reduce purge[clarification needed] during retorting.
Retorting achieves microbial stability with heat.

Disodium pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.
In baking powder, Disodium pyrophosphate is often labeled as food additive E450.
In cured meats, Disodium pyrophosphate speeds the conversion of sodium nitrite to nitrite (NO2−) by forming the nitrous acid (HONO) intermediate,[clarification needed] and can improve water-holding capacity.

Disodium pyrophosphate is also found in frozen hash browns and other potato products, where Disodium pyrophosphate is used to keep the color of the potatoes from darkening.
Disodium pyrophosphate can leave a slightly bitter aftertaste in some products, but "the SAPP taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings."

Disodium pyrophosphate has limited direct uses in water treatment processes.
Disodium pyrophosphate can indirectly contribute to certain aspects of water treatment.

Disodium pyrophosphate is sometimes employed as a pH adjuster and buffering agent in water treatment applications where precise pH control is necessary.
Disodium pyrophosphate can help stabilize and maintain the desired pH range, optimizing treatment processes.

Disodium pyrophosphate can act as a sequestering agent, chelating metal ions and preventing their precipitation or interference with water treatment chemicals.
Its ability to bind with metal ions aids in minimizing scaling and maintaining the efficiency of water treatment equipment.

Disodium pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Disodium pyrophosphate is a white, water-soluble that serves as a buffering and chelating agent, with many applications in the food industry.

When crystallised from water, Disodium pyrophosphate forms hexahydrate, but Disodium pyrophosphate dehydrates above room temperature.
Disodium pyrophosphate is a polyvalent anion with a high affinity for polyvalent cations.

Disodium pyrophosphate is a popular leavening agent found in baking powders.
Disodium pyrophosphate combines with sodium bicarbonate to release carbon dioxide.

Disodium pyrophosphate is available in a variety of grades that effect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium pyrophosphate is usually used in very sweet cakes which mask the taste.

Disodium pyrophosphate is designated in the USA as generally recognized as safe for food use.
Disodium pyrophosphate is used in canned seafood to maintain color and reduce purge during retorting.

Retorting achieves microbial stability with heat.
Disodium pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.

Disodium pyrophosphate is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Disodium pyrophosphate.
Disodium pyrophosphate is used as an acidulant, buffering agent, and leavening agent.
Disodium pyrophosphate has a dough reaction rate of 24 – 28.

Disodium pyrophosphate is an all-purpose phosphate commonly used in prepared mixes, commercial baking powders, and cake doughnut mixes.
Disodium pyrophosphate and other sodium and potassium polyphosphates are widely used in food processing; in the E number scheme, they are collectively designated as E450, with the disodium form designated as E450(a).

In the United States, Disodium pyrophosphate is classified as generally recognized as safe (GRAS) for food use.
In canned seafood, Disodium pyrophosphate is used to maintain color and reduce purge[clarification needed] during retorting.

Retorting achieves microbial stability with heat.
Disodium pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.

In baking powder, Disodium pyrophosphate is often labeled as food additive E450.
In cured meats, Disodium pyrophosphate speeds the conversion of sodium nitrite to nitrite (NO2−) by forming the nitrous acid (HONO) intermediate,[clarification needed] and can improve water-holding capacity.

Disodium pyrophosphate is also found in frozen hash browns and other potato products, where Disodium pyrophosphate is used to keep the color of the potatoes from darkening.
Disodium pyrophosphate can leave a slightly bitter aftertaste in some products, but "the SAPP taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings.
Disodium pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.

As a leavening acid which combines with baking soda to release carbon dioxide to improve the texture and volume of baked goods.
As a chelating agent to chelate iron to prevent discoloration in processed potato.
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties.

Disodium pyrophosphate is derived from amyloid precursor protein.
The protein consists of 612 amino acids.
Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP.

Disodium pyrophosphate has neuroprotective, neurogenic and neurotrophic functions.
Amyloid precursor protein a also stimulates gene expression and protein expression.
In leather treatment, Disodium pyrophosphate can be used to remove iron stains on hides during processing.

Disodium pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.
When added to scalding water, Disodium pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
Disodium pyrophosphate in petroleum production, Disodium pyrophosphate can be used as a dispersant in oil well drilling muds.

Disodium pyrophosphate can also be found in frozen hash browns and other potato products, where Disodium pyrophosphate is used to keep the color of the potatoes from darkening.
Disodium pyrophosphate is a sodium salt of pyrophosphoric acid, and its chemical formula is Na2H2P2O7.

Disodium pyrophosphate in the food industry is as a leavening agent.
Disodium pyrophosphate releases carbon dioxide gas when Disodium pyrophosphate reacts with alkalis, such as baking soda (sodium bicarbonate), when exposed to moisture and heat.

This gas production causes dough or batter to rise, resulting in baked goods with a lighter texture.
Disodium pyrophosphate is often used in baking powder formulations to provide a delayed or slow-acting leavening effect.

Disodium pyrophosphate acts as a pH buffer in various food products, helping to control and stabilize their acidity or alkalinity.
Disodium pyrophosphate is used in processed foods to maintain the desired pH level, preventing changes in flavor, color, and texture.

Disodium pyrophosphate can also serve as an emulsifying agent in certain food products, helping to blend ingredients that would not naturally mix together, such as oil and water.
Disodium pyrophosphate is commonly used in a variety of food products, including baked goods like cakes, muffins, and pancakes, as well as in pancakes, waffles, and other batter-based items.

Disodium pyrophosphate is also used in certain dairy products, such as processed cheeses, to help improve their melting and texture.
Disodium pyrophosphate may be used in meat products as a pH regulator, in canned seafood to maintain product quality, and in potato products like French fries to prevent discoloration.

Uses of Disodium pyrophosphate:
Disodium pyrophosphate is used Buffering Agents, Food & Beverage, Food Additives, Levelling Agents, Oil Field Services, Chelants, and Leather.

Food uses:
Disodium pyrophosphate is a popular leavening agent found in baking powders.

Disodium pyrophosphate combines with sodium bicarbonate to release carbon dioxide:
Na2H2P2O7 + NaHCO3 → Na3HP2O7 + CO2 + H2O

Disodium pyrophosphate is available in a variety of grades that affect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium pyrophosphate is usually used in very sweet cakes which mask the off-taste.

Disodium pyrophosphate used as buffering agent, leavening agent, sequestrant agent.
Disodium pyrophosphate can be used in canned food, ham, meat,baking powder and so on.

Disodium pyrophosphate in baking powder, New Zealand, 1950s
Disodium pyrophosphate and other sodium and potassium polyphosphates are widely used in food processing.

In canned seafood, Disodium pyrophosphate is used to maintain color and reduce purge during retorting.
Retorting achieves microbial stability with heat.

Disodium pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.
Disodium pyrophosphate is used as a tartar control agent in toothpastes.
Disodium pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.

In baking powder, Disodium pyrophosphate is often labeled as food additive E450.
In cured meats, Disodium pyrophosphate speeds the conversion of sodium nitrite to nitrite (NO2−) by forming the nitrous acid (HONO) intermediate, and can improve water-holding capacity.

Disodium pyrophosphate is also found in frozen hash browns and other potato products, where Disodium pyrophosphate is used to keep the color of the potatoes from darkening.

Disodium pyrophosphate can stabilize hydrogen peroxide solutions against reduction.
Disodium pyrophosphate can leave a slightly bitter aftertaste in some products, but "the Disodium pyrophosphate taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings."
In leather treatment, Disodium pyrophosphate can be used to remove iron stains on hides during processing.

When added to scalding water, Disodium pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
In petroleum production, Disodium pyrophosphate can be used as a dispersant in oil well drilling muds.
Disodium pyrophosphate is used in cat foods as a palatability additive.

Because Disodium pyrophosphate is slow acting and does not react quickly with baking soda, Disodium pyrophosphate is the most commonly used leavening acid for self rising flour for the home baker.
Per 21 C.F.R. § 137.180(a) 2018, self rising flour must contain enough leavening acid to neutralize the baking soda, but the combination of both can not exceed 4.5 parts per 100 parts flour.

The quantity of leavening acid needed hinges on Disodium pyrophosphate's neutralizing value (NV) which is defined as the quantity of baking soda needed to neutralize 100 parts of leavening acid.
For Disodium pyrophosphate, NV is 70.

Because Disodium pyrophosphate can have a slight bitter taste, Disodium pyrophosphate’s important to use sufficient baking soda in applications as well as use this leavening acid in combination with sugary goods such as doughnuts and cakes.

In canned tuna, Disodium pyrophosphate prevents harmless struvite crystals from forming.
Cake doughnuts are an important application for Disodium pyrophosphate, where initial gas production is necessary for buoyancy in a fryer system.
Also, Disodium pyrophosphate is useful for cakes, where initial gas production is necessary for consistency of pan fill.

Other non-bakery food applications of Disodium pyrophosphate include use as a chelating agent for processed potatoes, an emulsifying agent in cheeses and a curing accelerator in processed meats.
Disodium pyrophosphate can be used as a leavening chemical for bread to help Disodium pyrophosphate rise.

Disodium pyrophosphate's used in sausage to enhance flavor and color.
In french fries, the chemical reduces levels of a carcinogen called acrylamide.

Disodium pyrophosphate also prevents discoloration in potatoes and sugar syrups.
Disodium pyrophosphate is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.
Disodium pyrophosphate is widely used as thinner in oil well drilling muds and even as an industrial cleaner.

Disodium pyrophosphate's key advantages are:
Aids in the removal of calcium and reduces pH in cement contaminated fluids.
At low concentration levels, Disodium pyrophosphate is fast-acting and effective.

Aids break up clay particles and sediments, which enables them to be extracted during oil well development.
Disodium pyrophosphate is used in the chemical clean up of fluids which have been contaminated by cement.
Disodium pyrophosphate decreases the viscosity and gel strengths in freshwater drilling fluids.

Disodium pyrophosphate is used as a deflocculant (thinner) in freshwater mud systems.
Disodium pyrophosphate is often used to break up mud rings when water drilling and is also used to thin out cement before cementing casing.

In cementing applications, Disodium pyrophosphate is used for two primary purposes:
Contaminated drilling mud can result in fluid loss, thickening time, and viscosity.
Disodium pyrophosphate is used to disperse and displace drilling muds to avoid mud being affected by cement contamination.

Solids carrying fluid or drilling mud must be removed from the perforation channels and the rock face to allow a good cement bond and complete fill-up of the voids.
Incorporating Disodium pyrophosphate into the spacer will help remove residual muds and provide a cleaner surface to which the cement can bond.

Disodium pyrophosphate is used as an acidulant, buffering agent, coagulant, emulsifying agent, dispersing agent, protein modifier, and sequestrant.
Actively thins out reactive clays.
In non-dairy creamers, Disodium pyrophosphate is added to protect the proteins from heat dehydration, to stabilize the fat emulsion, and to buffer Disodium pyrophosphate.

Processed potatoes are protected from iron-induced darkening when treated with Disodium pyrophosphate.
Addition of Disodium pyrophosphate to albacore tuna during canning decreases or prevents formation of struvite crystals.

Disodium pyrophosphate is used in meat processing to accelerate development of red color in wieners, bologna, and other emulsion-type meat products.
Disodium pyrophosphate can be used as an emulsifying agent during cheese processing to produce a hard, non-melting cheese product.

Disodium pyrophosphate is Baking powder, used in baking and to control the fermenting speed, to increase the producing strength.
Disodium pyrophosphateis used in instant noodles to reduce time after subjecting to water.

Disodium pyrophosphate is also used in biscuits and cakes, to reduce fermenting time, to decrease the destroying, to maintain the clear gaps, finally to extend products storage.
Disodium pyrophosphate is used Vegetables (esp. potatoes) processing.

Disodium pyrophosphate is used Seafood, meat, cheese processing.
Disodium pyrophosphate is speedly fermentation, water retaining agent and quality improver, used in bread, biscuits, meat, aquatic products and so on.

As quality improver, Disodium pyrophosphate enhances complexation,PH value and Ionic strength.
According to rules, Disodium pyrophosphate's max adding quantity is 3.0g/KG in biscuits and 1.0-3.0g/KG in bread.

Disodium pyrophosphate is reactive not only with sodium bicarbonate, but also with calcium salts, proteins and heat.
Disodium pyrophosphate dispersant is used in much the same manner as polyphosphate dispersants and is subject to the same temperature limitations.
Due to its acidic nature, Disodium pyrophosphate is especially effective for treating cement contamination.

Disodium pyrophosphate dispersant is efficient for bentonite muds and is often used in conjunction with a tannin or quebracho compound.
Disodium pyrophosphate dispersant can also be used to treat calcium contamination, especially contamination resulting from cement.

Because of Disodium pyrophosphate's acidic nature, Disodium pyrophosphate dispersant is not normally used in muds where the pH exceeds 9.5.
Disodium pyrophosphate is one of the two acid components used in commercial baking powders.

Disodium pyrophosphate gives baking powder the time and temperature element contributing to the "Double Acting" power.
Regular Disodium pyrophosphate is used in cakes, sponges and refrigerated dough where a slower reactivity is desired.

Usage 1g of sodium bicarbonate to 1.38g Disodium pyrophosphate or as recipe indicates
Disodium pyrophosphate (SAPP), or disodium dihydrogen pyrophosphate, Disodium pyrophosphate's food grade is commonly used with sodium bicarbonate as a leavening agent in bakery products.

Also, Disodium pyrophosphate maintains the color in processed potatoes and also prevents struvite crystal in canned seafood.
The European food additive number for Disodium pyrophosphate is E450(i), Disodium pyrophosphate.
1. Bakery
2. Canned Sea Food
3. Potato Products

Disodium pyrophosphate is a white, crystalline powder or granular material with various applications in the food industry.

KEYWORDS:
7758-16-9, 231-835-0, Disodium dihydrogen diphosphate, Diphosphoric acid disodium salt, Pyrophosphoric Acid Disodium Salt, H5WVD9LZUD, Sodium pyrophosphate (Na2H2P2O7), DSSTox_RID_78658, CHEMBL3184949, LS-2432

Recommended use in following applications: as a constituent of baking powder, as a constituent of blanching solutions for preventing after-cooking darkening of potatoes, as a constituent of phosphate mized in meat processing, as a constituent of cheese emulsifying salts, as a general buffer and acidifying agent in foodstuffs, as a dispersant in oil well drilling muds, in leather treatment to remove iron stains, in the stabilization of hydrogen peroxide solutions, as a cleaning agent, in conjunction with sulphamic acidn in certain dairy applications, as seafood preservative.

To use: as leavening agent
Applications include food &|beverage (popular leavening agent found in baking powder, used in very sweet cakes which mask the off-tast, canned seafood, Disodium pyrophosphate is used to maintain color and reduce purge, frozen hash browns and other potato products, where Disodium pyrophosphate is used to keep the color of the potatoes from darkening)|agriculture (pet food used in cat foods as a palatability additive, removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter and |industrial (petroleum production, Disodium pyrophosphate can be used as a dispersant in oil well drilling muds, leather treatment to remove iron stains on hides, dairy applications for cleaning, remove soapstone).

Disodium pyrophosphate is used as a buffering and chelating agent, with many applications in the food industry.
Disodium pyrophosphate is one of the popular food additives and ingredients in most countries.

Disodium pyrophosphate used as buffering agent, leavening agent, sequestrant agent.
Disodium pyrophosphate can be used in canned food, ham, meat,baking powder and so on.

Disodium pyrophosphate is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.
Disodium pyrophosphate is used as a leavening agent, reducing zymosis time and can also be used as a water retention agent, and a quality improver for meat and sea food processing.
Disodium pyrophosphate is used strengthen the feed nutrition .

Disodium pyrophosphate, often abbreviated as SAPP is an edible phosphoric salt available as a white crystalline powder in the market.
In food and beverage industry, Disodium pyrophosphate is mostly used as a leavening agent in self-rising and baked goods and as a quality improver for meat and fish processing.

Besides food and beverage, Disodium pyrophosphate is also used in leather industry for leather processing and petroleum industry in the drilling of oil wells as dispersants.
Hence, the manufacturers are offering Disodium pyrophosphate in food grade or chemical so that their product can be utilized in all the above mentioned end-use industries and applications.

Consumers of Disodium pyrophosphate such as bakery producers are preferring the use of Disodium pyrophosphate as Disodium pyrophosphate can offer variable rates of reaction and leavening by gas production based on its granulation.
They are using Disodium pyrophosphate alone or in combination with other leavening agents depending on the requirement of product.

Disodium pyrophosphate, or SAPP, is used in the food industry.
More specially, Disodium pyrophosphate is used for certain types of baking powder and baking creams in addition to working as a leavening agent for prepared cake and doughnut mixes.
Disodium pyrophosphate maintains the natural white color of cooked potatoes.

Disodium pyrophosphate is used as chelating agent or buffering agent in many Food & Industrial applications.
Disodium pyrophosphate is used to remove Iron stains during processing of leather.
Disodium pyrophosphate is used as a dispersant in oil well drilling application.

Disodium pyrophosphate is a leavening agent, preservative, sequestrant, and buffer which is mildly acidic with a ph of 4.1.
Disodium pyrophosphate is moderately soluble in water, with a solubility of 15 g in 100 ml at 25°c.

Disodium pyrophosphate is used in doughnuts and biscuits for its variable gas release rate during the mixing, bench action, and baking process.
Disodium pyrophosphate is used in baking powder as a leavening agent.

Disodium pyrophosphate is used in canned fish products to reduce the level of undesired struvite crystals (magnesium ammonium phosphate hexahydrate) by complexing the magnesium.
Disodium pyrophosphate is used to sequester metals in processed potatoes.

Disodium pyrophosphate is currently used by the sausage industry to accelerate development of cured meat color.
The cured color accelerator was examined, through sensory evaluation and instrumental measurements, for its effects on the texture of frankfurters.

Disodium pyrophosphate is anhydrous form, pyrophosphate salt used in buffers.
Disodium pyrophosphate is used as a deflocculant (thinner) in freshwater mud systems.

Disodium pyrophosphate is often used to break up mud rings when water drilling and is also used to thin out cement before cementing casing.
Disodium pyrophosphate is used as leavening agent in baking powders, combining with sodium bicarbonate to release carbon dioxide.

Disodium pyrophosphate speeds the conversion of sodium nitrite to nitrite in cured meats and can improve water-holding capacity.
Disodium pyrophosphate is also found in potato products, where Disodium pyrophosphate prevents darkening.

Disodium pyrophosphate can be also be used in leather treatment; In some dairy applications for cleaning purposes and in petroleum production; etc.
Disodium pyrophosphate is used contaminated drilling mud can result in fluid loss, thickening time, and viscosity.

Disodium pyrophosphate is used to disperse and displace drilling muds to avoid mud being affected by cement contamination.
Disodium pyrophosphate is used solids carrying fluid or drilling mud must be removed from the perforation channels and the rock face to allow a good cement bond and complete fill-up of the voids.

Incorporating Disodium pyrophosphate into the spacer will help remove residual muds and provide a cleaner surface to which the cement can bond.
Disodium pyrophosphate can be used to remove iron stains on hides during processing.

Disodium pyrophosphate can stabilize hydrogen peroxide solutions against reduction.
Disodium pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.

When added to scalding water, Disodium pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
In petroleum production, Disodium pyrophosphate can be used as a dispersant in oil well drilling muds.

Disodium pyrophosphate is used in cat foods as a palatability additive.
Disodium pyrophosphate is used as a tartar control agent in toothpastes.

Disodium pyrophosphate can be used to remove iron stains on hides during processing.
Disodium pyrophosphate can stabilize hydrogen peroxide solutions against reduction.

Disodium pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.
when added to scalding water, Disodium pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.

In petroleum production, Disodium pyrophosphate can be used as a dispersant in oil well drilling muds.
Disodium pyrophosphate is used in cat foods as a palatability additive.

Disodium pyrophosphate is used as a tartar control agent in toothpastes
Disodium pyrophosphate dispersant is used in much the same manner as polyphosphate dispersants and is subject to the same temperature limitations.

Due to its acidic nature, Disodium pyrophosphate is especially effective for treating cement contamination.
Disodium pyrophosphate dispersant is efficient for bentonite muds and is often used in conjunction with a tannin or quebracho compound.

Disodium pyrophosphate dispersant can also be used to treat calcium contamination, especially contamination resulting from cement.
Because of its acidic nature, SAPP dispersant is not normally used in muds where the pH exceeds 9.5.

Disodium pyrophosphate food grade is used as an acid component in baking powder; as a chelating agent or combines with other polyphosphates to sequester magnesium and iron ions, e.g. chelate iron during the processing of potatoes to prevent a dark discoloration.
Disodium pyrophosphate can be used as a leavening chemical for bread to help Disodium pyrophosphate rise.

Disodium pyrophosphate's used in sausage to enhance flavor and color.
In french fries, the chemical reduces levels of a carcinogen called acrylamide, according to an article from the Center for Science in the Public Interest.

Disodium pyrophosphate also prevents discoloration in potatoes and sugar syrups.
In canned tuna, Disodium pyrophosphate prevents harmless struvite crystals from forming.

Disodium pyrophosphate is used together with baking powder as a leavening agent to release carbon dioxide.
Disodium pyrophosphate is ideal for refrigerated doughs, cakes, muffins and pancake mixes where a slow reaction rate is desired.

Disodium pyrophosphate is often used with fast-acting leavenings such as monocalcium phosphate in double-acting baking powder or sometimes added with another slow action leavening acid, GDL.
Disodium pyrophosphate can be used to replace sulfur dioxide, sulfites and bisulfites to maintain the appearance and texture of cooked potato products.

The application of Disodium pyrophosphate reduces the dark color from after-cooking darkening in cooked and processed potato products, such as in oil-blanched french fries and potato salad.
Disodium pyrophosphate is Baking powder, used in baking and to control the fermenting speed, to increase the producing strength.

Disodium pyrophosphate is used in instant noodles to reduce time after subjecting to water.
Disodium pyrophosphate is also used in biscuits and cakes, to reduce fermenting time, to decrease the destroying, to maintain the clear gaps, finally to extend products storage.

Disodium pyrophosphate is speedly fermentation, water retaining agent and quality improver, used in bread, biscuits, meat, aquatic products and so on.
As quality improver, Disodium pyrophosphate enhances complexation,PH value and Ionic strength.

According to rules, Disodium pyrophosphates max adding quantity is 3.0g/KG in biscuits and 1.0-3.0g/KG in bread.
Disodium pyrophosphate is used in sausages to enhance flavor and color.
Disodium pyrophosphate is used in biscuits and cakes, Disodium pyrophosphate can shorten the fermentation time, reduce Disodium pyrophosphate breakage rate, loosen the gaps neatly, and prolong the storage period.

Disodium pyrophosphate is used as a quality improver for bakery foods such as bread, biscuits, meat and aquatic products, etc.
Disodium pyrophosphate can improve the complex metal ions, PH value and ionic strength of foods, thereby improving the adhesion and water holding capacity of foods. In French Fries, Disodium pyrophosphate SAPP can reduce levels of a carcinogen called acrylamide.

Disodium pyrophosphate can also prevent discoloration of potatoes and syrup.
In canned tuna, Disodium pyrophosphate can prevent the formation of harmless struvite crystals.
In canned seafood, Disodium pyrophosphate can retain color during cooking and reduce cleaning.

In cured meats, Disodium pyrophosphate accelerates the conversion of sodium nitrite to nitrite by forming a nitrous acid intermediate and can improve water retention.
Disodium pyrophosphate is used in frozen hash browns and other potato products to prevent potatoes from darkening.
Disodium pyrophosphate may leave a slightly bitter aftertaste in some products, but adding calcium ions, sugar, or flavoring can mask the taste.

In leather processing, Disodium pyrophosphate can be used to remove iron stains from raw hides during processing.
Disodium pyrophosphate can stabilize the hydrogen peroxide solution against reduction.
In certain dairy applications, Disodium pyrophosphate can be used with sulfamic acid for cleaning, especially soapstone removal.

In oil production, Disodium pyrophosphate can be used as a dispersant for oil well drilling mud.
Disodium pyrophosphate is used as a tartar control agent in toothpaste.
Disodium pyrophosphate is commonly used as a leavening agent in baked goods, such as cakes, muffins, pancakes, waffles, and biscuits.

Disodium pyrophosphate works by releasing carbon dioxide gas when Disodium pyrophosphate reacts with alkalis like baking soda (sodium bicarbonate) in the presence of moisture and heat.
This gas production causes the dough or batter to rise, resulting in the characteristic light and airy texture of these products.
Disodium pyrophosphate is an essential component of double-acting baking powder, a leavening agent used in a wide range of baked goods.

Double-acting baking powder releases gas in two stages: once when mixed with wet ingredients and again when exposed to the heat of the oven.
This two-stage action provides better control over the leavening process and helps achieve consistent results in baking.
Disodium pyrophosphate acts as a pH buffer in various food products.

Disodium pyrophosphate helps control and stabilize the pH (acidity or alkalinity) of food items, preventing undesirable changes in flavor, color, and texture.
Disodium pyrophosphate is particularly useful in processed foods to maintain the desired pH level.

Disodium pyrophosphate serves as an emulsifying agent.
Disodium pyrophosphate helps blend ingredients that would not naturally mix, such as oil and water.

This property is valuable in the production of salad dressings, sauces, and some dairy products to create stable and uniform mixtures.
Disodium pyrophosphate is used in the meat industry as a pH regulator and moisture retention agent in various processed meat products.

Disodium pyrophosphate helps improve the texture and quality of these products.
Disodium pyrophosphate can be found in certain dairy products, especially processed cheeses, to enhance their melting and textural characteristics.
Disodium pyrophosphate assists in achieving a smooth and creamy texture in cheese-based products.

In potato-based products like French fries and hash browns, Disodium pyrophosphate is employed to prevent discoloration and maintain the appealing color of the potatoes during processing and frying.
Disodium pyrophosphate is used in canned seafood products to help maintain product quality and texture, particularly in products like canned tuna.
Disodium pyrophosphate may be used in various other food items, such as canned soups, gravies, and sauces, where Disodium pyrophosphate contributes to texture and stability.

Benefits of Disodium pyrophosphate:
Controlled leavening acid
Prevents oxidation/colour change
Humectant
Buffering agent
Stabiliser
Acidulant

Functions of Disodium pyrophosphate:
Leavening acids provide air and volume to the baked good structure, but also affect the characteristics of the dough.
Besides reacting with baking soda to produce the gas carbon dioxide, these acids form ionic bonds with the starches and proteins in the dough.

Disodium pyrophosphate dissolves readily to form the anion pyrophosphate which interacts with the proteins in a baked good system to provide a moist texture.
Also, Disodium pyrophosphate provides a buffer system for the dough in the pH range 7.3-7.5, which influences the color of the baked product.

Advantages of Disodium pyrophosphate:
Widely available and economical thinner effective for treatment of cement contamination
Concentrated chemical that is effective at low treatment levels
Can be used with most water-base mud types

Preparation of Disodium pyrophosphate:
Disodium pyrophosphate is produced from sodium dihydrogenmonophosphate by heating at 200-250℃:
Na2CO3+2H3PO4→2NaH2PO4+H2O+CO2↑
2NaH2PO4→Na2H2P2O7+H2O

Disodium pyrophosphate is a condensed phosphate, commonly synthesized by the neutralization of phosphoric acid with sodium hydroxide or sodium carbonate at the ratio of 1:1 to produce monosodium phosphate (NaH2PO4), and then heated approximately 250°C to remove the water.
2 NaH2PO4 → Na2H2P2O7 + H2O

Production of Disodium pyrophosphate:

Commercial Production:
Disodium pyrophosphate is manufactured by partially neutralizing food grade phosphoric acid with sodium hydroxide or sodium carbonate to form monosodium phosphate.
Dehydration of monosodium phosphate at 250°C will form SAPP.
Currently, there is no known natural method for the production of Disodium pyrophosphate.

Origin of Disodium pyrophosphate:
In the eighteenth century and earlier, bakers relied upon yeast to leaven all baked goods.
However, using yeast for leavening baked goods was tedious and bakers began to explore the use of chemical leavening systems.
In 1846, baking soda was discovered as a leavening agent and that led to further discoveries of acids to react with baking soda, such as SAPP.

Commercially, Disodium pyrophosphate was introduced into baking powder blends towards the end of the nineteenth century.
Disodium pyrophosphate is a preferred leavening acid because Disodium pyrophosphate is less expensive and stronger than other leavening acids introduced previously.

Safety of Disodium pyrophosphate:
As with many powdered food ingredients, inhaling fine Disodium pyrophosphate powder can lead to respiratory irritation.
Inhaling the dust should be avoided.
Similarly, direct eye contact with the powder may cause irritation, and Disodium pyrophosphate is advisable to take precautions when handling the dry powder.

Disodium pyrophosphate itself is not typically considered a skin irritant, prolonged or repeated skin contact with the powder may lead to dryness or minor irritation for some individuals.
Disodium pyrophosphate is recommended to minimize skin contact and use protective gloves when handling SAPP in its dry form.

Disodium pyrophosphate is intended for use in food and is considered safe for consumption when used within established limits.
However, ingestion of the undiluted dry powder is not recommended, as Disodium pyrophosphate may cause discomfort and digestive upset.

As with any food additive, Disodium pyrophosphate should be used in accordance with recommended concentrations.
To ensure the safe use of Disodium pyrophosphate, Disodium pyrophosphate is crucial to adhere to food safety regulations and guidelines established by local and international authorities, such as the U.S. Food and Drug Administration (FDA) in the United States and similar agencies in other regions.

Disodium pyrophosphate is considered safe for consumption when used in accordance with established regulations and guidelines.
Disodium pyrophosphate is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA).

Handling and Storage of Disodium pyrophosphate:

Precautions for safe handling:

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.

Stability and Reactivity of Disodium pyrophosphate:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

First Aid Measures of Disodium pyrophosphate:

General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.

If inhaled:
If breathed in, move person into fresh air.
Consult a physician.

In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed:
Rinse mouth with water.
Consult a physician.

Indication of any immediate medical attention and special treatment needed:
No data available

Accidental Release Measures of Disodium pyrophosphate:

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Fire Fighting Measures of Disodium pyrophosphate:

Extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Further information:
No data available

Exposure Controls/personal Protection of Disodium pyrophosphate:

Personal protective equipment:

Eye/face protection:
Use safety glasses with side-shields.

Skin protection:
Handle with gloves.
Wash and dry hands.

Body Protection:
Use Impervious clothing.

Control of environmental exposure:
Do not let product enter drains.

Identifiers of Disodium pyrophosphate:
CAS Registry Number: 7758-16-9
Additional Names: Disodium dihydrogen pyrophosphate
Molecular Formula: H2Na2O7P2
Molecular Weight: 221.94
Percent Composition: H 0.91%, Na 20.72%, O 50.46%, P 27.91%
Line Formula: Na2H2P2O7
Literature References: Prepn: Bell, Inorg. Synth. 3, 98 (1950).
Properties: White, fused masses or powder. Dec at 220°. d (hexahydrate) 1.86. Sol in water, the soln having an acid reaction.
Density: d (hexahydrate) 1.86
Use: Chiefly in baking powders.

Properties of Disodium pyrophosphate:
Melting point: decomposes 220℃ [MER06]
Density (hexahydrate): 1.86
vapor pressure: 0Pa at 20℃
storage temp.: -70°C
solubility: H2O: 0.1 M at 20 °C, clear, colorless
form: white powder
color: White to Off-White
PH: 3.5-4.5 (20℃, 0.1M in H2O, freshly prepared)
Water Solubility: Fully miscible in water. Insoluble in alcohol and ammonia.
λmax: λ: 260 nm Amax: 0.11
λ: 280 nm Amax: 0.09
Merck: 13,8643
Stability: Stable.
InChI: InChI=1S/Na.H4O7P2.H/c;1-8(2,3)7-9(4,5)6;/h;(H2,1,2,3)(H2,4,5,6);
InChIKey: IQTFITJCETVNCI-UHFFFAOYSA-N
SMILES: O(P(O)(O)=O)P(O)(O)=O.[NaH]
LogP: -3.420 (est)

Appearance Form: powder
Color: white
pH: No data available
Melting point/freezing point: > 450 °C

Relative density: 2,63 at 22,5 °C
Water solubility: 170 g/l at 20 °C

Chemical formula: Na2H2P2O7
Molar mass: 221.94 g/mol
Appearance: White odorless powder

Density: 2.31 g/cm3
Melting point: >600 °C
Solubility in water: 11.9 g/100 mL (20 °C)
Refractive index (nD): 1.4645 (hexahydrate)
Assay: ≥ 95.0 %
Moisture (at 110oC): ≤ 0.50 %
pH (1 % Solution): 4.0 – 4.6
Water Insoluble Matter: ≤ 0.1 %
Phosphate (P2O5): 63.0 – 64.5 %

Rate of CO2 Release (at 2 mins): 13.0 – 17.0 %
Neutralising Value: ≥ 72.0 %
Fluoride (As F): ≤ 10.0 ppm
Arsenic (As As): ≤ 3.0 ppm
Lead (As Pb): ≤ 2.0 ppm
Cadmium (As Cd): ≤ 1.0 ppm
Heavy Metals (As Pb): ≤ 10.0 ppm
Mercury (As Hg): ≤ 1.0 ppm

IUPAC Name: Di-sodium di-hydrogen di-phosphate
Molecular Formula: Na2H2P2O7
Molecular Weight: 222.00
Appearance: White fine Powder
PH Range (1% w/v): 3.5 – 4.5
Pyro % (minimum): 98.00
P2O5 content % (minimum): 62.00
‘Na’ Content % (minimum): 20.00
Iron as ‘Fe’ content %: 0.02
Chloride as ‘Cl’ content %: 0.2
Sulfate as ‘SO4’ content %: 0.03

Specification of Disodium pyrophosphate:
Cyclic Phosphates: ≤ 2%
Arsenic: ≤ 3 ppm
Lead: ≤ 2 ppm
Fluoride: ≤ 10 ppm
Loss on drying: ≤ 0.5%
Assay: ≥ 95%
pH value: 3.8 - 4.2

Releated Compounds of Disodium pyrophosphate:
Tetrasodium pyrophosphate

Other anions:
Disodium phosphate
Pentasodium triphosphate
Sodium hexametaphosphate

Other cations:
Calcium pyrophosphate
Dipotassium pyrophosphate
DISODIUM RIBONUCLEOTIDES
SODIUM 5'-RIBONUCLEOTIDES; SODIUM RIBONUCLEOTIDES; Sodium 5'-ribonucleotides; sodium ribonucleotides, cas no: 4691-65-0
DISODIUM SALT
Disodium salt, with the chemical formula Na2S2O3·5H2O, is an efflorescent crystalline substance that dissolves well in water and is used in various applications such as gold mining, water treatment, analytical chemistry, photographic film development, and medicine.
Medically, Disodium salt is employed as an antidote for cyanide poisoning, a treatment for calciphylaxis, and to reduce side effects of cisplatin, a cancer medication, highlighting its inclusion in the World Health Organization's List of Essential Medicines.
In photography, Disodium salt acts as a fixer to dissolve silver salts from negatives, while in water treatment, it neutralizes chlorine in tap water and swimming pools, showcasing its versatility in industrial and medical applications.

CAS Number: 7772-98-7
EC Number: 231-867-5
Chemical Formula: Na2S2O3
Molar Mass: 158.11 g/mol

Synonyms: SODIUM THIOSULFATE, 7772-98-7, sodiumthiosulfate, Disodium thiosulfate, Hypo, Chlorine Control, Thiosulfuric acid, disodium salt, Sodium thiosulfate, anhydrous, disodium sulfurothioate, MFCD00003499, Na2S2O3, L0IYT1O31N, Thiosulfuric acid (H2S2O3), disodium salt, Sodothiol, sodium sulfothioate, Sodothiol; Sulfactol; Sulfothiorine, Chlorine Cure, Declor-It, Hypo (VAN), HSDB 592, EINECS 231-867-5, Na2O3S2, UNII-L0IYT1O31N, AI3-01237, sodium thiosulfat, sodium thio-sulfate, Sodium oxide sulfide, Hypo alcohol, in ethanol, anhydrous sodium thiosulfate, EC 231-867-5, DISODIUM THIOSULPHATE, sodium thiosulfate (anhydrous), SODIUM THIOSULFATE [MI], CHEMBL3753202, DTXSID9042417, SODIUM THIOSULFATE [HSDB], CHEBI:132112, Sodium thiosulfate, AR, >=98%, Sodium thiosulfate, LR, >=97%, SODIUM THIOSULFATE [WHO-DD], Sodium thiosulfate, p.a., 98.0%, AKOS015856704, AKOS016372312, SODIUM THIOSULFATE ANHYDROUS [II], BP-21059, Sodium thiosulfate, ReagentPlus(R), 99%, FT-0696570, O0522, D78333, Sodium thiosulfate, SAJ first grade, >=90.0%, disodium;dioxido-oxo-sulfanylidene-lambda6-sulfane, Q339866, Sodium thiosulfate, >=99.99% trace metals basis, Sodium thiosulfate, Vetec(TM) reagent grade, 99%, Thiosulfuric acid (H2S2O3), sodium salt (1:2), Sodium thiosulfate, anhydrous, Trace metals grade 99.99%, Sodium thiosulfate, purum p.a., anhydrous, >=98.0% (RT), Sodium thiosulfate [JAN] [USAN] [Wiki], Sodium hyposulfite, 231-791-2 [EINECS], 231-867-5 [EINECS], 7772-98-7 [RN], Dinatriumsulfurothioat [German] [ACD/IUPAC Name], Disodium sulfurothioate [ACD/IUPAC Name], Disodium thiosulfate, Hypo alcohol, MFCD00003499 [MDL number], sodium thiosulphate, Sulfurothioate de disodium [French] [ACD/IUPAC Name], Thiosulfuric acid disodium salt, Thiosulfuric acid, disodium salt, anhydrous sodium thiosulfate, antichlor, Declor-It, disodium sulfanesulfite, DISODIUM SULFANIDESULFONATE, DISODIUM THIOSULPHATE, disodium;dioxido-oxo-sulfanylidene-λ6-sulfane, Hypo, S-Hydril, sodium oxide sulfide, Sodium oxide sulfide (Na2S2O3 ), Sodium thiosulfate (Na2 S2 O3 ), Sodium thiosulfatemissing, Sodothiol, Sulfothiorine

Disodium salt is an inorganic compound with the formula Na2S2O3·xH2O, where x indicates the number of water molecules in Disodium salt.
Typically Disodium salt is available as the white or colorless pentahydrate, Na2S2O3·5H2O.
The solid is an efflorescent (loses water readily) crystalline substance that dissolves well in water.

Disodium salt is used in gold mining, water treatment, analytical chemistry, the development of silver-based photographic film and prints, and medicine.
The medical uses of Disodium salt include treatment of cyanide poisoning and pityriasis.
Disodium salt is on the World Health Organization's List of Essential Medicines.

Disodium salt also called as thiosulfuric acid or Sodium thiosulfate is an inorganic salt that is also available in the pentahydrates.
Disodium salt has a chemical formula of Na2S2O3.

Disodium salt appears as a bright white colourless crystal or even in powder form.
Disodium salt is known to possess Alkaline nature when decomposed to sulphide and sulfate in the air.

Disodium salt readily dissolves in water giving thiosulfate ions, one of the useful reducing agents.
The Copper (II) sulfate dissolves to give the cupric ion; in regard to a redox reaction with the thiosulfate, the cupric particles act like oxidizing agents.

Disodium salt is an inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio.
Disodium salt has a role as an antidote to cyanide poisoning, a nephroprotective agent and an antifungal drug.
Disodium salt contains a thiosulfate(2-).

Disodium salt is an industrial chemical which also has a long medical history.
Disodium salt was originally used as an intravenous medication for metal poisoning.

Disodium salt has since been approved for the treatment of certain rare medical conditions.
These include cyanide poisoning, calciphylaxis, and cisplatin toxicity.

In vitro assays have demonstrated that Disodium salt is an anti-inflammatory and neuroprotective agent.
Disodium salt therefore has potential for treating neurodegenerative diseases such as Alzheimer disease and Parkinson disease.

NaSH has similar properties and is somewhat more powerful than Disodium salt in these in vitro assays.
However Disodium salt has already been approved as an orally available treatment.
Disodium salt may therefore be a readily available candidate for treating neurodegenerative disorders such as Alzheimer disease and Parkinson disease.

Disodium salt is an industrial compound which has a long history of medical use.

Since Disodium salt is employed as a food preservative, the general population is widely exposed to this non-toxic compound.
For example, Disodium salt is typically added to table salt at less than 0.1% and to alcoholic beverages at less than 0.0005%.
Disodium salt is generally available as a non-prescription oral product.

Disodium salt is an inorganic sodium salt with the formula Na2S2O3 composed of a 2:1 mixture of sodium and thiosulfate ions.
The uses of Disodium salt are numerous, in particular as a fixing agent or to neutralize the effect of biocides such as dichlor, iodine and other oxidants, also, Disodium salt has a role as an antidote to cyanide poisoning, nephroprotective agent and antifungal.

Disodium salt is usually added to table salt at less than 0.1% and to alcoholic beverages at less than 0.0005%.
Disodium salt is usually available as an oral product without a prescription.

Disodium salt solutions are almost exclusively used to standardize Iodine solutions or as back-titrants in titrations using Iodine.
Solutions of Disodium salt are most commonly standardized with Potassium Dichromate or Potassium Iodate solutions, which generate Iodine from Iodide.
Starch indicator is typically used.

The reaction with Iodine is:
I3- + 2 S2O32- → 3 I- + S4O62- (Dithionite ion)

Titrations with standard Disodium salt solution are best conducted in the pH 5 - 9 range.
Since this is not always possible, the titrations should be conducted rapidly and with adequate stirring to insure rapid reaction of the Thiosulfate, thus minimizing any acid-accelerated decomposition.
This will also minimize the acid-catalyzed oxidation of Iodide (usually present in a titration involving Thiosulfate) to Iodate, which could lead to decreased accuracy.

Disodium salt solutions are subject to bacterial decomposition and chemical deterioration.
Disodium salt solutions decompose in acid solution resulting in the evolution of Sulfur Dioxide gas and precipitation of elemental Sulfur.
Contact with Carbon Dioxide in the air can produce the acidity leading to this decomposition, which is faster in more dilute Thiosulfate solutions.

Disodium salt, also known as sodium hydrosulfite, is used as an antidote to cyanide poisoning, but several studies have demonstrated that Disodium salt efficacy in some pathological conditions is related to ectopic calcification.
The mechanisms of action, by which Disodium salt exerts Disodium salt inhibitory effect on vascular mineralization, are not yet clear.

Disodium salt has been postulated that Disodium salt: (i) forms with calcium a more soluble complex than calcium phosphate and calcium oxalate, (ii) has antioxidant activity improving endothelial function, (iii) has acidosis properties.
However, O'Neil and Hardcastle demonstrated that the inhibitor effect of Disodium salt seems to be independent on calcium interactions or on pH, but could be due to a direct extracellular effect on calcification induced by cellular injury releasing cell debris and matrix vesicles.

Nevertheless, Disodium salt is used to treat calciphylaxis, kidney stones, uremic vascular calcification and coronary artery calcification.
Recently, intravenous Disodium salt has been used in a young boy with several deleterious mutations in ABCC6, ENPP1 and HBB genes and, over a period of 6 months, calcific stenosis of celiac and mesenteric arteries was not anymore detectable on arterial ultrasonography.
Follow-up evidenced a temporary efficacy of Disodium salt.

Two clinical trials highlight that Disodium salt treatment can be safe and can reduce the rate of coronary artery calcification progression in hemodialysis patients.

Disodium salt may be used to lessen some of the side effects of cisplatin (a cancer medicine).
Disodium salt is also used with another medicine in the emergency treatment of cyanide poisoning.

Disodium salt is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, cisplatin) for cancer that have not spread throughout the body.
This medicine is to be given only by or under the immediate supervision of your doctor.

Disodium salt is available in the following dosage forms:
Solution

Applications of Disodium salt:
We find various applications of Disodium salt in different fields such as medicine, photography, gold extraction and many other areas.

The other uses of Disodium salt are below;
Disodium salt is used in the manufacture of patinas
In industries, the chemical is used for the dechlorination of small water bodies like ponds, aquariums, etc

In photography, the chemical is used as a fixing agent to dissolve the silver salts from the negatives
The chemical can be utilized as a cleansing agent when dissolved in a vast quantity of warm water

Disodium salt is well-used as an antidote agent concerning the cyanide poisoning
In the medical field, Disodium salt is employed in the pharmaceutical preparations such as anionic surfactant aiding in dispersion
Apart from the above uses, the chemical substance also finds Disodium salt applications in the water treatment, leather tanning, neutralizing bleach, gold extraction, photographic film processing, and also in chemical heating pads.

Uses of Disodium salt:
Disodium salt is used predominantly in industry. For example, Disodium salt is used to convert dyes to their soluble colorless forms, which are called leuco.
Disodium salt is also used to bleach "wool, cotton, silk, ...soaps, glues, clay, sand, bauxite, and... edible oils, edible fats, and gelatin."

Disodium salt is added in small quantities to ammonium thiosulfate, which is used as a photographic fixing salt.
The hydrated salt is used as an anti-chlorine in bleaching, in wastewater purification, for reduction of dichromate in chromed leather production, and as a solvent for silver chloride in the chloride roasting of silver-containing minerals.

Disodium salt is used in paper bleaching, photography (fixer), silver extraction, dyeing textiles (mordant), and leather manufacturing.
Disodium salt is also used as an antidote for cyanide poisoning and in vet medicine for bloat and ringworm.

The action of Disodium salt is multifactorial since Disodium salt is a chelating agent of divalent cations, which also has antioxidant and vasodilator properties.

Disodium salt is used to treat cyanide poisoning.
Disodium salt is also used to reduce the side effects of the cancer drug cisplatin.

Disodium salt is used to treat, under certain conditions, calciphylaxis, kidney stones, uremic vascular calcification and coronary artery calcification.
Disodium salt would promote the healing of skin ulcerations, especially when treatment with hyperbaric oxygen therapy is applied concurrently.

Disodium salt is added in small amounts to ammonium thiosulfate, which is used as a photographic fixing salt.
Hydrated salt is used as an anti-chlorine in bleaching, Disodium salt simply reacts and forms sodium hydrogen sulfate or sodium bisulfate which is an inactive salt.

Medical uses:
Disodium salt is used in the treatment of cyanide poisoning.
Other uses include topical treatment of ringworm and tinea versicolor and treating some side effects of hemodialysis and chemotherapy.
In September 2022, the U.S. Food and Drug Administration (FDA) approved Disodium salt under the trade name Pedmark to lessen the risk of ototoxicity and hearing loss in infant, child, and adolescent cancer patients receiving the chemotherapy medication cisplatin.

Photographic processing:
Silver halides, e.g., AgBr, typical components of photographic emulsions, dissolve upon treatment with aqueous thiosulfate.
This application as a photographic fixer was discovered by John Herschel.

Disodium salt is used for both film and photographic paper processing; the Disodium salt is known as a photographic fixer, and is often referred to as 'hypo', from the original chemical name, hyposulphite of soda.
Ammonium thiosulfate is typically preferred to Disodium salt for this application.

Neutralizing chlorinated water:
Disodium salt is used to dechlorinate tap water including lowering chlorine levels for use in aquariums, swimming pools, and spas (e.g., following superchlorination) and within water treatment plants to treat settled backwash water prior to release into rivers.
The reduction reaction is analogous to the iodine reduction reaction.

In pH testing of bleach substances, Disodium salt neutralizes the color-removing effects of bleach and allows one to test the pH of bleach solutions with liquid indicators.
The relevant reaction is akin to the iodine reaction: thiosulfate reduces the hypochlorite (the active ingredient in bleach) and in so doing becomes oxidized to sulfate.

The complete reaction is:
4 NaClO + Na2S2O3 + 2 NaOH → 4 NaCl + 2 Na2SO4 + H2O

Similarly, Disodium salt reacts with bromine, removing the free bromine from the solution.
Solutions of Disodium salt are commonly used as a precaution in chemistry laboratories when working with bromine and for the safe disposal of bromine, iodine, or other strong oxidizers.

Industry Uses:
Agricultural chemicals (non-pesticidal)
Chain transfer agent
Cleaning agent
Corrosion inhibitor
Intermediate
Intermediates
Laboratory chemicals
Not Known or Reasonably Ascertainable
Other (specify)
Oxidizing/reducing agents
Processing aids not otherwise specified
Processing aids, not otherwise listed
Processing aids, specific to petroleum production
Reducing agent
Solids separation agents
Solvents (for cleaning or degreasing)
Surface modifier
Tanning agents not otherwise specified

Consumer Uses:
Cleaning agent
Not Known or Reasonably Ascertainable
Processing aids, not otherwise listed
Solvents (for cleaning or degreasing)

Industrial Processes with risk of exposure:
Pulp and Paper Processing
Sewer and Wastewater Treatment
Leather Tanning and Processing
Photographic Processing
Textiles (Printing, Dyeing, or Finishing)
Metal Extraction and Refining

Activities with risk of exposure:
Applying metallic patinas

Properties of Disodium salt:
Disodium salt is a colorless monoclinic crystal or white crystalline powder, odorless and salty.
The relative density for this is 1.667.

Water-soluble, Disodium salt solubility at 100°C is 231 g/100 ml of vapour.
Disodium salt salt decomposes at high temperatures to give sodium sulfate with sodium polysulfide.
Disodium salt dissociates in water and some other polar solvents.

When exposed to dilute acids such as dilute hydrochloric acid, Disodium salt salt undergoes a decomposition reaction to yield sulfur with sulfur dioxide.

Disodium salt possesses various chemical and physical properties as given below;
Disodium salt appears as a white translucent colourless crystal and is an inorganic compound.
Disodium salt is water-soluble substance and is also soluble in oil of turpentine but not in the alcohol.

Disodium salt has a melting point of about 48 to 52 C.
Disodium salt is highly stable in nature and is said to be incompatible with some strong oxidizing agents and strong acids.

Thiosulfate anion readily reacts with the dilute acids producing sulphur, sulphur dioxide and also water.
The chemical has a density measuring about 1.667 g/mL.

Structure of Disodium salt:
Two polymorphs are known as pentahydrate.
The anhydrous salt exists in several polymorphs.

In the solid state, the thiosulfate anion is tetrahedral in shape and is notionally derived by replacing one of the oxygen atoms by a sulfur atom in a sulfate anion.
The S-S distance indicates a single bond, implying that the terminal sulfur holds a significant negative charge and the S-O interactions have more double-bond character.

Disodium salt has a chemical formula of Na2S2O3 and the molar mass of about 158.11 g/mol.
Disodium salt well exists in the form of pentahydrate salts (Na2S2O3.5H2O), having a molar mass measuring about 248.18 g/mol.

The Disodium salt is an ionic compound which consists of two cations of sodium atom (Na+) and a negatively charged anion of thiosulfate (S2O3-).
Here the central atom consisting of sulphur bonds to the three oxygen atoms and also another atom of sulphur, all these through a single and also double bonds possessing resonance character.
The solid also exists in a monoclinic crystalline structure.

The thiosulfate anion is usually a tetrahedral structure and, is obtained by the replacement of one of the atoms of oxygen by the use of sulfur atom in the sulfate anion.

Manufacturing Methods of Disodium salt:
By-product liquor from sodium sulfide production is reacted with sulfur dioxide to yield Disodium salt; or organic nitro compounds are boiled with sodium polysulfide solution to yield a leach liquor of Disodium salt, which is then purified, concentrated and crystallized

By dissolving sulfur in sodium sulfite soln & then crystallizing.
Disodium salt is also prepared from waste liquors obtained in prodn of sodium sulfide, liquors containing sodium carbonate & small amt of sodium sulfite & sodium sulfate in addn to sulfide.

General Manufacturing Information of Disodium salt:

Industry Processing Sectors:
All Other Basic Inorganic Chemical Manufacturing
All Other Basic Organic Chemical Manufacturing
All Other Chemical Product and Preparation Manufacturing
Computer and Electronic Product Manufacturing
Electrical Equipment, Appliance, and Component Manufacturing
Fabricated Metal Product Manufacturing
Machinery Manufacturing
Mining (except Oil and Gas) and support activities
Miscellaneous Manufacturing
Not Known or Reasonably Ascertainable
Oil and Gas Drilling, Extraction, and Support activities
Paint and Coating Manufacturing
Paper Manufacturing
Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Petrochemical Manufacturing
Petroleum Refineries
Photographic Film, Paper, Plate, and Chemical Manufacturing
Services
Soap, Cleaning Compound, and Toilet Preparation Manufacturing
Synthetic Dye and Pigment Manufacturing
Textiles, apparel, and leather manufacturing
Transportation Equipment Manufacturing
Utilities
Wholesale and Retail Trade

Production of Disodium salt:
On an industrial scale, Disodium salt is produced chiefly from liquid waste products of sodium sulfide or sulfur dye manufacture.

In the laboratory, this salt can be prepared by heating an aqueous solution of sodium sulfite with sulfur or by boiling aqueous sodium hydroxide and sulfur according to this equation:
6 NaOH + 4 S → 2 Na2S + Na2S2O3 + 3 H2O

Principal reactions of Disodium salt:

Upon heating to 300 °C, Disodium salt decomposes to sodium sulfate and sodium polysulfide:
4 Na2S2O3 → 3 Na2SO4 + Na2S5

Thiosulfate salts characteristically decompose upon treatment with acids.
Initial protonation occurs at sulfur.

When the protonation is conducted in diethyl ether at −78 °C, H2S2O3 (thiosulfuric acid) can be obtained.
Disodium salt is a somewhat strong acid with pKas of 0.6 and 1.7 for the first and second dissociations, respectively.

Under normal conditions, acidification of solutions of this salt excess with even dilute acids results in complete decomposition to sulfur, sulfur dioxide, and water:
8 Na2S2O3 + 16 HCl → 16 NaCl + S8 + 8 SO2 + 8 H2O

Coordination chemistry:
Thiosulfate is a potent ligand for soft metal ions.
A typical complex is [Pd(S2O3)2(ethylenediamine)]2−, which features a pair of S-bonded thiosulfate ligands.

Disodium salt and ammonium thiosulfate have been proposed as alternative lixiviants to cyanide for extraction of gold.
The advantages of this approach are that (i) thiosulfate is far less toxic than cyanide and (ii) that ore types that are refractory to gold cyanidation (e.g. carbonaceous or Carlin-type ores) can be leached by thiosulfate.
Some problems with this alternative process include the high consumption of thiosulfate, and the lack of a suitable recovery technique, since [Au(S2O3)2]3− does not adsorb to activated carbon, which is the standard technique used in gold cyanidation to separate the gold complex from the ore slurry.

Iodometry:

In analytical chemistry, the most important use comes because the thiosulfate anion reacts stoichiometrically with iodine in aqueous solution, reducing Disodium salt to iodide as the thiosulfate is oxidized to tetrathionate:

2 S2O2−3 + I2 → S4O2−6 + 2 I−

Due to the quantitative nature of this reaction, as well as because Na2S2O3·5H2O has an excellent shelf-life, Disodium salt is used as a titrant in iodometry.
Na2S2O3·5H2O is also a component of iodine clock experiments.

This particular use can be set up to measure the oxygen content of water through a long series of reactions in the Winkler test for dissolved oxygen.
Disodium salt is also used in estimating volumetrically the concentrations of certain compounds in solution (hydrogen peroxide, for instance) and in estimating the chlorine content in commercial bleaching powder and water.

Aluminium cation reaction:
Disodium salt is used in analytical chemistry.

Disodium salt can, when heated with a sample containing aluminium cations, produce a white precipitate:
2 Al3+ + 3 S2O2−3 + 3 H2O → 3 SO2 + 3 S + 2 Al(OH)3

Organic chemistry:
Alkylation of Disodium salt gives S-alkylthiosulfates, which are called Bunte salts.
The alkylthiosulfates are susceptible to hydrolysis, affording the thiol.

This reaction is illustrated by one synthesis of thioglycolic acid:
ClCH2CO2H + Na2S2O3 → Na[O3S2CH2CO2H] + NaCl
Na[O3S2CH2CO2H] + H2O → HSCH2CO2H + NaHSO4

Pharmacology and Biochemistry of Disodium salt:

MeSH Pharmacological Classification:

Chelating Agents:
Chemicals that bind to and remove ions from solutions.
Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Antioxidants:
Naturally occurring or synthetic substances that inhibit or retard oxidation reactions.
They counteract the damaging effects of oxidation in animal tissues.

Antitubercular Agents:
Drugs used in the treatment of tuberculosis.

They are divided into two main classes:
"First-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

Stability and Reactivity of Disodium salt:

Reactivity:
Not normally reactive

Chemical Stability:
Normally stable.

Possibility of Hazardous Reactions:
Reacts with acids to form toxic and irritating sulfur dioxide gas.
Reacts with strong oxidizers to cause vigorous exothermic reactions.

Conditions to Avoid:
Avoid elevated temperatures.

Incompatibilities:

Strong oxidizers:
Causes vigorous exothermic reactions.

Acids:
Releases sulfur dioxide and/or hydrogen sulfide gas.

Hazardous Decomposition Products:
Sulfur dioxide gas, hydrogen sulfide gas and sodium sulfide residue.

Handling and Storage of Disodium salt:

Precautions For Safe Handling:
Avoid contact with skin, eyes and clothing.
Do not breathe dust or mist.

Use with adequate ventilation.
Wash thoroughly after handling.

If dissolving and mixing solutions:
With anhydrous material, the reaction is exothermic and the solution will retain heat; with the hydrate (crystal) material, the reaction is endothermic and the solution will cool.

Conditions For Safe Storage, Including Any Incompatibilities:
Store in a cool, dry, well-ventilated area away from acids and oxidizing agents.
Keep container closed when not in use and protect from physical damage.

First Aid Measures of Disodium salt:

SKIN:
Wash skin with plenty of soap and water.
Get medical attention if irritation persists.
Launder contaminated clothing before reuse.

EYES:
Flush eyes immediately with water for at least 15 minutes.
Remove contact lenses if present after the first 5 minutes if you can do so easily and continue flushing.
Get medical attention if irritation occurs and persists.

INHALATION:
Promptly remove to fresh air.
Get immediate medical attention if signs of suffocation, irritation or other symptoms develop.

INGESTION:
If conscious, immediately rinse mouth with water and give 1 glass of water to drink.
Do not induce vomiting unless directed to do so be medical personnel.
Get immediate medical attention.

MOST IMPORTANT SYMPTOMS/EFFECTS, ACUTE AND DELAYED:
May irritate the skin.
May cause irritation to the eyes.

May irritate the respiratory tract.
Reacts with acids to form toxic and irritating sulfur dioxide gas.

INDICATION OF IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT, IF NEEDED:
Treat symptomatically.

Fire Fighting Measures of Disodium salt:

Suitable (And Unsuitable) Extinguishing Media:
Material is not flammable.
Use extinguishing media appropriate for material in surrounding fire.

Special Protective Equipment And Precautions For Fire-fighting:
Wear NIOSH-approved self-contained breathing apparatus to protect against any release of toxic and/or irritating fumes.
Skin and eye protection should also be provided.
Use water-spray to keep fire-exposed containers cool, and to knock down vapors and gases.

Accidental Release Measures of Disodium salt:

Personal Precautions, Protective Equipment, And Emergency Procedures:
Wear appropriate personal protective equipment.

Environmental Precautions:
Spills and releases may have to be reported to Federal and/or local authorities.

Methods And Materials For Containment And Cleaning Up:
Promptly sweep up material with minimum dusting and shovel into an empty container with a cover.
Clean spill area with plenty of water.

Identifiers of Disodium salt:
CAS Number:
7772-98-7
(pentahydrate): 10102-17-7

ChEBI: CHEBI:132112
ChEMBL: (pentahydrate): ChEMBL2096650
ChemSpider: 22885
ECHA InfoCard: 100.028.970
EC Number: 231-867-5
E number: E539 (acidity regulators, ...)
PubChem CID: 24477
RTECS number: XN6476000

UNII:
L0IYT1O31N
(pentahydrate): HX1032V43M

CompTox Dashboard (EPA): DTXSID9042417
InChI: InChI=1S/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2

Key:
AKHNMLFCWUSKQB-UHFFFAOYSA-L
InChI=1/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2

Key:
AKHNMLFCWUSKQB-NUQVWONBAM
(pentahydrate): InChI=1S/2Na.H2O3S2.5H2O/c;;1-5(2,3)4;;;;;/h;;(H2,1,2,3,4);5*1H2/q2*+1;;;;;;/p-2

Key: PODWXQQNRWNDGD-UHFFFAOYSA-L

SMILES:
[Na+].[Na+].[O-]S([O-])(=O)=S
(pentahydrate): O.O.O.O.O.O=S([O-])([O-])=S.[Na+].[Na+]

CAS: 10102-17-7, 7732-18-5
Molecular Formula: H10Na2O8S2
Molecular Weight (g/mol): 248.172
InChI Key: PODWXQQNRWNDGD-UHFFFAOYSA-L
PubChem CID: 61475
ChEBI: CHEBI:32150
IUPAC Name: disodium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane;pentahydrate
SMILES: O.O.O.O.O.[O-]S(=O)(=S)[O-].[Na+].[Na+]

CAS number: 7772-98-7
EC number: 231-867-5
Hill Formula: Na₂O₃S₂
Molar Mass: 158.10 g/mol
HS Code: 2832 30 00
Quality Level: MQ200

Synonyms: Sodium thiosulfate
Linear Formula: Na2S2O3
CAS Number: 7772-98-7
Molecular Weight: 158.11

Properties of Disodium salt:
Chemical formula: Na2S2O3
Molar mass: 158.11 g/mol (anhydrous)
248.18 g/mol (pentahydrate)
Appearance: White crystals
Odor: Odorless
Density: 1.667 g/cm3
Melting point: 48.3 °C (118.9 °F; 321.4 K) (pentahydrate)
Boiling point: 100 °C (212 °F; 373 K) (pentahydrate, - 5H2O decomposition)
Solubility in water: 70.1 g/100 mL (20 °C)
231 g/100 mL (100 °C)
Solubility: negligible in alcohol
Refractive index (nD): 1.489

Density: 1.667 g/cm3 (20 °C)
Melting Point: 48 °C
pH value: 6.0 - 9.5 (50 g/l, H₂O, 20 °C)
Bulk density: 1350 kg/m3
Solubility: 701 g/l

Molecular Weight: 158.11 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 0
Exact Mass: 157.90842477 g/mol
Monoisotopic Mass: 157.90842477 g/mol
Topological Polar Surface Area: 104Ų
Heavy Atom Count: 7
Complexity: 82.6
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

Specifications of Disodium salt:
Assay (iodometric): ≥ 97.0 %
Identity: passes test
pH-value (5 %; water): 6.0 - 9.5
Sulphide (S): ≤ 0.002 %
Fe (Iron): ≤ 0.005 %
Heavy metals (as Pb): ≤ 0.005 %

Boiling Point: 100°C
Melting Point: 48.3°C
Physical Form: Liquid
Quantity: 1 L
Solubility Information: Soluble in water
Formula Weight: 248.18g/mol
Concentration or Composition (by Analyte or Components): 0.1mol/L
Density: 1.00g/mL
Chemical Name or Material: Sodium Thiosulfate Pentahydrate

Structure of Disodium salt:
Crystal structure: monoclinic

Related compounds of Disodium salt:

Other cations:
Thiosulfuric acid
Lithium thiosulfate
Potassium thiosulfate

Names of Disodium salt:

IUPAC name:
Sodium thiosulfate

Other names:
Sodium hyposulphite
Hyposulphite of soda
Hypo
DISODIUM TARTRATE
Disodium tartrate (Na2C4H4O6) is a salt used as an emulsifier and a binding agent in food products such as jellies, margarine, and sausage casings.
As a food additive, Disodium tartrate is known by the E number E335.
Because Disodium tartrate crystal structure captures a very precise amount of water, Disodium tartrate is also a common primary standard for Karl Fischer titration, a common technique to assay water content.

CAS Number: 6106-24-7
EC Number: 212-773-3
Hill Formula: Na2C4H4O6
Molar Mass: 230.08 g/mol

Disodium tartrate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.
Disodium tartrate is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Disodium tartrate is the organic sodium salt that is the disodium salt of L-tartaric acid.
Disodium tartrate has a role as a food emulsifier.
Disodium tartrate contains a L-tartrate(2-).

Disodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals.
Disodium tartrate is obtained as a byproduct of wine manufacturing.

Disodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient.
Disodium tartrate acts as an emulsifier and pH control agent in food products.
Disodium tartrate is commonly used as an emulsifier in cheese/cheese spread products and is not to exceed 4% concentration, according to Health Canada regulations.

Disodium tartrate belongs to the class of organic compounds known as beta hydroxy acids and derivatives.
Beta hydroxy acids and derivatives are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom.
Based on a literature review very few articles have been published on Disodium tartrate.

Disodium tartrate is a solid standard with water content of 15.66% determined by the technique of loss on drying at 150°C.
Disodium tartrate preparation from high-purity reagents and analysis is completed in an ISO/IEC 17025 and ISO 17034 accredited calibration laboratory.

Disodium tartrate is generally immediately available in most volumes.
High purity, submicron and nanopowder forms may be considered.

American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.

Disodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals.
Disodium tartrate is obtained as a byproduct of wine manufacturing.

Disodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient.
Disodium tartrate acts as an emulsifier and pH control agent in food products.

This monograph for Disodium tartrate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state (approximate), and aqueous solubility.
The monograph also details the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade specifications including: Assay, Loss on Drying, pH of a 5% Solution at 25.0 °C, Insoluble Matter, Chloride, Phosphate, Sulfate, Ammonium, Calcium, Heavy Metals, and Iron.

Disodium tartrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications.
Increases the rate of colchicine binding to tubulin.

Disodium tartrate is a crystalline salt of tartaric acid and sodium.
Disodium tartrate is a white powder that is soluble in water, alcohols, and ethers.

Disodium tartrate has been shown to be thermodynamically stable up to 350 °C, with a phase transition temperature of 230 °C.
Disodium tartrate has been used in the synthesis of polymaleic acid and other biological products.

Disodium tartrate was also shown to have an effect on the absorption of radiation by water vapor when Disodium tartrate was mixed with sodium carbonate.
The melting point of Disodium tartrate is about 195 °C, which means Disodium tartrate will decompose at temperatures above this value.

Disodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals.
Disodium tartrate is obtained as a byproduct of wine manufacturing.

Disodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient.
Disodium tartrate acts as an emulsifier and pH control agent in food products.

Disodium tartrate is commonly used as an emulsifier in cheese/cheese spread products and is not to exceed 4% concentration, according to Health Canada regulations.

Uses of Disodium Tartrate:
Disodium tartrate is used for standardizing Karl Fischer reagent, as a pharmaceutic aid (sequestering agent), and cathartic.
Disodium tartrate is used as an emulsifier, pH control agent, and sequestrant for foods.

Permitted for use as an inert ingredient in non-food pesticide products.
Disodium tartrate is used for standardizing Karl Fischer reagent, as a pharmaceutic aid (sequestering agent), and cathartic.

Disodium tartrate a naturally occurring chemical compound found in berries, grapes and various wines.
Disodium tartrate provides antioxidant properties and contributes to the sour taste within these products.

Disodium tartrate dibasic dihydrate may be used in the preparation of solid-state M–L compounds (M = bivalent metal ions ie., Mn, Fe, Co, Ni, Cu, Zn; L = tartrate).
Disodium tartrate may also be used in the preparation of copper (II) and cobalt (II) tartrate complexes by reacting with the corresponding metal salts.
These complexes can undergo thermal decomposition to form Cu and Co metal oxide nanoparticles.

Widespread uses by professional workers:
Disodium tartrate is used in the following products: laboratory chemicals.
Disodium tartrate is used in the following areas: scientific research and development.
Other release to the environment of Disodium tartrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Uses at industrial sites:
Disodium tartrate is used in the following products: laboratory chemicals.
Disodium tartrate is used for the manufacture of: chemicals.
Release to the environment of Disodium tartrate can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Industry Uses:
Cleaning agent

General Manufacturing Information of Disodium Tartrate:

Industry Processing Sectors:
Computer and Electronic Product Manufacturing
Electrical Equipment, Appliance, and Component Manufacturing
Fabricated Metal Product Manufacturing
Machinery Manufacturing
Transportation Equipment Manufacturing

Action Mechanism of Disodium Tartrate:
Disodium tartrate is a white, crystalline powder, used as an emulsifier and a binding agent.
Disodium tartrate can be used in jellies, cheeses, sausage casings and any foods which contain fats or oils.

Purification Methods of Disodium Tartrate:
Disodium tartrate crystallises from warm dilute aqueous NaOH on cooling.

Identifiers of Disodium Tartrate:
CAS Number:
868-18-8 (anhydrous)
6106-24-7 (dihydrate)
ChemSpider: 12786
PubChem CID: 13355
UNII: QTO9JB4MDD
DIA7C37AOW (dihydrate)
CompTox Dashboard (EPA): DTXSID1028021
InChI: InChI=1S/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2
Key: HELHAJAZNSDZJO-UHFFFAOYSA-L
InChI=1S/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2
Key: HELHAJAZNSDZJO-NUQVWONBAO
Key: HELHAJAZNSDZJO-UHFFFAOYSA-L
SMILES: [Na+].[Na+].O=C([O-])C(O)C(O)C([O-])=O

CAS: 6106-24-7
Molecular Formula: C4H10Na2O8
Molecular Weight (g/mol): 232.096
MDL Number: MFCD00150035
InChI Key: YAPIZISBZUXUIH-DGFHWNFOSA-N
PubChem CID: 131855972
IUPAC Name: (2R,3R)-2,3-dihydroxybutanedioic acid;sodium;dihydrate
SMILES: C(C(C(=O)O)O)(C(=O)O)O.O.O.[Na].[Na]

Synonyms: L-(+)-Tartaric acid disodium salt, Disodium tartrate dihydrate, Sodium tartrate dihydrate
Empirical Formula (Hill Notation): C4H4Na2O6 · 2H2O
CAS Number: 6106-24-7
Molecular Weight: 230.08
EC Number: 212-773-3

CAS number: 6106-24-7
EC number: 212-773-3
Hill Formula: C₄H₄Na₂O₆ * 2H₂O
Molar Mass: 230.08 g/mol
HS Code: 2918 13 00

Properties of Disodium Tartrate:
Chemical formula: C4H4Na2O6 (anhydrous)
C4H8Na2O8 (dihydrate)
Molar mass: 194.051 g/mol (anhydrous)
230.082 g/mol (dihydrate)
Appearance: white crystals
Density: 1.545 g/cm3 (dihydrate)
Solubility in water: soluble
Solubility: insoluble in ethanol

Density: 1.820 g/cm3 (20 °C)
pH value: 7.0 - 9 (50 g/l, H₂O, 20 °C)
Bulk density: 460 kg/m3
Solubility: 290 g/l

Molecular Weight: 194.05
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 1
Exact Mass: 193.98032641
Monoisotopic Mass: 193.98032641
Topological Polar Surface Area: 121 Ų
Heavy Atom Count: 12
Complexity: 123
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

Specifications of Disodium Tartrate:
Assay (perchloric acid titration): ≥ 99.5 %
pH-value (5 %; water): 7.0 - 8.0
Chloride (Cl): ≤ 0.0005 %
Phosphate (PO₄): ≤ 0.0005 %
Sulfate (SO₄): ≤ 0.002 %
Total nitrogen (N): ≤ 0.002 %
Heavy metals (as Pb): ≤ 0.0005 %
Ca (Calcium): ≤ 0.005 %
Fe (Iron): ≤ 0.0005 %

Color: White
Quantity: 25 g
Formula Weight: 194.05
Percent Purity: ≥98.0% (T)
Physical Form: Crystalline Powder
Chemical Name or Material: Disodium L-(+)-Tartrate Dihydrate

Names of Disodium Tartrate:

Regulatory process names:
Bisodium tartrate
Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, disodium salt
Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, sodium salt (1:2)
Butanedioic acid, 2,3-dihydroxy- (R-(R*,R*))-, disodium salt
Butanedioic acid, 2,3-dihydroxy- (theta-(theta,theta))-, disodium salt
Butanedioic acid, 2,3-dihydroxy-(R-(R*,R*))-, disodium salt (9CI)
Disodium 2,3-dihydroxybutanedioate, (R-(R*,R*))-
Disodium L-(+)-tartrate
Disodium tartrate
Disodium tartrate
disodium tartrate
Natrium (RR)-tartrat
Sal tartar
Sodium L-(+)-tartrate
Sodium tartrate
Tartaric acid, disodium salt

IUPAC names:
2,3-dihydroxybutanedioic acid sodium salt (1:2)
disodium (2R,3R)-2,3-dihydroxybutanedioate
disodium 2,3-dihydroxybutanedioate
disodium tartarate
disodium tartrate
DISODIUM TARTRATE, ANHYDROUS
disodium(2R,3R)-2,3-dihydroxybutanedioate
Sodio Tartrato 2-hidrato
Sodium tartrate
disodium (2R,3R)-2,3-dihydroxybutanedioate

Other names:
Sal tartar
Disodium tartrate
Bisodium tartrate
Sodium l-(+)-tartrate
E335

Other identifiers:
133-48-2
17990-54-4
58114-54-8
6106-24-7
868-18-8

Synonyms of Disodium Tartrate:
Sodium L-tartrate
Disodium L-(+)-tartrate
Bisodium tartrate
Sal tartar
868-18-8
Disodium tartrate
TARTARIC ACID, DISODIUM SALT
Sodium L-(+)-tartrate
disodium L-tartrate
Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, disodium salt
QTO9JB4MDD
Disodium (+/-)-tartrate
Disodium salt of L-(+)-tartaric acid
WDT27AD907
disodium (2R,3R)-2,3-dihydroxybutanedioate
CHEBI:63017
Sodium (2R,3R)-2,3-dihydroxysuccinate
Butanedioic acid, 2,3-dihydroxy-, disodium salt, (2R,3R)-rel-
Sodium (2R,3R)-2,3-dihydroxysuccinate(x:1)
Sodium tartrate [NF]
Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, sodium salt (1:2)
L-(+)-Tartaric acid disodium salt
Natrium (RR)-tartrat
51307-92-7
Sodiumtartrate
CCRIS 7318
sodium dl-tartrate
Disodium (2RS,3SR)-tartrate
EINECS 212-773-3
sodium L(+)-tartrate
UNII-QTO9JB4MDD
6106-24-7
UNII-WDT27AD907
SODIUM (+)-TARTRATE
SODIUM DEXTRO-TARTRATE
SODIUM TARTRATE [II]
SODIUM TARTRATE [MI]
SCHEMBL456386
SODIUM TARTRATE [FCC]
Disodium 2,3-dihydroxybutanedioate, (R-(R*,R*))-
SODIUM TARTRATE RACEMATE
INS NO.335(II)
Butanedioic acid, 2,3-dihydroxy-, sodium salt (1:2), (2R,3R)-rel-
CHEMBL2107781
DISODIUM TARTRATE [INCI]
DTXSID1028021
DTXSID2057861
SODIUM TARTRATE [MART.]
INS-335(II)
SODIUM TARTRATE [WHO-DD]
l(+)-tartaric acid disodium salt
SODIUM TARTRATE, L (+)-
Butanedioic acid, 2,3-dihydroxy- (R-(R*,R*))-, disodium salt
Butanedioic acid, 2,3-dihydroxy-(R-(R*,R*))-, disodium salt
E-335(II)
AKOS006240046
Butanedioic acid, 2,3-dihydroxy- (theta-(theta,theta))-, disodium salt
DB13707
Sodium(2R,3R)-2,3-dihydroxysuccinate
disodium (2R,3R)-2,3-dihydroxysuccinate
D4027
E78255
EN300-7817107
disodium (R-(R*,R*))-2,3-dihydroxybutanedioate
DISODIUM (+)-2,3-DIHYDROXYBUTANEDIOIC ACID
Q27132338
(R-(R*,R*))-2,3-dihydroxybutanedioic acid, disodium salt
BUTANEDIOIC ACID, 2,3-DIHYDROXY-, DISODIUM SALT, (R*,R*)-
Butanedioic acid, 2,3-dihydroxy-, disodium salt, (R*,R*)-(+-)-
BUTANEDIOIC ACID, 2,3-DIHYDROXY-, DISODIUM SALT, (R*,R*)-(+/-)-
DISODIUMPHOSPHATE 
Alkylol ammonium salt of a copolymer with acidic groups; BYK
DISOIDUM DIHYDROGEN PYROPHOSPHATE
Disodium dihydrogen pyrophosphate, also known as Sodium acid pyrophosphate, is a white, water soluble solid that has many applications in the food industry.
Disodium dihydrogen pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Disodium dihydrogen pyrophosphate is a popular leavening agent found in baking powders.

CAS Number: 7758-16-9
EC Number: 231-835-0
Molecular Formula: H5NaO7P2
Molcular Weight: 201.97

Synonyms: Disodium dihydrogen diphosphate, Diphosphoric acid, disodium salt, Disodium dihydrogen pyrophosphate, Disodium diphosphate, Sodium acid pyrophosphate, SAPP, Disodium, Pyrophosphate, Disodium Diphosphate, Disodium Dihydrogen Diphosphate, Disodium Dihydrogen Pyrophosphate, Diphosphoric Acid, Disodium Salt, Pyrophosphoric Acid, Disodium Salt, Disodium diphosphate, Disodium pytophosphate, Disodium dihydroge3 disodium salt, H5WVD9LZUD, Sodium pyrophosphate (Na2H2P2O7), Diphosphoric acid, sodium salt (1:2) , Dinatriumpyrophosphat, Sodium polyphosphates, Natrium polyphosphat, Sodium polyphosphatium phosphate, Natrium polyphosphatium DS42_Sodium Polyphosphate, dihydrogendiphosphate, DSSTox_RID_78658, DSSTox_GSID_28842 ,2Na.H2P2O7, Sodium dihydrogen pyrophosphate, Sodium polyphosphate, amorphous, CHEMBL3184949, DTXSID_GSID_28842, LS-2432, NCGC00258367-01, [hydroxy(oxido)phosphoryl] hydrogen phosphate, Sodium acid pyrophosphate, SAPP, Diphosphoric acid, disodium salt, Disodium acid pyrophosphate, Disodium dihydrogen diphosphate, Disodium dihydrogen pyrophosphate, Disodium diphosphate, Pyrophosphoric acid, disodium salt, Sodium pyrophosphate dibasic, disodium dihydrogen pyrophosphate, pyrophosphoric acid, disodium salt (8ci), sapp 40, disodiumdiphosphate, sapp, sodium acid pyrophosphate(sapp),sodium acid pyrophosphate (sapp), dspp, dihydrogen disodium pyrophosphate, disodium pyrophosphate (na2h2p2o7), sodiumpyrophosphate,acid, dinatriumpyrophosphat, disodium pytophospha, disodium pyrophosphate, disodium dihydrogen diphosphate, disodium pytophosphate, diphosphoricacid, disodium salt (9ci), sodiumpyrophosphate (na2h2p2o7) (6ci), sapp 28, sapp-rd 1, disodium dihydrogendiphosphate (na2h2p2o7), sodium hydrogen phosphate (na2h2p2o7), Disodium dihydrogen pyrophosphate, SAPP, E450, 7758-16-9, Disodium diphosphate, Sodium acid pyrophosphate, Disodium dihydrogen pyrophosphate, DISODIUM PYROPHOSPHATE, H5WVD9LZUD, disodium;[hydroxy(oxido)phosphoryl] hydrogen phosphate, MFCD00014246, Disodium acid pyrophosphate, Dinatriumpyrophosphat, Disodiumpytophosphate, Dinatriumpyrophosphat [German], Disodium dihydrogen diphosphate, Disodium dihydrogenpyrophosphate, HSDB 377, Pyrophosphoric acid, disodium salt, UNII-H5WVD9LZUD, Sodium pyrophosphate (Na2H2P2O7), EINECS 231-835-0, Sodium diphosphate dibasic, disodium hydrogen (hydrogen phosphonatooxy)phosphonate, Grahamsches salz, Glassy sodium phosphate, DSSTox_CID_8842, sodium dihydrogendiphosphate, EC 231-835-0, DSSTox_RID_78658, DSSTox_GSID_28842, SODIUMACIDPYROPHOSPHATE, Sodium pyrophosphate, dibasic, Sodium dihydrogen pyrophosphate, CHEMBL3184949, EINECS 272-808-3, Tox21_200813, DISODIUM PYROPHOSPHATE [HSDB], DISODIUM PYROPHOSPHATE [INCI], DISODIUM PYROPHOSPHATE [VANDF], AKOS015916169, AKOS024418779, SODIUM ACID PYROPHOSPHATE [MI], Diphosphoric acid, sodium salt (1:2), SODIUM ACID PYROPHOSPHATE [FCC], NCGC00258367-01, SODIUM ACID PYROPHOSPHATE [VANDF], CAS-68915-31-1

Disodium dihydrogen pyrophosphate is a food-grade chemical compound that belongs to the group of sodium phosphates.
Disodium dihydrogen pyrophosphate is a white, crystalline powder or granular material with various applications in the food industry.

Disodium dihydrogen pyrophosphate is recognized as a food additive and is commonly used for its leavening, buffering, and emulsifying properties.
Disodium dihydrogen pyrophosphate serves as a buffering, chelating and leavening agent.

Disodium dihydrogen pyrophosphate encodes a integral membrane protein.
Disodium dihydrogen pyrophosphate is a soluble protein generated by sequential cleavage with α and γ secretase.

Disodium dihydrogen pyrophosphate, also known as Sodium acid pyrophosphate, is an inorganic compound composed of sodium cation and pyrophosphate anion.
Disodium dihydrogen pyrophosphate is a white, water-soluble solid, commonly used as a buffer and chelating agent and has many applications in food processing industry.

Disodium dihydrogen pyrophosphate is a white monoclinic crystal powder.
Disodium dihydrogen pyrophosphates relative density is 1.86.

Disodium dihydrogen pyrophosphate is soluble in water, insoluble in alcohol.
Disodium dihydrogen pyrophosphate hydrolyzes to orthophosphate when heated in acid medium.

Disodium dihydrogen pyrophosphate is hygroscopic, forms hexahydrate in damp air, and decomposes to metaphosphate at above 220℃.
The leavening acid, Disodium dihydrogen pyrophosphate is an important component of double acting baking powder as well as self rising flour.

Disodium dihydrogen pyrophosphate reacts in stages and is desirable in baking applications for its slow action.
Disodium dihydrogen pyrophosphate or Sodium acid pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.

Disodium dihydrogen pyrophosphate is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.
When crystallized from water, Disodium dihydrogen pyrophosphate forms a hexahydrate, but Disodium dihydrogen pyrophosphate dehydrates above room temperature.

Disodium dihydrogen pyrophosphate is a polyvalent anion with a high affinity for polyvalent cations.
Disodium dihydrogen pyrophosphate, also known as Disodium pyrophosphate, Sodium acid pyrophosphate, is white crystalline powder, which has the relative density of 1.864 and can decompose into sodium metaphosphate when Disodium dihydrogen pyrophosphate is heated above 220℃.

Disodium dihydrogen pyrophosphate is easily soluble in water and can form chelates with Cu2+ and Fe2+.
The aqueous solution can be hydrolyzed to phosphoric acid by heating with dilute sulfuric acid or dilute mineral acid.

Disodium dihydrogen pyrophosphate is usually used in food processing industry.
Disodium dihydrogen pyrophosphate, or Disodium pyrophosphate, its food grade is commonly used with sodium bicarbonate as a leavening agent in bakery products; also, Disodium dihydrogen pyrophosphate maintains the color in processed potatoes and also prevents struvite crystal in canned seafood.

The European food additive number for Disodium dihydrogen pyrophosphate is E450(i).
Generally, Disodium dihydrogen pyrophosphate is vegan and gluten free.

Disodium dihydrogen pyrophosphate also known as Di-sodium Di-phosphate is an inorganic compound of sodium and pyrophosphate.
Disodium dihydrogen pyrophosphate is white and soluble in water.

Disodium dihydrogen pyrophosphate is manufactured with double drying process like other Pyrophosphates due to heating needed at a high temperature.
Disodium dihydrogen pyrophosphate is solubility in water is 13g Na2H2P2O7/100g H2O at 20 °C, and 20g at 80°C.

The pH of a 1% aqueous solution is 4.1. The usual commercial product is the anhydrous, nonhygroscopic salt in powder form.
The hexahydrate, Na2H2P2O7.6H2O, d 1.85, crystallizes from aqueous solution below 27 °C.

Above this temperature, Disodium dihydrogen pyrophosphate is converted to the anhydrous form.
Disodium dihydrogen pyrophosphate is used as a (tropically stable) acid carrier in baking powder, for improvement of flow properties in flour, for pH regulation, and in dental care products for prevention of tartar formation.

Disodium dihydrogen pyrophosphate is available in a variety of grades that affect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium dihydrogen pyrophosphate is usually used in very sweet cakes which mask the off-taste.

Disodium dihydrogen pyrophosphate is manufactured by partially neutralizing food grade phosphoric acid with sodium hydroxide or sodium carbonate to form monosodium phosphate.
Dehydration of monosodium phosphate at 250°C will form Disodium dihydrogen pyrophosphate.

Leavening acids provide air and volume to the baked good structure, but also affect the characteristics of the dough.
Besides reacting with baking soda to produce the gas carbon dioxide, these acids form ionic bonds with the starches and proteins in the dough.

Disodium dihydrogen pyrophosphate dissolves readily to form the anion pyrophosphate which interacts with the proteins in a baked good system to provide a moist texture.
Also, Disodium dihydrogen pyrophosphate provides a buffer system for the dough in the pH range 7.3-7.5, which influences the color of the baked product.

Disodium dihydrogen pyrophosphate is a white, crystalline powder or granular substance.
Disodium dihydrogen pyrophosphate is a sodium salt of pyrophosphoric acid and is commonly used as a food additive and in various industrial applications.

Disodium dihydrogen pyrophosphate has unique chemical properties that make Disodium dihydrogen pyrophosphate versatile in different processes.
Disodium dihydrogen pyrophosphate acts as a leavening agent in food production, helping dough rise and creating a light texture in baked goods.
In addition to its culinary uses, Disodium dihydrogen pyrophosphate is utilized as a buffering agent, stabilizer, and emulsifier in food processing.

Disodium dihydrogen pyrophosphate also finds application as a corrosion inhibitor, pH adjuster, and chelating agent in various industries.
Disodium dihydrogen pyrophosphate is a slow leavening acid and Disodium dihydrogen pyrophosphate may contain a suitable aluminum and/or calcium salt to control the rate of reaction.
Disodium dihydrogen pyrophosphate and other sodium and potassium polyphosphates are widely used in food processing; in the E number scheme, they are collectively designated as E450, with the disodium form designated as E450(a).

In the United States, Disodium dihydrogen pyrophosphate is classified as generally recognized as safe (GRAS) for food use.
In canned seafood, Disodium dihydrogen pyrophosphate is used to maintain color and reduce purge[clarification needed] during retorting.
Retorting achieves microbial stability with heat.

Disodium dihydrogen pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.
In baking powder, Disodium dihydrogen pyrophosphate is often labeled as food additive E450.
In cured meats, Disodium dihydrogen pyrophosphate speeds the conversion of sodium nitrite to nitrite (NO2−) by forming the nitrous acid (HONO) intermediate,[clarification needed] and can improve water-holding capacity.

Disodium dihydrogen pyrophosphate is also found in frozen hash browns and other potato products, where Disodium dihydrogen pyrophosphate is used to keep the color of the potatoes from darkening.
Disodium dihydrogen pyrophosphate can leave a slightly bitter aftertaste in some products, but "the SAPP taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings."

Disodium dihydrogen pyrophosphate has limited direct uses in water treatment processes.
Disodium dihydrogen pyrophosphate can indirectly contribute to certain aspects of water treatment.

Disodium dihydrogen pyrophosphate is sometimes employed as a pH adjuster and buffering agent in water treatment applications where precise pH control is necessary.
Disodium dihydrogen pyrophosphate can help stabilize and maintain the desired pH range, optimizing treatment processes.

Disodium dihydrogen pyrophosphate can act as a sequestering agent, chelating metal ions and preventing their precipitation or interference with water treatment chemicals.
Its ability to bind with metal ions aids in minimizing scaling and maintaining the efficiency of water treatment equipment.

Disodium dihydrogen pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.
Disodium dihydrogen pyrophosphate is a white, water-soluble that serves as a buffering and chelating agent, with many applications in the food industry.

When crystallised from water, Disodium dihydrogen pyrophosphate forms hexahydrate, but Disodium dihydrogen pyrophosphate dehydrates above room temperature.
Disodium dihydrogen pyrophosphate is a polyvalent anion with a high affinity for polyvalent cations.

Disodium dihydrogen pyrophosphate is a popular leavening agent found in baking powders.
Disodium dihydrogen pyrophosphate combines with sodium bicarbonate to release carbon dioxide.

Disodium dihydrogen pyrophosphate is available in a variety of grades that effect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium dihydrogen pyrophosphate is usually used in very sweet cakes which mask the taste.

Disodium dihydrogen pyrophosphate is designated in the USA as generally recognized as safe for food use.
Disodium dihydrogen pyrophosphate is used in canned seafood to maintain color and reduce purge during retorting.

Retorting achieves microbial stability with heat.
Disodium dihydrogen pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.

Disodium dihydrogen pyrophosphate is an anhydrous white powdered material, which complies with the specifications of the current Food Chemicals Codex for Disodium dihydrogen pyrophosphate.
Disodium dihydrogen pyrophosphate is used as an acidulant, buffering agent, and leavening agent.
Disodium dihydrogen pyrophosphate has a dough reaction rate of 24 – 28.

Disodium dihydrogen pyrophosphate is an all-purpose phosphate commonly used in prepared mixes, commercial baking powders, and cake doughnut mixes.
Disodium dihydrogen pyrophosphate and other sodium and potassium polyphosphates are widely used in food processing; in the E number scheme, they are collectively designated as E450, with the disodium form designated as E450(a).

In the United States, Disodium dihydrogen pyrophosphate is classified as generally recognized as safe (GRAS) for food use.
In canned seafood, Disodium dihydrogen pyrophosphate is used to maintain color and reduce purge[clarification needed] during retorting.

Retorting achieves microbial stability with heat.
Disodium dihydrogen pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.

In baking powder, Disodium dihydrogen pyrophosphate is often labeled as food additive E450.
In cured meats, Disodium dihydrogen pyrophosphate speeds the conversion of sodium nitrite to nitrite (NO2−) by forming the nitrous acid (HONO) intermediate,[clarification needed] and can improve water-holding capacity.

Disodium dihydrogen pyrophosphate is also found in frozen hash browns and other potato products, where Disodium dihydrogen pyrophosphate is used to keep the color of the potatoes from darkening.
Disodium dihydrogen pyrophosphate can leave a slightly bitter aftertaste in some products, but "the SAPP taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings.
Disodium dihydrogen pyrophosphate is an inorganic compound consisting of sodium cations and pyrophosphate anion.

As a leavening acid which combines with baking soda to release carbon dioxide to improve the texture and volume of baked goods.
As a chelating agent to chelate iron to prevent discoloration in processed potato.
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties.

Disodium dihydrogen pyrophosphate is derived from amyloid precursor protein.
The protein consists of 612 amino acids.
Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP.

Disodium dihydrogen pyrophosphate has neuroprotective, neurogenic and neurotrophic functions.
Amyloid precursor protein a also stimulates gene expression and protein expression.
In leather treatment, Disodium dihydrogen pyrophosphate can be used to remove iron stains on hides during processing.

Disodium dihydrogen pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.
When added to scalding water, Disodium dihydrogen pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
Disodium dihydrogen pyrophosphate in petroleum production, Disodium dihydrogen pyrophosphate can be used as a dispersant in oil well drilling muds.

Disodium dihydrogen pyrophosphate can also be found in frozen hash browns and other potato products, where Disodium dihydrogen pyrophosphate is used to keep the color of the potatoes from darkening.
Disodium dihydrogen pyrophosphate is a sodium salt of pyrophosphoric acid, and its chemical formula is Na2H2P2O7.

Disodium dihydrogen pyrophosphate in the food industry is as a leavening agent.
Disodium dihydrogen pyrophosphate releases carbon dioxide gas when Disodium dihydrogen pyrophosphate reacts with alkalis, such as baking soda (sodium bicarbonate), when exposed to moisture and heat.

This gas production causes dough or batter to rise, resulting in baked goods with a lighter texture.
Disodium dihydrogen pyrophosphate is often used in baking powder formulations to provide a delayed or slow-acting leavening effect.

Disodium dihydrogen pyrophosphate acts as a pH buffer in various food products, helping to control and stabilize their acidity or alkalinity.
Disodium dihydrogen pyrophosphate is used in processed foods to maintain the desired pH level, preventing changes in flavor, color, and texture.

Disodium dihydrogen pyrophosphate can also serve as an emulsifying agent in certain food products, helping to blend ingredients that would not naturally mix together, such as oil and water.
Disodium dihydrogen pyrophosphate is commonly used in a variety of food products, including baked goods like cakes, muffins, and pancakes, as well as in pancakes, waffles, and other batter-based items.

Disodium dihydrogen pyrophosphate is also used in certain dairy products, such as processed cheeses, to help improve their melting and texture.
Disodium dihydrogen pyrophosphate may be used in meat products as a pH regulator, in canned seafood to maintain product quality, and in potato products like French fries to prevent discoloration.

Uses of Disodium dihydrogen pyrophosphate:
Disodium dihydrogen pyrophosphate is used Buffering Agents, Food & Beverage, Food Additives, Levelling Agents, Oil Field Services, Chelants, and Leather.

Food uses:
Disodium dihydrogen pyrophosphate is a popular leavening agent found in baking powders.

Disodium dihydrogen pyrophosphate combines with sodium bicarbonate to release carbon dioxide:
Na2H2P2O7 + NaHCO3 → Na3HP2O7 + CO2 + H2O

Disodium dihydrogen pyrophosphate is available in a variety of grades that affect the speed of its action.
Because the resulting phosphate residue has an off-taste, Disodium dihydrogen pyrophosphate is usually used in very sweet cakes which mask the off-taste.

Disodium dihydrogen pyrophosphate used as buffering agent, leavening agent, sequestrant agent.
Disodium dihydrogen pyrophosphate can be used in canned food, ham, meat,baking powder and so on.

Disodium dihydrogen pyrophosphate in baking powder, New Zealand, 1950s
Disodium dihydrogen pyrophosphate and other sodium and potassium polyphosphates are widely used in food processing.

In canned seafood, Disodium dihydrogen pyrophosphate is used to maintain color and reduce purge during retorting.
Retorting achieves microbial stability with heat.

Disodium dihydrogen pyrophosphate is an acid source for reaction with baking soda to leaven baked goods.
Disodium dihydrogen pyrophosphate is used as a tartar control agent in toothpastes.
Disodium dihydrogen pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.

In baking powder, Disodium dihydrogen pyrophosphate is often labeled as food additive E450.
In cured meats, Disodium dihydrogen pyrophosphate speeds the conversion of sodium nitrite to nitrite (NO2−) by forming the nitrous acid (HONO) intermediate, and can improve water-holding capacity.

Disodium dihydrogen pyrophosphate is also found in frozen hash browns and other potato products, where Disodium dihydrogen pyrophosphate is used to keep the color of the potatoes from darkening.

Disodium dihydrogen pyrophosphate can stabilize hydrogen peroxide solutions against reduction.
Disodium dihydrogen pyrophosphate can leave a slightly bitter aftertaste in some products, but "the Disodium dihydrogen pyrophosphate taste can be masked by using sufficient baking soda and by adding a source of calcium ions, sugar, or flavorings."
In leather treatment, Disodium dihydrogen pyrophosphate can be used to remove iron stains on hides during processing.

When added to scalding water, Disodium dihydrogen pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
In petroleum production, Disodium dihydrogen pyrophosphate can be used as a dispersant in oil well drilling muds.
Disodium dihydrogen pyrophosphate is used in cat foods as a palatability additive.

Because Disodium dihydrogen pyrophosphate is slow acting and does not react quickly with baking soda, Disodium dihydrogen pyrophosphate is the most commonly used leavening acid for self rising flour for the home baker.
Per 21 C.F.R. § 137.180(a) 2018, self rising flour must contain enough leavening acid to neutralize the baking soda, but the combination of both can not exceed 4.5 parts per 100 parts flour.

The quantity of leavening acid needed hinges on Disodium dihydrogen pyrophosphate's neutralizing value (NV) which is defined as the quantity of baking soda needed to neutralize 100 parts of leavening acid.
For Disodium dihydrogen pyrophosphate, NV is 70.

Because Disodium dihydrogen pyrophosphate can have a slight bitter taste, Disodium dihydrogen pyrophosphate’s important to use sufficient baking soda in applications as well as use this leavening acid in combination with sugary goods such as doughnuts and cakes.

In canned tuna, Disodium dihydrogen pyrophosphate prevents harmless struvite crystals from forming.
Cake doughnuts are an important application for Disodium dihydrogen pyrophosphate, where initial gas production is necessary for buoyancy in a fryer system.
Also, Disodium dihydrogen pyrophosphate is useful for cakes, where initial gas production is necessary for consistency of pan fill.

Other non-bakery food applications of Disodium dihydrogen pyrophosphate include use as a chelating agent for processed potatoes, an emulsifying agent in cheeses and a curing accelerator in processed meats.
Disodium dihydrogen pyrophosphate can be used as a leavening chemical for bread to help Disodium dihydrogen pyrophosphate rise.

Disodium dihydrogen pyrophosphate's used in sausage to enhance flavor and color.
In french fries, the chemical reduces levels of a carcinogen called acrylamide.

Disodium dihydrogen pyrophosphate also prevents discoloration in potatoes and sugar syrups.
Disodium dihydrogen pyrophosphate is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.
Disodium dihydrogen pyrophosphate is widely used as thinner in oil well drilling muds and even as an industrial cleaner.

Disodium dihydrogen pyrophosphate's key advantages are:
Aids in the removal of calcium and reduces pH in cement contaminated fluids.
At low concentration levels, Disodium dihydrogen pyrophosphate is fast-acting and effective.

Aids break up clay particles and sediments, which enables them to be extracted during oil well development.
Disodium dihydrogen pyrophosphate is used in the chemical clean up of fluids which have been contaminated by cement.
Disodium dihydrogen pyrophosphate decreases the viscosity and gel strengths in freshwater drilling fluids.

Disodium dihydrogen pyrophosphate is used as a deflocculant (thinner) in freshwater mud systems.
Disodium dihydrogen pyrophosphate is often used to break up mud rings when water drilling and is also used to thin out cement before cementing casing.

In cementing applications, Disodium dihydrogen pyrophosphate is used for two primary purposes:
Contaminated drilling mud can result in fluid loss, thickening time, and viscosity.
Disodium dihydrogen pyrophosphate is used to disperse and displace drilling muds to avoid mud being affected by cement contamination.

Solids carrying fluid or drilling mud must be removed from the perforation channels and the rock face to allow a good cement bond and complete fill-up of the voids.
Incorporating Disodium dihydrogen pyrophosphate into the spacer will help remove residual muds and provide a cleaner surface to which the cement can bond.

Disodium dihydrogen pyrophosphate is used as an acidulant, buffering agent, coagulant, emulsifying agent, dispersing agent, protein modifier, and sequestrant.
Actively thins out reactive clays.
In non-dairy creamers, Disodium dihydrogen pyrophosphate is added to protect the proteins from heat dehydration, to stabilize the fat emulsion, and to buffer Disodium dihydrogen pyrophosphate.

Processed potatoes are protected from iron-induced darkening when treated with Disodium dihydrogen pyrophosphate.
Addition of Disodium dihydrogen pyrophosphate to albacore tuna during canning decreases or prevents formation of struvite crystals.

Disodium dihydrogen pyrophosphate is used in meat processing to accelerate development of red color in wieners, bologna, and other emulsion-type meat products.
Disodium dihydrogen pyrophosphate can be used as an emulsifying agent during cheese processing to produce a hard, non-melting cheese product.

Disodium dihydrogen pyrophosphate is Baking powder, used in baking and to control the fermenting speed, to increase the producing strength.
Disodium dihydrogen pyrophosphateis used in instant noodles to reduce time after subjecting to water.

Disodium dihydrogen pyrophosphate is also used in biscuits and cakes, to reduce fermenting time, to decrease the destroying, to maintain the clear gaps, finally to extend products storage.
Disodium dihydrogen pyrophosphate is used Vegetables (esp. potatoes) processing.

Disodium dihydrogen pyrophosphate is used Seafood, meat, cheese processing.
Disodium dihydrogen pyrophosphate is speedly fermentation, water retaining agent and quality improver, used in bread, biscuits, meat, aquatic products and so on.

As quality improver, Disodium dihydrogen pyrophosphate enhances complexation,PH value and Ionic strength.
According to rules, Disodium dihydrogen pyrophosphate's max adding quantity is 3.0g/KG in biscuits and 1.0-3.0g/KG in bread.

Disodium dihydrogen pyrophosphate is reactive not only with sodium bicarbonate, but also with calcium salts, proteins and heat.
Disodium dihydrogen pyrophosphate dispersant is used in much the same manner as polyphosphate dispersants and is subject to the same temperature limitations.
Due to its acidic nature, Disodium dihydrogen pyrophosphate is especially effective for treating cement contamination.

Disodium dihydrogen pyrophosphate dispersant is efficient for bentonite muds and is often used in conjunction with a tannin or quebracho compound.
Disodium dihydrogen pyrophosphate dispersant can also be used to treat calcium contamination, especially contamination resulting from cement.

Because of Disodium dihydrogen pyrophosphate's acidic nature, Disodium dihydrogen pyrophosphate dispersant is not normally used in muds where the pH exceeds 9.5.
Disodium dihydrogen pyrophosphate is one of the two acid components used in commercial baking powders.

Disodium dihydrogen pyrophosphate gives baking powder the time and temperature element contributing to the "Double Acting" power.
Regular Disodium dihydrogen pyrophosphate is used in cakes, sponges and refrigerated dough where a slower reactivity is desired.

Usage 1g of sodium bicarbonate to 1.38g Disodium dihydrogen pyrophosphate or as recipe indicates
Disodium dihydrogen pyrophosphate (SAPP), or Disodium pyrophosphate, Disodium dihydrogen pyrophosphate's food grade is commonly used with sodium bicarbonate as a leavening agent in bakery products.

Also, Disodium dihydrogen pyrophosphate maintains the color in processed potatoes and also prevents struvite crystal in canned seafood.
The European food additive number for Disodium dihydrogen pyrophosphate is E450(i), Disodium dihydrogen pyrophosphate.
1. Bakery
2. Canned Sea Food
3. Potato Products

Recommended use in following applications: as a constituent of baking powder, as a constituent of blanching solutions for preventing after-cooking darkening of potatoes, as a constituent of phosphate mized in meat processing, as a constituent of cheese emulsifying salts, as a general buffer and acidifying agent in foodstuffs, as a dispersant in oil well drilling muds, in leather treatment to remove iron stains, in the stabilization of hydrogen peroxide solutions, as a cleaning agent, in conjunction with sulphamic acidn in certain dairy applications, as seafood preservative.

To use: as leavening agent
Applications include food &|beverage (popular leavening agent found in baking powder, used in very sweet cakes which mask the off-tast, canned seafood, Disodium dihydrogen pyrophosphate is used to maintain color and reduce purge, frozen hash browns and other potato products, where Disodium dihydrogen pyrophosphate is used to keep the color of the potatoes from darkening)|agriculture (pet food used in cat foods as a palatability additive, removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter and |industrial (petroleum production, Disodium dihydrogen pyrophosphate can be used as a dispersant in oil well drilling muds, leather treatment to remove iron stains on hides, dairy applications for cleaning, remove soapstone).

Disodium dihydrogen pyrophosphate is used as a buffering and chelating agent, with many applications in the food industry.
Disodium dihydrogen pyrophosphate is one of the popular food additives and ingredients in most countries.

Disodium dihydrogen pyrophosphate used as buffering agent, leavening agent, sequestrant agent.
Disodium dihydrogen pyrophosphate can be used in canned food, ham, meat,baking powder and so on.

Disodium dihydrogen pyrophosphate is a white, water-soluble solid that serves as a buffering and chelating agent, with many applications in the food industry.
Disodium dihydrogen pyrophosphate is used as a leavening agent, reducing zymosis time and can also be used as a water retention agent, and a quality improver for meat and sea food processing.
Disodium dihydrogen pyrophosphate is used strengthen the feed nutrition .

Disodium dihydrogen pyrophosphate, often abbreviated as SAPP is an edible phosphoric salt available as a white crystalline powder in the market.
In food and beverage industry, Disodium dihydrogen pyrophosphate is mostly used as a leavening agent in self-rising and baked goods and as a quality improver for meat and fish processing.

Besides food and beverage, Disodium dihydrogen pyrophosphate is also used in leather industry for leather processing and petroleum industry in the drilling of oil wells as dispersants.
Hence, the manufacturers are offering Disodium dihydrogen pyrophosphate in food grade or chemical so that their product can be utilized in all the above mentioned end-use industries and applications.

Consumers of Disodium dihydrogen pyrophosphate such as bakery producers are preferring the use of Disodium dihydrogen pyrophosphate as Disodium dihydrogen pyrophosphate can offer variable rates of reaction and leavening by gas production based on its granulation.
They are using Disodium dihydrogen pyrophosphate alone or in combination with other leavening agents depending on the requirement of product.

Disodium dihydrogen pyrophosphate, or SAPP, is used in the food industry.
More specially, Disodium dihydrogen pyrophosphate is used for certain types of baking powder and baking creams in addition to working as a leavening agent for prepared cake and doughnut mixes.
Disodium dihydrogen pyrophosphate maintains the natural white color of cooked potatoes.

Disodium dihydrogen pyrophosphate is used as chelating agent or buffering agent in many Food & Industrial applications.
Disodium dihydrogen pyrophosphate is used to remove Iron stains during processing of leather.
Disodium dihydrogen pyrophosphate is used as a dispersant in oil well drilling application.

Disodium dihydrogen pyrophosphate is a leavening agent, preservative, sequestrant, and buffer which is mildly acidic with a ph of 4.1.
Disodium dihydrogen pyrophosphate is moderately soluble in water, with a solubility of 15 g in 100 ml at 25°c.

Disodium dihydrogen pyrophosphate is used in doughnuts and biscuits for its variable gas release rate during the mixing, bench action, and baking process.
Disodium dihydrogen pyrophosphate is used in baking powder as a leavening agent.

Disodium dihydrogen pyrophosphate is used in canned fish products to reduce the level of undesired struvite crystals (magnesium ammonium phosphate hexahydrate) by complexing the magnesium.
Disodium dihydrogen pyrophosphate is used to sequester metals in processed potatoes.

Disodium dihydrogen pyrophosphate is currently used by the sausage industry to accelerate development of cured meat color.
The cured color accelerator was examined, through sensory evaluation and instrumental measurements, for its effects on the texture of frankfurters.

Disodium dihydrogen pyrophosphate is anhydrous form, pyrophosphate salt used in buffers.
Disodium dihydrogen pyrophosphate is used as a deflocculant (thinner) in freshwater mud systems.

Disodium dihydrogen pyrophosphate is often used to break up mud rings when water drilling and is also used to thin out cement before cementing casing.
Disodium dihydrogen pyrophosphate is used as leavening agent in baking powders, combining with sodium bicarbonate to release carbon dioxide.

Disodium dihydrogen pyrophosphate speeds the conversion of sodium nitrite to nitrite in cured meats and can improve water-holding capacity.
Disodium dihydrogen pyrophosphate is also found in potato products, where Disodium dihydrogen pyrophosphate prevents darkening.

Disodium dihydrogen pyrophosphate can be also be used in leather treatment; In some dairy applications for cleaning purposes and in petroleum production; etc.
Disodium dihydrogen pyrophosphate is used contaminated drilling mud can result in fluid loss, thickening time, and viscosity.

Disodium dihydrogen pyrophosphate is used to disperse and displace drilling muds to avoid mud being affected by cement contamination.
Disodium dihydrogen pyrophosphate is used solids carrying fluid or drilling mud must be removed from the perforation channels and the rock face to allow a good cement bond and complete fill-up of the voids.

Incorporating Disodium dihydrogen pyrophosphate into the spacer will help remove residual muds and provide a cleaner surface to which the cement can bond.
Disodium dihydrogen pyrophosphate can be used to remove iron stains on hides during processing.

Disodium dihydrogen pyrophosphate can stabilize hydrogen peroxide solutions against reduction.
Disodium dihydrogen pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.

When added to scalding water, Disodium dihydrogen pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.
In petroleum production, Disodium dihydrogen pyrophosphate can be used as a dispersant in oil well drilling muds.

Disodium dihydrogen pyrophosphate is used in cat foods as a palatability additive.
Disodium dihydrogen pyrophosphate is used as a tartar control agent in toothpastes.

Disodium dihydrogen pyrophosphate can be used to remove iron stains on hides during processing.
Disodium dihydrogen pyrophosphate can stabilize hydrogen peroxide solutions against reduction.

Disodium dihydrogen pyrophosphate can be used with sulfamic acid in some dairy applications for cleaning, especially to remove soapstone.
when added to scalding water, Disodium dihydrogen pyrophosphate facilitates removal of hair and scurf in hog slaughter and feathers and scurf in poultry slaughter.

In petroleum production, Disodium dihydrogen pyrophosphate can be used as a dispersant in oil well drilling muds.
Disodium dihydrogen pyrophosphate is used in cat foods as a palatability additive.

Disodium dihydrogen pyrophosphate is used as a tartar control agent in toothpastes
Disodium dihydrogen pyrophosphate dispersant is used in much the same manner as polyphosphate dispersants and is subject to the same temperature limitations.

Due to its acidic nature, Disodium dihydrogen pyrophosphate is especially effective for treating cement contamination.
Disodium dihydrogen pyrophosphate dispersant is efficient for bentonite muds and is often used in conjunction with a tannin or quebracho compound.

Disodium dihydrogen pyrophosphate dispersant can also be used to treat calcium contamination, especially contamination resulting from cement.
Because of its acidic nature, SAPP dispersant is not normally used in muds where the pH exceeds 9.5.

Disodium dihydrogen pyrophosphate food grade is used as an acid component in baking powder; as a chelating agent or combines with other polyphosphates to sequester magnesium and iron ions, e.g. chelate iron during the processing of potatoes to prevent a dark discoloration.
Disodium dihydrogen pyrophosphate can be used as a leavening chemical for bread to help Disodium dihydrogen pyrophosphate rise.

Disodium dihydrogen pyrophosphate's used in sausage to enhance flavor and color.
In french fries, the chemical reduces levels of a carcinogen called acrylamide, according to an article from the Center for Science in the Public Interest.

Disodium dihydrogen pyrophosphate also prevents discoloration in potatoes and sugar syrups.
In canned tuna, Disodium dihydrogen pyrophosphate prevents harmless struvite crystals from forming.

Disodium dihydrogen pyrophosphate is used together with baking powder as a leavening agent to release carbon dioxide.
Disodium dihydrogen pyrophosphate is ideal for refrigerated doughs, cakes, muffins and pancake mixes where a slow reaction rate is desired.

Disodium dihydrogen pyrophosphate is often used with fast-acting leavenings such as monocalcium phosphate in double-acting baking powder or sometimes added with another slow action leavening acid, GDL.
Disodium dihydrogen pyrophosphate can be used to replace sulfur dioxide, sulfites and bisulfites to maintain the appearance and texture of cooked potato products.

The application of Disodium dihydrogen pyrophosphate reduces the dark color from after-cooking darkening in cooked and processed potato products, such as in oil-blanched french fries and potato salad.
Disodium dihydrogen pyrophosphate is Baking powder, used in baking and to control the fermenting speed, to increase the producing strength.

Disodium dihydrogen pyrophosphate is used in instant noodles to reduce time after subjecting to water.
Disodium dihydrogen pyrophosphate is also used in biscuits and cakes, to reduce fermenting time, to decrease the destroying, to maintain the clear gaps, finally to extend products storage.

Disodium dihydrogen pyrophosphate is speedly fermentation, water retaining agent and quality improver, used in bread, biscuits, meat, aquatic products and so on.
As quality improver, Disodium dihydrogen pyrophosphate enhances complexation,PH value and Ionic strength.

According to rules, Disodium dihydrogen pyrophosphates max adding quantity is 3.0g/KG in biscuits and 1.0-3.0g/KG in bread.
Disodium dihydrogen pyrophosphate is used in sausages to enhance flavor and color.
Disodium dihydrogen pyrophosphate is used in biscuits and cakes, Disodium dihydrogen pyrophosphate can shorten the fermentation time, reduce Disodium dihydrogen pyrophosphate breakage rate, loosen the gaps neatly, and prolong the storage period.

Disodium dihydrogen pyrophosphate is used as a quality improver for bakery foods such as bread, biscuits, meat and aquatic products, etc.
Disodium dihydrogen pyrophosphate can improve the complex metal ions, PH value and ionic strength of foods, thereby improving the adhesion and water holding capacity of foods. In French Fries, Disodium dihydrogen pyrophosphate SAPP can reduce levels of a carcinogen called acrylamide.

Disodium dihydrogen pyrophosphate can also prevent discoloration of potatoes and syrup.
In canned tuna, Disodium dihydrogen pyrophosphate can prevent the formation of harmless struvite crystals.
In canned seafood, Disodium dihydrogen pyrophosphate can retain color during cooking and reduce cleaning.

In cured meats, Disodium dihydrogen pyrophosphate accelerates the conversion of sodium nitrite to nitrite by forming a nitrous acid intermediate and can improve water retention.
Disodium dihydrogen pyrophosphate is used in frozen hash browns and other potato products to prevent potatoes from darkening.
Disodium dihydrogen pyrophosphate may leave a slightly bitter aftertaste in some products, but adding calcium ions, sugar, or flavoring can mask the taste.

In leather processing, Disodium dihydrogen pyrophosphate can be used to remove iron stains from raw hides during processing.
Disodium dihydrogen pyrophosphate can stabilize the hydrogen peroxide solution against reduction.
In certain dairy applications, Disodium dihydrogen pyrophosphate can be used with sulfamic acid for cleaning, especially soapstone removal.

In oil production, Disodium dihydrogen pyrophosphate can be used as a dispersant for oil well drilling mud.
Disodium dihydrogen pyrophosphate is used as a tartar control agent in toothpaste.
Disodium dihydrogen pyrophosphate is commonly used as a leavening agent in baked goods, such as cakes, muffins, pancakes, waffles, and biscuits.

Disodium dihydrogen pyrophosphate works by releasing carbon dioxide gas when Disodium dihydrogen pyrophosphate reacts with alkalis like baking soda (sodium bicarbonate) in the presence of moisture and heat.
This gas production causes the dough or batter to rise, resulting in the characteristic light and airy texture of these products.
Disodium dihydrogen pyrophosphate is an essential component of double-acting baking powder, a leavening agent used in a wide range of baked goods.

Double-acting baking powder releases gas in two stages: once when mixed with wet ingredients and again when exposed to the heat of the oven.
This two-stage action provides better control over the leavening process and helps achieve consistent results in baking.
Disodium dihydrogen pyrophosphate acts as a pH buffer in various food products.

Disodium dihydrogen pyrophosphate helps control and stabilize the pH (acidity or alkalinity) of food items, preventing undesirable changes in flavor, color, and texture.
Disodium dihydrogen pyrophosphate is particularly useful in processed foods to maintain the desired pH level.

Disodium dihydrogen pyrophosphate serves as an emulsifying agent.
Disodium dihydrogen pyrophosphate helps blend ingredients that would not naturally mix, such as oil and water.

This property is valuable in the production of salad dressings, sauces, and some dairy products to create stable and uniform mixtures.
Disodium dihydrogen pyrophosphate is used in the meat industry as a pH regulator and moisture retention agent in various processed meat products.

Disodium dihydrogen pyrophosphate helps improve the texture and quality of these products.
Disodium dihydrogen pyrophosphate can be found in certain dairy products, especially processed cheeses, to enhance their melting and textural characteristics.
Disodium dihydrogen pyrophosphate assists in achieving a smooth and creamy texture in cheese-based products.

In potato-based products like French fries and hash browns, Disodium dihydrogen pyrophosphate is employed to prevent discoloration and maintain the appealing color of the potatoes during processing and frying.
Disodium dihydrogen pyrophosphate is used in canned seafood products to help maintain product quality and texture, particularly in products like canned tuna.
Disodium dihydrogen pyrophosphate may be used in various other food items, such as canned soups, gravies, and sauces, where Disodium dihydrogen pyrophosphate contributes to texture and stability.

Benefits of Disodium dihydrogen pyrophosphate:
Controlled leavening acid
Prevents oxidation/colour change
Humectant
Buffering agent
Stabiliser
Acidulant

Functions of Disodium dihydrogen pyrophosphate:
Leavening acids provide air and volume to the baked good structure, but also affect the characteristics of the dough.
Besides reacting with baking soda to produce the gas carbon dioxide, these acids form ionic bonds with the starches and proteins in the dough.

Disodium dihydrogen pyrophosphate dissolves readily to form the anion pyrophosphate which interacts with the proteins in a baked good system to provide a moist texture.
Also, Disodium dihydrogen pyrophosphate provides a buffer system for the dough in the pH range 7.3-7.5, which influences the color of the baked product.

Advantages of Disodium dihydrogen pyrophosphate:
Widely available and economical thinner effective for treatment of cement contamination
Concentrated chemical that is effective at low treatment levels
Can be used with most water-base mud types

Preparation of Disodium dihydrogen pyrophosphate:
Disodium dihydrogen pyrophosphate is produced from sodium dihydrogenmonophosphate by heating at 200-250℃:
Na2CO3+2H3PO4→2NaH2PO4+H2O+CO2↑
2NaH2PO4→Na2H2P2O7+H2O

Disodium dihydrogen pyrophosphate is a condensed phosphate, commonly synthesized by the neutralization of phosphoric acid with sodium hydroxide or sodium carbonate at the ratio of 1:1 to produce monosodium phosphate (NaH2PO4), and then heated approximately 250°C to remove the water.
2 NaH2PO4 → Na2H2P2O7 + H2O

Production of Disodium dihydrogen pyrophosphate:

Commercial Production:
Disodium dihydrogen pyrophosphate is manufactured by partially neutralizing food grade phosphoric acid with sodium hydroxide or sodium carbonate to form monosodium phosphate.
Dehydration of monosodium phosphate at 250°C will form SAPP.
Currently, there is no known natural method for the production of Disodium dihydrogen pyrophosphate.

Origin of Disodium dihydrogen pyrophosphate:
In the eighteenth century and earlier, bakers relied upon yeast to leaven all baked goods.
However, using yeast for leavening baked goods was tedious and bakers began to explore the use of chemical leavening systems.
In 1846, baking soda was discovered as a leavening agent and that led to further discoveries of acids to react with baking soda, such as SAPP.

Commercially, Disodium dihydrogen pyrophosphate was introduced into baking powder blends towards the end of the nineteenth century.
Disodium dihydrogen pyrophosphate is a preferred leavening acid because Disodium dihydrogen pyrophosphate is less expensive and stronger than other leavening acids introduced previously.

Safety of Disodium dihydrogen pyrophosphate:
As with many powdered food ingredients, inhaling fine Disodium dihydrogen pyrophosphate powder can lead to respiratory irritation.
Inhaling the dust should be avoided.
Similarly, direct eye contact with the powder may cause irritation, and Disodium dihydrogen pyrophosphate is advisable to take precautions when handling the dry powder.

Disodium dihydrogen pyrophosphate itself is not typically considered a skin irritant, prolonged or repeated skin contact with the powder may lead to dryness or minor irritation for some individuals.
Disodium dihydrogen pyrophosphate is recommended to minimize skin contact and use protective gloves when handling SAPP in its dry form.

Disodium dihydrogen pyrophosphate is intended for use in food and is considered safe for consumption when used within established limits.
However, ingestion of the undiluted dry powder is not recommended, as Disodium dihydrogen pyrophosphate may cause discomfort and digestive upset.

As with any food additive, Disodium dihydrogen pyrophosphate should be used in accordance with recommended concentrations.
To ensure the safe use of Disodium dihydrogen pyrophosphate, Disodium dihydrogen pyrophosphate is crucial to adhere to food safety regulations and guidelines established by local and international authorities, such as the U.S. Food and Drug Administration (FDA) in the United States and similar agencies in other regions.

Disodium dihydrogen pyrophosphate is considered safe for consumption when used in accordance with established regulations and guidelines.
Disodium dihydrogen pyrophosphate is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA).

Handling and Storage of Disodium dihydrogen pyrophosphate:

Precautions for safe handling:

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.

Stability and Reactivity of Disodium dihydrogen pyrophosphate:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

First Aid Measures of Disodium dihydrogen pyrophosphate:

General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.

If inhaled:
If breathed in, move person into fresh air.
Consult a physician.

In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed:
Rinse mouth with water.
Consult a physician.

Indication of any immediate medical attention and special treatment needed:
No data available

Accidental Release Measures of Disodium dihydrogen pyrophosphate:

Environmental precautions:
Do not let product enter drains.

Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Fire Fighting Measures of Disodium dihydrogen pyrophosphate:

Extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Further information:
No data available

Exposure Controls/personal Protection of Disodium dihydrogen pyrophosphate:

Personal protective equipment:

Eye/face protection:
Use safety glasses with side-shields.

Skin protection:
Handle with gloves.
Wash and dry hands.

Body Protection:
Use Impervious clothing.

Control of environmental exposure:
Do not let product enter drains.

Identifiers of Disodium dihydrogen pyrophosphate:
CAS Registry Number: 7758-16-9
Additional Names: Disodium dihydrogen pyrophosphate
Molecular Formula: H2Na2O7P2
Molecular Weight: 221.94
Percent Composition: H 0.91%, Na 20.72%, O 50.46%, P 27.91%
Line Formula: Na2H2P2O7
Literature References: Prepn: Bell, Inorg. Synth. 3, 98 (1950).
Properties: White, fused masses or powder. Dec at 220°. d (hexahydrate) 1.86. Sol in water, the soln having an acid reaction.
Density: d (hexahydrate) 1.86
Use: Chiefly in baking powders.

Properties of Disodium dihydrogen pyrophosphate:
Melting point: decomposes 220℃ [MER06]
Density (hexahydrate): 1.86
vapor pressure: 0Pa at 20℃
storage temp.: -70°C
solubility: H2O: 0.1 M at 20 °C, clear, colorless
form: white powder
color: White to Off-White
PH: 3.5-4.5 (20℃, 0.1M in H2O, freshly prepared)
Water Solubility: Fully miscible in water. Insoluble in alcohol and ammonia.
λmax: λ: 260 nm Amax: 0.11
λ: 280 nm Amax: 0.09
Merck: 13,8643
Stability: Stable.
InChI: InChI=1S/Na.H4O7P2.H/c;1-8(2,3)7-9(4,5)6;/h;(H2,1,2,3)(H2,4,5,6);
InChIKey: IQTFITJCETVNCI-UHFFFAOYSA-N
SMILES: O(P(O)(O)=O)P(O)(O)=O.[NaH]
LogP: -3.420 (est)

Appearance Form: powder
Color: white
pH: No data available
Melting point/freezing point: > 450 °C

Relative density: 2,63 at 22,5 °C
Water solubility: 170 g/l at 20 °C

Chemical formula: Na2H2P2O7
Molar mass: 221.94 g/mol
Appearance: White odorless powder

Density: 2.31 g/cm3
Melting point: >600 °C
Solubility in water: 11.9 g/100 mL (20 °C)
Refractive index (nD): 1.4645 (hexahydrate)
Assay: ≥ 95.0 %
Moisture (at 110oC): ≤ 0.50 %
pH (1 % Solution): 4.0 – 4.6
Water Insoluble Matter: ≤ 0.1 %
Phosphate (P2O5): 63.0 – 64.5 %

Rate of CO2 Release (at 2 mins): 13.0 – 17.0 %
Neutralising Value: ≥ 72.0 %
Fluoride (As F): ≤ 10.0 ppm
Arsenic (As As): ≤ 3.0 ppm
Lead (As Pb): ≤ 2.0 ppm
Cadmium (As Cd): ≤ 1.0 ppm
Heavy Metals (As Pb): ≤ 10.0 ppm
Mercury (As Hg): ≤ 1.0 ppm

IUPAC Name: Di-sodium di-hydrogen di-phosphate
Molecular Formula: Na2H2P2O7
Molecular Weight: 222.00
Appearance: White fine Powder
PH Range (1% w/v): 3.5 – 4.5
Pyro % (minimum): 98.00
P2O5 content % (minimum): 62.00
‘Na’ Content % (minimum): 20.00
Iron as ‘Fe’ content %: 0.02
Chloride as ‘Cl’ content %: 0.2
Sulfate as ‘SO4’ content %: 0.03

Specification of Disodium dihydrogen pyrophosphate:
Cyclic Phosphates: ≤ 2%
Arsenic: ≤ 3 ppm
Lead: ≤ 2 ppm
Fluoride: ≤ 10 ppm
Loss on drying: ≤ 0.5%
Assay: ≥ 95%
pH value: 3.8 - 4.2

Releated Compounds of Disodium dihydrogen pyrophosphate:
Tetrasodium pyrophosphate

Other anions:
Disodium phosphate
Pentasodium triphosphate
Sodium hexametaphosphate

Other cations:
Calcium pyrophosphate
Dipotassium pyrophosphate
DISOPYRAMIDE
Disopyramide is an organoammonium phosphate.
Disopyramide belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
Disopyramide is available in both oral and intravenous forms and has a low degree of toxicity.

CAS Number: 3737-09-5
EC Number: 244-756-1
Molecular Formula: C21H29N3O
Molar mass: 339.483 g·mol−1

Synonyms: Disopyramide PHOSPHATE, 22059-60-5, Norpace, Disopyramide PHOSPHATE SALT, Rythmodan, Norpace Cr, SC 7031 phosphate, Dirythmin sa, Diso-duriles, DisopyramidePhosphate, EINECS 244-756-1, SC 7031 (phosphate), NSC-756744, SC-13957, SC-7031 PHOSPHATE, CHEBI:4658, N6BOM1935W, 22059-60-5 (phosphate), SC 13957, Norpace (TN), 2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate, Disopyramid phosphate, 4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate, 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide;phosphoric acid, alpha-(2-Diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamide phosphate, (+-)-alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1), 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate, 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate (1:1), 2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-, phosphate, alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1), 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, (+-)-, phosphate (1:1), SR-01000003039, Disopyramide (phosphate), UNII-N6BOM1935W, SCHEMBL41810, MLS000028431, SPECTRUM1500261, C21H29N3O.H3O4P, CHEMBL1201020, HMS501I11, DTXSID30944685, Disopyramide phosphate (JAN/USP), HMS1920I14, HMS2094K15, HMS2234B16, HMS3259J21, HMS3261C04, HMS3369L05, HMS3652M20, HMS3885J07, Pharmakon1600-01500261, Disopyramide PHOSPHATE [MI], XAA05960, Disopyramide PHOSPHATE [JAN], Tox21_500411, CCG-40209, Disopyramide PHOSPHATE [USAN], HY-12533A, NSC756744, Disopyramide PHOSPHATE [VANDF], AKOS040744844, Disopyramide PHOSPHATE [MART.], Disopyramide PHOSPHATE [USP-RS], Disopyramide PHOSPHATE [WHO-DD], LP00411, NC00683, NSC 756744, Disopyramide phosphate [USAN:BAN:JAN], NCGC00093836-01, NCGC00093836-02, NCGC00093836-03, NCGC00093836-04, NCGC00261096-01, SMR000058438, Disopyramide PHOSPHATE [ORANGE BOOK], LS-130131, Disopyramide PHOSPHATE [EP MONOGRAPH], Disopyramide phosphate [USAN:USP:BAN:JAN], EU-0100411, FT-0630479, S4143, SW196836-3, SW196836-4, Disopyramide PHOSPHATE [USP MONOGRAPH], C07740, D 6035, D00637, SR-01000003039-2, SR-01000003039-6, Q27106430, 4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide, (R)-4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate, 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide,phosphoric acid, 4-DIISOPROPYLAMINO-2-PHENYL-2-(2-PYRIDYL)BUTYRAMIDE PHOSPHATE, Disopyramide phosphate, European Pharmacopoeia (EP) Reference Standard, Disopyramide phosphate, United States Pharmacopeia (USP) Reference Standard, (+/-)-.ALPHA.-(2-(DIISOPROPYLAMINO)ETHYL)-.ALPHA.-PHENYL-2-PYRIDINEACETAMIDE PHOSPHATE (1:1), 2-PYRIDINEACETAMIDE, .ALPHA.-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, (+/-)-, PHOSPHATE (1:1), 223-110-2 [EINECS], 2-pyridineacetamide, a-[2-[bis(1-methylethyl)amino]ethyl]-a-phenyl-, 2-Pyridineacetamide, α-(2-(bis(1-methylethyl)amino)ethyl)-α-phenyl-, 2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl- [ACD/Index Name], 3737-09-5 [RN], 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamid [German] [ACD/IUPAC Name], 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide [ACD/IUPAC Name], 4-(Diisopropylamino)-2-phényl-2-(2-pyridinyl)butanamide [French] [ACD/IUPAC Name], 4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide, 4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide, 4-(dipropan-2-ylamino)-2-phenyl-2-(pyridin-2-yl)butanamide, a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide, a-[2-[Bis(1-methylethyl)amino]ethyl]a-phenyl-2-pyridineacetamide, disopiramida [Spanish] [INN], Disopyramide [French] [INN], Disopyramide [BAN] [INN] [JAN] [JP15] [USAN] [Wiki], Disopyramide, (R)-, Disopyramide, (S)-, disopyramidum [Latin] [INN], Isorythm, Lispine, MFCD00057366 [MDL number], Norpace [Trade name], Rythmodan [Trade name], α-[2-(DIISOPROPYLAMINO)ETHYL]-α-PHENYL-2-PYRIDINEACETAMIDE, α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide, дизопирамид [Russian] [INN], ديسوبيراميد [Arabic] [INN], 丙吡胺 [Chinese] [INN], Disopyramide free base, NORPACE CR, Rythmodan-La, ξ-Disopyramide, [3737-09-5] [RN], 1309283-08-6 [RN], 2-Pyridineacetamide, α-(2-(diisopropylamino)ethyl)-α-phenyl-, 2-Pyridineacetamide, α-[2-(diisopropylamino)ethyl]-α-phenyl-, 2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-, 3737-09-5 (free base), 38236-46-3 [RN], 4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide, 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide, 4-[bis(methylethyl)amino]-2-phenyl-2-(2-pyridyl)butanamide, 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide, 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanimidic acid, 4-[di(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide, 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide, 492056 [Beilstein], 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide, 54687-36-4 [RN], 74464-83-8 [RN], 74464-84-9 [RN], BS-17145, DB00280, Dicorantil, Disopiramida, Disopiramida [INN-Spanish], Disopyramide-d5, Disopyramidum, Disopyramidum [INN-Latin], MFCD00069254 [MDL number], n-desalkyl Disopyramide, Norpace®, Ritmodan, Rythmodan P [Trade name], Rythmodan®, Searle 703, α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide, α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-pyridineacetamide, γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide, γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide, дизопирамид, ديسوبيراميد, 丙吡胺

Disopyramide is an antiarrhythmic chemical used in the treatment of ventricular tachycardia.
Disopyramide is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent.

Disopyramide has a negative inotropic effect on the ventricular myocardium and significantly reduces contractility.
Disopyramide also has an anticholinergic effect on the heart, which is responsible for many negative side effects.
Disopyramide is available in both oral and intravenous forms and has a low degree of toxicity.

Disopyramide is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.
Disopyramide is used at industrial sites and in manufacturing.

Disopyramide is an organoammonium phosphate.

Disopyramide is a class Ia antiarrhythmic agent with cardiac depressant properties.
Disopyramide exerts Disopyramide actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential.

This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues.
Disopyramide prolongs the QT interval and causes a widening of the QRS complex.

Disopyramide also possesses some anticholinergic and local anaesthetic properties.
Disopyramide is used in the treatment of supraventricular tachycardia.

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine.
Disopyramide also possesses some anticholinergic and local anesthetic properties.

Disopyramide belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
An irregular heartbeat is a condition in which your heart beats irregularly, too fast, or too slow.
Disopyramide helps slow the heart rate and prevent arrhythmias (abnormal heart rhythms).

Disopyramide sulphate contains Disopyramide, ie anti-arrhythmic agents.
Disopyramide helps bring irregular heartbeats to a normal rhythm by blocking certain electrical signals in the heart.
Irregular heartbeat treatment reduces the risk of blood clots, heart attack or stroke.

Disopyramide should be taken as prescribed by the doctor.
Your doctor may monitor EKGs and blood pressure during treatment to monitor your dose.

Some people may experience common side effects such as blurred or double vision, stomach pain, little or no urination, and low blood sugar.
Most of these side effects of Disopyramide do not require medical attention and will gradually improve over time.
However, if the side effects persist, please consult your doctor.

Please tell your doctor if you are known to be allergic to Disopyramide or any other medicines.
Disopyramide is not recommended for use in children.
Pregnant or breastfeeding women are advised to consult a doctor before taking Disopyramide.

Before taking Disopyramide, tell your doctor if you have kidney or liver disease, enlarged prostate, glaucoma (increased eye pressure) or low potassium levels in the blood (hypokalaemia).
Do not take Disopyramide if you are already taking other medicines to regulate your heartbeat.

Do not drive or operate machinery as Disopyramide may cause blurred vision, dizziness and low blood pressure.
Use Disopyramide with caution if you are elderly (over 65 years of age), have a low body weight, or have kidney or liver problems.

Disopyramide is used to treat certain irregular heartbeats).
Disopyramide is in a class of medications called antiarrhythmic drugs.
Disopyramide works by making your heart more resistant to abnormal activity.

Continuing Education Activity:
Disopyramide is a chemical used to treat heart rhythm abnormalities that can be life-threatening, such as ventricular tachycardia/fibrillation, or associated with increased morbidity and mortality, such as atrial fibrillation and hypertrophic cardiomyopathy.
This activity reviews several important aspects of this chemical, including indications, mechanism of action, applications, side effects, contraindications, monitoring, and toxicity.
This important knowledge of this chemical can improve interprofessional healthcare team outcomes.

Objectives:
Describe the mechanism of action of Disopyramide.
Describe possible side effects of Disopyramide.

Explains the importance of monitoring when using Disopyramide as an antiarrhythmic chemical.
Outline professional team strategies for improving care coordination and communication when using Disopyramide to maximize the benefits of this chemical and minimize Disopyramide side effects.

Indications:
In 1962, new antiarrhythmic drugs were needed apart from quinidine and procainamide, which were the main antiarrhythmic agents available at the time.
Disopyramide is the selected agent among more than 500 compounds synthesized for the research program of new antiarrhythmic agents.
The chemical structures of Disopyramide are similar to the synthetic muscarinic antagonist lacquer, which explains Disopyramide anticholinergic property.

Although Disopyramide is rarely used for heart rhythm abnormalities due to the availability of newer drugs that provide better efficacy and favorable side-effect profiles, Disopyramide is still the drug of choice for vagal-mediated atrial fibrillation such as sleep-induced or atrial fibrillation in athlete groups.
The effectiveness of Disopyramide in these conditions is due to Disopyramide anticholinergic activity, which abolishes the parasympathetic tone.

Disopyramide is also a third-line antiarrhythmic agent for a patient with coronary artery disease.
Also, a patient with left ventricular hypertrophy has impaired depolarization, which can induce torsade de pointes.

Therefore, antiarrhythmics that prolong the QT interval are avoided, but if sotalol or amiodarone is unsuccessful or unsuitable, Disopyramide may be an alternative.
In a patient with atrial fibrillation and hypertrophic obstructive cardiomyopathy (HOCM), Disopyramide is the agent of choice, other than amiodarone, as Disopyramide may decrease the left ventricular outflow tract (LVOT) gradient (off-label use).

Data from a multicenter study of the safety and efficacy of Disopyramide in obstructive cardiomyopathy showed that Disopyramide significantly reduced the SVOT gradient from 75+/- 33 to 40+/-32 mmHg in 78 patients (66% of study subjects) (P<0.0001). has shown. ) and raises the New York Heart Association functional class (NYHA FC) from 23+/-07 to 17+/-06 (P<0.0001).
When Disopyramide is used in combination with a non-dihydropyridine calcium channel blocker or beta blocker, they can effectively prevent recurrence of AF in HCOM patients.

Patients with ventricular premature beat (VPB) or premature ventricular complexes (PVC) may have a high symptom burden.
Disopyramide can be used in patients without structural heart disease, although Disopyramide efficacy is less than ablation.
In addition, based on a randomized, double-blind, placebo-controlled one-year follow-up study, Disopyramide (n=44) was effective in maintaining sinus rhythm after electro cardioversion for atrial fibrillation compared to placebo (n=46) and was significantly different (%) at one-month follow-up. 70 vs 39%) and continues after twelve months (54% vs 30%).

Uses of Disopyramide:
Disopyramide is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as sustained ventricular tachycardia).
Disopyramide is used to restore normal heart rhythm and maintain a regular, steady heartbeat.

Disopyramide is known as an anti-arrhythmic drug.
Disopyramide works by blocking certain electrical signals in the heart that can cause an irregular heartbeat.
Treating an irregular heartbeat can decrease the risk for blood clots, and this effect can reduce your risk of heart attack or stroke.

Usage of Disopyramide:
Disopyramide comes as a capsule and an extended-release (long-acting) capsule to take by mouth.
Disopyramide capsules may be taken every 6 or 8 hours.

The extended-release capsule is usually taken every 12 hours.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take Disopyramide exactly as directed.
Do not take more or less of Disopyramide or take it more often than prescribed by your doctor.

Swallow the extended-release capsules; do not open, crush, or chew them.

Disopyramide helps control your condition but will not cure it.
Continue to take Disopyramide even if you feel well.
Do not stop taking Disopyramide without talking to your doctor.

Mechanism of action of Disopyramide:
Disopyramide's Class 1a activity is similar to that of quinidine in that Disopyramide targets sodium channels to inhibit conduction.
Disopyramide depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current.

This results in an increased threshold for excitation and a decreased upstroke velocity.
Disopyramide prolongs the PR interval by lengthening both the QRS and P wave duration.

This effect is particularly well suited in the treatment of ventricular tachycardia as Disopyramide slows the action potential propagation through the atria to the ventricles.
Disopyramide does not act as a blocking agent for beta or alpha adrenergic receptors, but does have a significant negative inotropic effect on the ventricular myocardium.
As a result, the use of Disopyramide may reduce contractile force up to 42% at low doses and up to 100% in higher doses compared to quinidine.

Levites proposed a possible secondary mode of action for Disopyramide, against reentrant arrhythmias after an ischemic insult.
Disopyramide decreases the inhomogeneity between infarcted and normal myocardium refractory periods; in addition to lengthening the refractory period.

This decreases the chance of re-entry depolarization, because signals are more likely to encounter tissue in a refractory state which cannot be excited.
This provides a possible treatment for atrial and ventricular fibrillation, as Disopyramide restores pacemaker control of the tissue to the SA and AV nodes.

Pharmacology and Biochemistry of Disopyramide:

MeSH Pharmacological Classification:

Anti-Arrhythmia Agents:
Agents used for the treatment or prevention of cardiac arrhythmias.
They may affect the polarization-repolarization phase of the action potential, Disopyramide excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Obstructive hypertrophic cardiomyopathy:
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease, occurring in 1:500 individuals in the general population.
Disopyramide is estimated that there are 600,000 individuals in the United States with hypertrophic cardiomyopathy.

The most common variant of HCM presents with left ventricular (LV) intracavitary obstruction due to systolic anterior motion of the mitral valve, and mitral-septal contact, diagnosed readily with echocardiography.
Pharmacologic treatment with negative inotropic drugs is first-line therapy.

Beta-blockers are used first, and while they improve symptoms of shortness of breath, chest pain and exercise intolerance, they do not reduce resting LV intraventricular pressure gradients and often are inadequate to control symptoms.
Many investigators and clinicians believe that Disopyramide controlled release is the most potent agent available for reducing resting pressure gradients and improving symptoms.

Disopyramide has been actively used for more than 30 years.
Disopyramide administration for obstructive HCM has a IB recommendation in the 2020 American Heart Association/American College of Cardiology Foundation guidelines for treatment of obstructive HCM.
A IB treatment recommendation indicates that a treatment is recommended, and may be useful, and beneficial.

Negative inotropes improve LV obstruction by decreasing LV ejection acceleration and hydrodynamic forces on the mitral valve.
Disopyramide's particular efficacy is due to Disopyramide potent negative inotropic effects; in head-to-head comparison, Disopyramide is more effective for gradient reduction than either beta-blocker or verapamil.

Disopyramide is most often administered with beta-blockade.
When used in patients resistant to beta-blockade, Disopyramide is effective in 60% of cases, reducing symptoms and gradient to the extent that invasive procedures such as surgical septal myectomy are not required.

Disopyramide, despite Disopyramide efficacy, has one main side effect that has limited Disopyramide use in the US, though Disopyramide has seen wider application in Canada, UK and Japan.
Vagal blockade predictably causes dry mouth, and in men with prostatism, may cause urinary retention.
Teichman et al. showed that pyridostigmine used in combination with Disopyramide substantially alleviates vagolytic side effects without compromising antiarrhythmic efficacy.

This combination has also been shown to be effective and safe in obstructive HCM in a large cohort of patients.
Some clinicians prescribe pyridostigmine sustained release (marketed in the US as Mestinon Timespan) to every patient begun on Disopyramide.
This combination increases acceptance of higher Disopyramide dosing, important since there is a dose-response correlation in obstructive HCM, higher doses yielding lower gradients.

Another concern about Disopyramide has been the hypothetical potential for inducing sudden death from Disopyramide type 1 anti-arrhythmic effects.
However, a multicenter registry and two recent cohort registries have largely reduced this concern, by showing sudden death rates lower than that observed from the disease itself.

These concerns about the drug must be viewed from the clinical perspective that Disopyramide is generally the last agent that is tried for patients before they are referred for invasive septal reduction with surgical septal myectomy (an open-heart operation) or alcohol septal ablation (a controlled heart attack).
Both of these invasive procedures have risk of morbidity and mortality.

For selected patients, a trial of oral Disopyramide is a reasonable approach before proceeding to invasive septal reduction.
Patients who respond to Disopyramide are continued on the drug.

Those who continue to have disabling symptoms or who experience side effects are promptly referred for septal reduction.
Using such a stepped strategy, investigators have reported that survival does not differ from that observed in the age-matched normal United States population.

Extracardiac effects:
Atropine like effects (anticholinergic)
Dry mouth
Constipation
Urinary retention – Disopyramide should not be given to patients with symptomatic prostatism.
Blurred vision
Glaucoma
Rash
Agranulocytosis

Additionally, Disopyramide may enhance the hypoglycaemic effect of gliclazide, insulin, and metformin.

Metabolism of Disopyramide:
Disopyramide can cause hypoglycemia, perhaps due to increased secretion of insulin, and can also potentiate the effects of conventional hypoglycemic drugs.
This effect may be due to Disopyramide chief metabolite mono-N dealkylDisopyramide, since many of the reported cases of hypoglycemia have been in patients with renal impairment, in which the metabolite accumulates.

In six subjects who were being considered for treatment with Disopyramide, serum glucose concentrations were measured at 13, 15, 17, and 19 hours after supper, with no further food, with and without the added administration of two modified-released tablets of Disopyramide 150 mg with supper and 12 hours later.
Disopyramide significantly reduced the serum glucose concentration at all measurement times by an average of 0.54 mmol/l.
The fall in serum glucose concentration was not related to the serum concentration of Disopyramide or the serum creatinine concentration; Disopyramide was greater in older patients and in underweight patients.

Hypoglycemia has also been reported in a 70-year-old woman with type 2 diabetes mellitus taking Disopyramide.

Clinical data of Disopyramide:
Trade names: Norpace
AHFS/Drugs.com: Monograph
MedlinePlus: a682408
Pregnancy category: AU: B2
Routes ofadministration: Oral, intravenous
ATC code: C01BA03 (WHO)

Legal status:
UK: POM (Prescription only)
US: ℞-only

Pharmacokinetic data of Disopyramide:
Bioavailability: High
Protein binding: 50% to 65% (concentration-dependent)
Metabolism: Hepatic (CYP3A4-mediated)
Elimination half-life: 6.7 hours (range 4 to 10 hours)
Excretion: Renal (80%)

Identifiers of Disopyramide:
IUPAC name: (RS)-4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
CAS Number: 3737-09-5
PubChem CID: 3114
IUPHAR/BPS: 7167
DrugBank: DB00280
ChemSpider: 3002
UNII: GFO928U8MQ
KEGG: D00303
ChEBI: CHEBI:4657
ChEMBL: ChEMBL517
CompTox Dashboard (EPA): DTXSID1045536
ECHA InfoCard: 100.021.010

Properties of Disopyramide:
Formula: C21H29N3O
Molar mass: 339.483 g·mol−1
Melting point: 94.5 to 95 °C (202.1 to 203.0 °F)
SMILES: O=C(N)C(c1ncccc1)(c2ccccc2)CCN(C(C)C)C(C)C
InChI: InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
Key:UVTNFZQICZKOEM-UHFFFAOYSA-N

Molecular Weight: 437.5 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 8
Exact Mass: 437.20795813 g/mol
Monoisotopic Mass: 437.20795813 g/mol
Topological Polar Surface Area: 137Ų
Heavy Atom Count: 30
Complexity: 459
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Names of Disopyramide:

Regulatory process names:
Disopyramide
Disopyramide

IUPAC names:
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
Disopyramide

Other identifiers:
3737-09-5
DISOPYRAMIDE
Disopyramide is an organoammonium phosphate.
Disopyramide belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
Disopyramide is available in both oral and intravenous forms and has a low degree of toxicity.

CAS Number: 3737-09-5
Formula: C21H29N3O
Molar mass: 339.483 g·mol−1

Disopyramide is an antiarrhythmic chemical used in the treatment of ventricular tachycardia.
Disopyramide is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent.

Disopyramide has a negative inotropic effect on the ventricular myocardium and significantly reduces contractility.
Disopyramide also has an anticholinergic effect on the heart, which is responsible for many negative side effects.
Disopyramide is available in both oral and intravenous forms and has a low degree of toxicity.

Disopyramide is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.
Disopyramide is used at industrial sites and in manufacturing.

Disopyramide is an organoammonium phosphate.

Disopyramide is a class Ia antiarrhythmic agent with cardiac depressant properties.
Disopyramide exerts Disopyramide actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential.

This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues.
Disopyramide prolongs the QT interval and causes a widening of the QRS complex.

Disopyramide also possesses some anticholinergic and local anaesthetic properties.
Disopyramide is used in the treatment of supraventricular tachycardia.

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine.
Disopyramide also possesses some anticholinergic and local anesthetic properties.

Disopyramide belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
An irregular heartbeat is a condition in which your heart beats irregularly, too fast, or too slow.
Disopyramide helps slow the heart rate and prevent arrhythmias (abnormal heart rhythms).

Disopyramide sulphate contains Disopyramide, ie anti-arrhythmic agents.
Disopyramide helps bring irregular heartbeats to a normal rhythm by blocking certain electrical signals in the heart.
Irregular heartbeat treatment reduces the risk of blood clots, heart attack or stroke.

Disopyramide should be taken as prescribed by the doctor.
Your doctor may monitor EKGs and blood pressure during treatment to monitor your dose.

Some people may experience common side effects such as blurred or double vision, stomach pain, little or no urination, and low blood sugar.
Most of these side effects of Disopyramide do not require medical attention and will gradually improve over time.
However, if the side effects persist, please consult your doctor.

Please tell your doctor if you are known to be allergic to Disopyramide or any other medicines.
Disopyramide is not recommended for use in children.
Pregnant or breastfeeding women are advised to consult a doctor before taking Disopyramide.

Before taking Disopyramide, tell your doctor if you have kidney or liver disease, enlarged prostate, glaucoma (increased eye pressure) or low potassium levels in the blood (hypokalaemia).
Do not take Disopyramide if you are already taking other medicines to regulate your heartbeat.

Do not drive or operate machinery as Disopyramide may cause blurred vision, dizziness and low blood pressure.
Use Disopyramide with caution if you are elderly (over 65 years of age), have a low body weight, or have kidney or liver problems.

Disopyramide is used to treat certain irregular heartbeats).
Disopyramide is in a class of medications called antiarrhythmic drugs.
Disopyramide works by making your heart more resistant to abnormal activity.

Continuing Education Activity:
Disopyramide is a chemical used to treat heart rhythm abnormalities that can be life-threatening, such as ventricular tachycardia/fibrillation, or associated with increased morbidity and mortality, such as atrial fibrillation and hypertrophic cardiomyopathy.
This activity reviews several important aspects of this chemical, including indications, mechanism of action, applications, side effects, contraindications, monitoring, and toxicity.
This important knowledge of this chemical can improve interprofessional healthcare team outcomes.

Objectives:
Describe the mechanism of action of Disopyramide.
Describe possible side effects of Disopyramide.

Explains the importance of monitoring when using Disopyramide as an antiarrhythmic chemical.
Outline professional team strategies for improving care coordination and communication when using Disopyramide to maximize the benefits of this chemical and minimize Disopyramide side effects.

Indications:
In 1962, new antiarrhythmic drugs were needed apart from quinidine and procainamide, which were the main antiarrhythmic agents available at the time.
Disopyramide is the selected agent among more than 500 compounds synthesized for the research program of new antiarrhythmic agents.
The chemical structures of Disopyramide are similar to the synthetic muscarinic antagonist lacquer, which explains Disopyramide anticholinergic property.

Although Disopyramide is rarely used for heart rhythm abnormalities due to the availability of newer drugs that provide better efficacy and favorable side-effect profiles, Disopyramide is still the drug of choice for vagal-mediated atrial fibrillation such as sleep-induced or atrial fibrillation in athlete groups.
The effectiveness of Disopyramide in these conditions is due to Disopyramide anticholinergic activity, which abolishes the parasympathetic tone.

Disopyramide is also a third-line antiarrhythmic agent for a patient with coronary artery disease.
Also, a patient with left ventricular hypertrophy has impaired depolarization, which can induce torsade de pointes.

Therefore, antiarrhythmics that prolong the QT interval are avoided, but if sotalol or amiodarone is unsuccessful or unsuitable, Disopyramide may be an alternative.
In a patient with atrial fibrillation and hypertrophic obstructive cardiomyopathy (HOCM), Disopyramide is the agent of choice, other than amiodarone, as Disopyramide may decrease the left ventricular outflow tract (LVOT) gradient (off-label use).

Data from a multicenter study of the safety and efficacy of Disopyramide in obstructive cardiomyopathy showed that Disopyramide significantly reduced the SVOT gradient from 75+/- 33 to 40+/-32 mmHg in 78 patients (66% of study subjects) (P<0.0001). has shown. ) and raises the New York Heart Association functional class (NYHA FC) from 23+/-07 to 17+/-06 (P<0.0001).
When Disopyramide is used in combination with a non-dihydropyridine calcium channel blocker or beta blocker, they can effectively prevent recurrence of AF in HCOM patients.

Patients with ventricular premature beat (VPB) or premature ventricular complexes (PVC) may have a high symptom burden.
Disopyramide can be used in patients without structural heart disease, although Disopyramide efficacy is less than ablation.
In addition, based on a randomized, double-blind, placebo-controlled one-year follow-up study, Disopyramide (n=44) was effective in maintaining sinus rhythm after electro cardioversion for atrial fibrillation compared to placebo (n=46) and was significantly different (%) at one-month follow-up. 70 vs 39%) and continues after twelve months (54% vs 30%).

Uses of Disopyramide:
Disopyramide is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as sustained ventricular tachycardia).
Disopyramide is used to restore normal heart rhythm and maintain a regular, steady heartbeat.

Disopyramide is known as an anti-arrhythmic drug.
Disopyramide works by blocking certain electrical signals in the heart that can cause an irregular heartbeat.
Treating an irregular heartbeat can decrease the risk for blood clots, and this effect can reduce your risk of heart attack or stroke.

Usage of Disopyramide:
Disopyramide comes as a capsule and an extended-release (long-acting) capsule to take by mouth.
Disopyramide capsules may be taken every 6 or 8 hours.

The extended-release capsule is usually taken every 12 hours.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take Disopyramide exactly as directed.
Do not take more or less of Disopyramide or take it more often than prescribed by your doctor.

Swallow the extended-release capsules; do not open, crush, or chew them.

Disopyramide helps control your condition but will not cure it.
Continue to take Disopyramide even if you feel well.
Do not stop taking Disopyramide without talking to your doctor.

Mechanism of action of Disopyramide:
Disopyramide's Class 1a activity is similar to that of quinidine in that Disopyramide targets sodium channels to inhibit conduction.
Disopyramide depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current.

This results in an increased threshold for excitation and a decreased upstroke velocity.
Disopyramide prolongs the PR interval by lengthening both the QRS and P wave duration.

This effect is particularly well suited in the treatment of ventricular tachycardia as Disopyramide slows the action potential propagation through the atria to the ventricles.
Disopyramide does not act as a blocking agent for beta or alpha adrenergic receptors, but does have a significant negative inotropic effect on the ventricular myocardium.
As a result, the use of Disopyramide may reduce contractile force up to 42% at low doses and up to 100% in higher doses compared to quinidine.

Levites proposed a possible secondary mode of action for Disopyramide, against reentrant arrhythmias after an ischemic insult.
Disopyramide decreases the inhomogeneity between infarcted and normal myocardium refractory periods; in addition to lengthening the refractory period.

This decreases the chance of re-entry depolarization, because signals are more likely to encounter tissue in a refractory state which cannot be excited.
This provides a possible treatment for atrial and ventricular fibrillation, as Disopyramide restores pacemaker control of the tissue to the SA and AV nodes.

Pharmacology and Biochemistry of Disopyramide:

MeSH Pharmacological Classification:

Anti-Arrhythmia Agents:
Agents used for the treatment or prevention of cardiac arrhythmias.
They may affect the polarization-repolarization phase of the action potential, Disopyramide excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Obstructive hypertrophic cardiomyopathy:
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease, occurring in 1:500 individuals in the general population.
Disopyramide is estimated that there are 600,000 individuals in the United States with hypertrophic cardiomyopathy.

The most common variant of HCM presents with left ventricular (LV) intracavitary obstruction due to systolic anterior motion of the mitral valve, and mitral-septal contact, diagnosed readily with echocardiography.
Pharmacologic treatment with negative inotropic drugs is first-line therapy.

Beta-blockers are used first, and while they improve symptoms of shortness of breath, chest pain and exercise intolerance, they do not reduce resting LV intraventricular pressure gradients and often are inadequate to control symptoms.
Many investigators and clinicians believe that Disopyramide controlled release is the most potent agent available for reducing resting pressure gradients and improving symptoms.

Disopyramide has been actively used for more than 30 years.
Disopyramide administration for obstructive HCM has a IB recommendation in the 2020 American Heart Association/American College of Cardiology Foundation guidelines for treatment of obstructive HCM.
A IB treatment recommendation indicates that a treatment is recommended, and may be useful, and beneficial.

Negative inotropes improve LV obstruction by decreasing LV ejection acceleration and hydrodynamic forces on the mitral valve.
Disopyramide's particular efficacy is due to Disopyramide potent negative inotropic effects; in head-to-head comparison, Disopyramide is more effective for gradient reduction than either beta-blocker or verapamil.

Disopyramide is most often administered with beta-blockade.
When used in patients resistant to beta-blockade, Disopyramide is effective in 60% of cases, reducing symptoms and gradient to the extent that invasive procedures such as surgical septal myectomy are not required.

Disopyramide, despite Disopyramide efficacy, has one main side effect that has limited Disopyramide use in the US, though Disopyramide has seen wider application in Canada, UK and Japan.
Vagal blockade predictably causes dry mouth, and in men with prostatism, may cause urinary retention.
Teichman et al. showed that pyridostigmine used in combination with Disopyramide substantially alleviates vagolytic side effects without compromising antiarrhythmic efficacy.

This combination has also been shown to be effective and safe in obstructive HCM in a large cohort of patients.
Some clinicians prescribe pyridostigmine sustained release (marketed in the US as Mestinon Timespan) to every patient begun on Disopyramide.
This combination increases acceptance of higher Disopyramide dosing, important since there is a dose-response correlation in obstructive HCM, higher doses yielding lower gradients.

Another concern about Disopyramide has been the hypothetical potential for inducing sudden death from Disopyramide type 1 anti-arrhythmic effects.
However, a multicenter registry and two recent cohort registries have largely reduced this concern, by showing sudden death rates lower than that observed from the disease itself.

These concerns about the drug must be viewed from the clinical perspective that Disopyramide is generally the last agent that is tried for patients before they are referred for invasive septal reduction with surgical septal myectomy (an open-heart operation) or alcohol septal ablation (a controlled heart attack).
Both of these invasive procedures have risk of morbidity and mortality.

For selected patients, a trial of oral Disopyramide is a reasonable approach before proceeding to invasive septal reduction.
Patients who respond to Disopyramide are continued on the drug.

Those who continue to have disabling symptoms or who experience side effects are promptly referred for septal reduction.
Using such a stepped strategy, investigators have reported that survival does not differ from that observed in the age-matched normal United States population.

Extracardiac effects:
Atropine like effects (anticholinergic)
Dry mouth
Constipation
Urinary retention – Disopyramide should not be given to patients with symptomatic prostatism.
Blurred vision
Glaucoma
Rash
Agranulocytosis

Additionally, Disopyramide may enhance the hypoglycaemic effect of gliclazide, insulin, and metformin.

Metabolism of Disopyramide:
Disopyramide can cause hypoglycemia, perhaps due to increased secretion of insulin, and can also potentiate the effects of conventional hypoglycemic drugs.
This effect may be due to Disopyramide chief metabolite mono-N dealkylDisopyramide, since many of the reported cases of hypoglycemia have been in patients with renal impairment, in which the metabolite accumulates.

In six subjects who were being considered for treatment with Disopyramide, serum glucose concentrations were measured at 13, 15, 17, and 19 hours after supper, with no further food, with and without the added administration of two modified-released tablets of Disopyramide 150 mg with supper and 12 hours later.
Disopyramide significantly reduced the serum glucose concentration at all measurement times by an average of 0.54 mmol/l.
The fall in serum glucose concentration was not related to the serum concentration of Disopyramide or the serum creatinine concentration; Disopyramide was greater in older patients and in underweight patients.

Hypoglycemia has also been reported in a 70-year-old woman with type 2 diabetes mellitus taking Disopyramide.

Clinical data of Disopyramide:
Trade names: Norpace
AHFS/Drugs.com: Monograph
MedlinePlus: a682408
Pregnancy category: AU: B2
Routes ofadministration: Oral, intravenous
ATC code: C01BA03 (WHO)

Legal status:
UK: POM (Prescription only)
US: ℞-only

Pharmacokinetic data of Disopyramide:
Bioavailability: High
Protein binding: 50% to 65% (concentration-dependent)
Metabolism: Hepatic (CYP3A4-mediated)
Elimination half-life: 6.7 hours (range 4 to 10 hours)
Excretion: Renal (80%)

Identifiers of Disopyramide:
IUPAC name: (RS)-4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
CAS Number: 3737-09-5
PubChem CID: 3114
IUPHAR/BPS: 7167
DrugBank: DB00280
ChemSpider: 3002
UNII: GFO928U8MQ
KEGG: D00303
ChEBI: CHEBI:4657
ChEMBL: ChEMBL517
CompTox Dashboard (EPA): DTXSID1045536
ECHA InfoCard: 100.021.010

Properties of Disopyramide:
Formula: C21H29N3O
Molar mass: 339.483 g·mol−1
Melting point: 94.5 to 95 °C (202.1 to 203.0 °F)
SMILES: O=C(N)C(c1ncccc1)(c2ccccc2)CCN(C(C)C)C(C)C
InChI: InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
Key:UVTNFZQICZKOEM-UHFFFAOYSA-N

Molecular Weight: 437.5 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 8
Exact Mass: 437.20795813 g/mol
Monoisotopic Mass: 437.20795813 g/mol
Topological Polar Surface Area: 137Ų
Heavy Atom Count: 30
Complexity: 459
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Names of Disopyramide:

Regulatory process names:
Disopyramide
Disopyramide

IUPAC names:
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
Disopyramide

Other identifiers:
3737-09-5

Synonyms of Disopyramide:
Disopyramide PHOSPHATE
22059-60-5
Norpace
Disopyramide PHOSPHATE SALT
Rythmodan
Norpace Cr
SC 7031 phosphate
Dirythmin sa
Diso-duriles
DisopyramidePhosphate
EINECS 244-756-1
SC 7031 (phosphate)
NSC-756744
SC-13957
SC-7031 PHOSPHATE
CHEBI:4658
N6BOM1935W
22059-60-5 (phosphate)
SC 13957
Norpace (TN)
2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate
Disopyramid phosphate
4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide;phosphoric acid
alpha-(2-Diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamide phosphate
(+-)-alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1)
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate (1:1)
2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-, phosphate
alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1)
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, (+-)-, phosphate (1:1)
SR-01000003039
Disopyramide (phosphate)
UNII-N6BOM1935W
SCHEMBL41810
MLS000028431
SPECTRUM1500261
C21H29N3O.H3O4P
CHEMBL1201020
HMS501I11
DTXSID30944685
Disopyramide phosphate (JAN/USP)
HMS1920I14
HMS2094K15
HMS2234B16
HMS3259J21
HMS3261C04
HMS3369L05
HMS3652M20
HMS3885J07
Pharmakon1600-01500261
Disopyramide PHOSPHATE [MI]
XAA05960
Disopyramide PHOSPHATE [JAN]
Tox21_500411
CCG-40209
Disopyramide PHOSPHATE [USAN]
HY-12533A
NSC756744
Disopyramide PHOSPHATE [VANDF]
AKOS040744844
Disopyramide PHOSPHATE [MART.]
Disopyramide PHOSPHATE [USP-RS]
Disopyramide PHOSPHATE [WHO-DD]
LP00411
NC00683
NSC 756744
Disopyramide phosphate [USAN:BAN:JAN]
NCGC00093836-01
NCGC00093836-02
NCGC00093836-03
NCGC00093836-04
NCGC00261096-01
SMR000058438
Disopyramide PHOSPHATE [ORANGE BOOK]
LS-130131
Disopyramide PHOSPHATE [EP MONOGRAPH]
Disopyramide phosphate [USAN:USP:BAN:JAN]
EU-0100411
FT-0630479
S4143
SW196836-3
SW196836-4
Disopyramide PHOSPHATE [USP MONOGRAPH]
C07740
D 6035
D00637
SR-01000003039-2
SR-01000003039-6
Q27106430
4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide
(R)-4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide,phosphoric acid
4-DIISOPROPYLAMINO-2-PHENYL-2-(2-PYRIDYL)BUTYRAMIDE PHOSPHATE
Disopyramide phosphate, European Pharmacopoeia (EP) Reference Standard
Disopyramide phosphate, United States Pharmacopeia (USP) Reference Standard
(+/-)-.ALPHA.-(2-(DIISOPROPYLAMINO)ETHYL)-.ALPHA.-PHENYL-2-PYRIDINEACETAMIDE PHOSPHATE (1:1)
2-PYRIDINEACETAMIDE, .ALPHA.-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, (+/-)-, PHOSPHATE (1:1)
223-110-2 [EINECS]
2-pyridineacetamide, a-[2-[bis(1-methylethyl)amino]ethyl]-a-phenyl-
2-Pyridineacetamide, α-(2-(bis(1-methylethyl)amino)ethyl)-α-phenyl-
2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl- [ACD/Index Name]
3737-09-5 [RN]
4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamid [German] [ACD/IUPAC Name]
4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide [ACD/IUPAC Name]
4-(Diisopropylamino)-2-phényl-2-(2-pyridinyl)butanamide [French] [ACD/IUPAC Name]
4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide
4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
4-(dipropan-2-ylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide
a-[2-[Bis(1-methylethyl)amino]ethyl]a-phenyl-2-pyridineacetamide
disopiramida [Spanish] [INN]
Disopyramide [French] [INN]
Disopyramide [BAN] [INN] [JAN] [JP15] [USAN] [Wiki]
Disopyramide, (R)-
Disopyramide, (S)-
disopyramidum [Latin] [INN]
Isorythm
Lispine
MFCD00057366 [MDL number]
Norpace [Trade name]
Rythmodan [Trade name]
α-[2-(DIISOPROPYLAMINO)ETHYL]-α-PHENYL-2-PYRIDINEACETAMIDE
α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide
дизопирамид [Russian] [INN]
ديسوبيراميد [Arabic] [INN]
丙吡胺 [Chinese] [INN]
Disopyramide free base
NORPACE CR
Rythmodan-La
ξ-Disopyramide
[3737-09-5] [RN]
1309283-08-6 [RN]
2-Pyridineacetamide, α-(2-(diisopropylamino)ethyl)-α-phenyl-
2-Pyridineacetamide, α-[2-(diisopropylamino)ethyl]-α-phenyl-
2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-
3737-09-5 (free base)
38236-46-3 [RN]
4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[bis(methylethyl)amino]-2-phenyl-2-(2-pyridyl)butanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanimidic acid
4-[di(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
492056 [Beilstein]
4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide
54687-36-4 [RN]
74464-83-8 [RN]
74464-84-9 [RN]
BS-17145
DB00280
Dicorantil
Disopiramida
Disopiramida [INN-Spanish]
Disopyramide-d5
Disopyramidum
Disopyramidum [INN-Latin]
MFCD00069254 [MDL number]
n-desalkyl Disopyramide
Norpace®
Ritmodan
Rythmodan P [Trade name]
Rythmodan®
Searle 703
α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide
α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide
α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-pyridineacetamide
γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide
γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide
дизопирамид
ديسوبيراميد
丙吡胺
DISOPYRAMIDE PHOSPHATE
Disopyramide phosphate is an organoammonium phosphate.
Disopyramide phosphate belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
Disopyramide phosphate is available in both oral and intravenous forms and has a low degree of toxicity.

CAS Number: 3737-09-5
Molecular Formula: C21H29N3O
Molar Mass: 339.483 g·mol−1

Synonyms: Disopyramide PHOSPHATE, 22059-60-5, Norpace, Disopyramide PHOSPHATE SALT, Rythmodan, Norpace Cr, SC 7031 phosphate, Dirythmin sa, Diso-duriles, DisopyramidePhosphate, EINECS 244-756-1, SC 7031 (phosphate), NSC-756744, SC-13957, SC-7031 PHOSPHATE, CHEBI:4658, N6BOM1935W, 22059-60-5 (phosphate), SC 13957, Norpace (TN), 2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium phosphate, Disopyramid phosphate, 4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate, 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide;phosphoric acid, alpha-(2-Diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamide phosphate, (+-)-alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1), 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate, 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, phosphate (1:1), 2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-, phosphate, alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide phosphate (1:1), 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-, (+-)-, phosphate (1:1), SR-01000003039, Disopyramide (phosphate), UNII-N6BOM1935W, SCHEMBL41810, MLS000028431, SPECTRUM1500261, C21H29N3O.H3O4P, CHEMBL1201020, HMS501I11, DTXSID30944685, Disopyramide phosphate (JAN/USP), HMS1920I14, HMS2094K15, HMS2234B16, HMS3259J21, HMS3261C04, HMS3369L05, HMS3652M20, HMS3885J07, Pharmakon1600-01500261, Disopyramide PHOSPHATE [MI], XAA05960, Disopyramide PHOSPHATE [JAN], Tox21_500411, CCG-40209, Disopyramide PHOSPHATE [USAN], HY-12533A, NSC756744, Disopyramide PHOSPHATE [VANDF], AKOS040744844, Disopyramide PHOSPHATE [MART.], Disopyramide PHOSPHATE [USP-RS], Disopyramide PHOSPHATE [WHO-DD], LP00411, NC00683, NSC 756744, Disopyramide phosphate [USAN:BAN:JAN], NCGC00093836-01, NCGC00093836-02, NCGC00093836-03, NCGC00093836-04, NCGC00261096-01, SMR000058438, Disopyramide PHOSPHATE [ORANGE BOOK], LS-130131, Disopyramide PHOSPHATE [EP MONOGRAPH], Disopyramide phosphate [USAN:USP:BAN:JAN], EU-0100411, FT-0630479, S4143, SW196836-3, SW196836-4, Disopyramide PHOSPHATE [USP MONOGRAPH], C07740, D 6035, D00637, SR-01000003039-2, SR-01000003039-6, Q27106430, 4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide, (R)-4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide phosphate, 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide,phosphoric acid, 4-DIISOPROPYLAMINO-2-PHENYL-2-(2-PYRIDYL)BUTYRAMIDE PHOSPHATE, Disopyramide phosphate, European Pharmacopoeia (EP) Reference Standard, Disopyramide phosphate, United States Pharmacopeia (USP) Reference Standard, (+/-)-.ALPHA.-(2-(DIISOPROPYLAMINO)ETHYL)-.ALPHA.-PHENYL-2-PYRIDINEACETAMIDE PHOSPHATE (1:1), 2-PYRIDINEACETAMIDE, .ALPHA.-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, (+/-)-, PHOSPHATE (1:1), 223-110-2 [EINECS], 2-pyridineacetamide, a-[2-[bis(1-methylethyl)amino]ethyl]-a-phenyl-, 2-Pyridineacetamide, α-(2-(bis(1-methylethyl)amino)ethyl)-α-phenyl-, 2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl- [ACD/Index Name], 3737-09-5 [RN], 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamid [German] [ACD/IUPAC Name], 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide [ACD/IUPAC Name], 4-(Diisopropylamino)-2-phényl-2-(2-pyridinyl)butanamide [French] [ACD/IUPAC Name], 4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide, 4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide, 4-(dipropan-2-ylamino)-2-phenyl-2-(pyridin-2-yl)butanamide, a-[2-(Diisopropylamino)ethyl]-a-phenyl-2-pyridineacetamide, a-[2-[Bis(1-methylethyl)amino]ethyl]a-phenyl-2-pyridineacetamide, disopiramida [Spanish] [INN], Disopyramide [French] [INN], Disopyramide [BAN] [INN] [JAN] [JP15] [USAN] [Wiki], Disopyramide, (R)-, Disopyramide, (S)-, disopyramidum [Latin] [INN], Isorythm, Lispine, MFCD00057366 [MDL number], Norpace [Trade name], Rythmodan [Trade name], α-[2-(DIISOPROPYLAMINO)ETHYL]-α-PHENYL-2-PYRIDINEACETAMIDE, α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide, дизопирамид [Russian] [INN], ديسوبيراميد [Arabic] [INN], 丙吡胺 [Chinese] [INN], Disopyramide free base, NORPACE CR, Rythmodan-La, ξ-Disopyramide, [3737-09-5] [RN], 1309283-08-6 [RN], 2-Pyridineacetamide, α-(2-(diisopropylamino)ethyl)-α-phenyl-, 2-Pyridineacetamide, α-[2-(diisopropylamino)ethyl]-α-phenyl-, 2-Pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-, 3737-09-5 (free base), 38236-46-3 [RN], 4-(diisopropylamino)-2-phenyl-2-(2-pyridyl)butanamide, 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide, 4-[bis(methylethyl)amino]-2-phenyl-2-(2-pyridyl)butanamide, 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide, 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanimidic acid, 4-[di(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide, 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide, 492056 [Beilstein], 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide, 54687-36-4 [RN], 74464-83-8 [RN], 74464-84-9 [RN], BS-17145, DB00280, Dicorantil, Disopiramida, Disopiramida [INN-Spanish], Disopyramide-d5, Disopyramidum, Disopyramidum [INN-Latin], MFCD00069254 [MDL number], n-desalkyl Disopyramide, Norpace®, Ritmodan, Rythmodan P [Trade name], Rythmodan®, Searle 703, α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide, α-(2-(Diisopropylamino)ethyl)-α-phenyl-2-pyridineacetamide, α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-pyridineacetamide, γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide, γ-Diisopropylamino-α-phenyl-α-(2-pyridyl)butyramide, дизопирамид, ديسوبيراميد, 丙吡胺

Disopyramide phosphate is an antiarrhythmic chemical used in the treatment of ventricular tachycardia.
Disopyramide phosphate is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent.

Disopyramide phosphate has a negative inotropic effect on the ventricular myocardium and significantly reduces contractility.
Disopyramide phosphate also has an anticholinergic effect on the heart, which is responsible for many negative side effects.
Disopyramide phosphate is available in both oral and intravenous forms and has a low degree of toxicity.

Disopyramide phosphate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.
Disopyramide phosphate is used at industrial sites and in manufacturing.

Disopyramide phosphate is an organoammonium phosphate.

Disopyramide phosphate phosphate is a class Ia antiarrhythmic agent with cardiac depressant properties.
Disopyramide phosphate phosphate exerts Disopyramide phosphate actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential.

This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues.
Disopyramide phosphate prolongs the QT interval and causes a widening of the QRS complex.

Disopyramide phosphate also possesses some anticholinergic and local anaesthetic properties.
Disopyramide phosphate phosphate is used in the treatment of supraventricular tachycardia.

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine.
Disopyramide phosphate also possesses some anticholinergic and local anesthetic properties.

Disopyramide phosphate belongs to a group of medicines called anti-arrhythmic agents used to treat irregular heartbeats.
An irregular heartbeat is a condition in which your heart beats irregularly, too fast, or too slow.
Disopyramide phosphate helps slow the heart rate and prevent arrhythmias (abnormal heart rhythms).

Disopyramide phosphate contains Disopyramide phosphate, ie anti-arrhythmic agents.
Disopyramide phosphate helps bring irregular heartbeats to a normal rhythm by blocking certain electrical signals in the heart.
Irregular heartbeat treatment reduces the risk of blood clots, heart attack or stroke.

Disopyramide phosphate should be taken as prescribed by the doctor.
Your doctor may monitor EKGs and blood pressure during treatment to monitor your dose.

Some people may experience common side effects such as blurred or double vision, stomach pain, little or no urination, and low blood sugar.
Most of these side effects of Disopyramide phosphate do not require medical attention and will gradually improve over time.
However, if the side effects persist, please consult your doctor.

Please tell your doctor if you are known to be allergic to Disopyramide phosphate or any other medicines.
Disopyramide phosphate is not recommended for use in children.
Pregnant or breastfeeding women are advised to consult a doctor before taking Disopyramide phosphate.

Before taking Disopyramide phosphate, tell your doctor if you have kidney or liver disease, enlarged prostate, glaucoma (increased eye pressure) or low potassium levels in the blood (hypokalaemia).
Do not take Disopyramide phosphate if you are already taking other medicines to regulate your heartbeat.

Do not drive or operate machinery as Disopyramide phosphate may cause blurred vision, dizziness and low blood pressure.
Use Disopyramide phosphate with caution if you are elderly (over 65 years of age), have a low body weight, or have kidney or liver problems.

Disopyramide phosphate is used to treat certain irregular heartbeats).
Disopyramide phosphate is in a class of medications called antiarrhythmic drugs.
Disopyramide phosphate works by making your heart more resistant to abnormal activity.

Continuing Education Activity:
Disopyramide phosphate is a chemical used to treat heart rhythm abnormalities that can be life-threatening, such as ventricular tachycardia/fibrillation, or associated with increased morbidity and mortality, such as atrial fibrillation and hypertrophic cardiomyopathy.
This activity reviews several important aspects of this chemical, including indications, mechanism of action, applications, side effects, contraindications, monitoring, and toxicity.
This important knowledge of this chemical can improve interprofessional healthcare team outcomes.

Objectives:
Describe the mechanism of action of Disopyramide phosphate.
Describe possible side effects of Disopyramide phosphate.

Explains the importance of monitoring when using Disopyramide phosphate as an antiarrhythmic chemical.
Outline professional team strategies for improving care coordination and communication when using Disopyramide phosphate to maximize the benefits of this chemical and minimize Disopyramide phosphate side effects.

Indications:
In 1962, new antiarrhythmic drugs were needed apart from quinidine and procainamide, which were the main antiarrhythmic agents available at the time.
Disopyramide phosphate is the selected agent among more than 500 compounds synthesized for the research program of new antiarrhythmic agents.
The chemical structures of Disopyramide phosphate are similar to the synthetic muscarinic antagonist lacquer, which explains Disopyramide phosphate anticholinergic property.

Although Disopyramide phosphate is rarely used for heart rhythm abnormalities due to the availability of newer drugs that provide better efficacy and favorable side-effect profiles, Disopyramide phosphate is still the drug of choice for vagal-mediated atrial fibrillation such as sleep-induced or atrial fibrillation in athlete groups.
The effectiveness of Disopyramide phosphate in these conditions is due to Disopyramide phosphate anticholinergic activity, which abolishes the parasympathetic tone.

Disopyramide phosphate is also a third-line antiarrhythmic agent for a patient with coronary artery disease.
Also, a patient with left ventricular hypertrophy has impaired depolarization, which can induce torsade de pointes.

Therefore, antiarrhythmics that prolong the QT interval are avoided, but if sotalol or amiodarone is unsuccessful or unsuitable, Disopyramide phosphate may be an alternative.
In a patient with atrial fibrillation and hypertrophic obstructive cardiomyopathy (HOCM), Disopyramide phosphate is the agent of choice, other than amiodarone, as Disopyramide phosphate may decrease the left ventricular outflow tract (LVOT) gradient (off-label use).

Data from a multicenter study of the safety and efficacy of Disopyramide phosphate in obstructive cardiomyopathy showed that Disopyramide phosphate significantly reduced the SVOT gradient from 75+/- 33 to 40+/-32 mmHg in 78 patients (66% of study subjects) (P<0.0001). has shown. ) and raises the New York Heart Association functional class (NYHA FC) from 23+/-07 to 17+/-06 (P<0.0001).
When Disopyramide phosphate is used in combination with a non-dihydropyridine calcium channel blocker or beta blocker, they can effectively prevent recurrence of AF in HCOM patients.

Patients with ventricular premature beat (VPB) or premature ventricular complexes (PVC) may have a high symptom burden.
Disopyramide phosphate can be used in patients without structural heart disease, although Disopyramide phosphate efficacy is less than ablation.
In addition, based on a randomized, double-blind, placebo-controlled one-year follow-up study, Disopyramide phosphate (n=44) was effective in maintaining sinus rhythm after electro cardioversion for atrial fibrillation compared to placebo (n=46) and was significantly different (%) at one-month follow-up. 70 vs 39%) and continues after twelve months (54% vs 30%).

Uses of Disopyramide phosphate:
Disopyramide phosphate is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as sustained ventricular tachycardia).
Disopyramide phosphate is used to restore normal heart rhythm and maintain a regular, steady heartbeat.

Disopyramide phosphate is known as an anti-arrhythmic drug.
Disopyramide phosphate works by blocking certain electrical signals in the heart that can cause an irregular heartbeat.
Treating an irregular heartbeat can decrease the risk for blood clots, and this effect can reduce your risk of heart attack or stroke.

Usage of Disopyramide phosphate:
Disopyramide phosphate comes as a capsule and an extended-release (long-acting) capsule to take by mouth.
Disopyramide phosphate capsules may be taken every 6 or 8 hours.

The extended-release capsule is usually taken every 12 hours.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take Disopyramide phosphate exactly as directed.
Do not take more or less of Disopyramide phosphate or take it more often than prescribed by your doctor.

Swallow the extended-release capsules; do not open, crush, or chew them.

Disopyramide phosphate helps control your condition but will not cure it.
Continue to take Disopyramide phosphate even if you feel well.
Do not stop taking Disopyramide phosphate without talking to your doctor.

Mechanism of action of Disopyramide phosphate:
Disopyramide phosphate's Class 1a activity is similar to that of quinidine in that Disopyramide phosphate targets sodium channels to inhibit conduction.
Disopyramide phosphate depresses the increase in sodium permeability of the cardiac myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current.

This results in an increased threshold for excitation and a decreased upstroke velocity.
Disopyramide phosphate prolongs the PR interval by lengthening both the QRS and P wave duration.

This effect is particularly well suited in the treatment of ventricular tachycardia as Disopyramide phosphate slows the action potential propagation through the atria to the ventricles.
Disopyramide phosphate does not act as a blocking agent for beta or alpha adrenergic receptors, but does have a significant negative inotropic effect on the ventricular myocardium.
As a result, the use of Disopyramide phosphate may reduce contractile force up to 42% at low doses and up to 100% in higher doses compared to quinidine.

Levites proposed a possible secondary mode of action for Disopyramide phosphate, against reentrant arrhythmias after an ischemic insult.
Disopyramide phosphate decreases the inhomogeneity between infarcted and normal myocardium refractory periods; in addition to lengthening the refractory period.

This decreases the chance of re-entry depolarization, because signals are more likely to encounter tissue in a refractory state which cannot be excited.
This provides a possible treatment for atrial and ventricular fibrillation, as Disopyramide phosphate restores pacemaker control of the tissue to the SA and AV nodes.

Pharmacology and Biochemistry of Disopyramide phosphate:

MeSH Pharmacological Classification:

Anti-Arrhythmia Agents:
Agents used for the treatment or prevention of cardiac arrhythmias.
They may affect the polarization-repolarization phase of the action potential, Disopyramide phosphate excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Obstructive hypertrophic cardiomyopathy:
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease, occurring in 1:500 individuals in the general population.
Disopyramide phosphate is estimated that there are 600,000 individuals in the United States with hypertrophic cardiomyopathy.

The most common variant of HCM presents with left ventricular (LV) intracavitary obstruction due to systolic anterior motion of the mitral valve, and mitral-septal contact, diagnosed readily with echocardiography.
Pharmacologic treatment with negative inotropic drugs is first-line therapy.

Beta-blockers are used first, and while they improve symptoms of shortness of breath, chest pain and exercise intolerance, they do not reduce resting LV intraventricular pressure gradients and often are inadequate to control symptoms.
Many investigators and clinicians believe that Disopyramide phosphate controlled release is the most potent agent available for reducing resting pressure gradients and improving symptoms.

Disopyramide phosphate has been actively used for more than 30 years.
Disopyramide phosphate administration for obstructive HCM has a IB recommendation in the 2020 American Heart Association/American College of Cardiology Foundation guidelines for treatment of obstructive HCM.
A IB treatment recommendation indicates that a treatment is recommended, and may be useful, and beneficial.

Negative inotropes improve LV obstruction by decreasing LV ejection acceleration and hydrodynamic forces on the mitral valve.
Disopyramide phosphate's particular efficacy is due to Disopyramide phosphate potent negative inotropic effects; in head-to-head comparison, Disopyramide phosphate is more effective for gradient reduction than either beta-blocker or verapamil.

Disopyramide phosphate is most often administered with beta-blockade.
When used in patients resistant to beta-blockade, Disopyramide phosphate is effective in 60% of cases, reducing symptoms and gradient to the extent that invasive procedures such as surgical septal myectomy are not required.

Disopyramide phosphate, despite Disopyramide phosphate efficacy, has one main side effect that has limited Disopyramide phosphate use in the US, though Disopyramide phosphate has seen wider application in Canada, UK and Japan.
Vagal blockade predictably causes dry mouth, and in men with prostatism, may cause urinary retention.
Teichman et al. showed that pyridostigmine used in combination with Disopyramide phosphate substantially alleviates vagolytic side effects without compromising antiarrhythmic efficacy.

This combination has also been shown to be effective and safe in obstructive HCM in a large cohort of patients.
Some clinicians prescribe pyridostigmine sustained release (marketed in the US as Mestinon Timespan) to every patient begun on Disopyramide phosphate.
This combination increases acceptance of higher Disopyramide phosphate dosing, important since there is a dose-response correlation in obstructive HCM, higher doses yielding lower gradients.

Another concern about Disopyramide phosphate has been the hypothetical potential for inducing sudden death from Disopyramide phosphate type 1 anti-arrhythmic effects.
However, a multicenter registry and two recent cohort registries have largely reduced this concern, by showing sudden death rates lower than that observed from the disease itself.

These concerns about the drug must be viewed from the clinical perspective that Disopyramide phosphate is generally the last agent that is tried for patients before they are referred for invasive septal reduction with surgical septal myectomy (an open-heart operation) or alcohol septal ablation (a controlled heart attack).
Both of these invasive procedures have risk of morbidity and mortality.

For selected patients, a trial of oral Disopyramide phosphate is a reasonable approach before proceeding to invasive septal reduction.
Patients who respond to Disopyramide phosphate are continued on the drug.

Those who continue to have disabling symptoms or who experience side effects are promptly referred for septal reduction.
Using such a stepped strategy, investigators have reported that survival does not differ from that observed in the age-matched normal United States population.

Extracardiac effects:
Atropine like effects (anticholinergic)
Dry mouth
Constipation
Urinary retention – Disopyramide phosphate should not be given to patients with symptomatic prostatism.
Blurred vision
Glaucoma
Rash
Agranulocytosis

Additionally, Disopyramide phosphate may enhance the hypoglycaemic effect of gliclazide, insulin, and metformin.

Metabolism of Disopyramide phosphate:
Disopyramide phosphate can cause hypoglycemia, perhaps due to increased secretion of insulin, and can also potentiate the effects of conventional hypoglycemic drugs.
This effect may be due to Disopyramide phosphate chief metabolite mono-N dealkylDisopyramide phosphate, since many of the reported cases of hypoglycemia have been in patients with renal impairment, in which the metabolite accumulates.

In six subjects who were being considered for treatment with Disopyramide phosphate, serum glucose concentrations were measured at 13, 15, 17, and 19 hours after supper, with no further food, with and without the added administration of two modified-released tablets of Disopyramide phosphate 150 mg with supper and 12 hours later.
Disopyramide phosphate significantly reduced the serum glucose concentration at all measurement times by an average of 0.54 mmol/l.
The fall in serum glucose concentration was not related to the serum concentration of Disopyramide phosphate or the serum creatinine concentration; Disopyramide phosphate was greater in older patients and in underweight patients.

Hypoglycemia has also been reported in a 70-year-old woman with type 2 diabetes mellitus taking Disopyramide phosphate.

Clinical data of Disopyramide phosphate:
Trade names: Norpace
AHFS/Drugs.com: Monograph
MedlinePlus: a682408
Pregnancy category: AU: B2
Routes ofadministration: Oral, intravenous
ATC code: C01BA03 (WHO)

Legal status:
UK: POM (Prescription only)
US: ℞-only

Pharmacokinetic data of Disopyramide phosphate:
Bioavailability: High
Protein binding: 50% to 65% (concentration-dependent)
Metabolism: Hepatic (CYP3A4-mediated)
Elimination half-life: 6.7 hours (range 4 to 10 hours)
Excretion: Renal (80%)

Identifiers of Disopyramide phosphate:
IUPAC name: (RS)-4-(Diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide
CAS Number: 3737-09-5
PubChem CID: 3114
IUPHAR/BPS: 7167
DrugBank: DB00280
ChemSpider: 3002
UNII: GFO928U8MQ
KEGG: D00303
ChEBI: CHEBI:4657
ChEMBL: ChEMBL517
CompTox Dashboard (EPA): DTXSID1045536
ECHA InfoCard: 100.021.010

Properties of Disopyramide phosphate:
Formula: C21H29N3O
Molar mass: 339.483 g·mol−1
Melting point: 94.5 to 95 °C (202.1 to 203.0 °F)
SMILES: O=C(N)C(c1ncccc1)(c2ccccc2)CCN(C(C)C)C(C)C
InChI: InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
Key:UVTNFZQICZKOEM-UHFFFAOYSA-N

Molecular Weight: 437.5 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 7
Rotatable Bond Count: 8
Exact Mass: 437.20795813 g/mol
Monoisotopic Mass: 437.20795813 g/mol
Topological Polar Surface Area: 137Ų
Heavy Atom Count: 30
Complexity: 459
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Names of Disopyramide phosphate:

Regulatory process names:
Disopyramide
Disopyramide

IUPAC names:
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide
Disopyramide

Other identifiers:
3737-09-5
DISPERBYK 180
DISTEARYL ETHER. N° CAS : 6297-03-6. Nom INCI : DISTEARYL ETHER. Nom chimique : Dioctadecyl ether. N° EINECS/ELINCS : 228-567-1. Ses fonctions (INCI) : Agent d'entretien de la peau : Maintient la peau en bon état
DISPERSANT DMA 40
Dispersant DMA 40 IUPAC Name sodium;oxolane-2,5-dione;2,4,4-trimethylpent-1-ene Dispersant DMA 40 InChI 1S/C8H16.C4H4O3.Na/c1-7(2)6-8(3,4)5;5-3-1-2-4(6)7-3;/h1,6H2,2-5H3;1-2H2;/q;;+1 Dispersant DMA 40 InChI Key JHBKNJSZAQSDFP-UHFFFAOYSA-N Dispersant DMA 40 Canonical SMILES CC(=C)CC(C)(C)C.C1CC(=O)OC1=O.[Na+] Dispersant DMA 40 Molecular Formula C12H20NaO3+ Dispersant DMA 40 CAS 37199-81-8 Dispersant DMA 40 European Community (EC) Number 609-343-6 Dispersant DMA 40 Solid Content(%+1) 40 Dispersant DMA 40 pH 5.0 - 6.0 Dispersant DMA 40 Viscosity(cps, max) 2000 Dispersant DMA 40 Chemical Composition Sodium Polycarboxylate Dispersant DMA 40 Molecular Weight 235.27 g/mol Dispersant DMA 40 Hydrogen Bond Donor Count 0 Dispersant DMA 40 Hydrogen Bond Acceptor Count 3 Dispersant DMA 40 Rotatable Bond Count 2 Dispersant DMA 40 Exact Mass 235.131014 g/mol Dispersant DMA 40 Monoisotopic Mass 235.131014 g/mol Dispersant DMA 40 Topological Polar Surface Area 43.4 Ų Dispersant DMA 40 Heavy Atom Count 16 Dispersant DMA 40 Formal Charge 1 Dispersant DMA 40 Complexity 185 Dispersant DMA 40 Isotope Atom Count 0 Dispersant DMA 40 Defined Atom Stereocenter Count 0 Dispersant DMA 40 Undefined Atom Stereocenter Count 0 Dispersant DMA 40 Defined Bond Stereocenter Count 0 Dispersant DMA 40 Undefined Bond Stereocenter Count 0 Dispersant DMA 40 Covalently-Bonded Unit Count 3 Dispersant DMA 40 Compound Is Canonicalized Yes Dispersant DMA 40 is an APEO-free, low-foaming, highly effective liquid dispersant for pigments and extenders in aqueous systems. It is compatible with all common synthetic emulsions, creates little foam and is effective in a wide pH range. It is very favorable in case of storage stability of highly filled emulsion paints. Recommended dosage level is 0.1-0.3%. The maximum shelf life is 12 months at temperature 5-40°C.Low foaming polymeric dispersing agent for textile application.Dispersant DMA 40 are linear polymers with a high molecular mass (Mr ≤ 100 000) and with many carboxylate groups. They are polymers of acrylic acid or copolymers of acrylic acid and maleic acid. The polymer is used as the sodium salt (see: sodium polyacrylate).Dispersant DMA 40 are used as builders in detergents.[2] Their high chelating power, even at low concentrations, reduces deposits on the laundry and inhibits the crystal growth of calcite.Dispersant DMA 40 ethers (PCE) are used as superplasticizers in concrete production.Dispersant DMA 40 are poorly biodegradable but have a low ecotoxicity. In the sewage treatment plant, the polymer remains largely in the sludge and is separated from the wastewater.Polyamino acids like polyaspartic acid and polyglutamic acid have better biodegradability but lower chelating performance than polyacrylates. They are also less stable towards heat and alkali. Since they contain nitrogen, they contribute to eutrophication.Water-soluble linear Dispersant DMA 40 are used in household cleaning products, e.g. in laundry detergents, automatic dishwashing detergents and various hard surface-cleaning formulations, and also in institutional and industrial cleaning processes and a variety of technical applications.Dispersant DMA 40 are used in low-phosphate and phosphate-free detergents for avoiding incrustation and soil redeposition. Their effect is not based on complexing properties and therefore not comparable with typical chelating agents. The mechanism is the dispersion of calcium carbonate or calcium phosphate and the suspended solids during washing processes. Major Dispersant DMA 40 used in detergents products comprise two different types of polymer families which distinguish in their technical applications and physical chemical properties: homopolymers of acrylic acid (P-AA) which is described in part I and copolymers of acrylic/maleic acid (P-AA/MA) which is described in part II of the report.The main pathway of Dispersant DMA 40 into the environment is via domestic waste water and sewage treatment to surface waters.Thus, the removal of Dispersant DMA 40 from waste water before and during waste water treatment is the crucial factor that governs the distribution of Dispersant DMA 40 into the environment.The outcome of this current environmental assessment provides a sound basis for the conclusion that the use of Dispersant DMA 40 homopolymers in detergent products does not pose risk to the environment.Scenarios relevant to the consumer exposure to Dispersant DMA 40 have been identified and assessed using a Margin of Safety approach.Dispersant DMA 40 are of low toxicity by all exposure routes examined.Based upon the available data, it is considered that exposure to Dispersant DMA 40 does not imply any particular hazard to humans.Owing to the presence of Dispersant DMA 40 in many commonly used household detergents, consumers are exposed to Dispersant DMA 40 mainly via the dermal route, but also to a minor extent via the oral and inhalation route.In summary, based on the available data, the human risk assessment considers the use of Dispersant DMA 40 in household laundry products and automatic dishwashing detergents as safe and of no concern with regard to consumer use.Important Dispersant DMA 40 in detergents are homopolymers of acrylic acid which are generally used as sodium salts.The various Dispersant DMA 40 are distinguished by the monomers used for their preparation, acrylic acid (AA) and their molecular weight (MW).Dispersant DMA 40 used in detergents are generally prepared by free-radical polymerisation of acrylic acid in aqueous solution.Dispersant DMA 40 are very stable compounds as the carboxyl part of the molecule is the only functional group.Abiotic degradation mechanisms like photolytic and hydrolytic processes do not significantly influence the environmental fate of Dispersant DMA 40.Experimental data on the bioaccumulation potential of Dispersant DMA 40 are not available.Dispersant DMA 40 are used in low-phosphate and phosphate-free detergents for avoiding incrustation and soil redeposition.Dispersant DMA 40 are usually not contained in manual dishwashing detergents.A typical mean concentration of Dispersant DMA 40 is 0.5 % for P-AA in laundry detergents. The contact time with the Dispersant DMA 40 in the course of handwashing is, according to A.I.S.E., very short (approx. 10 min) and the percutaneous absorption of high molecular weight polymers will be very low to non existant.In the following calculations the worst case assumption has been made that 1% of the Dispersant DMA 40 are available for percutaneous absorption.Assuming a fluid film thickness of 100 µm (0.1 mm or 0.01 cm) (Vermeire, 1993) on the skin and, as a worst case assumption, a percutaneous absorption of 1% for Dispersant DMA 40 in 24 h exposure time, the following amount of Dispersant DMA 40 absorbed via skin can be calculated.Thus, the systemic exposure of Dispersant DMA 40 resulting from this scenario is also considered to be negligible.Dispersant DMA 40, despite their solubility in water, are deposited in solid form and thus as a first rough estimation, the small amount of Dispersant DMA 40 absorbed via this route should be insignificant.Accidental or intentional overexposure to Dispersant DMA 40 may occur via laundry detergents. We know no fatal cases arising from oral uptake of Dispersant DMA 40.The accidental or intentional overexposure to Dispersant DMA 40 directly is not considered a likely occurrence for consumers, but it may occur via laundry detergents.Accidental ingestion of milligrams of Dispersant DMA 40 as a consequence of accidental ingestion of laundry and cleaning products is not expected to result in any significant adverse health effects, given the low toxicity profile of laundry and cleaning products in general.Accidental contact of Dispersant DMA 40 with the eyes is not expected to cause more than a slight irritation on the basis of the experimental data.Data on developmental toxicity demonstrate that Dispersant DMA 40 are not developmentally toxic in rats.In summary, based on the available data, the human risk assessment considers the use of Dispersant DMA 40 in household laundry products and automatic dishwashing detergents as safe and of no concern with regard to consumer use.
DISPEX ULTRA FA 4430
DESCRIPTION:

Dispex Ultra FA 4430 (formerly Lumiten N-OC 30) is a nonionic surfactant used to improve the storage stability of emulsion paints and their compatibility with cement and lime.

Dispex Ultra FA 4430 has chemical nature ethoxylate of a fatty alcohol in water

PHYSICAL AND CHEMICAL PROPERTIES OF DISPEX ULTRA FA 4430:
Physical form: liquid
Shelf life: subject to appropriate storage under the usual storage and temperature conditions, our product is durable for at least 6 months.
Typical properties:
• pH value (DIN EN 1162): ~ 6.5
• color (Hazen, DIN EN 1557): ~ 100
• water (DIN 51777): ~ 70%


APPLICATION OF DISPEX ULTRA FA 4430:
Dispex Ultra FA 4430 is a nonionic surfactant used to improve the storage stability of emulsion paints and their compatibility with cement and lime.
It can be used in interior paints, exterior paints and textured finishes.
Dispex Ultra FA 4430 offers performance highlights such as:
• excellent improvement of compatibility with cement and lime
• improvement of storage stability
• easier cleaning of equipment

Recommended concentrations: An addition level of about 0.3% - 1.0% in relation to the final formulation is recommended.
Storage: A cloudiness or precipitation can appear during storage at temperatures lower than 20°C. This effect is reversible at temperatures higher than 25°C.

SAFETY INFORMATION ABOUT DISPEX ULTRA FA 4430:

First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

DISPONIL AES 25
DESCRIPTION:

Disponil AES 25 is a primary emulsifier for emulsion polymerization.
Disponil AES 25 is an alkyl aryl polyglycol ether sulphate, sodium salt.
Disponil AES 25 complies with BfR and FDA food contact applications.


SAFETY INFORMATION ABOUT DISPONIL AES 25:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product


DISPONIL ODSLS
DESCRIPTION:

Disponil ODSLS is one of the ingredients that is listed on the shampoo bottle.
Disponil ODSLS is found in many cleaning and beauty products.
Disponil ODSLS lowers the surface tension between ingredients, which is why it’s used as a cleansing and foaming agent.



CAS NUMBER: 151-21-3

EC NUMBER: 277-362-3

MOLECULAR FORMULA: CH3(CH2)11OSO3Na

MOLECULAR WEIGHT: 288.38



DESCRIPTION:

Most concerns about Disponil ODSLS stem from the fact that it can be found in beauty and self-care products as well as in household cleaners.
Disponil ODSLS is a surfactant with a similar chemical formula.
Disponil ODSLS is milder and less irritating than SLS.
Disponil ODSLS is a commonly used ingredient mainly in cosmetics and detergents.
From a chemical point of view, Disponil ODSLS belongs to anionic surfactants.

Disponil ODSLS is a sodium salt of lauryl sulfuric acid.
The common name of this compound is sodium lauryl alcohol sulfate.
Disponil ODSLS is an anionic detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste, etc.) and for industrial uses.
Disponil ODSLS is an inexpensive and very effective foaming agent.
Disponil ODSLS is used in many cosmetic products for their cleaning and emulsifying properties.

Disponil ODSLS is derived from palm kernel oil or coconut oil.
In herbicides, Disponil ODSLS is used as a surfactant to improve absorption of the herbicidal chemicals and reduces time the product takes to be rainfast, when enough of the herbicidal agent will be absorbed.
Disponil ODSLS's chemical formula is CH3(CH2)11(OCH2CH2)nOSO3Na.
Disponil ODSLS is heterogeneous in the number of ethoxyl groups, where n is the mean.

Disponil ODSLS is the most common one in commercial products.
Disponil ODSLS is very similar to Disponil ODSLS (SLS) in terms of physical and chemical properties and application in cosmetic and detergent products.
The main difference is in the production process of these compounds: in case of Disponil ODSLS lauryl alcohol is only sulphated with SO3 and neutralized with NaOH, while in case of Disponil ODSLS it is first ethoxylated and only then sulphated and neutralized. Oxyethylation, commonly known as ethoxylation is a process in which ethylene oxide is attached.

This process is critical as it makes Disponil ODSLS less irritating to the skin than SLS.
Both of these compounds are perceived on the market as the main factors causing severe skin irritation.
This is not entirely true, because it is possible to develop really mild formulations with SLS or SLES.
However, this requires a thorough knowledge of surfactants, their specific properties, and especially their behaviour in the presence of other surfactants.
Surfactants are specific chemical compounds that behave completely differently when alone than if combined with other ingredients.
And yet cosmetic formulations contain lots of various ingredients.

Disponil ODSLS turns out that the addition of Cocamidopropyl Betaine to a formulation containing Disponil ODSLS greatly reduces its irritating potential.
Disponil ODSLS is also very important to select the appropriate concentrations of individual components.
There is a visible trend on the market to eliminate Disponil ODSLS from cosmetics.
However, this is not possible, as products containing Disponil ODSLS still constitute the largest part of the flushable cosmetics market.
Disponil ODSLS is an anionic surfactant naturally derived from coconut and/or palm kernel oil.

Disponil ODSLS usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl.
Disponil ODSLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes.
Disponil ODSLS is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry.
Disponil ODSLS also has some microbicidal activity.

Disponil ODSLS has very good washing, foaming, emulsifying and thickening properties in the presence of salt (NaCl).
These are the best anionic surfactants in terms of properties and so far not as effective and at the same time economically viable alternative has been found.
Disponil ODSLS is a surfactant, which basically means it has an effect on the surfaces it touches.
Disponil ODSLS’s used in a variety of products such as food thickeners, toothpaste, and floor cleaners.
Disponil ODSLS is also a foaming agent.
Many of these products use Disponil ODSLS to give a foaming action during the cleaning process.

Disponil ODSLS works as a surfactant, trapping oil and dirt in hair so it can be rinsed away with water.
Disponil ODSLS can help create a rich lather in products like body and hand wash, facial cleansers and bubble bath.
Disponil ODSLS also helps create the foaming action in toothpaste and helps remove food particles from teeth.
Disponil ODSLS is an effective surfactant used in household cleaning products to help remove oily stains and residues.
Because of its ability to break down oil and grease, SLS also is an ingredient in engine degreasers and industrial strength detergents.

As a food additive, Disponil ODSLS is used as an emulsifier or thickener and it helps acids mix better with liquids in fruit juices and punches, for example.
Multiple scientific bodies have reviewed Disponil ODSLS as an ingredient in personal care and cleaning products and determined its typical use in these applications to be safe for consumers and the environment.
Disponil ODSLS is used as an emulsifier or thickener.
For example, Disponil ODSLS helps make marshmallows and dried egg products light and fluffy.

Disponil ODSLS also helps acids mix better with liquids, for example in fruit juices and punches.
Disponil ODSLS is white (yellowish) commonly used in detergents and textile industry.
This bubbly froth-producing surfactant is derived naturally from coconut oil or palm kernel oil and is known for its widespread application in manufacturing cleansers, detergents, and cosmetics. Soluble in water, with anionic and non-ionic complex compatibility is good, good emulsification, foaming, osmosis, decontamination and dispersion properties, are widely used in toothpaste, shampoo, shampoo, shampoo, detergent, liquid washing, cosmetics and plastic mold release, lubrication and pharmaceutical, paper making, building materials, chemical industry, etc.



APPLICATION:

-hair shampoos,
-shower gels,
-bubble bath liquids,
-liquid hand soaps,
-shaving cosmetics,
-industrial detergents for washing and cleaning,
-professional car cosmetics.



PRODUCTION:

Disponil ODSLS is prepared by ethoxylation of dodecyl alcohol, which is produced industrially from palm kernel oil or coconut oil.
The resulting ethoxylate is converted to a half ester of sulfuric acid, which is neutralized by conversion to the sodium salt.
The related surfactant Disponil ODSLS is produced similarly, but without the ethoxylation step.
Disponil ODSLS is commonly used alternatives to SLS in consumer products.



CHARACTERISTICS AND PROPERTIES:

-Anionic surfactant (negatively charged).
-Consists of an alkyl moiety containing 12-14 atoms of carbon (non-polar part) and a sulfate moiety (polar part).
-The non-polar part in Disponil ODSLS has affinity to non-polar compounds, while the polar part is hydrophilic and most often binds with water molecules.
-Disponil ODSLS is a product of natural origin. According to ISO 16128, it contains 100% of renewable carbon.
-Disponil ODSLS is produced by reaction of lauryl alcohol, sulfur trioxide and sodium hydroxide.
-Disponil ODSLS can be derived from coconut oil (CNO) or palm kernel oil (PKO).
-Disponil ODSLS is available as an approx. 30% aqueous solution or as a powder/granules with an active ingredient content of approximately 95%.
-The concentration of Disponil ODSLS in consumer products varies by product and manufacturer, but is typically between 0.01% and 50% for cosmetic products and 1% to 30% for cleaning agents.
-Colour from colourless to light yellow.
-Tends to crystallize at low temperatures.
-Relatively cheap and readily available surfactant.



PROPERTIES:

-Molecular Weight: 288.38
-Hydrogen Bond Donor Count: 0
-Hydrogen Bond Acceptor Count: 4
-Rotatable Bond Count: 12
-Exact Mass: 288.13712473
-Monoisotopic Mass: 288.13712473
-Topological Polar Surface Area: 74.8 Ų
-Heavy Atom Count: 18
-Complexity: 249
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 0
-Undefined Atom Stereocenter Count: 0
-Defined Bond Stereocenter Count: 0
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 2
-Compound Is Canonicalized: Yes



STORAGE:

Store in an area without drain or sewer access.



SYNONYM:

Sodium laurly sulfate
151-21-3
Disponil ODSLS
Sodium dodecylsulfate
Sodium lauryl sulphate
Sodium dodecyl sulphate
Dodecyl sodium sulfate
Neutrazyme
Sodium n-dodecyl sulfate
Irium
Sulfuric acid monododecyl ester sodium salt
Dodecyl sulfate sodium salt
Dodecyl sulfate, sodium salt
Anticerumen
Duponal
Duponol
Gardinol
Sodium monododecyl sulfate
Dreft
Aquarex methyl
Duponol methyl
Solsol needles
Stepanol methyl
Duponol waqa
Stepanol wac
Stepanol waq
Duponol qx
Richonol af
Perlandrol L
Perlankrol L
Sipex sd
Sipex sd
Standapol wa-ac
Stepanol me dry
Duponol Me
Richonol A
Richonol C
Sintapon L
Duponol C
Maprofix LK
Standapol WAQ
Stepanol ME
Stepanol WA
Akyposal SDS
Carsonol SLS
Maprobix NEU
Maprofix NEU
Maprofix WAC
Aquarex ME
Dupanol WAQ
Duponol QC
Duponol WA
Duponol WA dry
Duponol WAQ
Empicol LPZ
Hexamol SLS
Melanol CL
Duponal WAQE
Duponol WAQE
Duponol WAQM
Sterling wa paste
Conco sulfate WA
Conco sulfate WN
Nikkol SLS
Orvus WA Paste
Sipex OP
Sipex SP
Sipex UB
Sipon LS
Sipon PD
Sipon WD
Detergent 66
Montopol La Paste
Sipon LSB
Maprofix WAC-LA
Sterling WAQ-CHCycloryl 21
Cycloryl 31Stepanol WA Paste
Conco Sulfate WAG
Conco Sulfate WAN
Conco Sulfate WA
Quolac EX-UB
Odoripon Al 95
sodiumdodecylsulfate
Avirol 118 conc
Cycloryl 580
Cycloryl 585N
Lauyl sodium sulfate
Maprofix 563
Sinnopon LS 95
Stepanol T 28
Sodium laurilsulfate
Steinapol NLS 90
Empicol LS 30
Empicol LX 28
Lauryl sodium sulfate
Melanol CL 30
NALSRewopol NLS 30
Standapol waq special
Standapol was 100
Sinnopon LS 100
Stepanol WA-100
Carsonol SLS Special
Standapol 112 conc
Stepanol ME Dry AW
Avirol 101
Emersal 6400
Monogen Y 100
Carsonol SLS Paste B
sodium;dodecyl sulfate
Stepanol methyl dry aw
Berol 452
Emal 10
EMAL O
Sipon LS 100
n-Dodecyl sulfate sodium
Sodium monolauryl sulfate
Monododecyl sodium sulfate
Sodiumlauryl ether sulfate
Lauryl sulfate sodium salt
Conco sulfate WA-120
Conco sulfate WA-1245
Dehydag sulfate GL emulsion
MFCD00036175
Emulsifier no. 104
Texapon k 12 p
CHEBI:8984
P and G Emulsifier 104
Disponil ODSLS ether
SLS
Sodium Laurylsulfate
NSC-402488
Texapon K 1296
NCI-C50191
Laurylsulfuric Acid Sodium Salt
Dodecyl alcohol, hydrogen sulfate, sodium salt
Dodecylsulfuric Acid Sodium Salt
DTXSID1026031
Disponil ODSLS, synthetic
Finasol osr2
Incronol SLS
Natriumlaurylsulfat
368GB5141J
NCGC00091020-03
E487
Jordanol SL-300
Finasol osr(sub 2)
Dodecyl sulfate sodium
Monagen Y 100
Perklankrol ESD 60
Caswell No. 779
Natrium laurylsulfuricum
12738-53-3
12765-21-8
1334-67-4
Laurylsiran sodny
Lauryl sulfate, sodium salt
Dehydrag sulfate gl emulsion
DTXCID906031
Dehydag sulphate GL emulsion
Laurylsiran sodny
Rhodapon UB
Disponil ODSLS 30%
CAS-151-21-3
CCRIS 6272
Lauryl sulfate sodium

HSDB 1315
Disponil ODSLS, dental grade
EINECS 205-788-1
EPA Pesticide Chemical Code 079011
NSC 402488
CP 75424
Empicol
AI3-00356
UNII-368GB5141J
sodiumlauryl sulfate
sodium dodecylsulphate
Sodium dedecyl sulfate
Sodium-dodecyl-S-SDS
IPC-SDS
sodium n-dodecyl sulphate
Disponil ODSLS NF
SDS (20% Solution)
sodium monododecyl sulphate
lauryl sulphate sodium salt
EC 205-788-1
dodecyl sulphate sodium salt
SCHEMBL1102
Disponil ODSLS, SDS
sodium dodecyl sulfate (sds)
Sulfuric acid monododecyl ester sodium salt (1:1)
CHEMBL23393
sodium dodecyl sulphate (sds)
dodecyl sulfuric acid sodium salt
Dodecyl sulphuric acid sodium sal
Disponil ODSLS (JP17/NF)
Disponil ODSLS [II]
Disponil ODSLS [MI]
BCP30594
CS-B1770
Disponil ODSLS [FCC]
Disponil ODSLS
Tox21_111059
Tox21_201614
Tox21_300149
BDBM50530482
SODIUM LAURILSULFATE
Disponil ODSLS
Disponil ODSLS
Disponil ODSLS
AKOS015897278
AKOS025147308
Tox21_111059_1
DB00815
Dodecyl sulfuric acid ester sodium salt
Disponil ODSLS
Disponil ODSLS
NCGC00091020-01
NCGC00091020-02
NCGC00254225-01
NCGC00259163-01
NCGC00274082-01
AS-14730
SODIUM LAURILSULFATE
Lauryl Sulfate, Sodium Salt (25% Aq.)
SODIUM LAURILSULFATE
D1403
FT-0603358
FT-0700721
I0352
S0588
D01045
EN300-103513
F16341
S-4600
S-460
SODIUM DODECYL SULFATE BIOTECH GRD 100G
Q422241
Sodium n-dodecyl sulfate, 98%, for electrophoresis
F0001-0539
Z1365432828
Sodium dodecylsulfate;Sodium lauryl sulphate;Dodecyl sodium sulfate
Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Disponil ODSLS

















DISSOLVINE GL
DISSOLVINE GL = TETRASODIUM GLUTAMATE DIACETATE


CAS No: 51981-21-6
EC Number: 257-573-7
Chemical formula: C9H9NO8Na4
Chemical name: L-glutamic acid N,N-diacetic acid, tetra sodium salt


Dissolvine GL 38% 200L is a glutamic acid, diacetic acid and tetra-sodium salt (GLDA-NA4), it's a pure product that contains no other weaker chelates as a substitute such as citrates or gluconate.
With 100% of the active content being GLDA, Dissolvine GL offers maximum chelation power and efficiency.
Dissolvine GL is a sustainable, innovative material.


Dissolvine GL(Glutamic acid diacetic acid) is a biobased sequestrant and chelating agent produced.
Dissolvine GL is based on natural amino acid salt, monosodium L-glutamate (MSG) and is readily biodegradable.
In cleaning formulations and under harsh washing conditions, Dissolvine GL complexes hard water ions very well and retains its high chelating values at elevated temperatures more than other chelating agents.


This solution is an important tool in controlling metal ion reactivity as it reduces the detrimental effect of metal catalysts in peroxide cleaners.
This can also be used to enhance the physical properties of metal ions, supplying iron for gas scrubbing and providing essential elements to growing plants.


Dissolvine GL 38% 200L is produced from the monosodium L-glutamic acid (MSG), a bio based naturally occurring amino acid, ensuring Dissolvine GL is readily bio-degradable.
This alongside the source material of plant based/sugar waste, Dissolvine GL is an environmentally friendly alternative.
The active ingredient in Dissolvine GL is glutamic acid diacetic acid, tetra sodium salt (GLDA).


Dissolvine GL has four carboxylic acid groups.
In combination with the nitrogen atom these acid groups can form strong bonds with di- and trivalent metals.
Dissolvine GL is based on the food-approved natural amino acid salt, monosodium L-glutamate (MSG).
MSG is produced by biochemical conversion of vegetable material (such as sugar beet waste).


Dissolvine GL (GLDA) products are effective biobased, bio-degradable chelates.
Dissolvine GL, a glutamic acid, diacetic acid and tetra-sodium salt (GLDA-NA4), is a pure product that contains no other weaker chelates as a substitute such as citrates or gluconate.
With 100% of the active content being GLDA, Dissolvine GL ensures maximum chelation power and efficiency.


Combining excellent performance with a superior ecological profile, this readily bio-degradable, eco-premium classified chelating agent, Dissolvine GL, is a shining example of a sustainable and innovative material that will add value to your products.
Dissolvine GL is produced from the monosodium L-glutamic acid (MSG), a biobased naturally occurring amino acid, ensuring Dissolvine GL is readily bio-degradable.


Coupled with the source material of plant based/sugar waste, Dissolvine GL is a green alternative.
Compared to EDTA and NTA, Dissolvine GL performs better when it comes to hard surface cleaning.
Dissolvine GL does not sensitize human skin, demonstrates enhanced biocidal boosting power and improved biodegradability properties. Compared to phosphates and phosphonates, Dissolvine GL is a far more effective chelating agent.


Dissolvine GL (GLDA Na) is a sustainable, innovative material that will add value to your product.
The active ingredients of Dissolvine GL are glutamic diacetic acid (GLDA), tetranarium salt.
Dissolvine GL is made up of four carboxyl groups.
Together with the nitrogen atom, these groups can form stable bonds with di- and trivalent metals.


Dissolvine GL includes natural amino acid salts, monosodium L-glutamate, approved for food use.
Dissolvine GL was created in the search for an environmentally friendly and safe complexing agent with improved properties and strong chelating (complexing) ability.
Dissolvine GL is easily degradable, harmless to humans, strong chelate, very soluble in acids and alkalis, effective in the pH range 2-12.


Compared to ethylenediaminetetraacetic acid (EDTA) and nitrile triacetic acid (NTA), Dissolvine GL (GLDA) performs better on hard surfaces.
Dissolvine GL does not affect human skin, has a high biocidal ability (enhances the action of biocides and preservatives), and is subject to rapid biodegradation.
Dissolvine GL has sustainability.


Dissolvine GL is the most environmentally friendly solution among bathrobes, as it is produced mainly from natural raw materials (for example, beet sugar production waste).
Numerous studies have shown that Dissolvine GL has the lowest environmental impact of all strong complexing agents.
Dissolvine GL is fully biodegradable.


Dissolvine GL has cleaning properties.
Dissolvine GL is gentle on the skin.
Dissolvine GL is non-GMO and non-irritating to eyes and skin.
Dissolvine GL is suitable for use in personal care and cosmetic products.


Dissolvine GL is by binding calcium ions and transition metal ions and enhancing the effect of preservatives, Dissolvine GL increases the shelf life of cosmetics.
Dissolvine GL safe for use in non food contact pesticides.
The EPA has added the chelating agent to its list of approved FIFRA Inert Ingredients, which means that Dissolvine GL is permitted in non food use pesticide products at a maximum concentration of 5% weight.


Dissolvine GL is readily biodegradable, has an excellent safety profile, is a suitable alternative to traditional products and is based on a natural, renewable source.
Dissolvine GL is the tetrasodium salt of L - glutamic acid - N , N -diacetic acid (GLDA-H 4 ), derived from the amino acid glutamic acid and known as Complexing agent of the aminopolycarboxylate type characterized by particularly high biodegradability and solubility.


Dissolvine GL is discussed as a "green" alternative to the most common chelators ethylenediaminetetraacetic acid (EDTA) and nitrilotriacetic acid (NTA) acquisition and presentation.
Dissolvine GL is tetrasodium glutamic acid oxalate (GLDA-NA4).
Dissolvine GL can combine the nitrogen atom in the center of the molecular structure with the second and third order metal ions, and bond through strong multiple bonds.


The starting material for Dissolvine GL is L - glutamic acid and in particular monosodium glutamate (MSG), which is much more water-soluble and produced as a flavor enhancer in quantities of over 3 million tons per year.
To achieve acceptable yields, MSG is converted at pH

Dissolvine GL is a white, highly water-soluble, hygroscopic solid that forms alkaline (typically pH 11.5) and pale yellow aqueous solutions.
In contrast to EDTA and NTA, Dissolvine GL dissolves very well in aqueous media over a wide pH range from 1 to 12.
The thermal stability (decomposition >280 °C) is significantly higher than that of EDTA and NTA ( >150°C).
Dissolvine GL is glutamic acid diacetic acid, tetra sodium salt (GLDA-Na4).


GLDA has four carboxylic acid groups and combined with a centralized nitrogen atom these carboxylate groups provide strong multiple bonds with diand trivalent metals ions.
The primary difference in these products is the active ingredient content (38% vrs 47%) and also that the ‘S’ version is high purity (NTA free).
Dissolvine GL, also known as Tetrasodium Dicarboxymethyl Glutamate, GLDA-Na4 for short.


Dissolvine GL is a new type of green degradable chelating agent, can replace traditional phosphonates, EDTA, NTA.
Dissolvine GL is suit for a wide pH range, with high solubility, high temperature resistance, strong detergency, no ecological toxicity, has synergistic effect with fungicides, and no irritation to skin and eyes.


Dissolvine GL is a rinsing aid.
Dissolvine GL is a vegetable-based chelating agent.
Dissolvine GL is a palm oil-, EDTA- and nitrilotriacetic acid (NTA)-free chelating agent.
Dissolvine GL research shows the ingredient is not a strong skin irritant.


Dissolvine GL exhibits dispersion properties combined with easier rinsing.
Dissolvine GL offers enhanced biocidal/preservative boosting power.
Dissolvine GL is recommended for wash-off formulations, wipes, shaving products, fragrances, toiletries, makeup, skin-, sun-, baby & oral care products.


Using a chelating agent helps to slow this process, allowing for the creation of products with improved stability and appearance.
This also improves the effectiveness of preservative ingredients, allowing us to use a lower percentage of these, for safer shelf-stable products.
Dissolvine GL is readily biodegradable with a high level of solubility over a wide pH range, thus a greener alternative to many other chelates and phosphates.


Dissolvine GL has Excellent chelating effect controlling metal catalyzed decomposition.
Dissolvine GL reduces water hardness and prevents precipitation.
Dissolvine GL boosts performance of preservatives improving shelf life.
Dissolvine GL Stabilizes the pH value and is effective in wide pH range.


Dissolvine GL does not sensitize human skin.
Dissolvine GL is Completely biodegradable as compared to phosphates and phosphonates.
Dissolvine GL is an effective alternative to EDTA.
Dissolvine GL, also known as Tetrasodium Dicarboxymethyl Glutamate, GLDA-Na4 for short.


Dissolvine GL is a new type of green degradable chelating agent, can replace traditional phosphonates, EDTA, NTA.
Dissolvine GL is suit for a wide pH range, with high solubility, high temperature resistance, strong detergency, no ecological toxicity, has synergistic effect with fungicides, and no irritation to skin and eyes.
Dissolvine GL is a safe synthetic chelating agent with natural origins.


Dissolvine GL is what's known as a 'chelating agent', an ingredient that inactivates metallic ions (charged particles) in product formulations.
Dissolvine GL is a high purity, versatile and readily biodegradable chelating agent based upon L-glutamic acid, a natural and renewable raw material.



USES and APPLICATIONS of DISSOLVINE GL:
Dissolvine GL is highly effective in the control of water hardness ions and can also be used in cleaning surfaces, descaling boilers, processing textiles and preventing scale formation.
Dissolvine GL can be used to replace NTA, EDTA, phosphates and phosphonates in several cleaning products and formulations.


Dissolvine GL is extensively used to control metal ions in water based systems for multiple applications.
In cleaning formulations and under harsh washing conditions, Dissolvine GL complexes hard water ions very well and retains its high chelating values at elevated temperatures more than other chelating agents.
Dissolvine GL demonstrates strong stain removing including those from tea, starches, meats and burnt milk staining.


With strong chelating powers, Dissolvine GL is highly effective in a wide variety of applications and specifically for use in acidic, alkaline and concentrated detergents.
Dissolvine GL is used as a builder for cleaners and detergents and presents an alternative to phosphates, nitrilotriacetic acid (NTA) and ethylenediaminetetraacetic acid (EDTA).


Dissolvine GL is also used in bath and shower products, cosmetics, hair care and colorings, powders, body treatments and personal care wipes.
In cleaning products, Dissolvine GL excellently binds hardness ions and maintains high chelating properties under high temperature and harsh acidic and alkaline environments.
Dissolvine GL is great for removing tea stains, protein stains and even burnt milk.


Dissolvine GL enhances the effectiveness of biocides and performs best on hard surfaces with shorter contact times than conventional EDTA and NTA complexes.
In personal care products the ingredient, called Dissolvine GL boosts preservative function and helps minimise discolouration.
Dissolvine GL (GLDA) is a chelating agent that is phosphorous free and replaces phosphates, phosphonates, EDTA and NTA.


Dissolvine GL is used cleaning agents, detergents, textile auxiliaries, daily chemicals, oilfield water treatment, pulp and paper auxiliaries, metal surface treatment, etc.
Dissolvine GL is suitable to be used in personal care and cosmetics products, due to the strong chelating ability of calcium and transition metal ions prolonging the shelf life of many products.


Dissolvine GL is used in cosmetics and personal care.
Dissolvine GL is used water treatment, Industrial detergents and cleaners, hard surface cleaners, Dishwashing Detergents, Laundry detergents HDL and LDL, paper industry, Cosmetic/personal care products, Textile auxiliaries, preservative booster.
Dissolvine GL serves the same function in formulations as EDTA, without the health and environmental concerns.


Dissolvine GL is used in bath soaps, detergents and non-spray deodorant product.
Dissolvine GL is often found in sunscreen, facial cleanser, shampoo, makeup, lotion, and other products.
Dissolvine GL is highly effective in removing stains and increases the activity of substances that kill or limit the growth of harmful organisms.


Dissolvine GL also promotes the preservation and stability of soaps.
The dispersion properties of Dissolvine GL also keep soils suspended in the wash and rinse water, preventing re-deposition of dirt on cleaned surfaces and guaranteeing easy rinsing in applications such as dishwashing.
Dissolvine GL is made from plant material, readily biodegradable, with high solubility over a wide pH range.


Strong chelating ability of Dissolvine GL:
Dissolvine GL has a good effect on all kinds of difficult-to-clean calcium scales or difficult-to-clean equipment.
Dissolvine GL is a multi-purpose, clear, liquid chelating agent and preservative booster.
Dissolvine GL is widely used in personal care, cleaning and detergents, industrial cleaning and oil industry.


Dissolvine GL usually appears as an odourless white powder that is soluble in water, and is used as a multi-purpose, clear, liquid chelating agent and preservative booster.
Dissolvine GL is used Cleaning and detergents, Industrial cleaning, Oil industry, personal care, and Pulp and paper.
Dissolvine GL binds with metal ions in the water supply to prevent scale formation.


Soils form complexes with metal ions and bind to surfaces.
These bonds make cleaning and removal of these earth-metal complexes difficult.
The strong chelating and dispersing properties of Dissolvine GL facilitate the removal of metal ions from soils, resulting in greatly improved cleaning performance.


Fewer water droplets left on surfaces reduces the need to rinse repeatedly to get soap off (and therefore reduces water consumption).
Dissolvine GL works as a stabilizer in cosmetic formulations to prevent the natural discoloration of shampoos and gels.
Dissolvine GL is used to enhance and preservative the formulation's ingredients and also acts as a heavy metal chelating agent.
Dissolvine GL has many uses from foods to personal care products.


On an industrial level Dissolvine GL is used in the cutting of fabrics, in the processing or grinding of metals and in the operations of sanding or stripping.
Dissolvine GL is NTA free and also works great as a protective enhancer.
Dissolvine GL can be used as a more sustainable alternative to phosphonates and commonly used chelating agents (NTA and EDTA) in a wide number of applications.


Dissolvine GL can be used in many applications such as industrial and household cleaners for improving the detergency.
Dissolvine GL when added to a formulation can help stabilize the product and prevent discoloration.
Dissolvine GL is used as a chelating agent.
Dissolvine GL also reduces the effect of Calcium and Magnesium ions resulting in better surfactant performance.


Dissolvine GL is used Shampoo Release agent to improve stability in shampoos and cleansers
Dissolvine GL is used Textile Industry to prevent metal ion impurities from changing colors of dyed products
Foods used as preservatives to prevent catalytic oxidative discoloration in certain foods
Dissolvine GL can replace EDTA 1:1 and can be used in products as well as cosmetics and personal care products.


Dissolvine GL works as a chelating agent : Dissolvine GL prevents precipitates from forming inside the product in which it is inserted that could alter the stability and final pleasantness of the cosmetic.
Dissolvine GL is used as a preservative.
Dissolvine GL can be widely used in Personal Care and Cleaning applications.


Dissolvine GL is used Excellent chelating/rinsing agent compared to conventional options good guardians.
Dissolvine GL is suitable to be used in personal care and cosmetics
Dissolvine GL is added to products for skin care, body and hair care, make-up, but also to cleaners, disposable wet wipes and soaps.
Dissolvine GL is also found in detergents, cleansing wipes, bar soap, and other cleaning products.


Dissolvine GL stabilizes the color of the product and improves their durability.
Commercial use of Dissolvine GL: body lotions, skin cream, Shampoo, Toothpastes, and makeup.
Dissolvine GL is found in the following products:
liquid and solid soap, solid shampoo, intimate hygiene products, baby wipes, face lotions and cleansers, make up, skincare products, sun cream.


Dissolvine GL is a multi-purpose clear liquid agent that supports the effectiveness of preservatives.
We can find Dissolvine GL, for example, in hair and body cosmetics, make-up, etc.
Dissolvine GL works as a stabilizer in cosmetic formulations to prevent the natural discoloration of soaps shampoos and gels.
Dissolvine GL also acts as a chelating agent and is used to enhance and preserve the formulation's ingredients.


Dissolvine GL is NTA free and also functions great as a preservative booster.
Dissolvine GL bonds with metal ions in the water supply to prevent scale formation.
The strong chelating and dispersion properties of Dissolvine GL facilitate the removal of metal ions from soils leading to a greatly improved cleaning performance.


In larger quantities Dissolvine GL will enhance the cleaning ability and prevent deactivation of active ingredients during use.
Dissolvine GL can also be found in detergents, waxes, polishes, disinfectants, pest control products and air care products.
Dissolvine GL is found in sunscreen, facial cleanser, shampoo, makeup, lotion, and other products.
Dissolvine GL can be found in shampoos, conditioners, make-up, but also in wet wipes or soaps.


Dissolvine GL offers unique opportunity for skin friendly personal care product development.
Dissolvine GL is also used in personal care products.
Dissolvine GL is free from genetically modified raw materials and is not irritating to skin or eyes, these properties are suitable in the development of new personal care products.


Dissolvine GL is used Mild chelating agent, which helps to stabilize the formulation
Dissolvine GL operates across wide range of pH making it conducive to use in strongly alkaline hard surface cleaning applications that includes food processing, kitchen cleaning and automatic dishwashing products.
Dissolvine GL acts as a rinsing aid in products.


Dissolvine GL is used in cosmetic products as a support for preservatives.
Dissolvine GL extends the shelf life of the product and prevents the growth of microorganisms.
Dissolvine GL is a plant-based chelating agent.
Chelators are substances that are used to maintain the stability and appearance of cosmetic products.


Dissolvine GL is used in sunscreens, facial cleansers, shampoos, makeup, lotions.
You can also find Dissolvine GL in detergents, cleansing wipes, bar soap, and other cleaning products.
Dissolvine GL is used Hard Surface Cleaners, Laundry Detergents HDL and LDL, Cosmetics/Personal Care Products, Industrial Cleaners, Shaving Products, Pulp and Paper Production, Gas Sweetener, Wet wipes, Polymer Production, Dishwashing Liquids, Textile, protective booster, Fertilizers, Distribution aid for micronutrients for plants


-Boilers:
Dissolvine GL is used to prevent lime formation in boilers due to water hardness.
-CHELATING:
Binds metal ions that could adversely affect the stability and quality of cosmetic products
-Titrations:
Dissolvine GL is Used in complexometric titrations and analysis of water hardness


-Uses of Dissolvine GL:
Dissolvine GL solutions for broad portfolio of industrial applications: Dissolvine GL is instrumental in reducing the detrimental effect of metal ions in various industrial processes such as paper manufacturing, personal care formulations, food processing industry, pharmaceutical formulations, metal working area etc.


-Dissolvine GL and skin:
Dissolvine GL is very gentle on the skin and has antibacterial effects.
Dissolvine GL helps with inflammatory symptoms and acne.


-Dissolvine GL and hair:
Dissolvine GL is added to anti-dandruff shampoo.
Dissolvine GL prevents their formation and gently cares for the scalp.


-Formulation flexibility, compatibility and Synergy:
There is an increased interest in the use of Dissolvine GL in disinfectant formulations.
Like tetrasodium ethylenediaminetetraacetic acid (EDTA), Dissolvine GL can be used together with biocides to improve the biocidal performance of a disinfection system.


-High solubility under wide pH:
Dissolvine GL has good solubility in strong acid to high alkali systems, and has better advantages for formulating high active ingredients and low water content formulation systems.


-Dissolvine GL Has the effect of antiseptic and synergistic:
Because it has natural amino acid components, Dissolvine GL has a stronger binding ability with animal cell walls, and thus play a role in antiseptic and synergistic.


-Good stability under high temperature:
By thermogravimetric analysis, Dissolvine GL is tested at 170°C for 6 hours or at 150°C for a week.
Dissolvine GL has no decomposition and is extremely stable.
Compared with other chelating agent products at 100°C, Dissolvine GL has the best performance.


-Application of Dissolvine GL:
*cleaning agents,
*detergents,
*textile auxiliaries,
*daily chemicals,
*oilfield water treatment,
*pulp and paper auxiliaries,
*metal surface treatment, etc.


-Applications of Dissolvine GL:
• Domestic and Industrial Dishwashing
• Detergents
• Descaling
• Personal Care
• Industrial Cleaning
• Pulp Bleaching
• Dishwashing


-High solubility under wide pH:
Dissolvine GL has good solubility in strong acid to high alkali systems, and has better advantages for formulating high active ingredients and low water content formulation systems.


-Good stability under high temperature :
By thermogravimetric analysis, Dissolvine GL is tested at 170°C for 6 hours or at 150°C for a week.
Dissolvine GL has no decomposition and is extremely stable.
Compared with other chelating agent products at 100°C, Dissolvine GL has the best performance.


-Strong chelating ability:
Dissolvine GL has a good effect on all kinds of difficult-to-clean calcium scales or difficult-to-clean equipment.
-Has the effect of antiseptic and synergistic:
Because Dissolvine GL has natural amino acid components, it has a stronger binding ability with animal cell walls, and thus play a role in antiseptic and synergistic.
After experiments, we found that Dissolvine GL has obvious antiseptic and sterilization synergies in many fungicides, which can save 20%-80% of the usage.



GREEN ALTERNATIVE FOR NTA, EDTA, PHOSPHATES AND PHOSPHONATES:
• Readily biodegradable strong
sequestrant
• Excellent eco & toxicological profile
• Based on a natural and sustainable source
• High solubility over wide pH range



COMPARED TO NTA AND EDTA:
• Better eco & tox properties
• Better boost of biocidal activity
• Better hard surface cleaning



COMPARED TO PHOSPHATES AND PHOSPHONATES:
• No contribution to eutrophication
• Better eco & tox properties
• Stronger chelating power
• Better stain removal



FEATURES AND BENEFITS OF DISSOLVINE GL:
An important ingredient in Personal Cares formulations providing benefits that include:
• Enhancing the effectiveness of biological preservatives
- Use less preservatives.
- Effective on molds and both gram positive and gram negative bacteria
• Hard water management
- Improved foam
- Better cleansing
• Improved shelf life and product appearance
- Preventing rancidity
- Protecting the intended color and odor of your formulation
• increases the brightness of the skin,
• moisturizes the dermis in depth,
• reduces wrinkles
• makes the lines of expression less pronounced
• it is emollient, nourishes and softens the skin



PHYSICAL and CHEMICAL PROPERTIES of DISSOLVINE GL:
Molecular Weigh: 351.13
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 9
Rotatable Bond Count: 5
Exact Mass: 350.99189337
Monoisotopic Mass: 350.99189337
Topological Polar Surface Area: 164 Ų
Heavy Atom Count: 22
Formal Charge: 0

Complexity: 314
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 5
Compound Is Canonicalized: Yes
Assay: 95.00 to 100.00

Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in: water
Solubility: Soluble in DMSO
Molecular Weight: 354.15
Appearance: Solid powder
Storage: Dry, dark and at 0 - 4 C for short term (days to weeks)
or -20 C for long term (months to years).

Appearance: Light yellow viscous liquid
Content /%: ≥47
pH value: ≥8.5
Density(20℃) g/cm3: ≥1.20
Appearance: Clear colorless to turbid yellowish liquid
Odor: Characteristic odor
Color (APHA): 100 Max
pH (1% aq.): 10.0-12.0
Freezing point (℃): 0 Max



FIRST AID MEASURES of DISSOLVINE GL:
-Inhalation:
Remove victim to fresh air.
-Skin Contact:
Remove contaminated clothing, shoes and equipment.
Wash all affected areas with soapand plenty of water.
Wash contaminated clothing and shoes before reuse.
-Eye Contact:
Flush eyes with large quantities of running water for a minimum of 15 minutes.
If the victim is wearing contact lenses, remove them.
-Ingestion:
Give several glasses of water.
Give fluids again.



ACCIDENTAL RELEASE MEASURES of DISSOLVINE GL:
-Methods for containment:
Safely stop source of spill.
-Methods for clean-up:
Soak up liquid residue with a suitable absorbent such as clay, sawdust or kitty litter.



FIRE FIGHTING MEASURES of DISSOLVINE GL:
-Flammable properties:
Not flammable or combustible.
*Extinguishing Media:
Use water fog or spray, dry chemical, foam or carbon dioxide extinguishing agents.
-Fire & Explosion Hazards:
This product is not defined as flammable or combustible and should not be a firehazard.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DISSOLVINE GL:
-Engineering Controls & Ventilation:
Special ventilation is usually not required under normal use conditions.
-Personal Protective Equipment (PPE):
*Hygiene Measures:
All food and smoking materials should be kept in a separate area away from the storage/use location.
Before eating, drinking and smoking, hands and faceshould be thoroughly washed.



HANDLING and STORAGE of DISSOLVINE GL:
-Storage:
Keep containers closed and dry.
This material is suitable for any general chemical storage area.
Store in PVC, PE, stainless steel or bituminized tanks.
-Recommended Storage Temperature:
Store in a cool and dry place at ambient temperature (below 25°C / 77°F).
-General Comments:
Containers should not be opened until ready for use.
Opened containers must be closedagain properly.
It is advised to re-test the product after three years of storage



STABILITY and REACTIVITY of DISSOLVINE GL:
-Chemical stability:
This product is stable under recommended storage and handling conditions.
It is not self-reactive and is not sensitive to physical impact.
-Possibility of hazardous reactions:
Hazardous polymerization is not expected to occur under normal temperatures and pressures.



SYNONYMS:
Tetrasodium Glutamate Diacetate
Tetrasodium Dicarboxymethyl Glutamate
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE
L-GLUTAMIC ACID
N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT L-GLUTAMIC ACID
TETRASODIUM GLUTAMATE DIACETATE
TETRASODIUM N,N-BIS(CARBOXYLATOMETHYL)-L-GLUTAMATE
TETRASODIUM SALT L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-
L-Aspartic Acid, N, N-bis(zarboxylatomethyl )-L-glutamate
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
tetrasodium glutamate diacetate
GLDA
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
5EHL50I4MY
N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium Salt
Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate
tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioate
L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
UNII-5EHL50I4MY
DTXSID2052158
Q25393000
Sodium (S)-2-(bis(carboxylatomethyl)amino)pentanedioate
N,N-BIS-(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUMN SALT
N,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water)
tetrasodium mono((S)-2-(bis(carboxymethyl)amino)-4-carboxybutanoate)
L-glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE

DISSOLVINE GL
EC Number: 257-573-7
EC Name: Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
CAS Number: 51981-21-6
Molecular formula: C9H9NO8Na4
IUPAC Name: tetrasodium 2-[bis(carboxylatomethyl)amino]pentanedioate

Dissolvine GL, brand name for GLDA, is the latest, most green and strong chelate in our range.
Dissolvine GL is a safe and readily biodegradable chelating agent that can be used as alternative for phosphates, NTA and EDTA, in a number of applications, such as detergents, personal care and cosmetics, hard surface cleaning, automatic and mechanical dishwashing, oilfield etc.
Dissolvine GL has an exceptional high solubility at high and low pH.
The majority of the molecule originates from a natural, renewable source.

CAS No: 51981-21-6
Molecular formula: C9H9NO8Na4
Chemical name: L-glutamic acid N,N-diacetic acid, tetrasodium salt; GLDA-Na 4
INCI name: Tetrasodium Glutamate Diacetate; Tetrasodium Dicarboxymethyl Glutamate Tetrasodium Glutamate Diacetate, also known as Tetrasodium Dicarboxymethyl Glutamate, GLDA-Na4 for short.
GLDA-Na4 is a new type of green degradable chelating agent, can replace traditional phosphonates, EDTA, NTA.
Dissolvine GL is suit for a wide pH range, with high solubility, high temperature resistance, strong detergency, no ecological toxicity, has synergistic effect with fungicides, and no irritation to skin and eyes.

Dissolvine GL aminopolycarboxylate-based chelating agents (examples of classic ones are EDTA and DTPA) are used extensively to control metal ions in water-based systems for countless applications.
Dissolvine GL are highly effective in the control of water hardness ions and find wide application in cleaning surfaces, descaling boilers, processing textiles and preventing scale formation.
For control of metal ion reactivity, Dissolvine GL are an important tool for reducing the detrimental effect of metal catalysts in peroxide cleaners and in pulp bleaching for paper manufacturing, improving personal care formulations, stabilizing food products and for pharmaceutical formulations.
Finally, they are also used extensively to enhance the chemical and physical properties of metal ions ranging from metal plating, providing essential elements to growing plants and supplying iron for H2S gas scrubbing.
While classical aminopolycarboxylates provide outstanding performance in terms of cost effectiveness and versatility, Dissolvine GL may not always fulfill all the needs of the customer in terms of performance, properties and health, safety and environmental considerations.
Recognizing this, Nouryon is constantly seeking to develop innovative and more environmentally friendly products with excellent chelating performance to complement our existing product range.
Dissolvine GL is an outcome of our continuing effort to develop new and improved products.
Produced from monosodium L-glutamic acid (MSG) which is a biobased naturally occurring amino acid, GLDA is readily biodegradable and offers a high solubility over a wide pH range.
Dissolvine GL does not sensitize human skin, provides enhanced biocidal boosting power and improved biodegradability properties.
Compared to phosphates, GLDA is a far more effective chelating agent and does not contribute to eutrophication.

Applications of Dissolvine GL:
cleaning agents,
detergents,
textile auxiliaries,
daily chemicals,
oilfield water treatment,
pulp and paper auxiliaries,
metal surface treatment, etc.

Technical Specifications of Dissolvine GL
Appearance: Light yellow viscous liquid
Content /%: ≥47
pH value: ≥8.5
Density(20℃) g/cm3: ≥1.20

Features of Dissolvine GL
High solubility under wide pH
Dissolvine GL has good solubility in strong acid to high alkali systems, and has better advantages for formulating high active ingredients and low water content formulation systems.
Good stability under high temperature

By thermogravimetric analysis, Dissolvine GL is tested at 170°C for 6 hours or at 150°C for a week.
Dissolvine GL has no decomposition and is extremely stable.
Compared with other chelating agent products at 100°C, Dissolvine GL has the best performance.

Strong chelating ability
Dissolvine GL has a good effect on all kinds of difficult-to-clean calcium scales or difficult-to-clean equipment.

Has the effect of antiseptic and synergistic
Because Dissolvine GL has natural amino acid components, Dissolvine GL has a stronger binding ability with animal cell walls, and thus play a role in antiseptic and synergistic.
After experiments, we found that GLDA has obvious antiseptic and sterilization synergies in many fungicides, which can save 20%-80% of the usage.

Dissolvine GL
Chemical family: Chelate
CAS number: 51981-21-6
Physical form: Liquid
Molecular Weight: 351.1
Chemical name: Glutamic acid, N,N-diacetic acid, tetra sodium salt
Molecular drawing: Chelate

Applications of Dissolvine GL
Boosting agent for disinfecting products (with low skin irritation).
Improved detergency at high water hardness.
Hard surface cleaning performance is improved in combination with gluco(hepto)nates Scale removal at high pH Scale inhibitor in laundering and dishwashing applications.
Booster for stain removal in dish washing detergents better than citrates and phosphates Scum inhibitor in bathroom cleaners.
Improved cleaning & foaming in shampoo applications.
Storage stabilization of bleaching agents (perborates / percarbonates) and unsaturated alkyl chain based surfactants.
Transport cleaners: Oil and Iron removal at high pH replacement for NTA

Nouryon’s range of Dissolvine® GL (GLDA) products are effective biobased, bio-degradable chelates.
With strong chelating powers, they are highly effective in a wide variety of applications and specifically for use in acidic, alkaline and concentrated detergents.
Combining excellent performance with a superior ecological profile, this readily bio-degradable, eco-premium classified chelating agent is a shining example of a sustainable and innovative material that will add value to your products.


Dissolvine GL, a glutamic acid, diacetic acid and tetra-sodium salt (GLDA-NA4), is a pure product that contains no other weaker chelates as a substitute such as citrates or gluconate.
With 100% of the active content being GLDA, Dissolvine® GL ensures maximum chelation power and efficiency.
Dissolvine GL is produced from the monosodium L-glutamic acid (MSG), a biobased naturally occurring amino acid, ensuring Dissolvine GL is readily bio-degradable.
Coupled with the source material of plant based/sugar waste, Dissolvine GL is a green alternative.

Dissolvine GL is not manufactured from monochloroacetic acid as it is known to release chloride in the system which can cause pitting and corrosion of stainless steel; this can damage the tanks in which the material is stored, and the Chlorine remains present also in the end-formulated product.
For this reason, Nouryon’s manufacturing processes are different to ensure minimal Chlorine presence.

In cleaning formulations and under harsh washing conditions,Dissolvine GL complexes hard water ions very well and retains its high chelating values at elevated temperatures more than other chelating agents.
Dissolvine GL demonstrates strong stain removing including those from tea, starches, meats and burnt milk staining.
With strong biocidal boosting and preservative boosting powers, fewer biocides and preservatives are needed to achieve similar results.

As part of the Dissolvine GL range there are 3 grades we offer:
Dissolvine GL – Standard grade, 38% active solids in solution, ideal for I&I applications
Dissolvine GL – High Purity, NTA free grade with 47% solids in solution, ideal for highly concentrated formulations and Home and Body care applications
Dissolvine GL – Spray-dried grade, 82% active solids in solid form.

CAS#: 51981-21-6
Product Industry: Clean Label

Description of Dissolvine GL
Dissolvine GL is a high purity, versatile and readily biodegradable chelate based upon L-glutamic acid, a natural and renewable raw material.
Dissolvine GL officially received DfE designation and the recognition from the U.S.
EPA that Dissolvine GL is green and performs highly effectively.
Compared to EDTA and NTA,Dissolvine GL performs better when it comes to hard surface cleaning.
Dissolvine GL does not sensitize human skin, demonstrates enhanced biocidal boosting power and improved biodegradability properties.
Compared to phosphates and phosphonates, it is a far more effective chelating agent.
Dissolvine GL is also used in bath and shower products, cosmetics, hair care and colorings, powders, body treatments and personal care wipes.
Dissolvine GL is used as a builder for cleaners and detergents and presents an alternative to phosphates, nitrilotriacetic acid (NTA) and ethylenediaminetetraacetic acid (EDTA).

Functional features of Dissolvine GL
Chemical and physical properties of Dissolvine GL
Dissolvine GL product range including various chemical and physical properties.
Dissolvine GL (offered in EMEA) and Dissolvine GL-47-S (offered worldwide) are standard multi-purpose liquid chelating agents.
The primary difference in these products is the active ingredient content (38 % vrs 47%) and also that the ‘S’ version is high purity (NTA free).
Dissolvine GL is a spray dried equivalent of the liquid product, Dissolvine GL-47-S, is convenient for the preparation of highly concentrated formulations (solid or liquid).
This solid product readily dissolves in water to yield a clear, slightly yellow liquid, is hygroscopic and should be stored in closed bags or containers until it is used.

Liquid density of Dissolvine GL
The density of the liquid can be used as a quick reference to check the concentration of the material.

Solubility of Dissolvine GL
A special feature of GLDA is its extremely high solubility under a wide range of conditions from strongly acidic to high caustic conditions and in between.
For strong chelating agents this property is unique to GLDA and allows the preparation of formulated products with a high active ingredient and low water content.
Besides sparking creative ideas on developing innovative formulations with GLDA – this also has a beneficial impact on our environment.
Higher assay mixtures means less inert water is present and therefore less packaging is needed and less packaging waste is generated.
High assay products also reduce the shipping and storage of water present in formulated products, important especially to stores who have limited display space on their shelves.
Ultimately the environment and we as consumers benefit the most.
Not only does GLDA offer greater solubility at high pH, but it is the only strong chelate allowing highly concentrated solutions to be stable at low pH.
Exceptional solubility that GLDA exhibits in weak acids like acetic acid, to strong acids like HCl and even concentrated NaOH.
Formulating with highly soluble GLDA reduces the water that needs to be used to maintain clarity of a cleaning formulation and may allow for a greater variety and concentration of other additives to be used.

Main functionalities OF Dissolvine GL
in applications
Enhanced cleaning
complexing hard water ions
One of the main reasons why chelates are added to a wide variety of products and processes is to complex the hard water ions Ca2+ and Mg2+.
These ions need to be complexed to prevent their precipitation as unwanted scale or turbidity and to allow other chemicals in the formulation, such as surfactants, to do their job properly.
Most formulations or process streams contain other components that compete for the hard water ions so the chelate should have a higher affinity for these ions than the other components.
Addition of chelates – like GLDA – to control metal ion interactions that occur with soil and surfactants and even bacteria can greatly enhance the cleaning and preserving/sanitizing property of the cleaning formulation.
To illustrate the calcium binding efficiency of GLDA, experiments have been performed with various chelating agents and the Ca2+ ion indicator Hydroxy Naphtol Blue (HNB) that is used here as a competitive chelating agent.
HNB has a relatively high affinity for calcium and colors from blue to red when fully complexed to calcium.
As a result, the color of a solution containing Ca2+ ions, HNB and the chelate to be tested gives a measure for the calcium binding efficiency of the chelate vs.

Readily biodegradable chelating agents.
Metal
ion
Bacteria
Hydroxide
Stain & soil attached to surface
Anionic surfactant

Ca2+ complexing efficiency (%) OF Dissolvine GL
EDTA GLDA* NTA* STPP IDS* EDDS* Citrate*the HNB.
The finding here is that Dissolvine GL is the most effective biodegradable chelating agent for the complexation of hard water ions.
Another measure of the ability to soften water is which is a plot of water hardness vs. log K in the presence of an equal molar concentration of GLDA and other common chelates.
As seen GLDA is capable of achieving low water hardness levels due to its strong binding with Ca2+ ions.
The ability of GLDA to soften water and prevent Ca2+ precipitation with an anionic surfactant.
In the presence of medium hard water the liquid anionic soap readily forms ‘soap scum’ and deactivates the surfactant.
Addition of the weaker chelate citrate has limited benefit in preventing this deactivation – but addition of GLDA shows adequate softening ability.
Addition of small quantities of GLDA to a formulation can help stabilize the product and prevent discoloration or formation of turbidity from reaction of trace metal ions that may be present or contaminate the product during use.
Addition of larger quantities of GLDA will lead to enhanced cleaning ability and prevent deactivation of active ingredients during use.

Dissolving scales of Dissolvine GL
In addition to preventing precipitation of scale,
Dissolvine® chelating agents are used to remove unwanted scale.
The most frequently encountered scales consist of calcium, barium and iron as their carbonate, sulfate or oxide.
Compared to other aminopolycarboxylates, phosphonates and succinates,Dissolvine GL is the best readily biodegradable chelate for the removal of CaCO3 scale.

Dissolvine GL-47-S is a Glutamic acid, N,N-diacetic acid, tetrasodium salt (GLDA) Dissolvine GL is a bio-based, readily biodegradable, cruelty free, globally acceptable and effective chelating agent for Personal Care. With an outstanding environmental profile and friendly INCI name, it’s an ideal choice to bring enhanced preservation, stability, and performance to your formulations. Dissolvine GL is available as a 47% solution in water, Dissolvine GL-47-S in solid form.
INCI Name: Tetrasodium Glutamate Diacetate
Function: Chelating Agent, Bleaching Agent
CAS Number: 51981-21-6

Identification & Functionality of Dissolvine GL
Chemical Family: Sodium Salts
Chemical Name: Tetrasodium Glutamate Diacetate
INCI Name: Tetrasodium Glutamate Diacetate
Cleaning Ingredients Functions
Bleaching Agent

Chelating Agent
Cosmetic Ingredients Functions
Chelating Agent
CAS No.: 51981-21-6
EC No.: 257-573-7
Technologies
Cleaning Ingredients

Cosmetic Ingredients
Product Families
Cleaning Ingredients — Builders & Chelators
Chelating Agents
Cleaning Ingredients — Functional Additives
Performance Additives
Cosmetic Ingredients — Functionals
Stabilizers


Dissolvine GL (Glutamic acid diacetic acid) is a biobased sequestrant and chelating agent produced by AkzoNobel.
This product can be used to replace NTA, EDTA, phosphates and phosphonates in several cleaning products and formulations.
Dissolvine® GL is based on natural amino acid salt, monosodium L-glutamate (MSG) and is readily biodegradable.

Applications of Dissolvine GL:
Domestic and Industrial Dishwashing
Detergents
Descaling
Personal Care
Industrial Cleaning
Pulp Bleaching

Bio-Content Basis: 86%
Renewable Feedstock: Derived from natural amino acid salt, monosodium L-glutamate (MSG)

Dissolvine GL is a glutamic acid, diacetic acid and tetra-sodium salt (GLDA-NA4), it's a pure product that contains no other weaker chelates as a substitute such as citrates or gluconate.
With 100% of the active content being GLDA, Dissolvine GL offers maximum chelation power and efficiency.
Dissolvine is a sustainable, innovative material. It is extensively used to control metal ions in water based systems for multiple applications.
Dissolvine GL is highly effective in the control of water hardness ions and can also be used in cleaning surfaces, descaling boilers, processing textiles and preventing scale formation.
In cleaning formulations and under harsh washing conditions, Dissolvine GL complexes hard water ions very well and retains its high chelating values at elevated temperatures more than other chelating agents.
This solution is an important tool in controlling metal ion reactivity as Dissolvine GL reduces the detrimental effect of metal catalysts in peroxide cleaners.
This can also be used to enhance the physical properties of metal ions, supplying iron for gas scrubbing and providing essential elements to growing plants.
Dissolvine GL is produced from the monosodium L-glutamic acid (MSG), a bio based naturally occurring amino acid, ensuring Dissolvine GL is readily bio-degradable.
This alongside the source material of plant based/sugar waste, Dissolvine GL is an environmentally friendly alternative.
Please note, this product can only be delivered to commercial premises. To view our full range of industrial chemicals

IDENTIFICATION OF Dissolvine GL
Product identifier
Trade name : Dissolvine GL
REACH Registration Number : 01-2119493601-38-0000
Relevant identified uses of the substance or mixture and uses advised against
Use of the
Substance/Mixture
Specific use(s): Chelating agent
Details of the supplier of the safety data sheet

EPA awards the DfE designation only to chemicals that pass the strict DfE criteria after the agency's scientific team screens each ingredient for potential human health and environmental impacts.
The DfE mark helps consumers and commercial businesses identify products that are determined to be effective and safe according to the DfE assessment program.
Some 2,800 products have received the DfE designation.

Dissolvine GL, which is derived predominantly from U.S.-grown corn and readily biodegradable, is used by the leading makers of cleaning products as a chelating agent to control hard water ions.
Dissolvine GL is used in household detergents and dishwashing products, as well as in personal care and cosmetics products.
In detergent, for example, it helps boost the cleaning power and is highly effective at stain removal, even at higher temperatures.
Dissolvine GL is used as a builder for cleaners and detergents as an alternative to phosphates, nitrilotriacetic acid (NTA) and ethylenediaminetetraacetic acid (EDTA).

Readily biodegradable strong sequestrant
Excellent eco & toxicological profile
Based on a natural and sustainable source
High solubility over wide pH range
Compared to NTA and EDTA:
Better eco & tox properties
Better boost of biocidal activity
Better hard surface cleaning

Compared to phosphates and phosphonates:
No contribution to eutrophication
Better eco & tox properties
Stronger chelating power
Better stain removal

For use in applications:
Domestic and Industrial
Dishwashing
Detergents
Descaling
Personal Care
Industrial Cleaning
Pulp Bleaching

Introduction Dissolvine aminopolycarboxylate-based chelates are used extensively to control metal ions in water-based systems for countless applications.
Dissolvine GL are highly effective in the control of water hardness ions and find wide application in cleaning surfaces, descaling boilers, processing textile and preventing scale in heating systems.
In another area, the control of metal reactivity, they are important processing tools for reducing the detrimental effect of metals in pulp bleaching for paper manufacturing, improving personal care formulations, stabilizing food products and for pharmaceutical formulations.
Finally, they are also used extensively in metalworking areas, ranging from metal plating, dosing essential elements to plants and supplying iron for the development of photographic films and paper using silver halide technology.
The sheer diversity of application demonstrates the versatility of the Dissolvine chelate product range.
Although classical aminopolycarboxylates are excellent performers in terms of cost effectiveness and versatility, they do not always meet all the needs of the customer.
Recognizing this fact, AkzoNobel is constantly seeking to develop even more environmentally benign products with an excellent chelating performance to complement our existing product range.
Dissolvine GL has been developed as part of this continuing quest to find new and improved products.
Produced from natural and sustainable raw materials, Dissolvine GL is readily biodegradable, with a high solubility over a wide ph range.
Compared to EDTA and NTA, Dissolvine GL performs better when it comes to hard surface cleaning.
Dissolvine GL does not sensitize human skin, demonstrates enhanced biocidal boosting power and improved biodegradability properties.
Compared to phosphates and phosphonates, it is a far more effective chelating agent.
Also, Dissolvine GL does not contribute to eutrophication and has improved toxicological properties.
Product description Chemical structure The active ingredient in Dissolvine GL is glutamic acid diacetic acid, tetra sodium salt (GLDA).
As shown below, GLDA has four carboxylic acid groups.
In combination with the nitrogen atom these acid groups can form strong bonds with di- and trivalent metals.
Chemical formula: C 9 H 9 NO 8 Na 4

Ecological footprint Dissolvine GL is based on the food-approved natural amino acid salt, Dissolvine GL.
Dissolvine GL is produced by biochemical conversion of vegetable material (such as sugar beet waste).
This results in a good biological breakdown as is confirmed by the Closed Bottle biodegradability test (OECD 301D).
The greener nature of Dissolvine GL, compared to a wellknown chelate such as EDTA has also been quantified using internationally accepted standards: A biobased content analysis using ASTM-D6866 executed by a third party confirms the green nature of Dissolvine GL.
The measured mean biobased content of 53 percent is very close to the theoretical percentage of green carbon atoms in GLDA, i.e. the ones derived from vegetable MSG.
These account for 5 out of a total of 9 carbon atoms.

Description OF Dissolvine GL:
CROSS-REFERENCE TO RELATED APPLICATION
This application claims the benefit of priority to U.S.

FIELD OF THE INVENTION
The present invention relates to cleansing compositions that are useful in cleansing the skin and hair and are characterized by having low irritation characteristics in combination with sufficient viscosity in the absence of ethoxylated surfactants.

BACKGROUND OF THE INVENTION
Cleansing compositions typically contain nonionic, anionic and/or amphoteric surfactants.
Of the nonionic surfactants, ethoxylated surfactants are typically utilized to increase the viscosity of the composition.
This leads to less dripping of the product and nice product aesthetics.

However, as is recognized in the art, there is a concern of ethoxylated surfactants potentially containing 1,4-dioxane and associated safety concerns.
Therefore, Dissolvine GL is desirable to provide cleansing compositions that are free of ethoxylated surfactants.

Removal of ethoxylated surfactants results in low viscosity, which is undesirable.
Therefore, there is a need for mild cleansing compositions that are free of ethoxylated surfactants and have sufficient viscosity.

SUMMARY OF THE INVENTION
The present invention relates to a cleansing composition comprising, consisting essentially of and consisting of: (a) from about 3% to about 20% by weight based on the total weight of the composition of an amphoteric surfactant; and (b) an alkyl glucoside surfactant, wherein a ratio of alkyl glucoside surfactant to amphoteric surfactant is at least 1 to 1, the composition is free of ethoxylated surfactants, and the composition has a viscosity of at least 2000 centipoise.

DETAILED DESCRIPTION OF THE INVENTION
Applicants have discovered that the skin cleansing compositions of this invention exhibit a unique and unexpected combination of properties including relatively low irritation and relatively high viscosity for non-ethoxylated cleansing compositions.
This makes the compositions of this invention ideal for skin and hair care, including baby and infant skin, cosmetic or cleansing compositions.
The term “free of ethoxylated surfactants” means the compositions of the present invention contain less than 1%, for example less than 0.1% or 0% by weight ethoxylated surfactant.
To provide a more concise description, some of the quantitative expressions given herein are not qualified with the term “about”.
Dissolvine GL is understood that whether the term “about” is used explicitly or not, every quantity given herein is meant to refer to the actual given value, and Dissolvine GL is also meant to refer to the approximation to such given value that would reasonably be inferred based on the ordinary skill in the art, including approximations due to the experimental and/or measurement conditions for such given value.

To provide a more concise description, some of the quantitative expressions herein are recited as a range from about amount X to about amount Y.
Dissolvine GL is understood that wherein a range is recited, the range is not limited to the recited upper and lower bounds, but rather includes the full range from about amount X through about amount Y, or any amount or range therein.

Amphoteric Surfactants
Compositions of the present invention include an amphoteric surfactant. Nonlimiting examples of amphoteric surfactants are those selected from the group consisting of betaines, alkyliminoacetates, iminodialkanoates, and aminoalkanoates.
Examples of amphoteric surfactants of the present invention include disodium lauroamphodiacetate, sodium lauroamphoacetate, cetyl dimethyl betaine, cocoamidopropyl betaine, and oleyl betaine.

Other examples of suitable betaine compounds include dodecyldimethylammonium acetate, tetradecyldimethylammonium acetate, hexadecyldimethylammonium acetate, alkyldimethylammonium acetate wherein the alkyl group averages about 12 to 18 carbon atoms in length, dodecyldimethylammonium butanoate, tetradecyldimethylammonium butanoate, hexadecyldimethylammonium butanoate, dodecyldimethylammonium hexanoate, hexadecyldimethylammonium hexanoate, tetradecyldimethylammonium pentanoate and tetradecyldipropyl ammonium pentanoate.
The amount of amphoteric surfactant in the compositions of the present invention may range from about 3% to about 20% by weight, for example from about, 4% to about 18% by weight and from about7% to about 15% by weight based on the total weight of the composition.

Alkyl Glucoside
Compositions according to the present invention also include an alkyl glucoside surfactant.
Suitable alkyl glucoside surfactants include, but are not limited to, decyl glucoside, coco glucoside, lauryl glucoside, and polyglyceryl esters, such as but not limited to polyglyceryl-10 laurate and polyglyceryl-10 oleate.
The amount of alkyl glucoside surfactant in the compositions of the present invention may range from about 3% to about 20% by weight, for example from about 4% to about 18% by weight, and from about 7% to about 15% by weight based on the total weight of the composition.

Compositions according to the present invention may also include an anionic surfactant. Suitable anionic surfactants include, but are not limited to, sodium coco sulfate. The amount of anionic surfactant in the compositions of the present invention may range from about 0.1% to about 5% by weight, for example from about 0.1% to about 3% by weight based on the total weight of the composition.
When an anionic surfactant is present in the compositions of the present invention, the ratio of the total amount of alkyl glucoside surfactant and anionic surfactant to amphoteric surfactant is at least 1 to 1.

Compositions according to the present invention have a viscosity of 2000 centipoise or more (Brookfield LVF, 6 rpm, spindle no. 2) at 25° C. in a stripped down formulation (water and surfactants).
The viscosity of the final formulation is at least 1000 centipoise (under the same testing conditions).

The cleansing compositions produced may further contain any of a variety of other components nonexclusively including additives which enhance the appearance, feel and fragrance of the compositions, such as colorants, fragrances, preservatives, pH adjusting agents and the like.
Any of a variety of non-ethoxylated nonionic surfactants are suitable for use in the compositions of this invention. Examples of suitable nonionic surfactants include, but are not limited to, alkyl polyglucosides, polyglyceryl esters, mixtures thereof, and the like.
Certain preferred nonionic surfactants include alkyl polyglucosides, such as but not limited to coco-glucoside and decyl-glucoside, and polyglyceryl esters, such as but not limited to polyglyceryl-10 laurate and polyglyceryl-10 oleate.

Any of a variety of commercially available secondary conditioners, such as volatile silicones, which impart additional attributes, such as gloss to the hair are suitable for use in this invention.
In one embodiment, the volatile silicone conditioning agent has an atmospheric pressure boiling point less than about 220° C.
The volatile silicone conditioner may be present in an amount of from about 0 percent to about 3 percent, e.g. from about 0.25 percent to about 2.5 percent or from about 0.5 percent to about 1 percent, based on the overall weight of the composition.

Any of a variety of commercially available humectants, which are capable of providing moisturization and conditioning properties to the personal cleansing composition, are suitable for use in this invention. The humectant may be present in an amount of from about 0 percent to about 10 percent, e.g. from about 0.5 percent to about 5 percent or from about 0.5 percent to about 3 percent, based on the overall weight of the composition.
Examples of suitable humectants nonexclusively include: 1) water soluble liquid polyols selected from the group comprising glycerine, propylene glycol, hexylene glycol, butylene glycol, dipropylene glycol, and mixtures thereof; 2)polyalkylene glycol of the formula: HO—(R″O)b—H, wherein R″ is an alkylene group having from about 2 to about 3 carbon atoms and b is an integer of from about 2 to about 10; 3) polyethylene glycol ether of methyl glucose of formula CH3—C6H10O5—(OCH2CH2)c—OH, wherein c is an integer from about 5 to about 25; 4) urea; and 5) mixtures thereof, with glycerine being the preferred humectant.

Examples of suitable chelating agents include those which are capable of protecting and preserving the compositions of this invention. Preferably, the chelating agent is ethylenediamine tetracetic acid (“EDTA”), and more preferably is tetrasodium EDTA, available commercially from Dow Chemical Company of Midland, Michigan under the tradename, “Versene 100XL” and is present in an amount, based upon the total weight of the composition, from about 0 to about 0.5 percent or from about 0.05 percent to about 0.25 percent.

Suitable preservatives include organic acid preservatives may include benzoic acid and alkali metal and ammonium salts thereof (e.g. sodium benzoate), sorbic acid and alkali metal and ammonium salts thereof (e.g. potassium sorbate), p-Anisic acid and alkali metal and ammonium salts thereof, and salicylic acid and alkali metal and ammonium salts thereof.
The pH of the composition may be adjusted to the appropriate acidic value using any cosmetically acceptable organic or inorganic acid, such as citric acid, acetic acid, glycolic acid, lactic acid, malic acid, tartaric acid, or hydrochloric acid.

In one embodiment of the composition, sodium benzoate is present in the composition in an amount, based upon the total weight of the composition, from about 0 to about 0.5 percent. In another embodiment, potassium sorbate is present in the composition in an amount, based upon the total weight of the composition, from about 0 to about 0.6 percent, more preferably from about 0.3 to about 0.5 percent.

The ethoxylate free surfactant cleansing composition according to the present invention may include shampoos, 2 in 1 shampoo-conditioners, hair and body washes, washes, baths, gels, lotions, creams and the like.

The present invention provides for methods of cleansing a portion of the body including the skin and hair comprising contacting the body with the cleansing composition of the present invention.
The methods and compositions of this invention illustratively disclosed herein suitably may be practiced in the absence of any component, ingredient, or step which is not specifically disclosed herein.
Several examples are set forth below to further illustrate the nature of the invention and the manner of carrying it out. However, the invention should not be considered as being limited to the details thereof.

Computed Properties of Dissolvine GL

Molecular Weight: 351.13
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 9
Rotatable Bond Count. 5
Exact Mass: 350.99189337
Monoisotopic Mass: 350.99189337
Topological Polar Surface Area: 164 Ų
Heavy Atom Count: 22
Formal Charge : 0
Complexity: 314
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 5
Compound Is Canonicalized: Yes

Synonyms of Dissolvine GL
51981-21-6
tetrasodium glutamate diacetate
GLDA
Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
5EHL50I4MY
N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium Salt
L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioate
N,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water)
UNII-5EHL50I4MY
EINECS 257-573-7
DISSOLVINE GL
CHELEST CMG-40
EC 257-573-7
DTXSID2052158
MFCD01862262
TETRASODIUM GLUTAMATE DIACETATE [INCI]
DISSOLVINE GL-38
DISSOLVINE GL-38 = TETRASODIUM GLUTAMATE DIACETATE


CAS Number 51981-21-6
EC Number: 257-573-7
Chemical formula GLDA-Na4 / C9H9NO8Na4
Chemical name Glutamic acid, N,N-biacetic acid, tetrasodium salt


Dissolvine GL-38 is a concentrated aqueous solution of an amino acid based natural chelating agent.
Dissolvine GL-38 is highly effective at low concentrations of water at a very wide acidic and alkaline pH range.
Dissolvine GL-38 is readily biodegradable and can be considered as one of the most environmentally friendly chelators without compromising product performance.


Dissolvine GL-38 is the latest, most green and strong chelate.
Dissolvine GL-38 has an exceptional high solubility at high and low pH.
The majority of the molecule originates from a natural, renewable source.
Dissolvine GL-38 are standard multi-purpose liquid chelating agent.


Dissolvine GL-38 is amino polycarboxylate chelating agents.
Dissolvine GL-38 forms stable chelates with polyvalent metal ions over a wide pH range.
Dissolvine GL-38 is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.


Dissolvine GL-38 is a rinsing aid.
Dissolvine GL-38 is a vegetable-based chelating agent.
Dissolvine GL-38 is a palm oil-, EDTA- and nitrilotriacetic acid (NTA)-free chelating agent.
Dissolvine GL-38 research shows the ingredient is not a strong skin irritant.


Dissolvine GL-38 exhibits dispersion properties combined with easier rinsing.
Dissolvine GL-38 offers enhanced biocidal/preservative boosting power.
Dissolvine GL-38 is recommended for wash-off formulations, wipes, shaving products, fragrances, toiletries, makeup, skin-, sun-, baby & oral care products.


Using a chelating agent helps to slow this process, allowing for the creation of products with improved stability and appearance.
This also improves the effectiveness of preservative ingredients, allowing us to use a lower percentage of these, for safer shelf-stable products.
Dissolvine GL-38 is readily biodegradable with a high level of solubility over a wide pH range, thus a greener alternative to many other chelates and phosphates.


Dissolvine GL-38 has Excellent chelating effect controlling metal catalyzed decomposition.
Dissolvine GL-38 reduces water hardness and prevents precipitation.
Dissolvine GL-38 boosts performance of preservatives improving shelf life.
Dissolvine GL-38 Stabilizes the pH value and is effective in wide pH range.


Dissolvine GL-38 does not sensitize human skin.
Dissolvine GL-38 is Completely biodegradable as compared to phosphates and phosphonates.
Dissolvine GL-38 is an effective alternative to EDTA.
Dissolvine GL-38 , also known as Tetrasodium Dicarboxymethyl Glutamate, GLDA-Na4 for short.


Dissolvine GL-38 is a new type of green degradable chelating agent, can replace traditional phosphonates, EDTA, NTA.
Dissolvine GL-38 is suit for a wide pH range, with high solubility, high temperature resistance, strong detergency, no ecological toxicity, has synergistic effect with fungicides, and no irritation to skin and eyes.
Dissolvine GL-38 is a safe synthetic chelating agent with natural origins.


Dissolvine GL-38 is what's known as a 'chelating agent', an ingredient that inactivates metallic ions (charged particles) in product formulations.
Dissolvine GL-38 is a high purity, versatile and readily biodegradable chelating agent based upon L-glutamic acid, a natural and renewable raw material.



USES and APPLICATIONS of DISSOLVINE GL-38:
As a conditioner, Dissolvine GL-38 softens well, it turns out a pleasant to the touch soft, naturally soft fabric.
Dissolvine GL-38 is as if after washing the clothes were dried in the yard.
Dissolvine GL-38 is a safe and readily biodegradable chelating agent that can be used as alternative for phosphates, NTA and EDTA, in a number of applications, such as detergents, personal care and cosmetics, hard surface cleaning, automatic and mechanical dishwashing, oilfield etc.


Dissolvine GL-38 is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Dissolvine GL-38 is used in the following products: washing & cleaning products, polishes and waxes, air care products and biocides (e.g. disinfectants, pest control products).


Other release to the environment of Dissolvine GL-38 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Release to the environment of Dissolvine GL-38 can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and industrial abrasion processing with high release rate (e.g. sanding operations or paint stripping by shot-blasting).


Other release to the environment of Dissolvine GL-38 is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Dissolvine GL-38 can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material).


Dissolvine GL-38 is used cleaning agents, detergents, textile auxiliaries, daily chemicals, oilfield water treatment, pulp and paper auxiliaries, metal surface treatment, etc.
Dissolvine GL-38 is suitable to be used in personal care and cosmetics products, due to the strong chelating ability of calcium and transition metal ions prolonging the shelf life of many products.


Dissolvine GL-38 L is used in cosmetics and personal care.
Dissolvine GL-38 is used water treatment, Industrial detergents and cleaners, hard surface cleaners, Dishwashing Detergents, Laundry detergents HDL and LDL, paper industry, Cosmetic/personal care products, Textile auxiliaries, preservative booster.
Dissolvine GL-38 serves the same function in formulations as EDTA, without the health and environmental concerns.


Dissolvine GL-38 is used in bath soaps, detergents and non-spray deodorant product.
Dissolvine GL-38 is often found in sunscreen, facial cleanser, shampoo, makeup, lotion, and other products.
Dissolvine GL-38 is highly effective in removing stains and increases the activity of substances that kill or limit the growth of harmful organisms.


Dissolvine GL-38 also promotes the preservation and stability of soaps.
The dispersion properties of Dissolvine GL-38 also keep soils suspended in the wash and rinse water, preventing re-deposition of dirt on cleaned surfaces and guaranteeing easy rinsing in applications such as dishwashing.
Dissolvine GL-38 is made from plant material, readily biodegradable, with high solubility over a wide pH range.


Strong chelating ability of Dissolvine GL-38:
Dissolvine GL-38 has a good effect on all kinds of difficult-to-clean calcium scales or difficult-to-clean equipment.
Dissolvine GL-38 is a multi-purpose, clear, liquid chelating agent and preservative booster.
Dissolvine GL-38 is widely used in personal care, cleaning and detergents, industrial cleaning and oil industry.


Dissolvine GL-38 usually appears as an odourless white powder that is soluble in water, and is used as a multi-purpose, clear, liquid chelating agent and preservative booster.
Dissolvine GL-38 is used Cleaning and detergents, Industrial cleaning, Oil industry, personal care, and Pulp and paper.
Dissolvine GL-38 binds with metal ions in the water supply to prevent scale formation.


Soils form complexes with metal ions and bind to surfaces.
These bonds make cleaning and removal of these earth-metal complexes difficult.
The strong chelating and dispersing properties of Dissolvine GL-38 facilitate the removal of metal ions from soils, resulting in greatly improved cleaning performance.


Fewer water droplets left on surfaces reduces the need to rinse repeatedly to get soap off (and therefore reduces water consumption).
Dissolvine GL-38 works as a stabilizer in cosmetic formulations to prevent the natural discoloration of shampoos and gels.
Dissolvine GL-38 is used to enhance and preservative the formulation's ingredients and also acts as a heavy metal chelating agent.
Dissolvine GL-38 has many uses from foods to personal care products.


On an industrial level Dissolvine GL-38 is used in the cutting of fabrics, in the processing or grinding of metals and in the operations of sanding or stripping.
Dissolvine GL-38 is NTA free and also works great as a protective enhancer.
Dissolvine GL-38 can be used as a more sustainable alternative to phosphonates and commonly used chelating agents (NTA and EDTA) in a wide number of applications.


Dissolvine GL-38 can be used in many applications such as industrial and household cleaners for improving the detergency.
Dissolvine GL-38 when added to a formulation can help stabilize the product and prevent discoloration.
Dissolvine GL-38 is used as a chelating agent.
Dissolvine GL-38 also reduces the effect of Calcium and Magnesium ions resulting in better surfactant performance.


Dissolvine GL-38 is used Shampoo Release agent to improve stability in shampoos and cleansers
Dissolvine GL-38 is used Textile Industry to prevent metal ion impurities from changing colors of dyed products
Foods used as preservatives to prevent catalytic oxidative discoloration in certain foods
Dissolvine GL-38 can replace EDTA 1:1 and can be used in products as well as cosmetics and personal care products.


Dissolvine GL-38 works as a chelating agent : Dissolvine GL-38 prevents precipitates from forming inside the product in which it is inserted that could alter the stability and final pleasantness of the cosmetic.
Dissolvine GL-38 is used as a preservative.
Dissolvine GL-38 can be widely used in Personal Care and Cleaning applications.


Dissolvine GL-38 is used Excellent chelating/rinsing agent compared to conventional options good guardians.
Dissolvine GL-38 is suitable to be used in personal care and cosmetics
Dissolvine GL-38 is added to products for skin care, body and hair care, make-up, but also to cleaners, disposable wet wipes and soaps.
Dissolvine GL-38 is also found in detergents, cleansing wipes, bar soap, and other cleaning products.


Dissolvine GL-38 stabilizes the color of the product and improves their durability.
Commercial use of Dissolvine GL-38: body lotions, skin cream, Shampoo, Toothpastes, and makeup.
Dissolvine GL-38 is found in the following products:
liquid and solid soap, solid shampoo, intimate hygiene products, baby wipes, face lotions and cleansers, make up, skincare products, sun cream.


Dissolvine GL-38 is a multi-purpose clear liquid agent that supports the effectiveness of preservatives.
We can find Dissolvine GL, for example, in hair and body cosmetics, make-up, etc.
Dissolvine GL-38 works as a stabilizer in cosmetic formulations to prevent the natural discoloration of soaps shampoos and gels.
Dissolvine GL-38 also acts as a chelating agent and is used to enhance and preserve the formulation's ingredients.


Dissolvine GL-38 is NTA free and also functions great as a preservative booster.
Dissolvine GL-38 bonds with metal ions in the water supply to prevent scale formation.
The strong chelating and dispersion properties of Dissolvine GL-38 facilitate the removal of metal ions from soils leading to a greatly improved cleaning performance.


In larger quantities Dissolvine GL-38 will enhance the cleaning ability and prevent deactivation of active ingredients during use.
Dissolvine GL-38 can also be found in detergents, waxes, polishes, disinfectants, pest control products and air care products.
Dissolvine GL-38 is found in sunscreen, facial cleanser, shampoo, makeup, lotion, and other products.
Dissolvine GL-38 can be found in shampoos, conditioners, make-up, but also in wet wipes or soaps.


Dissolvine GL-38 offers unique opportunity for skin friendly personal care product development.
Dissolvine GL-38 is also used in personal care products.
Dissolvine GL-38 is free from genetically modified raw materials and is not irritating to skin or eyes, these properties are suitable in the development of new personal care products.


Dissolvine GL-38 is used Mild chelating agent, which helps to stabilize the formulation
Dissolvine GL-38 operates across wide range of pH making it conducive to use in strongly alkaline hard surface cleaning applications that includes food processing, kitchen cleaning and automatic dishwashing products.
Dissolvine GL-38 acts as a rinsing aid in products.


Dissolvine GL-38 is used in cosmetic products as a support for preservatives.
Dissolvine GL-38 extends the shelf life of the product and prevents the growth of microorganisms.
Dissolvine GL-38 is a plant-based chelating agent.
Chelators are substances that are used to maintain the stability and appearance of cosmetic products.


Dissolvine GL-38 is used in sunscreens, facial cleansers, shampoos, makeup, lotions.
You can also find Dissolvine GL-38 in detergents, cleansing wipes, bar soap, and other cleaning products.
Dissolvine GL-38 is used Hard Surface Cleaners, Laundry Detergents HDL and LDL, Cosmetics/Personal Care Products, Industrial Cleaners, Shaving Products, Pulp and Paper Production, Gas Sweetener, Wet wipes, Polymer Production, Dishwashing Liquids, Textile, protective booster, Fertilizers, Distribution aid for micronutrients for plants


-Boilers:
Dissolvine GL-38 is used to prevent lime formation in boilers due to water hardness.
-CHELATING:
Binds metal ions that could adversely affect the stability and quality of cosmetic products
-Titrations:
Dissolvine GL-38 is Used in complexometric titrations and analysis of water hardness


-Uses of Dissolvine GL-38:
Dissolvine GL-38 solutions for broad portfolio of industrial applications: Dissolvine GL-38 is instrumental in reducing the detrimental effect of metal ions in various industrial processes such as paper manufacturing, personal care formulations, food processing industry, pharmaceutical formulations, metal working area etc.


-Dissolvine GL-38 and skin:
Dissolvine GL-38 is very gentle on the skin and has antibacterial effects.
Dissolvine GL-38 helps with inflammatory symptoms and acne.


-Dissolvine GL-38 and hair:
Dissolvine GL-38 is added to anti-dandruff shampoo.
Dissolvine GL-38 prevents their formation and gently cares for the scalp.


-Formulation flexibility, compatibility and Synergy:
There is an increased interest in the use of Dissolvine GL-38 in disinfectant formulations.
Like tetrasodium ethylenediaminetetraacetic acid (EDTA), Dissolvine GL-38 can be used together with biocides to improve the biocidal performance of a disinfection system.


-High solubility under wide pH:
Dissolvine GL-38 has good solubility in strong acid to high alkali systems, and has better advantages for formulating high active ingredients and low water content formulation systems.


-Dissolvine GL-38 Has the effect of antiseptic and synergistic:
Because it has natural amino acid components, Dissolvine GL-38 has a stronger binding ability with animal cell walls, and thus play a role in antiseptic and synergistic.


-Good stability under high temperature:
By thermogravimetric analysis, Dissolvine GL-38 is tested at 170°C for 6 hours or at 150°C for a week.
Dissolvine GL-38 has no decomposition and is extremely stable.
Compared with other chelating agent products at 100°C, Dissolvine GL-38 has the best performance.


-Dissolvine GL-38 – Standard grade, 38% active solids in solution, ideal for I&I applications:
*Synergistic complexing agent for disinfectants (low skin irritation)
*Significantly enhances cleaning power in case of increased water hardness
*The cleaning effect on hard surfaces is enhanced in combination with glucoheptonates.
*Descaler for high pH
*Dissolvine GL-38 is inhibitor of scale formation during washing and in dishwashing detergents.
*Dissolvine GL-38 enhances stain-removing power in dishwashing detergents, better than citrates and phosphates
*Scale inhibitor in sanitary ware cleaners
*Dissolvine GL-38 improves cleansing power and lather in shampoo production
*Dissolvine GL-38 provides storage stability for products containing bleaches such as perborates and percarbonates, as well as surfactants based on an unsaturated alkyl chain. Vehicle cleaning: high pH oil and rust removal, NTA chelating agent can be substituted in the formulation


-Applications of Dissolvine GL-38:
*Automatic dishwash tabs, gels and capsules
*Cleaning products
*Cosmetics


-Household cleaners and detergents uses of Dissolvine GL-38:
Liquid laundry detergents, stain removers, conditioners, dishwasher detergents, surface cleaners;
-Cosmetic care products uses of Dissolvine GL-38:
Liquid soaps, shampoos, hair balms, shower gels and foams, wet wipes, balms, face and body creams.


-Applications of Dissolvine GL-38:
*Synergistic complexing agent for disinfectants (with low skin irritation)
*Significantly enhances cleaning power at increased water hardness
*Hard surface cleaning action is enhanced in combination with glucoheptonates
*Descaling agent at high pH
*Scale inhibitor washing time and in dishwashing detergents. Enhances stain removal capacity in dishwashing detergents, better than citrates and phosphates
*Scale inhibitor in sanitary ware cleaners
*Improves cleaning power and foaming in the shampoo industry
*Provides storage stability for products containing bleaches such as perborates and percarbonates, and unsaturated alkyl chain surfactants.
*Cleaning of vehicles: removal of oil and rust at high pH, ​​it is possible to replace the NTA complexing agent in the recipe



BENEFITS OF DISSOLVINE GL-38:
*biodegradable & non toxic
*Scale prevention and removal
*Improves the bleaching process
*Produced from Bio-based raw material (L-Glutamic acid)



FUNCTIONS OF DISSOLVINE GL-38:
*Chelating Agent
*Stabilizer-Viscosity



PHYSICAL and CHEMICAL PROPERTIES of DISSOLVINE GL-38:
Molecular Weigh: 351.13
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 9
Rotatable Bond Count: 5
Exact Mass: 350.99189337
Monoisotopic Mass: 350.99189337
Topological Polar Surface Area: 164 Ų
Heavy Atom Count: 22
Formal Charge: 0

Complexity: 314
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 5
Compound Is Canonicalized: Yes
Assay: 95.00 to 100.00

Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in: water
Solubility: Soluble in DMSO
Molecular Weight: 354.15
Appearance: Solid powder
Storage: Dry, dark and at 0 - 4 C for short term (days to weeks)
or -20 C for long term (months to years).

Appearance: Light yellow viscous liquid
Content /%: ≥47
pH value: ≥8.5
Density(20℃) g/cm3: ≥1.20
Appearance: Clear colorless to turbid yellowish liquid
Odor: Characteristic odor
Color (APHA): 100 Max
pH (1% aq.): 10.0-12.0
Freezing point (℃): 0 Max



FIRST AID MEASURES of DISSOLVINE GL-38:
-Inhalation:
Remove victim to fresh air.
-Skin Contact:
Remove contaminated clothing, shoes and equipment.
Wash all affected areas with soapand plenty of water.
Wash contaminated clothing and shoes before reuse.
-Eye Contact:
Flush eyes with large quantities of running water for a minimum of 15 minutes.
If the victim is wearing contact lenses, remove them.
-Ingestion:
Give several glasses of water.
Give fluids again.



ACCIDENTAL RELEASE MEASURES of DISSOLVINE GL-38:
-Methods for containment:
Safely stop source of spill.
-Methods for clean-up:
Soak up liquid residue with a suitable absorbent such as clay, sawdust or kitty litter.



FIRE FIGHTING MEASURES of DISSOLVINE GL-38:
-Flammable properties:
Not flammable or combustible.
*Extinguishing Media:
Use water fog or spray, dry chemical, foam or carbon dioxide extinguishing agents.
-Fire & Explosion Hazards:
This product is not defined as flammable or combustible and should not be a firehazard.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DISSOLVINE GL-38:
-Engineering Controls & Ventilation:
Special ventilation is usually not required under normal use conditions.
-Personal Protective Equipment (PPE):
*Hygiene Measures:
All food and smoking materials should be kept in a separate area away from the storage/use location.
Before eating, drinking and smoking, hands and faceshould be thoroughly washed.



HANDLING and STORAGE of DISSOLVINE GL-38:
-Storage:
Keep containers closed and dry.
This material is suitable for any general chemical storage area.
Store in PVC, PE, stainless steel or bituminized tanks.
-Recommended Storage Temperature:
Store in a cool and dry place at ambient temperature (below 25°C / 77°F).
-General Comments:
Containers should not be opened until ready for use.
Opened containers must be closedagain properly.
It is advised to re-test the product after three years of storage



STABILITY and REACTIVITY of DISSOLVINE GL-38:
-Chemical stability:
This product is stable under recommended storage and handling conditions.
It is not self-reactive and is not sensitive to physical impact.
-Possibility of hazardous reactions:
Hazardous polymerization is not expected to occur under normal temperatures and pressures.



SYNONYMS:
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE
Tetrasodium Glutamate Diacetate
Tetrasodium Dicarboxymethyl Glutamate
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE
L-GLUTAMIC ACID
N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT L-GLUTAMIC ACID
TETRASODIUM GLUTAMATE DIACETATE
TETRASODIUM N,N-BIS(CARBOXYLATOMETHYL)-L-GLUTAMATE
TETRASODIUM SALT L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-
L-Aspartic Acid, N, N-bis(zarboxylatomethyl )-L-glutamate
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
tetrasodium glutamate diacetate
GLDA
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
5EHL50I4MY
N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium Salt
Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate
tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioate
L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
UNII-5EHL50I4MY
DTXSID2052158
Q25393000
Sodium (S)-2-(bis(carboxylatomethyl)amino)pentanedioate
N,N-BIS-(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUMN SALT
N,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water)
tetrasodium mono((S)-2-(bis(carboxymethyl)amino)-4-carboxybutanoate)
L-glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)


DISSOLVINE GL-47-S
DISSOLVINE GL-47-S = TETRASODIUM GLUTAMATE DIACETATE


CAS Number 51981-21-6
EC Number: 257-573-7
Chemical formula: GLDA-Na4 / C9H9NO8Na4
Chemical Name: Glutamic acid, N,N-diacetic acid, tetra sodium salt


Dissolvine GL-47-S is Aminopolycarboxylate chelating agent (glutamic acid, N,N-diacetic acid tetrasodium salt, CAS# 51981-21-6) that is 58% biobased (ASTM D6866).
Dissolvine GL-47-S is also readily biodegradable and safe for man and the environment.
Dissolvine GL-47-S is available as a 47% solution in water, Dissolvine GL-47-S in solid form.


Dissolvine GL-47-S is a high purity, versatile and readily biodegradable chelate based upon L-glutamic acid, a natural and renewable raw material.
Dissolvine GL-47-S is a far more effective chelating agent compared to phosphates and phosphonates
Dissolvine GL-47-S acts as a chelating agent.


Dissolvine GL-47-S is a Glutamic acid, N,N-diacetic acid, tetrasodium salt (GLDA) Dissolvine GL-47-S is a bio-based, readily biodegradable, cruelty free, globally acceptable and effective chelating agent for Personal Care.
With an outstanding environmental profile and friendly INCI name, Dissolvine GL-47-S’s an ideal choice to bring enhanced preservation, stability, and performance to your formulations.


Dissolvine GL-47-S is a high purity, versatile and readily biodegradable chelate based on L-glutamic acid, a natural and renewable raw material.
“The Green Chelate,” Dissolvine GL-47-S (Tetrasodium Glutamate Diacetate) is a high purity, versatile and readily biodegradable chelate based upon L-glutamic acid, a natural and renewable raw material.
In November 2013, Dissolvine GL-47-S officially received DfE designation and the recognition from the U.S. EPA that Dissolvine GL-47-S is green and performs highly effectively.


Dissolvine GL-47-S is a high purity, versatile and readily biodegradable chelate based upon L-glutamic acid, a natural and renewable raw material.
Dissolvine GL-47-S is transparent pale yellow liquid with a slight ammonia smell.
Dissolvine GL-47-S are standard multi-purpose liquid chelating agents.


Dissolvine GL-47-S is tetrasodium glutamic acid oxalate (GLDA-NA4). GLDA has four carboxylic acid groups, which can combine the nitrogen atom in the center of the molecular structure with the second-order and third-order metal ions, through a strong multiple bonds for bonding.
Dissolvine GL-47-S is made from food-grade natural amino acid salt monosodium L-glutamate (MSG).
Using this bio-based raw material enables more than half of the carbon in GLDA to be bio-based.


This natural amino acid structure in the molecule of Dissolvine GL-47-S makes it easily recognized as food by bacteria, thus making GLDA easy to biodegrade.
Dissolvine GL-47-S is a strong chelating agent for hard water metal ions (such as Ca2+), which can enhance the softness, cleaning power and stability of detergent formulations.
Dissolvine GL-47-S has strong compatibility and stability for most enzyme preparations.


Dissolvine GL-47-S (GLDA Na) are amino polycarboxylate chelating agents.
Dissolvine GL-47-S, is convenient for the preparation of highly concentrated formulations (solid or liquid).
Dissolvine GL-47-S readily dissolves in water to yield a clear, slightly yellow liquid, is hygroscopic and should be stored in closed bags or containers until it is used.


Dissolvine GL-47-S is a rinsing aid.
Dissolvine GL-47-S is a vegetable-based chelating agent.
Dissolvine GL-47-S is a palm oil-, EDTA- and nitrilotriacetic acid (NTA)-free chelating agent.
Dissolvine GL-47-S research shows the ingredient is not a strong skin irritant.


Dissolvine GL-47-S exhibits dispersion properties combined with easier rinsing.
Dissolvine GL-47-S offers enhanced biocidal/preservative boosting power.
Dissolvine GL-47-S is recommended for wash-off formulations, wipes, shaving products, fragrances, toiletries, makeup, skin-, sun-, baby & oral care products.


Using a chelating agent helps to slow this process, allowing for the creation of products with improved stability and appearance.
This also improves the effectiveness of preservative ingredients, allowing us to use a lower percentage of these, for safer shelf-stable products.
Dissolvine GL-47-S is readily biodegradable with a high level of solubility over a wide pH range, thus a greener alternative to many other chelates and phosphates.


Dissolvine GL-47-S has Excellent chelating effect controlling metal catalyzed decomposition.
Dissolvine GL-47-S reduces water hardness and prevents precipitation.
Dissolvine GL-47-S boosts performance of preservatives improving shelf life.
Dissolvine GL-47-S Stabilizes the pH value and is effective in wide pH range.


Dissolvine GL-47-S does not sensitize human skin.
Dissolvine GL-47-S is Completely biodegradable as compared to phosphates and phosphonates.
Dissolvine GL-47-S is an effective alternative to EDTA.
Dissolvine GL-47-S , also known as Tetrasodium Dicarboxymethyl Glutamate, GLDA-Na4 for short.


Dissolvine GL-47-S is a new type of green degradable chelating agent, can replace traditional phosphonates, EDTA, NTA.
Dissolvine GL-47-S is suit for a wide pH range, with high solubility, high temperature resistance, strong detergency, no ecological toxicity, has synergistic effect with fungicides, and no irritation to skin and eyes.
Dissolvine GL-47-S is a safe synthetic chelating agent with natural origins.


Dissolvine GL-47-S is what's known as a 'chelating agent', an ingredient that inactivates metallic ions (charged particles) in product formulations.
Dissolvine GL-47-S is a high purity, versatile and readily biodegradable chelating agent based upon L-glutamic acid, a natural and renewable raw material.



USES and APPLICATIONS of DISSOLVINE GL-47-S:
Dissolvine GL-47-S is used boosting agent for disinfecting products, scale inhibitor in laundering and dishwashing applications, booster for stain removal in dish washing detergents, scum inhibitor in bathroom cleaners, shampoo applications, transport cleaners.
Dissolvine GL-47-S can be used in bath & shower products, cosmetics, hair care & colourings, powders, body treatments, personal care wipes, and also as a builder for cleaners and detergents.


Dissolvine GL-47-S – High Purity, NTA free grade with 47% solids in solution, ideal for highly concentrated formulations and Home and Body care applications.
In personal care & cosmetics, Dissolvine GL-47-S is used for controlling metal catalyzed decomposition for better shelf life, controlling water hardness and prevention of precipitation, boosting the performance of preservatives.


Dissolvine GL-47-S is used in bath, shower products, color cosmetic, ethnic hair, hair color/dye, hair gel, hair spray, mousse, powder, shampoo, styling product, treatment, and wipes.
Dissolvine GL-47-S is used additives for personal cleansing and cosmetics, hair styling and hair care.


Dissolvine GL-47-S is used cleaning agents, detergents, textile auxiliaries, daily chemicals, oilfield water treatment, pulp and paper auxiliaries, metal surface treatment, etc.
Dissolvine GL-47-S is suitable to be used in personal care and cosmetics products, due to the strong chelating ability of calcium and transition metal ions prolonging the shelf life of many products.


Dissolvine GL-47-S is used in cosmetics and personal care.
Dissolvine GL-47-S is used water treatment, Industrial detergents and cleaners, hard surface cleaners, Dishwashing Detergents, Laundry detergents HDL and LDL, paper industry, Cosmetic/personal care products, Textile auxiliaries, preservative booster.
Dissolvine GL-47-S serves the same function in formulations as EDTA, without the health and environmental concerns.


Dissolvine GL-47-S is used in bath soaps, detergents and non-spray deodorant product.
Dissolvine GL-47-S is often found in sunscreen, facial cleanser, shampoo, makeup, lotion, and other products.
Dissolvine GL-47-S is highly effective in removing stains and increases the activity of substances that kill or limit the growth of harmful organisms.


Dissolvine GL-47-S also promotes the preservation and stability of soaps.
The dispersion properties of Dissolvine GL-47-S also keep soils suspended in the wash and rinse water, preventing re-deposition of dirt on cleaned surfaces and guaranteeing easy rinsing in applications such as dishwashing.
Dissolvine GL-47-S is made from plant material, readily biodegradable, with high solubility over a wide pH range.


Strong chelating ability of Dissolvine GL-47-S :
Dissolvine GL-47-S has a good effect on all kinds of difficult-to-clean calcium scales or difficult-to-clean equipment.
Dissolvine GL-47-S is a multi-purpose, clear, liquid chelating agent and preservative booster.
Dissolvine GL-47-S is widely used in personal care, cleaning and detergents, industrial cleaning and oil industry.


Dissolvine GL-47-S usually appears as an odourless white powder that is soluble in water, and is used as a multi-purpose, clear, liquid chelating agent and preservative booster.
Dissolvine GL-47-S is used Cleaning and detergents, Industrial cleaning, Oil industry, personal care, and Pulp and paper.
Dissolvine GL-47-S binds with metal ions in the water supply to prevent scale formation.


Soils form complexes with metal ions and bind to surfaces.
These bonds make cleaning and removal of these earth-metal complexes difficult.
The strong chelating and dispersing properties of Dissolvine GL-47-S facilitate the removal of metal ions from soils, resulting in greatly improved cleaning performance.


Fewer water droplets left on surfaces reduces the need to rinse repeatedly to get soap off (and therefore reduces water consumption).
Dissolvine GL-47-S works as a stabilizer in cosmetic formulations to prevent the natural discoloration of shampoos and gels.
Dissolvine GL-47-S is used to enhance and preservative the formulation's ingredients and also acts as a heavy metal chelating agent.
Dissolvine GL-47-S has many uses from foods to personal care products.


On an industrial level Dissolvine GL-47-S is used in the cutting of fabrics, in the processing or grinding of metals and in the operations of sanding or stripping.
Dissolvine GL-47-S is NTA free and also works great as a protective enhancer.
Dissolvine GL-47-S can be used as a more sustainable alternative to phosphonates and commonly used chelating agents (NTA and EDTA) in a wide number of applications.


Dissolvine GL-47-S can be used in many applications such as industrial and household cleaners for improving the detergency.
Dissolvine GL-47-S when added to a formulation can help stabilize the product and prevent discoloration.
Dissolvine GL-47-S is used as a chelating agent.
Dissolvine GL-47-S also reduces the effect of Calcium and Magnesium ions resulting in better surfactant performance.


Dissolvine GL-47-S is used Shampoo Release agent to improve stability in shampoos and cleansers
Dissolvine GL-47-S is used Textile Industry to prevent metal ion impurities from changing colors of dyed products
Foods used as preservatives to prevent catalytic oxidative discoloration in certain foods
Dissolvine GL-47-S can replace EDTA 1:1 and can be used in products as well as cosmetics and personal care products.


Dissolvine GL-47-S works as a chelating agent : Dissolvine GL-47-S prevents precipitates from forming inside the product in which it is inserted that could alter the stability and final pleasantness of the cosmetic.
Dissolvine GL-47-S is used as a preservative.
Dissolvine GL-47-S can be widely used in Personal Care and Cleaning applications.


Dissolvine GL-47-S is used Excellent chelating/rinsing agent compared to conventional options good guardians.
Dissolvine GL-47-S is suitable to be used in personal care and cosmetics
Dissolvine GL-47-S is added to products for skin care, body and hair care, make-up, but also to cleaners, disposable wet wipes and soaps.
Dissolvine GL-47-S is also found in detergents, cleansing wipes, bar soap, and other cleaning products.


Dissolvine GL-47-S stabilizes the color of the product and improves their durability.
Commercial use of Dissolvine GL-47-S L: body lotions, skin cream, Shampoo, Toothpastes, and makeup.
Dissolvine GL-47-S is found in the following products:
liquid and solid soap, solid shampoo, intimate hygiene products, baby wipes, face lotions and cleansers, make up, skincare products, sun cream.


Dissolvine GL-47-S is a multi-purpose clear liquid agent that supports the effectiveness of preservatives.
We can find Dissolvine GL-47-S , for example, in hair and body cosmetics, make-up, etc.
Dissolvine GL-47-S works as a stabilizer in cosmetic formulations to prevent the natural discoloration of soaps shampoos and gels.
Dissolvine GL-47-S also acts as a chelating agent and is used to enhance and preserve the formulation's ingredients.


Dissolvine GL-47-S is NTA free and also functions great as a preservative booster.
Dissolvine GL-47-S bonds with metal ions in the water supply to prevent scale formation.
The strong chelating and dispersion properties of Dissolvine GL-47-S facilitate the removal of metal ions from soils leading to a greatly improved cleaning performance.


In larger quantities Dissolvine GL-47-S will enhance the cleaning ability and prevent deactivation of active ingredients during use.
Dissolvine GL-47-S can also be found in detergents, waxes, polishes, disinfectants, pest control products and air care products.
Dissolvine GL-47-S is found in sunscreen, facial cleanser, shampoo, makeup, lotion, and other products.
Dissolvine GL-47-S can be found in shampoos, conditioners, make-up, but also in wet wipes or soaps.


Dissolvine GL-47-S offers unique opportunity for skin friendly personal care product development.
Dissolvine GL-47-S is also used in personal care products.
Dissolvine GL-47-S is free from genetically modified raw materials and is not irritating to skin or eyes, these properties are suitable in the development of new personal care products.


Dissolvine GL-47-S is used Mild chelating agent, which helps to stabilize the formulation
Dissolvine GL-47-S operates across wide range of pH making it conducive to use in strongly alkaline hard surface cleaning applications that includes food processing, kitchen cleaning and automatic dishwashing products.
Dissolvine GL-47-S acts as a rinsing aid in products.


Dissolvine GL-47-S is used in cosmetic products as a support for preservatives.
Dissolvine GL-47-S extends the shelf life of the product and prevents the growth of microorganisms.
Dissolvine GL-47-S is a plant-based chelating agent.
Chelators are substances that are used to maintain the stability and appearance of cosmetic products.


Dissolvine GL-47-S is used in sunscreens, facial cleansers, shampoos, makeup, lotions.
You can also find Dissolvine GL-47-S in detergents, cleansing wipes, bar soap, and other cleaning products.
Dissolvine GL-47-S is used Hard Surface Cleaners, Laundry Detergents HDL and LDL, Cosmetics/Personal Care Products, Industrial Cleaners, Shaving Products, Pulp and Paper Production, Gas Sweetener, Wet wipes, Polymer Production, Dishwashing Liquids, Textile, protective booster, Fertilizers, Distribution aid for micronutrients for plants


-Boilers:
Dissolvine GL-47-S is used to prevent lime formation in boilers due to water hardness.
-CHELATING:
Binds metal ions that could adversely affect the stability and quality of cosmetic products
-Titrations:
Dissolvine GL-47-S is Used in complexometric titrations and analysis of water hardness


-Uses of Dissolvine GL-47-S :
Dissolvine GL-47-S solutions for broad portfolio of industrial applications:
Dissolvine GL-47-S is instrumental in reducing the detrimental effect of metal ions in various industrial processes such as paper manufacturing, personal care formulations, food processing industry, pharmaceutical formulations, metal working area etc.


-Dissolvine GL-47-S and skin:
Dissolvine GL-47-S is very gentle on the skin and has antibacterial effects.
Dissolvine GL-47-S helps with inflammatory symptoms and acne.


-Dissolvine GL-47-S and hair:
Dissolvine GL-47-S is added to anti-dandruff shampoo.
Dissolvine GL-47-S prevents their formation and gently cares for the scalp.


-Formulation flexibility, compatibility and Synergy:
There is an increased interest in the use of Dissolvine GL-47-S in disinfectant formulations.
Like tetrasodium ethylenediaminetetraacetic acid (EDTA), Dissolvine GL-47-S can be used together with biocides to improve the biocidal performance of a disinfection system.


-High solubility under wide pH:
Dissolvine GL-47-S has good solubility in strong acid to high alkali systems, and has better advantages for formulating high active ingredients and low water content formulation systems.


-Dissolvine GL-47-S Has the effect of antiseptic and synergistic:
Because it has natural amino acid components, Dissolvine GL-47-S has a stronger binding ability with animal cell walls, and thus play a role in antiseptic and synergistic.


-Good stability under high temperature:
By thermogravimetric analysis, Dissolvine GL-47-S is tested at 170°C for 6 hours or at 150°C for a week.
Dissolvine GL-47-S has no decomposition and is extremely stable.
Compared with other chelating agent products at 100°C, Dissolvine GL-47-S has the best performance.


-Applications of Dissolvine GL-47-S:
*washable and indelible cosmetics, including children's
*hypoallergenic high-performance laundry and dishwashing detergents


-Applications of Dissolvine GL-47-S:
*Boosting agent for disinfecting products (with low skin irritation)
*Improved detergency at high water hardness
*Hard surface cleaning performance is improved in combination with *Gluco(hepto)nates.
*Scale removal at high pH
*Scale inhibitor in laundering and dishwashing applications.
*Booster for stain removal in dish washing detergents better than citrates and phosphates
*Scum inhibitor in bathroom cleaners
*Improved cleaning & foaming in shampoo applications.
*Storage stabilization of bleaching agents (perborates / percarbonates) and unsaturated alkyl chain based surfactants.
*Transport cleaners: Oil and Iron removal at high pH replacement for NTA



PROPERTIES OF DISSOLVINE GL-47-S:
Dissolvine GL-47-S is a highly purified, fully biodegradable complexing agent based on L-glutamic acid, a renewable raw material of natural origin.
Dissolvine GL-47-S improves the washing properties of the product in hard water.
Dissolvine GL-47-S enhances the action of preservatives against bacteria and fungi.
Dissolvine GL-47-S improves the shelf life and appearance of the product.



FUNCTIONS OF DISSOLVINE GL-47-S:
(1) Derived from natural products, reproducible and rapidly biodegradable
(2) Longer storage time (decomposition of metal catalysts can be controlled)
(3) Avoid hard water affecting its cleaning ability
(4) Experiments have shown that the dosage of preservatives can be reduced and the irritation to the skin can be reduced (because Ca and Mg in bacteria can be chelated ions, disrupt cell membranes)
(5) Performance is better than EDTA



BENEFITS OF DISSOLVINE GL-47-S:
*Enhanced Shelf Life
*Chelating
*Cleaning
*Cleansing
*Rancidity Inhibition
*Foaming
*Preservative Boosting
*Improves Foam Stiffness



PHYSICAL and CHEMICAL PROPERTIES of DISSOLVINE GL-47-S:
Appearance: clear liquid
Assay: as GLDA-Na4 47.4% min
pH of a 1% w/v dilution: 11.0 – 12.0
Color: 250 APHA max
NTA-Na3: < 0.10%
Mol. Weight: 351.1
Miscibility with water : any desired ratio.
Specific Gravity : approx. 1.40
Appearance: Form liquid
Color: pale yellow
Odor: slight ammonia odor
Boiling Point: 221-230°F (105-110°C)
Bulk Density: not applicable
Evaporation Rate (Butyl Acetate=1): not determined
Melting Point: < 5°F / < -15°C [crystallization point]

Odor Threshold: not determined
pH: 11-12 (1% solution)
Partition Coefficient: (n-octanol/water):
Log Pow Solubility in water: miscible
Solubility in other solvents: not determined
Specific Gravity: 1.38 – 1.42
Vapor Density (Air = 1): same as water
Vapor Pressure: same as water
Viscosity: 100-200 mPa.s (68°F / 20°C)
Volatiles (% by weight): not determined
Other: not determined
Flammability: not flammable or combustible
Flash Point (Method): not applicable
Upper Flammable Limit (% by volume): not applicable
Lower Flammable Limit (% by volume): not applicable
Auto-Ignition Temperature: not applicable

Chemical formula: GLDA-Na4
Physical form: liquid
Appearance: clear liquid
Odor slightly: ammonia like odorless
NTA (wt %): < 0.10
Assay (wt %): 47.4 min
pH (1% wv aqueous solution): 11.0 – 12.0
Liquid density(kg/m3): approx. 1400
Viscosity** (mPa.s): 90-150
Freezing point (°C): < -15
Solubility in water(g/l water): miscible in all ratios
Solubility in water at low pH(wt%): miscible in all ratios
Solubility in Ethylene Glycol(wt%): miscible in all ratios
Solubility in 5M NaOH(wt%): miscible in all ratios
COD (mg/g): 345-385



FIRST AID MEASURES of DISSOLVINE GL-47-S:
-Inhalation:
Remove victim to fresh air.
-Skin Contact:
Remove contaminated clothing, shoes and equipment.
Wash all affected areas with soapand plenty of water.
Wash contaminated clothing and shoes before reuse.
-Eye Contact:
Flush eyes with large quantities of running water for a minimum of 15 minutes.
If the victim is wearing contact lenses, remove them.
-Ingestion:
Give several glasses of water.
Give fluids again.



ACCIDENTAL RELEASE MEASURES of DISSOLVINE GL-47-S:
-Methods for containment:
Safely stop source of spill.
-Methods for clean-up:
Soak up liquid residue with a suitable absorbent such as clay, sawdust or kitty litter.



FIRE FIGHTING MEASURES of DISSOLVINE GL-47-S:
-Flammable properties:
Not flammable or combustible.
*Extinguishing Media:
Use water fog or spray, dry chemical, foam or carbon dioxide extinguishing agents.
-Fire & Explosion Hazards:
This product is not defined as flammable or combustible and should not be a firehazard.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DISSOLVINE GL-47-S:
-Engineering Controls & Ventilation:
Special ventilation is usually not required under normal use conditions.
-Personal Protective Equipment (PPE):
*Hygiene Measures:
All food and smoking materials should be kept in a separate area away from the storage/use location.
Before eating, drinking and smoking, hands and faceshould be thoroughly washed.



HANDLING and STORAGE of DISSOLVINE GL-47-S:
-Storage:
Keep containers closed and dry.
This material is suitable for any general chemical storage area.
Store in PVC, PE, stainless steel or bituminized tanks.
-Recommended Storage Temperature:
Store in a cool and dry place at ambient temperature (below 25°C / 77°F).
-General Comments:
Containers should not be opened until ready for use.
Opened containers must be closedagain properly.
It is advised to re-test the product after three years of storageV



STABILITY and REACTIVITY of DISSOLVINE GL-47-S:
-Chemical stability:
This product is stable under recommended storage and handling conditions.
It is not self-reactive and is not sensitive to physical impact.
-Possibility of hazardous reactions:
Hazardous polymerization is not expected to occur under normal temperatures and pressures.



SYNONYMS:
L-Glutamic acid, N,N-diacetic acid tetrasodium salt (GLDA-Na4)
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE
Tetrasodium Glutamate Diacetate
Tetrasodium Dicarboxymethyl Glutamate
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE
L-GLUTAMIC ACID
N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT L-GLUTAMIC ACID
TETRASODIUM GLUTAMATE DIACETATE
TETRASODIUM N,N-BIS(CARBOXYLATOMETHYL)-L-GLUTAMATE
TETRASODIUM SALT L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-
L-Aspartic Acid, N, N-bis(zarboxylatomethyl )-L-glutamate
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
tetrasodium glutamate diacetate
GLDA
Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate
5EHL50I4MY
N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium Salt
Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate
tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioate
L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
UNII-5EHL50I4MY
DTXSID2052158
Q25393000
Sodium (S)-2-(bis(carboxylatomethyl)amino)pentanedioate
N,N-BIS-(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUMN SALT
N,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water)
tetrasodium mono((S)-2-(bis(carboxymethyl)amino)-4-carboxybutanoate)
L-glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
Tetrasodium N , N -bis(carboxylatomethyl) -L -glutamate
L -glutamic acid N , N -diacetic acid tetrasodium salt
( S )-glutamic acid N , N -diacetic acid tetrasodium salt
N , N -bis (carboxymethyl) -L -glutamic acid tetrasodium salt
GLDA-Na 4
TETRASODIUM GLUTAMATE DIACETATE ( INCI )
Dissolvine GL
CHELEST CMG-40
DISSOLVINE GL
GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4)
L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT
L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT
N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT
TETRASODIUM GLUTAMATE DIACETATE [INCI]
TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE




DISTEARYL ETHER
1-octadecoxyoctadecane; Octadecane, 1,1‘-oxybis-; 1-octadecoxyoctadecane; cas no: 6297-03-6
DI-T-BUTYL HYDROXYPHENYLAMINO BISOCTYLTHIOTRIAZINE
Bis(1,1-dimethylethyl)peroxide; DTBP; tert-Butylperoxide; Di-Tertiary-butyl Peroxide; Cadox; TBP; 2-(tert-Butylperoxy)-2-methylpropane; Perossido di butile terziario; Peroxyde de butyle tertiaire; cas no: 110-05-4
DI-TERT BUTYL PEROXIDE
Di-tert butyl peroxide is a clear, water-white liquid.
Di-tert butyl peroxide or DTBP is an organic compound consisting of a peroxide group bonded to two tert-butyl groups.
Di-tert butyl peroxide has a specific gravity of 0.79, which is lighter than water, and it will float on the surface.

CAS Number: 110-05-4
Molecular Formula: C8H18O2
Molecular Weight: 146.23
EINECS Number: 203-733-6

Di-tert butyl peroxide is one of the most stable organic peroxides, due to the tert-butyl groups being bulky.
Di-tert butyl peroxide is a colorless liquid.
Di-tert butyl peroxide, often abbreviated as DTBP, is a chemical compound with the molecular formula (C4H9)2O2.

Di-tert butyl peroxide is a peroxide compound that contains two tert-butyl groups (2,2-dimethylpropyl groups) attached to the oxygen atom in the peroxide functional group.
The chemical structure of Di-tert butyl peroxide is (CH3)3COOC(CH3)3.
Di-tert butyl peroxide is a white crystalline solid at room temperature and is highly flammable.

Di-tert butyl peroxide is commonly used as a radical initiator in various chemical reactions, particularly in polymerization processes.
When heated or subjected to certain conditions, it decomposes to generate alkoxyl and alkyl radicals, which initiate polymerization reactions.
Di-tert butyl peroxide is a colourless, mobile liquid, consisting of technically pure di-(tert.butyl) peroxide.

This highly volatile Di-tert butyl peroxide is used as an initiator (radical source) in the polymerisation of monomers, crosslinking of polyethylene, and rheology control of polypropylene.
Di-tert butyl peroxide is nonpolar and insoluble in water.
Di-tert butyl peroxide is a strong oxidizer and may ignite organic materials or explode if shocked or in contact with reducing agents.

In addition to being an oxidizer, Di-tert butyl peroxide is highly flammable.
Di-tert butyl peroxide has a boiling point of 231°F (110°C) and a flash point of 65°F (18°C).
The NFPA 704 designation is health 3, flammability 2, and reactivity 4.

The prefix “oxy” for oxidizer is placed in the white section at the bottom of the 704 diamond.
Di-tert butyl peroxide consists of a peroxide group bonded to two tert-butyl groups.
Since the tert-butyl groups are bulky, it is one of the most stable organic peroxides.

Di-tert butyl peroxide, also known as DTBP, is an organic compound used in polymer chemistry and organic synthesis as a radical initiator.
Ungraded products supplied by TCI America are generally suitable for common industrial uses or for research purposes but typically are not suitable for human consumption or therapeutic use.
Di-tert butyl peroxide is a reactive oxygen species that has been used as an oxidant in organic synthesis.

Di-tert butyl peroxide is typically produced by the oxidation of tert-butanol with hydrogen peroxide and sodium citrate.
Di-tert butyl peroxide has been shown to be highly resistant to degradation, even at high pH values.
Di-tert butyl peroxide has also been shown to induce neuronal death in vivo, which may be due to its ability to produce hydroxyl radicals and other reactive oxygen species.

Di-tert butyl peroxide can be used for wastewater treatment because it reacts with organic matter and produces less sludge than chlorine.
Di-tert butyl peroxide also has the ability to react with chemicals in a variety of ways, including transfer reactions, such as the addition of alcohols or esters.
Di-tert butyl peroxide bond undergoes homolysis at temperatures above 100 °C.

For this reason Di-tert butyl peroxide is commonly used as a radical initiator in organic synthesis and polymer chemistry.
The decomposition reaction proceeds via the generation of methyl radicals.

(CH3)3COOC(CH3)3 → 2 (CH3)3CO•
(CH3)3CO• → (CH3)2CO + CH•3
2 CH•3 → C2H6

Di-tert butyl peroxide can in principle be used in engines where oxygen is limited, since the molecule supplies both the oxidizer and the fuel.
Di-tert butyl peroxide is widely used as a catalyst and reaction initiator.
Knowledge of the peroxide content is important in such applications.

This test method provides a procedure for determining the active peroxide content of commercial Di-tert butyl peroxide.
Di-tert butyl peroxide is an organic peroxide.
Di-tert butyl peroxide is a relatively stable compound at room temperature, but it can decompose exothermically when heated or exposed to light.

This decomposition leads to the release of radicals, which can initiate polymerization reactions.
Di-tert butyl peroxide is commonly used as an initiator in the production of various types of polymers.
Di-tert butyl peroxide can initiate the polymerization of monomers like styrene, vinyl chloride, and other unsaturated compounds.

The generated radicals help link monomers together to form polymer chains.
Di-tert butyl peroxide's stability is attributed to the presence of bulky tert-butyl groups on the peroxide oxygen atoms.
These groups hinder the decomposition of the peroxide, making it less reactive at room temperature compared to other peroxides.

Due to its potential for thermal decomposition, Di-tert butyl peroxide should be handled with care.
Di-tert butyl peroxide is highly flammable, and its decomposition can lead to fire or explosion.
Proper storage and handling procedures are essential, and it should be stored away from heat, open flames, and other sources of ignition.

Di-tert butyl peroxide, like other organic peroxides, is subject to regulations and safety guidelines to minimize the risks associated with its use and storage.
Users typically need to be trained in its safe handling and storage.
Di-tert butyl peroxide can be used in chemical synthesis for other purposes, such as the oxidation of organic compounds or the production of organic peracids.

Melting point: -30 °C
Boiling point: 109-110 °C(lit.)
Density: 0.796 g/mL at 25 °C(lit.)
vapor pressure: 40 mm Hg ( 20 °C)
refractive index: n20/D 1.3891(lit.)
Flash point: 34 °F
storage temp.: Store at +15°C to +25°C.
solubility: 0.063g/l
form: Liquid
color: Clear
Odor: distinctive odor
Water Solubility: immiscible
Merck: 14,3461
BRN: 1735581
Stability: May decompose explosively if heated, subjected to shock, or treated with reducing agents. Highly flammable. Refrigerate.
InChIKey: LSXWFXONGKSEMY-UHFFFAOYSA-N
LogP: 3.2 at 22℃

The explosive instability of the lower dialkyl peroxides (e.g., dimethyl peroxide) and Di-tert butyl peroxide decreases rapidly with increasing chain length and degree of branching, the di-tert-alkyl derivatives being amongst the most stable class of peroxides.
Though many 1,1-bis-peroxides have been reported, few have been purified because of the higher explosion hazards compared with the monofunctional peroxides.
Di-tert butyl peroxide is unlikely that this derivative would be particularly unstable compared to other peroxides in it's class, Bretherick 1979v.

Di-tert butyl peroxide initiates polymerization through a free radical mechanism.
When heated or exposed to specific conditions, it undergoes homolytic cleavage, breaking the oxygen-oxygen bond.
This results in the formation of two alkoxyl (RO•) and two alkyl (R•) radicals.

These radicals can initiate the polymerization of unsaturated monomers by abstracting hydrogen atoms from the monomers and forming covalent bonds.
This process continues, leading to the growth of polymer chains.
The stability and shelf-life of Di-tert butyl peroxide can vary depending on storage conditions, including temperature, light exposure, and presence of impurities.

Di-tert butyl peroxide is important to monitor and control these factors to ensure its effectiveness as a polymerization initiator.
Di-tert butyl peroxide is used in the production of various types of polymers, including polyethylene, polypropylene, and polystyrene.
Di-tert butyl peroxides ability to initiate polymerization at specific sites on monomers contributes to the development of unique polymer structures.

Due to its potential for thermal decomposition, Di-tert butyl peroxide poses safety risks.
In addition to its flammability, it can lead to the generation of hazardous decomposition products.
Handling and storage should comply with safety regulations, and personal protective equipment (PPE) should be used when working with this compound.

Efforts have been made to recycle Di-tert butyl peroxide and other peroxides in some industrial processes to reduce waste.
Regeneration involves treating waste peroxides to recover their useful compounds while minimizing environmental impact.
Di-tert butyl peroxide is a commonly used initiator in polymerization, there are alternative initiators and methods available for specific applications.

The choice of initiator depends on factors like reaction conditions, desired polymer properties, and safety considerations.
Di-tert butyl peroxide typically perform quality control tests to ensure the compound's purity and consistency.
Impurities in the peroxide can affect its performance as an initiator.

Di-tert butyl peroxide is just one of the possible isomers of tert-butyl peroxides.
There are several isomers with different arrangements of tert-butyl groups around the peroxide oxygen atom.
Some other common isomers include mono-tert-butyl peroxide and tert-butyl hydroperoxide.

In addition to its use as an initiator for polymerization, Di-tert butyl peroxide is used in the cross-linking of elastomers (rubber-like materials).
Cross-linking enhances the mechanical properties, such as strength and resilience, of elastomers.
When handling Di-tert butyl peroxide, it is essential to refer to its safety data sheet (SDS) for specific information on its hazards, safety precautions, and first aid measures in case of accidents.

The transportation and storage of Di-tert butyl peroxides are regulated due to its flammability and potential hazards.
Di-tert butyl peroxide should be stored in a cool, well-ventilated area, away from heat sources, flames, and incompatible materials.
Special containers designed for peroxide storage may be used.

Di-tert butyl peroxide is incompatible with various substances, including reducing agents, acids, and some metals.
Mixing it with incompatible materials can lead to dangerous reactions, including fires or explosions.

Proper disposal methods for Di-tert butyl peroxide and its waste should follow local, state, and federal regulations.
Often, peroxides are deactivated and disposed of through controlled chemical processes or by professional waste disposal services.
The development of new peroxide initiators and improved methods for polymerization is an ongoing area of research in the field of materials science and polymer chemistry.

Uses
The decomposition reaction proceeds via the generation of methyl radicals.
The peroxide bond undergoes homolysis at temperatures above 100 °C.
Hence Di-tert butyl peroxide is commonly used as a radical initiator in organic synthesis and polymer chemistry.

Di-tert butyl peroxide can in principle be used in engines where oxygen is limited, since the molecule supplies both the oxidizer and the fuel.
Di-tert butyl peroxide has been used as a radical initiator to induce free radical polymerization.
Di-tert butyl peroxide has also been used as a cetane enhancer in a study to determine the phase behavior of carboxylate-based extended surfactant reverse micellar microemulsions with ethanol and vegetable oil/diesel blends.

Di-tert butyl peroxide can be used for the market segments: polymer production, polymer crosslinking and acrylics production with their different applications/functions.
Di-tert butyl peroxide is used in the following products: polymers.
Di-tert butyl peroxide is used for the manufacture of: plastic products and chemicals.

Release to the environment of Di-tert butyl peroxide can occur from industrial use: as processing aid and as processing aid.
A peroxidic crosslinking agent for polyethylene (HDPE and LDPE).
At below 150°C no premature crosslinking (scorch) occurs.

Usage level: 0.5-2% w/w of product as supplied on the material to be crosslinked.
Special advantages: Extremely effective and relatively scorch free.
Volatile, odour free decomposition products, and no blooming of the vulcanisate surface.

The high volatility of the product demands that closed systems are applied during compounding and diffusion processes with polyethylene powder.
Di-tert butyl peroxide is used especially in extrusion processes ( RAM-Extrusion for pressure pipes).
Di-tert butyl peroxide has been used as a radical initiator to induce free radical polymerization.

Di-tert butyl peroxide has also been used as a cetane enhancer in a study to determine the phase behavior of carboxylate-based extended surfactant reverse micellar microemulsions with ethanol and vegetable oil/diesel blends.
Di-tert butyl peroxide is commonly used to initiate the polymerization of various monomers, leading to the formation of polymers.
Di-tert butyl peroxide plays a crucial role in the production of plastics, rubber, and elastomers.

Some specific applications include the production of polyethylene, polypropylene, and polystyrene.
In addition to initiating polymerization, Di-tert butyl peroxide is used to cross-link elastomers (such as natural rubber and synthetic rubber).
Cross-linking improves the mechanical properties of these materials, making them more durable and heat-resistant.

This is especially important in the manufacturing of tires and other rubber products.
Di-tert butyl peroxide can be used in chemical synthesis to introduce peroxide groups into organic compounds or to oxidize certain functional groups.
This has applications in the preparation of specific chemical intermediates.

Di-tert butyl peroxide is used in the production of adhesives and sealants to initiate the polymerization of the adhesive, allowing it to bond to various surfaces effectively.
Di-tert butyl peroxide can be used in the curing of resins and composites. It initiates the curing process, leading to the formation of a hardened, durable material.
Di-tert butyl peroxide can be used to initiate oxidative reactions. For example, it can be employed to initiate the formation of organic peracids.

Di-tert butyl peroxide is used in the manufacturing of various plastic products.
Di-tert butyl peroxide can initiate the polymerization of monomers like styrene and vinyl chloride, leading to the production of thermoplastic polymers used in a wide range of applications, including packaging materials, toys, and automotive components.
Di-tert butyl peroxide is employed in the production of composite materials.

Di-tert butyl peroxide helps initiate the polymerization of the resin matrix in composite materials, enabling the reinforcement fibers (such as fiberglass or carbon fiber) to bond with the matrix.
This results in lightweight, strong, and durable composite materials used in aerospace, automotive, and construction industries.
In the production of foam materials, such as expanded polystyrene (EPS) or polyurethane foam, Di-tert butyl peroxide is used as a blowing agent.

When Di-tert butyl peroxide decomposes, it releases gases, creating a foaming effect, which expands and solidifies the foam material.
Di-tert butyl peroxide can be found in the formulations of adhesives and sealants, where it helps initiate the curing or polymerization process, allowing these materials to bond to surfaces effectively.
Di-tert butyl peroxide's used in both industrial and consumer applications.

In addition to cross-linking elastomers, Di-tert butyl peroxide is used in the production of various rubber products, including tires, hoses, and gaskets.
Cross-linking enhances the mechanical properties and resilience of rubber materials.
Di-tert butyl peroxide can be employed in the textile industry to initiate polymerization reactions for fabric treatments.

Di-tert butyl peroxide's also used in the formulation of coatings for surfaces, such as paints and varnishes.
Di-tert butyl peroxide is used in chemical research and development for its radical-initiating properties.
Di-tert butyl peroxide can be a valuable tool for scientists working on the synthesis of new materials, compounds, or chemical reactions.

In some cases, Di-tert butyl peroxide may find applications in the development of certain medical devices or pharmaceutical products, where it contributes to the polymerization or cross-linking of specific materials.
Di-tert butyl peroxide can be used in water treatment processes to initiate oxidation reactions, breaking down contaminants and pollutants in wastewater.

Health Hazard
Di-tert butyl peroxide is slightly toxic by inhalation andin general exhibits low to very low toxicityby other routes.
However, toxic effectsare observed only at very high concentrations.Rats exposed to 4103-ppm vapor developedhead and neck tremor after 10 minutesof exposure (Floyd and Stockinger 1958).
Other symptoms were weakness, hyperactivity,and labored breathing.

Di-tert butyl peroxide is nonirritating to the skin and mildon the eyes.
Di-tert butyl peroxide is reported to cause lungand blood tumors in mice (NIOSH 1986).
However, its carcinogenicity is not yet fullyestablished.

Fire Hazard
Highly flammable and reactive; flash point 18°C (64.4°F); vapor pressure 19.5 torr at 20°C (68°F); vapor density 5.03.
Di-tert butyl peroxides decomposition products are ethane and acetone, which enhance the fire hazard.
Di-tert butyl peroxide use a water spray to fight fire and to keep the containers cool.

Di-tert butyl peroxide forms an explosive mixture with air. The explosive range is not reported.
Di-tert butyl peroxides decomposition products may explode above its boiling point, 111°C (231.8°F).

However, as it is thermally stable and shock insensitive, its explosion hazard is much lower.
Di-tert butyl peroxide may, however, react with explosive violence when in contact with easily oxidizable substances.

Storage
Store in a cool and well-ventilated areaisolated from easily oxidizable materials.
Protect against physical damage.
Shippingcontainers are amber glass and polyethylenebottles or steel drums not exceeding 100-lbcapacity.

Synonyms
Di-tert-butyl peroxide
110-05-4
tert-Butyl peroxide
Di-t-butyl peroxide
t-Butyl peroxide
Cadox
Peroxide, bis(1,1-dimethylethyl)
Trigonox B
2-(tert-Butylperoxy)-2-methylpropane
tert-Butylperoxide
Cadox TBP
Kayabutyl D
Perbutyl D
Interox DTB
Bis(tert-butyl) peroxide
Di-tert-butylperoxid
Peroxyde de butyle tertiaire
Di-tert-butyl peroxyde
Di-tert-Butyl hydroperoxide
di-tert-butylperoxide
Perossido di butile terziario
NSC 673
2-tert-butylperoxy-2-methylpropane
Bis(1,1-dimethylethyl) peroxide
Di-tertiary-butyl peroxide
M7ZJ88F4R1
DTXSID2024955
NSC-673
(Tributyl)peroxide
DTXCID704955
Bis(t-butyl)peroxide
2,2'-dioxybis(2-methylpropane)
CAS-110-05-4
di-t butyl peroxide
Di-tert-butylperoxid [German]
CCRIS 4613
di(t-butyl) peroxide
Di-tert-butyl peroxyde [Dutch]
HSDB 1326
EINECS 203-733-6
Peroxyde de butyle tertiaire [French]
BIS(1,1-DIMETHYLETHYL)PEROXIDE
Perossido di butile terziario [Italian]
UNII-M7ZJ88F4R1
t-butylperoxide
tBuOOtBu
Di-t-butylperoxide
di-tertbutylperoxide
ditert.butylperoxide
2-tert-butylperoxy-2-methyl-propane
MFCD00008803
di-tertbutyl peroxide
ditert-butyl peroxide
di-tert.butyl peroxide
di-tertiarybutylperoxide
ditertiary butylperoxide
ditertiarybutyl peroxide
Peroxide, tert-butyl-
di(tert.-butyl)peroxide
di(tert.butyl) peroxide
di-tert.-butyl peroxide
di-tertiary butylperoxide
ditertiary butyl peroxide
(tert-C4H9O)2
di-tertiary butyl peroxide
DTBP [MI]
Peroxide, bis-tert-butyl-
EC 203-733-6
SCHEMBL14861
NSC673
CHEMBL1558599
(CH3)3CO-OC(CH3)3
2-tert-butyldioxy-2-methylpropane
Tox21_201461
Tox21_300099
AKOS015902599
2-(tert-Butylperoxy)-2-methylpropane #
NCGC00091801-01
NCGC00091801-02
NCGC00091801-03
NCGC00254065-01
NCGC00259012-01
tert-Butyl peroxide (Luperox DI), 97%
Luperox(R) DI, tert-Butyl peroxide, 98%
D3411
FT-0625359
BIS(1,1-DIMETHYLETHYL)PEROXIDE [HSDB]
A802134
Q413043
t-butyl peroxide bis(1,1-di-methylethyl)peroxide
J-002365
J-520402
WLN: 1X1 & 1 & OOX1 & 1 & 1
F0001-0215
DI-TERT-BUTYL PEROXIDE
Di-tert-butyl peroxide is also known as DTBP, peroxide bis(1,1-dimethylethyl) and tert-Butyl peroxide.
Di-tert-butyl peroxide is a transparant liquid which has C8H18O2 as chemical formula.


CAS Number: 110-05-4
EC Number: 203-733-6
MDL number: MFCD00008803
Linear Formula: (CH3)3COOC(CH3)3
Chemical formula: C8H18O2



SYNONYMS:
Peroxide, bis(1,1-dimethylethyl), tert-Butyl peroxide, Bis(tert-butyl) peroxide, Cadox TBP, DTBP, Trigonox B, (tert-C4H9O)2, Cadox, Di-tert-butyl peroxyde, Di-tert-butylperoxid, Perossido di butile terziario, Peroxyde de butyle tertiaire, t-Butyl peroxide, Bis(1,1-dimethylethyl) peroxide, Di-t-butyl peroxide, Di-tertiary-butyl peroxide, t-butyl peroxide bis(1,1-di-methylethyl)peroxide, Peroxide, tert-butyl-, Interox DTB, Kayabutyl D, NSC 673, Perbutyl D, Peroxide, bis-tert-butyl-, 2-(tert-Butylperoxy)-2-methylpropane, tert-Butyl peroxide, Di-tert-butyl peroxide, 110-05-4, Di-t-butyl peroxide, t-Butyl peroxide, Cadox, Peroxide, bis(1,1-dimethylethyl), Trigonox B, Cadox TBP, Kayabutyl D, Perbutyl D, Interox DTB, Bis(tert-butyl) peroxide, Di-tert-butylperoxid, Peroxyde de butyle tertiaire, Di-tert-butyl peroxyde, Di-tert-Butyl hydroperoxide, di-tert-butylperoxide, Perossido di butile terziario, NSC 673, Bis(1,1-dimethylethyl) peroxide, Di-tertiary-butyl peroxide, M7ZJ88F4R1, DTXSID2024955, NSC-673, (Tributyl)peroxide, DTXCID704955, Bis(t-butyl)peroxide, 2,2'-dioxybis(2-methylpropane), CAS-110-05-4, UNII-M7ZJ88F4R1, t-butylperoxide, tBuOOtBu, Di-t-butylperoxide, di-tertbutylperoxide, ditert.butylperoxide, MFCD00008803, di-tertbutyl peroxide, ditert-butyl peroxide, di-tert.butyl peroxide, di-tertiarybutylperoxide, ditertiary butylperoxide, ditertiarybutyl peroxide, Peroxide, tert-butyl-, di(tert.-butyl)peroxide, di(tert.butyl) peroxide, di-tert.-butyl peroxide, di-tertiary butylperoxide, (tert-C4H9O)2, di-tertiary butyl peroxide, DTBP [MI], Peroxide, bis-tert-butyl-, EC 203-733-6, SCHEMBL14861, NSC673, CHEMBL1558599, (CH3)3CO-OC(CH3)3, 2-tert-butyldioxy-2-methylpropane, Tox21_201461, Tox21_300099, AKOS015902599, NCGC00091801-01, NCGC00091801-02, NCGC00091801-03, NCGC00254065-01, NCGC00259012-01, tert-Butyl peroxide (Luperox DI), 97%, Luperox(R) DI, tert-Butyl peroxide, 98%, D3411, NS00006093, BIS(1,1-DIMETHYLETHYL)PEROXIDE [HSDB], A802134, Q413043, t-butyl peroxide bis(1,1-di-methylethyl)peroxide, J-002365, J-520402, WLN: 1X1 & 1 & OOX1 & 1 & 1, F0001-0215, di-tert-butyl peroxide, tert-butyl peroxide, di-t-butyl peroxide, cadox, peroxide, bis 1,1-dimethylethyl, dtbp, trigonox b, t-butyl peroxide, cadox tbp, kayabutyl d, Peroxide, bis(1,1-dimethylethyl), tert-Butyl peroxide, Bis(tert-butyl) peroxide, Cadox TBP, DTBP, Trigonox B, (tert-C4H9O)2, Cadox, Di-tert-butyl peroxyde, Di-tert-butylperoxid, Perossido di butile terziario, Peroxyde de butyle tertiaire, t-Butyl peroxide, Bis(1,1-dimethylethyl) peroxide, Di-t-butyl peroxide, Di-tertiary-butyl peroxide, t-butyl peroxide bis(1,1-di-methylethyl)peroxide, Peroxide, tert-butyl-, Interox DTB, Kayabutyl D, NSC 673, Perbutyl D, Peroxide, bis-tert-butyl-, di-tert-butyl peroxide,tert-butyl peroxide,di-t-butyl peroxide,cadox,peroxide, bis 1,1-dimethylethyl,dtbp,trigonox b,t-butyl peroxide,cadox tbp,kayabutyl d, Bis(1,1-dimethylethyl)peroxide, Bis(t-butyl)peroxide, Bis(tert-butyl) peroxide, Cadox, Cadox TBP, DTBP, Di-t-butyl peroxide, Di-tert-Butyl hydroperoxide, Trigonox B, t-Butyl peroxide, tert-Butyl peroxide, UN3107, tert-Butyl peroxide , Luperox(R) DI, tert-Butyl peroxide, (tert-C4H9O)2, (tributyl)peroxide, 2-(tert-Butylperoxy)-2-methylpropane, Aztec di-t-butyl peroxoide, bis(1,1-dimethylethyl)-peroxid, bis(t-butyl)peroxide, Bis(tert-butyl) peroxide, bis(tert-butyl)peroxide, DTBP, 2-(tert-Butylperoxy)-2-methylpropane, TERT-BUTYL PEROXIDE, DI-T-BUTYL PEROXIDE, Trigonox b, (tributyl)peroxide, bis(tert-butyl)peroxide, DI-TERTIARY-BUTYL PEROXIDE, Cadox, cadoxtbp,



Di-tert-butyl peroxide is a volatile, slightly yellow transparent liquid, which is an alkyl hydrogen organic peroxide.
Di-tert-butyl peroxide is an efficient initiator (30% active ingredient in odorless mineral spirits) to produce low-density polyethylene (LDPE) and (meth)acrylates.


Di-tert-butyl peroxide is typically produced by the oxidation of tert-butanol with hydrogen peroxide and sodium citrate.
Di-tert-butyl peroxide has been shown to be highly resistant to degradation, even at high pH values.
Di-tert-butyl peroxide has also been shown to induce neuronal death in vivo, which may be due to its ability to produce hydroxyl radicals and other reactive oxygen species.


Di-tert-butyl peroxide can be used for wastewater treatment because it reacts with organic matter and produces less sludge than chlorine.
Di-tert-butyl peroxide is also known as DTBP, peroxide bis(1,1-dimethylethyl) and tert-Butyl peroxide.
Di-tert-butyl peroxide is a transparant liquid which has C8H18O2 as chemical formula.


Di-tert-butyl peroxide is an organic compound used in polymer chemistry and organic synthesis as a radical initiator.
Di-tert-butyl peroxide is a clear, water-white or yellow liquid.
Di-tert-butyl peroxide is insoluble in water.


Di-tert-butyl peroxide is faintly yellow clear liquid.
Di-tert-butyl peroxide is insoluble in water.
In most cases a combination of Di-tert-butyl peroxide with other peroxides is used to ensure a broad reactivity range.


Di-tert-butyl peroxide is a reactive oxygen species that has been used as an oxidant in organic synthesis.
Di-tert-butyl peroxide is a highly efficient initiator for the production of low density polyethylene (LDPE).
Di-tert-butyl peroxide is an initiator for the (co-)polymerization of ethylene and (meth)acrylates.


Furthermore, Di-tert-butyl peroxide contributes to the production of polymers and various materials, acting as a cross-linker in the synthesis of polyolefins.
Di-tert-butyl peroxide is an organic compound consisting of a peroxide group bonded to two tert-butyl groups.


Di-tert-butyl peroxide is insoluble in water.
Di-tert-butyl peroxide is one of the most stable organic peroxides, due to the tert-butyl groups being bulky.
Di-tert-butyl peroxide is a colorless liquid.


Di-tert-butyl peroxide is a clear colorless liquid.
Di-tert-butyl peroxide is a clear, water-white liquid.
Di-tert-butyl peroxide has a specific gravity of 0.79, which is lighter than water, and it will float on the surface.


Di-tert-butyl peroxide is nonpolar and insoluble in water.
Di-tert-butyl peroxide is a stable organic peroxide that releases free radicals upon decomposition at elevated temperatures.
With the chemical formula C8H18O2, Di-tert-butyl peroxide serves as an organic peroxide compound.


Di-tert-butyl peroxide finds extensive applications in both research and industry.
Di-tert-butyl peroxide plays a crucial role as an initiator in polymerization reactions and acts as a catalyst for organic synthesis.
Di-tert-butyl peroxide is commonly used as a radical initiator in polymerization reactions and exhibits solubility in organic solvents but not in water.


Di-tert-butyl peroxide is an efficient initiator for the production of Low Density Polyethylene (LDPE).
Di-tert-butyl peroxide is used both for tubular and autoclave processes.
Di-tert-butyl peroxide also has the ability to react with chemicals in a variety of ways, including transfer reactions, such as the addition of alcohols or esters.


The mechanisms of these reactions are still being studied.
Di-tert-butyl peroxide is a transparant liquid which has C8H18O2 as chemical formula.
Di-tert-butyl peroxide is a colorless, volatile liquid characterized by its sweet odor.


Di-tert-butyl peroxideplays a crucial role as an initiator in polymerization reactions and acts as a catalyst for organic synthesis.
Furthermore, Di-tert-butyl peroxide contributes to the production of polymers and various materials, acting as a cross-linker in the synthesis of polyolefins.


Di-tert-butyl peroxide is a strong oxidizer and may ignite organic materials or explode if shocked or in contact with reducing agents.
In addition to being an oxidizer, Di-tert-butyl peroxide is highly flammable.
Di-tert-butyl peroxide has a boiling point of 231°F (110°C) and a flash point of 65°F (18°C).


The NFPA 704 designation is health 3, flammability 2, and reactivity 4.
The prefix “oxy” for oxidizer is placed in the white section at the bottom of the 704 diamond.
Di-tert-butyl peroxide is a clear colorless liquid.


Di-tert-butyl peroxide is a colorless, volatile liquid characterized by its sweet odor.
With the chemical formula C8H18O2, Di-tert-butyl peroxide serves as an organic peroxide compound.
Di-tert-butyl peroxide finds extensive applications in both research and industry.



USES and APPLICATIONS of DI-TERT-BUTYL PEROXIDE:
Di-tert-butyl peroxide finds application in alkylating reactions, facilitating α-functionalization of α-amino carbonyl compounds.
Di-tert-butyl peroxide is used in formulation or re-packing, at industrial sites and in manufacturing.
In practice, combinations of two or more peroxides with diverging activities are used to reduce the residual monomer content in the final polymer and to increase reactor efficiency.


Di-tert-butyl peroxide is an efficient initiator (30% active ingredient in odorless mineral spirits) for the production of Low Density Polyethylene (LDPE).
Di-tert-butyl peroxide is used for both tubular and autoclave processes.
Release to the environment of Di-tert-butyl peroxide can occur from industrial use: formulation of mixtures and formulation in materials.


Di-tert-butyl peroxide also plays a role in methylation reactions, acting as a direct aromatic methylation agent when combined with a palladium catalyst.
The shelf life of Di-tert-butyl peroxide is 3 months.
Di-tert-butyl peroxide is used as an initiator for the (co)polymerization of ethylene, styrene, acrylates and methacrylates.


In most cases a combination with other peroxides is used to ensure a broad reactivity range.
Di-tert-butyl peroxide may also be used for the polymerization and copolymerization of styrene in the temperature range of 95-185°C.
Di-tert-butyl peroxide is used as ignition accelerator for diesel fuels.


Di-tert-butyl peroxide is used as a cross-linking agent (rubber and resins).
Di-tert-butyl peroxide is used as initiator for the production of Low Density Polyethylene (LDPE).
Further Di-tert-butyl peroxide finds its application in the polymerization and copolymerization of styrene, olefins and acrylic resins and as modification agent of polypropylene degradation.


The reaction mechanism involves both radical and non-radical pathways, with reductive elimination playing a crucial role in forming important C-C bonds.
Di-tert-butyl peroxide is used as a polymerization catalyst for acrylonitrile polymers and resins (including olefins, styrene, styrenated alkyds, and silicones).


Di-tert-butyl peroxide is used as curing agent for styrenated alkyds and silicone rubbers.
Being thermally unstable substance, it may undergo self-accelerating decomposition.
Di-tert-butyl peroxide is used for tubular and autoclave processes.


Di-tert-butyl peroxide can be used for the market segments: polymer production, polymer crosslinking and acrylics production with their different applications/functions.
Di-tert-butyl peroxide is an efficient initiator for the production of Low Density Polyethylene (LDPE).


Di-tert-butyl peroxide is used both for tubular and autoclave processes.
Di-tert-butyl peroxide is used as a crosslinking agent for unsaturated polyesters and silicone rubbers, also as a polymerization initiator.
Di-tert-butyl peroxide is used as an initiator for high-temperature, high-pressure polymerizations of ethylene and halogenated ethylene.


Di-tert-butyl peroxide is used in the synthesis of polyketones.
Di-tert-butyl peroxide is used as a finishing catalyst for polystyrene.
Di-tert-butyl peroxide is used both for tubular and autoclave processes.


In most cases a combination of Di-tert-butyl peroxide with other peroxides is used to ensure a broad reactivity range.
Di-tert-butyl peroxide is used for both tubular and autoclave processes.
Di-tert-butyl peroxide is widely used as a crosslinking agent for unsaturated polyester and silicone rubber, a polymerization initiator for monomers, a polypropylene modifier, a rubber vulcanizing agent, etc.


Di-tert-butyl peroxide is used in the following products: polymers.
This substance is used for the manufacture of: plastic products and chemicals.
Release to the environment of Di-tert-butyl peroxide can occur from industrial use: as processing aid and as processing aid.


Release to the environment of Di-tert-butyl peroxide can occur from industrial use: manufacturing of the substance.
Di-tert-butyl peroxide is used as initiator for the production of Low Density Polyethylene (LDPE).
The decomposition reaction proceeds via the generation of methyl radicals.


Di-tert-butyl peroxide is mainly used as initiator for polymerization reaction (such as elimination of monomer after polymerization of PVC and polyacrylic lotion).
Further Di-tert-butyl peroxide finds its application in the polymerization and copolymerization of styrene, olefins and acrylic resins and as modification agent of polypropylene degradation.


Di-tert-butyl peroxide is used for synthesis.
Di-tert-butyl peroxide can be used for the market segments: polymer production, polymer crosslinking and acrylics production with their different applications/functions.


The decomposition reaction proceeds via the generation of methyl radicals.
In most cases a combination with other peroxides is used to ensure a broad reactivity range.
Di-tert-butyl peroxide is used both for tubular and autoclave processes.


In most cases a combination with other peroxides is used to ensure a broad reactivity range.
Di-tert-butyl peroxide can be used for the market segments: polymer production, polymer crosslinking and acrylics production with their different applications/functions.


In most cases, combinations with other peroxides are used to ensure a wide reaction range.
Di-tert-butyl peroxide is used as a cross-linking agent (rubber and resins).
Di-tert-butyl peroxide can also be widely used as a raw material for synthesizing other organic peroxides.


The peroxide bond undergoes homolysis at temperatures above 100°C.
Hence Di-tert-butyl peroxide is commonly used as a radical initiator in organic synthesis and polymer chemistry.
Di-tert-butyl peroxide can in principle be used in engines where oxygen is limited, since the molecule supplies both the oxidizer and the fuel.


Di-tert-butyl peroxide has been used as a radical initiator to induce free radical polymerization.
Di-tert-butyl peroxide has also been used as a cetane enhancer in a study to determine the phase behavior of carboxylate-based extended surfactant reverse micellar microemulsions with ethanol and vegetable oil/diesel blends.


Di-tert-butyl peroxide is widely used as crosslinking agent of unsaturated polyester and silicone rubber, polymerization initiator of monomer, polypropylene modifier, rubber curing agent
Di-tert-butyl peroxide is used in tube and autoclave processes.


-Applications of Di-tert-butyl peroxide in organic synthesis:
*Alkylating reactions:
Di-tert-butyl peroxide is a compound that finds application in alkylating reactions, specifically in the α-alkylation of α-amino carbonyl compounds using simple alkanes.

This reaction is noteworthy as Di-tert-butyl peroxide proceeds through the cleavage of dual sp (3) C-H bonds, providing a facile pathway for the α-functionalization of α-amino ketones and α-amino esters.
The use of Di-tert-butyl peroxide as a promoter allows for the radical pathway to be involved in this transformation.

The radical mechanism involves the generation of alkyl radicals from the simple alkanes, which then react with the α-amino carbonyl compounds to form the desired α-alkylated products.

This method demonstrates the versatility and utility of Di-tert-butyl peroxide in the field of alkylating reactions, particularly in the context of α-functionalization.

Di-tert-butyl peroxide provides a convenient and efficient route for the introduction of alkyl groups onto α-amino ketones and α-amino esters, expanding the synthetic possibilities for these important classes of compounds.



METHYLATION REACTION OF DI-TERT-BUTYL PEROXIDE:
Di-tert-butyl peroxide has been widely used in the methylation reaction as a direct aromatic methylation process with palladium (PdCl2) catalyst.
In a study, the mechanism of methylation reactions using Di-tert-butyl peroxide has been elucidated through energy calculations based on M06 density functional theory.

The research specifically focuses on the introduction of methyl radicals to the ortho position of the commonly used substrate, 2-phenylpyridine, via Di-tert-butyl peroxide.

By identifying the key intermediates and transition states in the reaction sequence, the reaction mechanism is explained.
Different possibilities regarding the coordination site between the substrate and the catalyst as well as subsequent mechanisms are discussed in detail.

The main mechanistic events include:
(a) oxidative or solvolysis of the peroxide O-O bond,
(b) C-H bond activation,
(c) C-C bond activation, and
(d) reductive elimination leading to the transfer of the methyl group onto the aromatic ring.

Both radical and non-radical pathways are considered. In the non-radical pathway, the lowest energy path involves C-H bond activation prior to peroxide coordination to palladium, followed by O-O bond cleavage and C-C bond activation.
Intermediate species generated through reductive elimination play a crucial role in forming important C-C bonds between the methyl and aromatic carbon.

In the non-radical pathway, the energy barrier for C-C bond activation is higher and identified as the rate-limiting step of the reaction.
However, in the radical pathway, the activation energy for C-C bond cleavage is lower than that for peroxide O-O bond cleavage.
It is found that a combination of both radical and non-radical pathways, involving the formation of a palladium methyl intermediate, is the most favorable route.

The predicted mechanism is consistent with experimental observations of the PdCl2-catalyzed methylation reaction using tert-butyl peroxide on 2-phenylpyridine.



FUNCTION AND USE OF DI-TERT-BUTYL PEROXIDE:
Di-tert-butyl peroxide is used as a modifier of drying oil, adding this product can significantly improve the drying properties of castor oil, whale oil, tung oil, soybean oil and linseed oil.

Adding to other plastics can improve Di-tert-butyl peroxide's gloss and chemical resistance.
As a crosslinking agent, Di-tert-butyl peroxide can be used in silicone rubber, synthetic and natural rubber, polyethylene, EVA and EPT, etc.
As a polymerization initiator, Di-tert-butyl peroxide can be used for polystyrene and polyethylene.



REACTIVITY PROFILE OF DI-TERT-BUTYL PEROXIDE:
The explosive instability of the lower dialkyl peroxides (e.g., dimethyl peroxide) and 1,1-bis-peroxides decreases rapidly with increasing chain length and degree of branching, the di-tert-alkyl derivatives being amongst the most stable class of peroxides.

Though many 1,1-bis-peroxides have been reported, few have been purified because of the higher explosion hazards compared with the monofunctional peroxides.
Di-tert-butyl peroxide is unlikely that this derivative would be particularly unstable compared to other peroxides in it's class, Bretherick 1979v.



PROPERTIES OF DI-TERT-BUTYL PEROXIDE:
Di-tert-butyl peroxide is an organic peroxide with the chemical formula (CH3)3COOOH.
Di-tert-butyl peroxide is a colorless to yellow liquid with a characteristic odor.

Di-tert-butyl peroxide is soluble in organic solvents such as ethers, hydrocarbons, and halogenated solvents, but it is insoluble in water. One of the notable characteristics of Di-tert-butyl peroxide is its stability at room temperature.
However, when exposed to elevated temperatures, Di-tert-butyl peroxide undergoes slow decomposition, releasing free radicals.

This property makes Di-tert-butyl peroxide useful as a radical initiator in various chemical reactions.
Di-tert-butyl peroxide exhibits stability in the presence of moisture and most acids.
Di-tert-butyl peroxide can maintain its integrity under these conditions without decomposition.

However, it is important to note that Di-tert-butyl peroxide decomposes in the presence of strong bases.
In summary, Di-tert-butyl peroxide is a versatile organic peroxide used primarily as a radical initiator in polymerization reactions.

Di-tert-butyl peroxide is stable at room temperature, soluble in organic solvents, but insoluble in water.
Di-tert-butyl peroxide’s-controlled decomposition at high temperatures releases free radicals, making it valuable in a wide range of industrial applications.



CHMEICAL PROPERTIES OF DI-TERT-BUTYL PEROXIDE:
Di-tert-butyl peroxide consists of a peroxide group bonded to two tert-butyl groups.
Since the tert-butyl groups are bulky, Di-tert-butyl peroxide is one of the most stable organic peroxides.



REACTIONS OF DI-TERT-BUTYL PEROXIDE:
The peroxide bond undergoes homolysis at temperatures above 100°C.
For this reason Di-tert-butyl peroxide is commonly used as a radical initiator in organic synthesis and polymer chemistry.

The decomposition reaction proceeds via the generation of methyl radicals.
(CH3)3COOC(CH3)3 → 2 (CH3)3CO•(CH3)3CO• → (CH3)2CO + CH•3
2 CH•3 → C2H6
Di-tert-butyl peroxide can in principle be used in engines where oxygen is limited, since the molecule supplies both the oxidizer and the fuel



PHYSICAL and CHEMICAL PROPERTIES of DI-TERT-BUTYL PEROXIDE:
Chemical formula: C8H18O2
Molar mass: 146.230 g·mol−1
Density: 0.796 g/cm3
Melting point: −40 °C (−40 °F; 233 K)
Boiling point: 109 to 111 °C (228 to 232 °F; 382 to 384 K)
CAS Number: 110-05-4
Molecular Weight: 146.23
Beilstein: 1735581
EC Number: 203-733-6
MDL number: MFCD00008803
Physical state: clear, liquid

Color: colorless
Odor: very faint
Melting point/freezing point:
Melting point/range: < -29 °C -
Initial boiling point and boiling range: 109 - 110 °C - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: > 99 %(V)
Flash point: 6 °C at ca.1.013 hPa - closed cup
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: 7,5 mPa.s at 20 °C
Water solubility: 0,171 g/l at 20 °C
Partition coefficient: n-octanol/water:
log Pow: 3,2 at 22 °C
Vapor pressure: 53 hPa at 20 °C
Density: 0,796 g/mL at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available

Oxidizing properties: none
Other safety information: No data available
Molecular Weight: 146.23 g/mol
XLogP3-AA: 2.1
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 3
Exact Mass: 146.130679813 g/mol
Monoisotopic Mass: 146.130679813 g/mol
Topological Polar Surface Area: 18.5Ų
Heavy Atom Count: 10
Formal Charge: 0

Complexity: 80.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CAS number: 110-05-4
EC index number: 617-001-00-2
EC number: 203-733-6
Hill Formula: C₈H₁₈O₂

Molar Mass: 146.23 g/mol
HS Code: 2909 60 90
Density: 0.80 g/cm3 (20 °C)
Flash point: 6 °C
Ignition temperature: 182 °C
Melting Point: -40 °C
Vapor pressure: 53 hPa (20 °C)
Solubility: 0.063 g/l
CBNumber:CB8852799
Molecular Formula:C8H18O2
Molecular Weight:146.23

MDL Number:MFCD00008803
MOL File:110-05-4.mol
Melting point: -30 °C
Boiling point: 109-110 °C(lit.)
Density: 0.796 g/mL at 25 °C(lit.)
vapor pressure: 40 mm Hg ( 20 °C)
refractive index: n20/D 1.3891(lit.)
Flash point: 34 °F
storage temp.: Store at +15°C to +25°C.
solubility: 0.063g/l
form: Liquid

color: Clear
Odor: distinctive odor
Water Solubility: immiscible
Merck: 14,3461
BRN: 1735581
Stability: May decompose explosively if heated,
subjected to shock, or treated with reducing agents.
InChIKey: LSXWFXONGKSEMY-UHFFFAOYSA-N
LogP: 3.2 at 22℃
CAS DataBase Reference 110-05-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances: TERT-BUTYL PEROXIDE
FDA 21 CFR: 176.170; 177.2600

EWG's Food Scores: 1
FDA UNII: M7ZJ88F4R1
NIST Chemistry Reference: Di-tert-butyl peroxide(110-05-4)
EPA Substance Registry System: Di-tert-butyl peroxide (110-05-4)
Molecular formula: C8H18O2
Molecular weight: 146.22 CAS number: 110-05-4
Density: 0.794(20℃)
Melting point: -40℃.
Molecular Formula / Molecular Weight: C8H18O2 = 146.23
Physical State (20 deg.C): Liquid
Storage Temperature: <0°C

Condition to Avoid: Heat Sensitive
CAS RN: 110-05-4
Reaxys Registry Number: 1735581
PubChem Substance ID: 87558545
Merck Index (14): 3461
Melting Point: -30°C
Density: 0.8000g/mL
Boiling Point: 109°C to 110°C
Flash Point: 6°C
Infrared Spectrum: Authentic
Assay Percent Range: 0.1% max. Tert-butyl hydroperoxide (GC)

Linear Formula: (CH3)3COOC(CH3)3
Refractive Index: 1.3880 to 1.39
Merck Index: 15, 3508
Specific Gravity: 0.8
Solubility Information: Solubility in water: immiscible.
Other solubilities: soluble in most organic solvents
IUPAC Name: 2-tert-butylperoxy-2-methylpropane
Viscosity: 0.9 mPa.s (20°C)
Formula Weight: 146.23
Percent Purity: 99%
Physical Form: Liquid

Color: Clear
Water Solubility: immiscible
Formula: C₈H₁₈O₂
MW: 146,23 g/mol
Boiling Pt: 109 °C (1013 hPa)
Melting Pt: < –25 °C
Density: 0,798 g/cm³ (20 °C)
Flash Pt: 12 °C
MDL Number: MFCD00008803
CAS Number: 110-05-4
EINECS: 203-733-6
Merck Index: 12,03515



FIRST AID MEASURES of DI-TERT-BUTYL PEROXIDE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DI-TERT-BUTYL PEROXIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully with liquid-absorbent material.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of DI-TERT-BUTYL PEROXIDE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Remove container from danger zone and cool with water.
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DI-TERT-BUTYL PEROXIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 30 min
*Body Protection:
Flame retardant antistatic protective clothing.
*Respiratory protection:
Recommended Filter type: Respirator.
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DI-TERT-BUTYL PEROXIDE:
-Precautions for safe handling:
*Advice on protection against fire and explosion:
Take precautionary measures against static discharge.
*Hygiene measures:
Change contaminated clothing.
Wash hands after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
*Storage stability:
Recommended storage temperature:
2 - 8 °C



STABILITY and REACTIVITY of DI-TERT-BUTYL PEROXIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available


DI-TERT-BUTYL PEROXIDE (DTBP)


Di-tert-butyl peroxide (DTBP) is an organic compound commonly used as a radical initiator in polymerization reactions.​
Di-tert-butyl peroxide (DTBP) has a molecular weight of 146.23 g/mol.

CAS Number: 110-05-4
EC Number: 203-733-6

Synonyms: Bis(1,1-dimethylethyl) peroxide, tert-Butyl peroxide, Peroxide, bis(1,1-dimethylethyl), DTBP, tert-Butyl hydroperoxide, Bis(tert-butyl) peroxide, Di-tert-butyl dioxidane, Peroxide, di-tert-butyl, 2,5-Dimethyl-2,5-dihydroperoxide hexane, Peroxydi-tert-butane, t-Butylperoxide, Di-tert-butylperoxide, Di-tert-butyldioxygen, DTBO, Di-tert-butyl diperoxide, Peroxide, di-t-butyl, DTB, Tert-butylperoxyl, DTP, Di-tert-butyl ether peroxide, Di-tert-butyl-oxide, DTBP, tert-Butylperoxy-tert-butyl, tert-Butylperoxide, Di-tert-butylperoxid, Bis(t-butyl)peroxide, 2,2'-Peroxybis(isobutane), DTBO2, DTBP-O2, Di-t-butyl peroxide, Di-tert-butyl-oxy, Peroxybis(isobutane), Tert-butyl ether peroxide, 2,5-Dimethyl-2,5-dihydroperoxide hexane, Peroxide, bis(1,1-dimethylethyl), tert-Butyl hydroperoxide, Tert-butyl ether hydroperoxide, DTBO, Bis(tert-butylperoxide), Di-t-butylperoxide, Tert-butyl peroxyl, 1,1-Dimethylethyl peroxide, Di-tert-butyl hydroperoxide, Di-t-butyl diperoxide, Tert-butyl bis-peroxide, Di-tert-butyloxy, DTBP-O, Di-t-butyl peroxy, Bis-tert-butyl peroxide, Di-t-butyl bisperoxide, Tert-butyl ether diperoxide, Tert-butyl ether peroxy, Tert-butyl ether dihydroperoxide, DTBP ether, Di-tert-butyl bis-hydroperoxide, DTB peroxide, Di-tert-butyl dihydroperoxide, DTB dihydroperoxide, Tert-butyl ether dihydroperoxide, DTBP-ether



APPLICATIONS


Di-tert-butyl peroxide (DTBP) is widely used as a radical initiator in the polymerization of monomers like styrene and ethylene.
Di-tert-butyl peroxide (DTBP) is employed in the production of polystyrene, helping to initiate the polymerization process.

Di-tert-butyl peroxide (DTBP) is used in the manufacture of high-density polyethylene (HDPE) to improve the material's strength and thermal resistance.
In the rubber industry, Di-tert-butyl peroxide (DTBP) is used as a crosslinking agent to enhance the elasticity and durability of rubber products.

Di-tert-butyl peroxide (DTBP) serves as a curing agent for unsaturated polyester resins, aiding in the formation of strong and durable composites.
Di-tert-butyl peroxide (DTBP) is utilized in the synthesis of acrylic resins, which are used in paints, coatings, and adhesives.
Di-tert-butyl peroxide (DTBP) is a key ingredient in the production of polyethylene foams, which are used in packaging and insulation.

Di-tert-butyl peroxide (DTBP) plays a role in the production of crosslinked polyethylene (PEX) pipes, which are widely used in plumbing and heating systems.
Di-tert-butyl peroxide (DTBP) is used in the initiation of graft polymerization, which involves attaching polymer chains to a backbone polymer.

Di-tert-butyl peroxide (DTBP) is employed in the manufacture of impact-resistant polystyrene (HIPS), which is used in appliances and electronics.
DTBP is used in the preparation of high-performance thermoplastics, such as polycarbonate and polyamide.

Di-tert-butyl peroxide (DTBP) serves as an initiator in the polymerization of vinyl acetate to produce polyvinyl acetate (PVA), a key component in adhesives.
Di-tert-butyl peroxide (DTBP) is utilized in the synthesis of styrene-butadiene rubber (SBR), which is used in tires and other rubber products.

Di-tert-butyl peroxide (DTBP) is used in the production of polypropylene, enhancing its strength and thermal stability.
Di-tert-butyl peroxide (DTBP) is a key component in the synthesis of block copolymers, which have applications in adhesives, coatings, and elastomers.

Di-tert-butyl peroxide (DTBP) is employed in the manufacture of ion-exchange resins, which are used in water treatment and purification.
Di-tert-butyl peroxide (DTBP) is used as a vulcanizing agent in the production of silicone rubber, which is used in seals, gaskets, and medical devices.
Di-tert-butyl peroxide (DTBP) plays a role in the production of epoxy resins, which are used in coatings, adhesives, and composite materials.

Di-tert-butyl peroxide (DTBP) is used in the initiation of polymerization reactions for the production of various plastic materials.
Di-tert-butyl peroxide (DTBP) is utilized in the synthesis of specialty polymers, which have applications in electronics, aerospace, and automotive industries.
Di-tert-butyl peroxide (DTBP) is used in the preparation of flame-retardant materials, enhancing their resistance to ignition and combustion.

Di-tert-butyl peroxide (DTBP) serves as a catalyst in the polymerization of acrylates and methacrylates, which are used in coatings and adhesives.
Di-tert-butyl peroxide (DTBP) is employed in the production of polyvinyl chloride (PVC) to improve its heat stability and mechanical properties.

Di-tert-butyl peroxide (DTBP) is used in the manufacture of elastomers, which are materials with high elasticity and resilience.
Di-tert-butyl peroxide (DTBP) is a key component in the production of polymeric materials used in medical devices, packaging, and consumer goods.

Di-tert-butyl peroxide (DTBP) is used as a polymerization initiator in the production of low-density polyethylene (LDPE), commonly used in plastic bags and film.
Di-tert-butyl peroxide (DTBP) is an essential initiator in the production of ethylene-vinyl acetate (EVA) copolymers, which are used in hot melt adhesives and foam products.
Di-tert-butyl peroxide (DTBP) is used in the synthesis of thermoplastic elastomers, which combine the properties of rubber and plastic.

Di-tert-butyl peroxide (DTBP) is a crucial component in the production of styrene-acrylonitrile (SAN) copolymers, which are used in automotive parts and household appliances.
Di-tert-butyl peroxide (DTBP) is used as a polymerization initiator for the production of acrylic fibers, which are used in textiles and clothing.
Di-tert-butyl peroxide (DTBP) is involved in the manufacture of polymethyl methacrylate (PMMA), a transparent plastic used as a glass substitute.

Di-tert-butyl peroxide (DTBP) is utilized in the production of acrylonitrile-butadiene-styrene (ABS) copolymers, which are used in 3D printing and injection molding.
Di-tert-butyl peroxide (DTBP) is employed in the preparation of ionomer resins, which are used in golf balls and food packaging.
Di-tert-butyl peroxide (DTBP) serves as a crosslinking agent in the production of high-performance rubber materials, such as those used in automotive seals and hoses.
Di-tert-butyl peroxide (DTBP) is used in the polymerization of vinyl chloride to produce polyvinyl chloride (PVC), used in pipes, cables, and flooring.

Di-tert-butyl peroxide (DTBP) is a key component in the manufacture of epoxy adhesives, providing strong bonding properties for industrial applications.
Di-tert-butyl peroxide (DTBP) is used in the production of synthetic resins, which are used in coatings, adhesives, and composite materials.

Di-tert-butyl peroxide (DTBP) plays a role in the synthesis of phenolic resins, which are used in molding compounds and laminates.
Di-tert-butyl peroxide (DTBP) is utilized in the production of polyolefin elastomers, which are used in automotive parts and consumer goods.

Di-tert-butyl peroxide (DTBP) is employed in the manufacture of high-impact polystyrene (HIPS), used in packaging, toys, and appliances.
Di-tert-butyl peroxide (DTBP) is used in the initiation of free radical polymerization reactions in the production of various plastic materials.

Di-tert-butyl peroxide (DTBP) serves as a polymerization initiator in the production of butadiene rubber, which is used in tires and footwear.
Di-tert-butyl peroxide (DTBP) is used in the synthesis of functional polymers, which have applications in drug delivery and biotechnology.

Di-tert-butyl peroxide (DTBP) is employed in the production of styrene-butadiene latex, which is used in carpet backing and paper coatings.
DTBP is used in the preparation of polyethylene terephthalate (PET), a plastic used in bottles and textiles.

Di-tert-butyl peroxide (DTBP) is a key component in the synthesis of acrylic coatings, providing durability and weather resistance.
Di-tert-butyl peroxide (DTBP) is used in the manufacture of elastomeric foams, which are used in insulation and cushioning materials.
Di-tert-butyl peroxide (DTBP) is involved in the production of acrylonitrile copolymers, which are used in barrier resins and packaging materials.

Di-tert-butyl peroxide (DTBP) serves as an initiator in the polymerization of methacrylate monomers, which are used in dental materials and coatings.
Di-tert-butyl peroxide (DTBP) is employed in the production of crosslinked polyethylene (XLPE), used in electrical cables and heat-resistant tubing.
Di-tert-butyl peroxide (DTBP) is sensitive to light and heat, which can accelerate its decomposition.

Di-tert-butyl peroxide (DTBP) is classified as a hazardous substance due to its flammability and potential health effects.
Di-tert-butyl peroxide (DTBP) is commonly stored in amber glass bottles to protect it from light-induced degradation.

The compound is also used in the study of the thermal decomposition of organic peroxides.
Di-tert-butyl peroxide (DTBP) can be used as a fuel additive to improve combustion efficiency in certain applications.

Its chemical stability at low temperatures makes it a valuable initiator in controlled radical polymerization.
DTBP releases tert-butyl radicals upon decomposition, which are highly reactive and initiate polymerization.

Di-tert-butyl peroxide (DTBP) is often used in combination with other peroxides to tailor the polymerization process for specific applications.
In industrial settings, DTBP is typically used in concentrations ranging from 0.1% to 1% by weight.
Di-tert-butyl peroxide (DTBP) is regulated by safety guidelines due to its reactive nature and potential hazards.

Its decomposition products include tert-butyl alcohol and oxygen, both of which can contribute to its reactivity.
Understanding the properties and handling requirements of DTBP is crucial for its safe and effective use in various chemical processes.



DESCRIPTION


Di-tert-butyl peroxide (DTBP) is an organic compound commonly used as a radical initiator in polymerization reactions.​
Di-tert-butyl peroxide (DTBP) has a molecular weight of 146.23 g/mol.
Di-tert-butyl peroxide (DTBP) is a colorless liquid at room temperature and has a distinct, ether-like odor.

Di-tert-butyl peroxide (DTBP) decomposes exothermically, releasing heat and gases, making it useful in controlled polymerization processes.
Di-tert-butyl peroxide (DTBP) is insoluble in water but readily dissolves in organic solvents such as benzene and toluene.
The boiling point of DTBP is approximately 111°C (232°F).

Due to its flammable nature, DTBP must be handled with care and stored in a cool, well-ventilated area away from ignition sources.
Di-tert-butyl peroxide (DTBP) is often used in the production of polymers like polyethylene and polystyrene, where it acts as an initiator.

Di-tert-butyl peroxide (DTBP) is a key component in crosslinking polyethylene, improving the material's mechanical and thermal properties.
The peroxide functional group in DTBP makes it highly reactive and suitable for initiating radical chain reactions.

In addition to polymerization, DTBP is used in the synthesis of fine chemicals and pharmaceuticals.
Di-tert-butyl peroxide (DTBP) can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation.
Di-tert-butyl peroxide (DTBP) should be handled with appropriate personal protective equipment, including gloves and goggles.



PROPERTIES


Physical Properties:


Molecular Weight: 146.23 g/mol
Appearance: Colorless liquid
Odor: Ether-like
Density: 0.79 g/cm³ at 20°C
Boiling Point: 111°C (232°F)
Melting Point: -40°C (-40°F)
Refractive Index: 1.393 at 20°C
Vapor Pressure: 18 mmHg at 20°C
Solubility: Insoluble in water; soluble in organic solvents such as benzene, ethanol, and acetone
Viscosity: 0.73 mPa·s at 20°C
Flash Point: 6°C (43°F), closed cup
Autoignition Temperature: 200°C (392°F)


Chemical Properties:

Chemical Structure: Contains two tert-butyl groups bonded to a peroxide functional group
Functional Groups: Peroxide group (-O-O-)
Decomposition: Exothermic decomposition, releasing tert-butyl radicals and oxygen
Reactivity: Reactive with acids, bases, and reducing agents; sensitive to heat and light
Flammability: Highly flammable liquid
Stability: Stable under recommended storage conditions; decomposes upon exposure to heat or light
pH: Neutral in its pure form
Partition Coefficient (Log P): 2.7
Heat of Combustion: -39.6 kJ/mol
Heat of Formation: -302 kJ/mol
Activation Energy for Decomposition: Approximately 150 kJ/mol
Specific Heat Capacity: 1.88 J/g·K
Enthalpy of Vaporization: 36.2 kJ/mol



FIRST AID


Inhalation:

Symptoms:
DTBP inhalation may cause respiratory irritation, coughing, shortness of breath, dizziness, and headache.

Immediate Actions:
Move the person to fresh air immediately.
Keep the person calm and at rest.
If breathing is difficult, provide oxygen if available.
If not breathing, begin artificial respiration or CPR.

Medical Attention:
Seek immediate medical attention.
Inform medical personnel about the exposure to DTBP.


Skin Contact:

Symptoms:
Skin contact with DTBP can cause irritation, redness, and burns.

Immediate Actions:
Remove contaminated clothing and shoes immediately.
Rinse the affected area thoroughly with plenty of water for at least 15 minutes.
Wash the skin with soap and water.

Medical Attention:
Seek medical advice if irritation or pain persists.
Inform the medical personnel about the chemical involved.


Eye Contact:

Symptoms:
Eye exposure to DTBP can cause irritation, redness, pain, and blurred vision.

Immediate Actions:
Rinse eyes immediately with plenty of water for at least 15 minutes.
Hold the eyelids open and move the eyeballs in all directions to ensure thorough rinsing.
Remove contact lenses if present and easy to do so.

Medical Attention:
Seek immediate medical attention, preferably from an eye specialist.
Inform the medical personnel about the chemical involved.


Ingestion:

Symptoms:
Ingesting DTBP can cause gastrointestinal irritation, nausea, vomiting, and abdominal pain.

Immediate Actions:
Do not induce vomiting.
Rinse the mouth thoroughly with water.
If the person is conscious and alert, give small amounts of water to drink.

Medical Attention:
Seek immediate medical attention.
Inform the medical personnel about the chemical ingested.



HANDLING AND STORAGE


Handling:

General Precautions:
Handle DTBP in a well-ventilated area to avoid the accumulation of vapors.
Ensure that all handling and processing equipment is designed to prevent accidental release.
Use appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats.
Avoid breathing vapors, mists, or dust.

Safe Handling Practices:
Open containers carefully and handle them in a manner that minimizes the risk of spills or releases.
Use tools and equipment that are spark-resistant and grounded to avoid static discharge.
Do not handle DTBP near open flames, sparks, or hot surfaces.
Use fume hoods or local exhaust ventilation to capture vapors at the source.
Avoid contact with skin, eyes, and clothing by using protective barriers and following hygiene practices.

Hygiene Measures:
Wash hands and any exposed skin thoroughly with soap and water after handling DTBP.
Remove contaminated clothing and wash it before reuse.
Avoid eating, drinking, or smoking in areas where DTBP is handled or stored.

Spill and Leak Response:
Immediately contain and control any spills or leaks using inert absorbent materials such as sand or vermiculite.
Do not use combustible absorbents like sawdust.
Dispose of contaminated materials according to local, state, and federal regulations.
Clean the affected area thoroughly to remove residual contamination.


Storage:

Storage Location:
Store DTBP in a cool, dry, and well-ventilated area away from incompatible substances.
Keep storage areas away from direct sunlight, sources of heat, and ignition sources.
Ensure that storage areas are equipped with appropriate fire suppression systems.

Container Requirements:
Store DTBP in tightly closed, original containers made of materials compatible with organic peroxides.
Use containers that are resistant to corrosion and designed to withstand pressure changes.
Ensure containers are properly labeled with the chemical name, hazards, and handling instructions.

Temperature Control:
Maintain storage temperatures below 30°C (86°F) to prevent decomposition.
Avoid freezing temperatures, as crystallization can occur, potentially affecting the stability of DTBP.
Monitor storage temperatures regularly using appropriate equipment.

Segregation:
Store DTBP separately from incompatible materials such as acids, bases, reducing agents, and combustibles.
Keep DTBP away from food, feedstuffs, and drinking water supplies.
Use secondary containment measures, such as spill trays, to prevent contamination in case of leaks.

Fire Protection:
Store DTBP in an area equipped with explosion-proof electrical installations and appropriate fire suppression systems.
Ensure fire extinguishers, suitable for organic peroxides, are readily accessible.
Post "No Smoking" and "Flammable" signs in storage and handling areas.

Inventory Management:
Implement a first-in, first-out (FIFO) inventory system to prevent prolonged storage.
Regularly inspect storage containers for signs of degradation or leaks.
Keep an up-to-date inventory record of DTBP, including quantities and storage locations.

Emergency Preparedness:
Develop and implement an emergency response plan specific to DTBP.
Train personnel in emergency response procedures, including spill response and fire fighting.
Ensure emergency showers and eyewash stations are accessible in storage and handling areas.
Diacetone Acrylamide
SYNONYMS Poly(Oxy-1,2-Ethanediyl), .alpha.-(3-Carboxy-1-Oxo-3-Sulfopropyl)-.omega.-(Dodecyloxy)-, Disodium Salt CAS NO:39354-45-5 SYNONYMS Poly(Oxy-1,2-Ethanediyl), .alpha.-(3-Carboxy-1-Oxo-3-Sulfopropyl)-.omega.-(Dodecyloxy)-, Disodium Salt CAS NO:39354-45-5
Diallyl phthalate
Diallyl Phthalate; Allyl phthalate; Dapon R; Phthalic Acid Diallyl Ester; Dapon 35; Phthalic acid CAS NO:131-17-9
Diallyldimethylammonium chloride
1-octadecoxyoctadecane; Octadecane, 1,1‘-oxybis-; 1-octadecoxyoctadecane; cas no: 6297-03-6
Dibasic Ester
N,N-Dibenzylamine; (N-Benzylaminomethyl)benzene; N-(Phenylmethyl)benzenemethanamine; DBA; N-Benzylbenzylamine; Bibenzylamine CAS NO:103-49-1
Dibenzylamine
N,N-Dibenzylamine; (N-Benzylaminomethyl)benzene; N-(Phenylmethyl)benzenemethanamine; DBA; N-Benzylbenzylamine; Bibenzylamine; DBZA; DIBAM; Vulcaid 28; forLabetalol; DIBENZYLAMINE; Bibenzylamine; Accelerator DBA; Dibenzylamine 98%; Dibenzylamine,98%; N,N-DIBENZYLAMINE CAS NO:103-49-1
Dibutyl adipate
BUTYL CARBONATE; DIBUTYL CARBONATE; n-Butyl carbonate; n-C4H9OC(O)OC4H9-n; DI-N-BUTYL CARBONATE; Carbonic acid dibutyl; carbonicaciddibutylester; Carbonicacid,dibutylester; Di-n-butyl carbonate,98+%; Carbonic acid,dibutyl ester CAS NO:542-52-9
Dibutyl Carbonate
Maleic acid dibutyl ester; Butyl maleate; DBM; Di-n-butyl maleate; Bibutyl maleate; 2-Butenedioic acid dibutyl ester; Dibutylester kyseliny maleinove; Dibutylmaleinat; Maleinsäuredibutylester; Dibutylester kyseliny maleinove CAS NO: 105-76-0
Dibutyl Maleate
Maleic acid dibutyl ester; Butyl maleate; DBM; Di-n-butyl maleate; Bibutyl maleate; 2-Butenedioic acid dibutyl ester; Dibutylester kyseliny maleinove; Dibutylmaleinat; Maleinsäuredibutylester; Dibutylester kyseliny maleinove CAS NO: 105-76-0
Dibutyl Sulfate
Di-n-butyl sulfate; Dibutylsulfate; Sulfuric acid dibutyl ester; sulfate de butyl; CAS NO: 625-22-9
Dicyclohexylamine
Didecyldimonium bicarbonate; 1-Decanaminium, N-decyl-N,N-dimethyl-, carbonate (1:1); Didecyldimethylammonium bicarbonate (1to1); didecyl dimethyl ammonium bicarbonate; N-Decyl-N,N-dimethyl-1-decanaminium carbonate CAS NO:148812-65-1
Dicyclohexylcarbodiimide
DICYCLOHEXYLCARBODIIMIDE; Dicyclohexylcarbodiimide; DCC; Dicyclocarbodiimide; DCC; 1,3-Dicyclohexylcarbodiimide; N,N'-methanetetraylbis-Cyclohexaamine; DCCD; N,N'-dicyclohexylcarbodiimide; N,N'-methanetetraylbiscyclohexanamine; Bis(cyclohexyl)carbodiimide; cas no: 538-75-0
Dicyclopentadiene
N,N-Dibutyl-1,3-propanediamine; 3-(Dibutylamino)propylamine; N,N-DIMETHYL-1,3-PROPANEDIAMINE; 3-(Dimethylamino)-1-propylamine; 1,3-Propanediamine, N,N-dimethyl-; 3-Aminopropyldimethylamine; Dimethylaminopropylamine cas no : 102-83-0
didecyl dimethyl ammonium chloride
Didecyl dimethyl ammonium chloride; Didecyldimethylammonium chloride; N-decyl-N,N-dimethyldecan-1-aminium chloride; Astop; Quaternium 12; Arquad 10; Bardac 22; DDAC; Britewood Q CAS NO:7173-51-5
Diehtylene Glycol
3-Oxa-1,5-pentanediol; Bis(2-hydroxyethyl)ether; DEG; 2,2'-Oxydiethanol; Diglycol; Dihydroxydiethyl ether; 2,2'-Dihydroxyethyl ether; Ethylene diglycol; 2,2'-Oxybisethanol; 2-(2-Hydroxyethoxy)ethanol CAS NO: 111-46-6
diethylene glycol
Diéthylène-glycol, 2,2'-Oxydiéthanol, 3-Oxapentane-1,5-diol, Diglycol, DEG, cas no : 111-46-6, Synonyme CISMeF : diglycol; 2,2' oxydiéthanol; 3-oxapentane-1,5-diol; diéthylèneglycol; ethylene diglycol; dihydroxy ethyl ether; 2,2'-Oxydiéthanol;Comme dans le cas de l'éthylène glycol, le mélange d'eau et de diéthylène glycol peut être utilisé comme antigel. La température de fusion du mélange est abaissée, ce qui le rend intéressant pour des utilisations dans des climats froids. De plus la température d'ébullition de ce produit étant élevée, plus que dans le cas de l'éthylène glycol, ce mélange est également plus intéressant sous les climats chauds.Il est utilisé : comme plastifiant pour le PVC (polychlorure de vinyle), dans les systèmes de climatisation et les déshumidificateurs.comme désinfectant sous forme d'aérosol.comme agent de dessiccation pour la déshydratation du gaz naturel.2,2' -oxybisethanol. 2,2' -oxybisethanol; diethylene glycol; 2,2'-oxydiethanol Diethylene glycol; Bis (2-hydroxyethyl) ether; DEG; Diethylene glycol; diethyleneglycol; 2,2' -oksibisetanol (hr); 2,2' -Oksibisetanoli (fi); 2,2' -oxibisetanol (ro); 2,2' -oxietanol (sv); 2,2' -oxydietanol (sk); 2,2'-oksibisetanoldietilenglikolis (lt); 2,2'-oksidietanol (sl); 2,2'-oksydietanol (no); 2,2'-ossidietanolo (it); 2,2'-oxidietanol (es); 2,2'-oxydiethan-1-ol (cs); 2,2'-oxydiethanol (da); 2,2'-oxydiéthanol (fr); 2,2'-οξυδισαιθανόλη (el); 2,2'-оксибисетанол (bg); 2,2`-oksybisetanol (pl); 2,2’-oksibis-etanols (lv); 2,2’-oksübisetanool (et); 2,2’-oxibiszetanol (hu); 2-idrossietil etere (it); diethylenglycol (da); diethylenglykol (cs); dietilen glicol (ro); dietilen glicole (it); dietilen-glikol (hr); dietilenglicol (pt); dietilenglikolis (lt); dietilén-glikol (hu); dietilēnglikols (lv); dietlenglikol (sl); dietylenglykol (no); Dietylieeniglykoli (fi); dietylénglykol (sk); dietüleenglükool (et); diéthylène glycol (fr); glikol dietylenowy (pl); διαιθυλενογλυκόλη (el); диетилен гликол (bg); Ethanol, 2,2'-oxybis-; (2-hydroxyethoxy) ethan-2-ol; (2-hydroxyethoxy)ethan-2-ol; (2-hydroxyethoxy)ethan-2-ol2,2'-Oxydiethanol2,2-oxydiethanol2-(2-hydroxyethoxy)ethanol; DEG; Di-ethylene Glycol; Diethylene Glycol; (DEG)Diethyleneglycol; Diethylenglycol; Diethylenglykol; 2,2''-oxydiethanol; 2,2'- ossidietanolo; 2,2'-DIHYDROXYDIETHYL ETHER; 2,2'-oxybisenthanol; 2,2'-Oxybisethanol; 2,2'-oxydiethano; 2,2'-oxydiethanol; diethylene-glycol; 2,2'Oxybisethanol; 2,2-Oxybisethanol; 2,2-Oxydiethanol; 2,2`-oxybisethanol; 2,2’-Oxybisethanol; 2,2’-oxydiethanol; 2,2′-Oxydiethanol; 2-(2 hydroxyethoxy)ethanol; 2-(2-butoxyethoxy)ethanol diethylene glycol monobutyl ether; 2-(2-Hydroxyethoxy)ethan-1-ol; 2-(2-hydroxyethoxy)ethan-1-ol); 2-(2-Hydroxyethoxy)ethanol; 2-(2-hydroxyethoxy)ethanol ; 2.2'-Oxybisethanol; 3-ossa-1,5-pentandiolo; 3-oxopentan-1,5-diol 1.3; Agent T294; Bis(2-hydroxyethyl) ether; Bis(2-hydroxyethyl)ether; CH2OHCH2OCH2CH2OH; Di(ethylenglicol); Di-ethylene Glycol; diethylen glycol; Diethylene Glycol (DEG); Diethylene glycol; 2-Hydroxyethyl ether; Bis(2-hydroxyethyl) ether; Diglycol; DIETHYLENE-GLYCOL; ethan-1,2-diol;glycol ether; Reaction mass of 1309-37-1 and 1317-65-3 and 20344-49-4 and 61791-23-9. s: .beta.,.beta.'-Dihydroxydiethyl ether; 2,2'-Oxybis[ethano]; 2,2'-Oxybis[ethanol]; 2,2'-Oxyethanol; 2- hydroxyethoxy)ethan-2-ol; 3-Oxapentamethylene-1,5-diol; 3-Oxapentane-1,5-diol; Bis(.beta.-hydroxyethyl) ether; Bis(.beta.-hydroxyethyl)ether; Di Ethylene Glycol; Di ethyleneglycol; Dicol; Diethylene glcyol; DiethyleneGlycolTech; Dietylene glycol; Digenos; Diglycol; diglycol glycol; Digol; Dihydroxyethyl ether; Ethanol, 2,2'-oxybis- (9CI); Ethylene diglycol; Glicole Dietilenico; Glycol ethyl ether
Diethylenetriamine ( DETA)
DETA; N-(2-aminoethyl)-1,2-Ethanediamine; DTA; 2,2'-Diaminodiethylamine; Aminoethylethanediamine; 1,4,7-Triazaheptane; Bis(2-aminoethyl)amine; N-(2-aminoethyl)ethylenediamine; 3-Azapentane-1,5-diamine; Bis(beta-aminoethyl)amine; 2,2'-Iminobis(ethanamine); 2,2'-Iminobisethylamine; CAS NO: 111-40-0
Diethylethanolamine ( DEAE)
Diethylaminoethanol; 2-Dietilaminoetanol; 2-Diéthylaminoéthanol; 2-Diethylaminoethanol; 2-Hydroxytriethylamine; 2-N,N-diethylaminoethanol; beta-diethylaminoethanol; beta-hydroxytriethylamine; diethyl(2-hydroxyethyl)amine; Diethylaminoethanol; Diethylethanolamine; DEAE; N-diethylaminoethanol; N,N-Diethyl-2-hydroxyethylamine; N,N-Diethylethanolamine; N,N-diethyl-N-(beta-hydroxyethyl) Amine; CAS NO : 100-37-8
Diisopropanolamine
Diisopropanolamine; Bis(2-hydroxypropyl)amine; DI(2-Hydroxy-n-propyl) amine; 1,1'-imino-bis(2-propanol); DIPA; 2,2'-dihydroxy-dipropyl-amine; 1,1'-iminodipropan-2-ol; Bis(2-hydroxypropyl)amine; Bis(2-propanol)amine; Dipropyl-2,2'-dihydroxy-amine; CAS NO: 110-97-4
Dimethicone 100,350,1000
DIMETHICONE, N° CAS : 63148-62-9 / 9006-65-9 / 9016-00-6 - Diméthicone ou Polydiméthylsiloxane, Autres langues : Dimethicon, Dimeticona, Dimeticone, Nom INCI : DIMETHICONE, Nom chimique : Dimethicone, Additif alimentaire : E900, Classification : Silicone. Le diméthicone nommé aussi PDMS est un silicone qui n'est soumis à aucune restriction européenne. C'est aussi le silicone le plus utilisé dans les produits cosmétiques. Son rôle est de produire un film de surface autour du cheveu et sur la peau, pour les protéger ensuite (effet occlusif, avec ce que cela peut impliquer). Il apporte aussi de la douceur aux produits et rend agréable l'utilisation de crèmes et de shampoings. C'est un peu "le couteau Suisse du chimiste" : on l'utilise un peu à toutes les sauces, pour rendre les produits plus brillants, plus agréables et donc plus vendeurs, ou encore pour venir compenser l'effet desséchant de certains ingrédients comme les tensioactifs.Ses fonctions (INCI): Anti-moussant : Supprime la mousse lors de la fabrication / réduit la formation de mousse dans des produits finis liquides. Emollient : Adoucit et assouplit la peau. Agent d'entretien de la peau : Maintient la peau en bon état. Agent de protection de la peau : Aide à éviter les effets néfastes des facteurs externes sur la peau
Dimethyl 1,4-Cyclohexanedicarboxylate
SYNONYMS POLYLINK DETDA;Benzenediamine, ar,ar-diethyl-ar-methyl-;Diethyltoluylendiamin;ar,ar-diethyl-ar-methyl-benzenediamin;ar,ar-diethyl-ar-methylbenzenediamine;ar,ar-diethyl-ar-methyl-Benzenediamine;diethyl tolamine;Amino-(diethylamino)-toluene, isomer mixture;DETDA;Diethylmethylbenzenediamine;Diethyltoluenediamine;Devcon Flexane 80 Putty Curing Agent;3,5-Diethyltoluene-2,4/2,6-diamine Cas no :68479-98-1
Dimethyl Disulfide
DMF; N,N-Dimethylmethanamide; Formic acid dimethylamide; N,N-Dimethylformamide;N-Formyldimethylamine; Dimethylamid kyseliny mravenci (Czech); Dimethylformamid (German); Dimetilformamide (Italian) N,N-Dimetilformamida (Spanish); DMF; Dwumetyloformamid (Polish) CAS NO: 68-12-2
Dimethyl Formamide
DMF; N,N-Dimethylmethanamide; Formic acid dimethylamide; N,N-Dimethylformamide;N-Formyldimethylamine; Dimethylamid kyseliny mravenci (Czech); Dimethylformamid (German); Dimetilformamide (Italian) N,N-Dimetilformamida (Spanish); DMF; Dwumetyloformamid (Polish) CAS NO: 68-12-2
Dimethyl Phosphite
DIMETHYL SUCCINATE, N° CAS : 106-65-0, Nom INCI : DIMETHYL SUCCINATE, Nom chimique : Dimethyl succinate, N° EINECS/ELINCS : 203-419-9. Emollient : Adoucit et assouplit la peau. Agent masquant : Réduit ou inhibe l'odeur ou le goût de base du produit. Agent d'entretien de la peau : Maintient la peau en bon état.Solvant : Dissout d'autres substances
Dimethyl Sulfoxide
Methanesulfinylmethane; Methyl sulfoxide; Dimethyl(oxido)sulfur; DMSO; Methylsulfinylmethane; Dimethyl sulfoxyde; Sulfinylbis(methane); Dimetil sulfóxido (Spanish); Diméthylsulfoxyde (French) CAS NO: 67-68-5
Dimethylbutyryl Chloride
Dimethylbutyryl Chloride; Cloruro de 2,2-dimetilbutirilo; Chlorure de 2,2-diméthylbutyryle; 2,2-Dimethylbutyrylchlorid; cas no: 5856-77-9
Dimethylethanolamine
SYNONYMS 2-(Dimethylamino)Ethanol; N,N-Dimethyl-N-ethanolamine; N,N-Dimethyl-2-aminoethanol; beta-Dimethylaminoethyl alcohol; beta-hydroxyethyldimethylamine; Ddimethylaminoethanol; Deanol; Dimethylethanolamine; Dimethylaminoaethanol (German); N,N-Dimethyl-2-Hydroxyethylamine; N,N-Dimethylaminoethanol; N,N-dimethyl-N-(2-hydroxyethyl)amine; Cas no: 108-01-0
dimethylformamide
N,N'-Dimethylurea; symmetric Dimethylurea;N,N'-Dimethylharnstoff (German); Urea, 1,3-dimethyl-; DMU; 1,3-Dimetilurea (Spanish); 1,3-Diméthylurée (French); CAS NO: 96-31-1
Dimethylolbutanoic Acid
DMF; N,N-Dimethylmethanamide; Formic acid dimethylamide; N,N-Dimethylformamide;N-Formyldimethylamine; Dimethylamid kyseliny mravenci (Czech); Dimethylformamid (German); Dimetilformamide (Italian) N,N-Dimetilformamida (Spanish); DMF; Dwumetyloformamid (Polish) CAS NO: 68-12-2
Dimethylolpropionic Acid
DMF; N,N-Dimethylmethanamide; Formic acid dimethylamide; N,N-Dimethylformamide;N-Formyldimethylamine; Dimethylamid kyseliny mravenci (Czech); Dimethylformamid (German); Dimetilformamide (Italian) N,N-Dimetilformamida (Spanish); DMF; Dwumetyloformamid (Polish) CAS NO: 68-12-2
Dimethylurea
Dioctyl hexanedioate; Di-n-octyl adipate CAS NO:123-79-5
Dioctyl Sulfosuccinate
CHLORINE DIOXIDE, N° CAS : 10049-04-4 - Dioxyde de chlore, Nom INCI : CHLORINE DIOXIDE, Additif alimentaire : E926, Ses fonctions (INCI): Antimicrobien : Aide à ralentir la croissance de micro-organismes sur la peau et s'oppose au développement des microbes, Déodorant : Réduit ou masque les odeurs corporelles désagréables. Noms français : BIOXIDE DE CHLORE;BIOXYDE DE CHLORE; Chlore, dioxyde de; Chlorine dioxide; Dioxyde de chlore. Noms anglais : CHLORIDE DIOXIDE; Chlorine dioxide; CHLORINE DIOXYDE. Utilisation: Le dioxyde de chlore est surtout utilisé en tant qu'agent blanchissant dans l'industrie des pâtes et papiers, où il remplace de plus en plus le chlore pour des raisons écologiques. Il se retrouve aussi dans plusieurs autres applications, bien que son usage y soit plus restreint: dans le blanchissement de fibres textiles comme désinfectant dans plusieurs usines d'eau potable dans l'industrie alimentaire pour le contrôle des microbes dans les champs pétrolifères pour enlever des biofilms, contrôler les odeurs ou neutraliser certains composés. Alcide Anthium dioxcide Chlorine dioxide chlorine dioxide ... % Chlorine dioxide generated from sodium chlorite and sodium bisulphate Chlorine dioxide generated from sodium chlorite by electrolysis chlorine dioxide Chlorine oxide Chlorine oxide (ClO2) Chlorine peroxide Chlorine(IV) oxide Chloroperoxyl Chloryl radical Doxcide 50 Purite Translated names chloordioxide (nl) chloordioxide ... % (nl) chlordioxid (da) chlordioxid ... % (da) chloro dioksidas (lt) chloro dioksidas ... % (lt) diossido di cloro (it) diossido di cloro . . . % (it) dioxid de clor (mt) dioxid de clor….% (mt) dioxyde de chlore (fr) dioxyde de chlore à ... % (fr) ditlenek chloru (pl) ditlenek chloru. . . % (pl) dióxido de cloro (es) dióxido de cloro . . . % (es) dióxido de cloro a ... % (pt) hlora dioksīds (lv) hlora dioksīds . . . % (lv) kloordioksiid (et) kloordioksiid, . . . % (et) Klooridioksidi (fi) Klooridioksidi . . . % (fi) klordioksid (no) klordioksid … % (no) klordioxid (sv) klorov dioksid (hr) klorov dioksid . . . % (sl) klorov dioksid ... % (hr) klorxid . . . % (sv) klór-dioxid (hu) klór-dioxid ...% (oldat) (hu) oxid chloričitý (cs) oxid chloričitý ... % (sk) oxid chloričitý ...% (cs) διοξείδιο του χλωρίου (el) διοξείδιο του χλωρίου . . . % (el) хлорен диоксид (bg) хлорен диоксид ... % (bg) anthium dioxide Chlorine Dioxide (or dioxygen chloride) chlorine dioxide aqueous solution Chlorine dioxide solution Chlorine dioxide water solution chlorous acid; Chlorine dioxide [Wiki] 10049-04-4 [RN] Chloranyl, dioxido- [ACD/Index Name] Chlorosyloxidanyl chlorosyloxy ClO2(.) Dioxido-λ5-chloranyl Dioxido-λ5-chloranyl [German] Dioxydo-λ5-chloranyl [French] Alcide chlorine oxide chlorine peroxide Chlorine(IV) oxide chloroperoxyl dioxidochlorine(.) dioxido-λ(5)-chloranyl Doxcide 50 O2Cl(.)
Dipotassium Phosphate
dipropylene glycol; Oxybispropanol; Di-sec-alcohol; Bis(2-hydroxy-propyl)ether; cas no: 25265-71-8
DİPROPYLENE GLYCOL DİBENZOATE
Dibenzoate Dipropylene glycol dibenzoate is a widely used plasticizer that has ether linkages linked with two benzoate groups his product is a transparent oily liquid of colorless to yellow.
Dipropylene glycol dibenzoate soluble in aliphatic hydrocarbons and aromatic hydrocarbons, insoluble in water.
Dipropylene Glycol Dibenzoate is useful in applications such as latex caulks, adhesive, and sealants, coatings and vinyl plastisols.

EINECS/ List number: 248-258-5
CAS number: 27138-31-4
Molecular Formula: C20H22O5
Molecular Weight: 342.39

Dipropylene Glycol Dibenzoate is a polar, high-solvating plasticizer.
Dipropylene Glycol Dibenzoate is useful in applications such as latex caulks, adhesive, and sealants, coatings and vinyl plastisols. is compatible with a wide range of polar polymers and rubbers.
Dipropylene glycol dibenzoate Dipropylene glycol dibenzoate is a highly soluble benzoate plasticizer, and its main component is dipropylene glycol dibenzoate.

Dipropylene glycol dibenzoate is a chemical compound that belongs to the family of dibenzoate esters.
Dipropylene Glycol Dibenzoate is useful in applications such as latex caulks, adhesive, and sealants, coatings and vinyl plastisols.
Dipropylene glycol dibenzoate is formed through the esterification reaction between dipropylene glycol and benzoic acid.

Dipropylene glycol dibenzoate is commonly used as a plasticizer in various applications, primarily in the production of polyvinyl chloride (PVC) and other polymers.
Dipropylene glycol dibenzoate is primarily used as a plasticizer, which means it is added to polymers to improve their flexibility, durability, and workability.
Dipropylene glycol dibenzoate helps to reduce brittleness and increases the overall flexibility of the material.

Dipropylene glycol dibenzoate finds significant use in the production of PVC-based products such as vinyl flooring, cables, hoses, and synthetic leather.
By incorporating Dipropylene glycol dibenzoate, the PVC materials become more pliable and easier to process during manufacturing.
Dipropylene glycol dibenzoate is known for its low volatility, which means it has a minimal tendency to evaporate at normal temperatures.

Dipropylene glycol dibenzoate makes it suitable for applications where long-term stability and low migration are required.
Dipropylene glycol dibenzoate offers good stability and resistance to heat, light, and oxidation, ensuring the longevity of the materials it is incorporated into.
Dipropylene glycol dibenzoate helps prevent the degradation of polymers, thereby extending their lifespan.

Dipropylene glycol dibenzoate is considered to be a relatively safe and environmentally friendly plasticizer compared to some other alternatives.
Dipropylene glycol dibenzoate has low toxicity and does not pose significant risks to human health or the environment when used as directed.
Dipropylene glycol dibenzoate is essential to handle dipropylene glycol dibenzoate with proper safety precautions and follow the recommended guidelines provided by the manufacturer or relevant regulatory agencies.

Dipropylene glycol dibenzoate is an ester compound that is formed by the reaction between dipropylene glycol (a type of glycol) and benzoic acid (an aromatic carboxylic acid). Dipropylene glycol dibenzoate is commonly used as a plasticizer in various industries.

Dipropylene glycol dibenzoate is added to polymer materials, such as PVC (polyvinyl chloride), to increase their flexibility, improve their processing characteristics, and enhance their overall performance.
Plasticizers like Dipropylene glycol dibenzoate help to reduce the brittleness of polymers and make them more pliable and easier to handle during manufacturing.

Dipropylene glycol dibenzoate enhances the flexibility and elasticity of polymers, allowing them to be easily shaped, molded, or extruded into desired forms.
Dipropylene glycol dibenzoate provides stability to the polymer materials, preventing them from becoming brittle or susceptible to cracking over time.
Dipropylene glycol dibenzoate improves the durability and lifespan of the end products.

Dipropylene glycol dibenzoate has low volatility, meaning it has a minimal tendency to evaporate at normal temperatures.
This property ensures that the plasticizer remains in the polymer matrix, reducing the risk of migration and maintaining the desired properties of the material.
Dipropylene glycol dibenzoate exhibits good heat resistance, which is crucial for applications that involve exposure to elevated temperatures.

Dipropylene glycol dibenzoate is often selected as a plasticizer due to its relatively low toxicity and environmental impact compared to some other alternatives, however, as with any chemical substance, it is important to handle and dispose of Dipropylene glycol dibenzoate properly, following recommended guidelines and regulations.
Dipropylene glycol dibenzoate serves as a plasticizer that improves the performance and workability of polymers, particularly PVC, in various industries such as construction, automotive, and consumer goods.

Dipropylene glycol dibenzoate is regulated by various authorities depending on the country or region.
Dipropylene glycol dibenzoate is generally considered safe for use in approved applications when handled and used according to recommended guidelines.
Dipropylene glycol dibenzoate is compatible with many polymers, it may not be suitable for all applications.

Dipropylene glycol dibenzoate is always recommended to perform compatibility tests and consult technical data sheets or manufacturers' recommendations before using Dipropylene glycol dibenzoate as a plasticizer.
Dipropylene glycol dibenzoate should be stored in a cool, dry place away from direct sunlight and heat sources.
Proper ventilation is necessary, and containers should be tightly sealed. It is important to follow safety precautions, including wearing appropriate protective equipment when handling Dipropylene glycol dibenzoate.

Boiling point: 232 °C5 mm Hg(lit.)
Density: 1.12 g/mL at 25 °C(lit.)
vapor pressure: 0Pa at 25℃
refractive index: n20/D 1.528(lit.)
Flash point: >230 °F
storage temp.: Sealed in dry,Room Temperature
Water Solubility: 8.69mg/L at 20℃
LogP: 3.9 at 20℃
Melting point : -37℃
Flash point: 199℃ (open cup)
Specific gravity at: 25℃ 1.12g/ml
Solubility: Practically insoluble in water

Dipropylene glycol dibenzoate is regulated by various authorities depending on the country or region.
Dipropylene glycol dibenzoate is generally considered safe for use in approved applications when handled and used according to recommended guidelines.
Dipropylene glycol dibenzoate is compatible with many polymers, it may not be suitable for all applications.

Dipropylene glycol dibenzoate, recommended to perform compatibility tests and consult technical data sheets or manufacturers' recommendations before using Dipropylene glycol dibenzoate as a plasticizer.
Dipropylene glycol dibenzoate should be stored in a cool, dry place away from direct sunlight and heat sources.
Proper ventilation is necessary, and containers should be tightly sealed.
Dipropylene glycol dibenzoate is important to follow safety precautions, including wearing appropriate protective equipment when handling Dipropylene glycol dibenzoate.

Dipropylene glycol dibenzoate is known for its high plasticizing efficiency, meaning that it can effectively reduce the glass transition temperature of polymers even at relatively low concentrations.
This allows for a greater degree of flexibility and softness in the final material.

Dipropylene glycol dibenzoate exhibits low migration tendencies, meaning it has a reduced likelihood of leaching out of the polymer matrix over time.
This property is crucial for applications where maintaining the integrity and stability of the plasticizer within the material is essential.
Dipropylene glycol dibenzoate is compatible with a wide range of additives commonly used in polymer formulations.

Dipropylene glycol dibenzoate can be blended with other plasticizers, stabilizers, flame retardants, pigments, and fillers to achieve desired material properties and performance characteristics.
Dipropylene glycol dibenzoate offers good resistance to ultraviolet (UV) radiation, which helps to prevent degradation and discoloration of the polymer material when exposed to sunlight or other sources of UV light.
This is particularly important for outdoor applications.

Dipropylene glycol dibenzoate has a relatively low viscosity, which makes it easy to handle and incorporate into various polymer systems.
This property allows for efficient mixing and processing during the production of plasticized materials.

Dipropylene glycol dibenzoate exhibits moderate solvent properties, which means it can dissolve or disperse certain substances.
This property can be advantageous in certain applications where Dipropylene glycol dibenzoate is used as a solvent or carrier for other additives or active ingredients.

The slight aromatic odor of Dipropylene glycol dibenzoate can help mask or minimize any unpleasant odors associated with the polymers or other components in a formulation.
This can be particularly beneficial in applications where odor control is desired, such as in certain consumer products.
Dipropylene glycol dibenzoate can contribute to the formation of a uniform and flexible film when applied to surfaces.

Dipropylene glycol dibenzoate is useful in coatings and adhesive applications, where Dipropylene glycol dibenzoate can help improve film integrity, adhesion, and durability.
Dipropylene glycol dibenzoate exhibits good thermal stability, allowing it to maintain its plasticizing properties and performance even at elevated temperatures.
Dipropylene glycol dibenzoateis important for applications that involve processing or exposure to heat, such as during extrusion or molding processes.

Dipropylene glycol dibenzoate has low volatility, meaning it has a low tendency to vaporize or evaporate at normal temperatures.
Dipropylene glycol dibenzoate contributes to the long-term stability of plasticized materials, as it reduces the risk of the plasticizer escaping from the polymer matrix over time.

Dipropylene glycol dibenzoate is classified as a non-phthalate plasticizer, which means it does not contain phthalates, a group of chemicals that have been subject to regulatory scrutiny due to potential health and environmental concerns.
Dipropylene glycol dibenzoate provides an alternative option for formulators seeking phthalate-free plasticizers.
Dipropylene glycol dibenzoate exhibits good resistance to extraction, which means it is less likely to be extracted by liquids or other substances that come into contact with the plasticized material.

Dipropylene glycol dibenzoate helps to maintain the integrity and properties of the plasticized product, even when exposed to solvents or other extractive substances.
Dipropylene glycol dibenzoate is used as a plasticizer in adhesive formulations to improve their flexibility, tack, and bond strength.
Dipropylene glycol dibenzoate can enhance the adhesive properties and enable effective bonding on various substrates.

Dipropylene glycol dibenzoate can affect the mechanical properties of polymer materials.
By adjusting the concentration of Dipropylene glycol dibenzoate, it is possible to modify characteristics such as flexibility, tensile strength, elongation, and impact resistance to meet specific application requirements.

Dipropylene glycol dibenzoate generally has good storage stability, maintaining its properties over time when stored under proper conditions.
Dipropylene glycol dibenzoate is important to store Dipropylene glycol dibenzoate in a cool, dry place and protect it from moisture, extreme temperatures, and exposure to light.

Dipropylene glycol dibenzoate is compatible with various processing aids used in polymer manufacturing, such as lubricants, anti-blocking agents, and anti-static agents.
This compatibility allows for smooth processing and improved performance during production.
Dipropylene glycol dibenzoate as a plasticizer may result in a slight reduction in the transparency of polymer materials, particularly in clear or transparent formulations.

Dipropylene glycol dibenzoate effect is dependent on factors such as the concentration of Dipropylene glycol dibenzoate and the specific polymer system.
Dipropylene glycol dibenzoate is utilized in paint and coating formulations as a coalescing agent and plasticizer.
Dipropylene glycol dibenzoate aids in film formation, promotes uniformity, and enhances the durability and flexibility of the dried film.

Dipropylene glycol dibenzoate has good compatibility with various fillers and pigments commonly used in polymer formulations.
This compatibility allows for uniform dispersion and helps to maintain the physical and mechanical properties of the plasticized material.
Dipropylene glycol dibenzoate has been approved for certain food contact applications, however, it is essential to check specific regulations and compliance requirements in the respective country or region to ensure its safe use in food-related applications.

Dipropylene glycol dibenzoate is not readily biodegradable if environmental concerns are a priority, it is important to consider proper waste management practices and recycling options for plasticized materials containing Dipropylene glycol dibenzoate.
Dipropylene glycol dibenzoate can be used in combination with other plasticizers to achieve synergistic effects and optimize the performance of the polymer system.
By blending Dipropylene glycol dibenzoate with other compatible plasticizers, it is possible to enhance the overall plasticization efficiency and tailor the material properties to specific requirements.

Dipropylene glycol dibenzoate may be subject to regulatory standards and specifications set by industry organizations.
Dipropylene glycol dibenzoate can present challenges in the recycling of plasticized materials.
Dipropylene glycol dibenzoate may impact the recyclability of certain polymers or complicate the separation of materials during the recycling process.

Dipropylene glycol dibenzoate is often used in electrical insulation applications.
Dipropylene glycol dibenzoate helps to improve the flexibility and handling characteristics of wire and cable insulation, while also providing electrical insulation properties.
Dipropylene glycol dibenzoate is considered to have a relatively low environmental impact compared to some other plasticizers.

Dipropylene glycol dibenzoate may be subject to regulations and restrictions in different jurisdictions.
Dipropylene glycol dibenzoate is essential to comply with local regulations, such as REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) in the European Union or the Toxic Substances Control Act (TSCA) in the United States, when using Dipropylene glycol dibenzoate.

Uses
Dipropylene glycol dibenzoate is widely used as a plasticizer in PVC (polyvinyl chloride) products.
Dipropylene glycol dibenzoate improves the flexibility, workability, and durability of PVC materials, including vinyl flooring, vinyl films, wire and cable insulation, synthetic leather, and PVC-based consumer goods.
Dipropylene glycol dibenzoate is employed as a plasticizer and coalescing agent in paint and coating formulations.

Dipropylene glycol dibenzoate helps enhance film formation, improve flexibility, and promote adhesion.
Dipropylene glycol dibenzoate is commonly used in architectural coatings, industrial coatings, and solvent-based paints.
Dipropylene glycol dibenzoate is utilized as a plasticizer in adhesive and sealant formulations.

Dipropylene glycol dibenzoate improves the flexibility and tackiness of the adhesive, enhancing its bonding strength and performance.
Dipropylene glycol dibenzoate finds application in various adhesive types, including pressure-sensitive adhesives, construction adhesives, and sealants.
Dipropylene glycol dibenzoate is used as a plasticizer in printing inks, particularly in flexographic and gravure inks.

Dipropylene glycol dibenzoate enhances ink flow, improves printability, and helps maintain the desired viscosity and tack of the ink.
Dipropylene glycol dibenzoate can be incorporated as a plasticizer in elastomers and rubber formulations to improve their flexibility and processability.
Dipropylene glycol dibenzoate finds use in rubber compounds, gaskets, seals, and other rubber products.

Dipropylene glycol dibenzoate is utilized in various automotive applications, including interior trim, gaskets, seals, and wire and cable insulation.
Dipropylene glycol dibenzoate is plasticizing properties help improve the performance and durability of automotive components.
Dipropylene glycol dibenzoate is sometimes used as a plasticizer in textile coatings and leather finishes.

Dipropylene glycol dibenzoate is employed as a plasticizer in wire and cable insulation to enhance flexibility, improve handling characteristics, and provide electrical insulation properties.
Dipropylene glycol dibenzoate is commonly used in the production of power cables, telecommunications cables, and other electrical wiring applications.
Dipropylene glycol dibenzoate is used as a plasticizer in the production of synthetic leather and upholstery materials.

Dipropylene glycol dibenzoate helps improve the softness, flexibility, and durability of the synthetic leather, making it suitable for various applications in the furniture, automotive, and fashion industries.
Dipropylene glycol dibenzoate is utilized as a plasticizer in the production of vinyl floorings, vinyl tiles, and wallcoverings.
Dipropylene glycol dibenzoate enhances the flexibility and workability of these materials, making them easy to install and resistant to wear and tear.

Dipropylene glycol dibenzoate is sometimes used in the manufacturing of medical and healthcare products.
Dipropylene glycol dibenzoate can be found in applications such as medical tubing, healthcare equipment, and prosthetic devices, where its plasticizing properties contribute to flexibility and performance.
Dipropylene glycol dibenzoate can be incorporated into plastic films and packaging materials to improve their flexibility, elongation, and impact resistance.

Dipropylene glycol dibenzoate helps ensure the integrity of the packaging and protects the contents from damage during handling and transportation.
Dipropylene glycol dibenzoate is used in certain personal care products such as cosmetics, lotions, and creams as a solubilizer and emollient.
Dipropylene glycol dibenzoate helps to enhance product texture, spreadability, and moisturizing properties.

Dipropylene glycol dibenzoate finds application in construction and building materials such as caulks, sealants, and joint compounds.
Dipropylene glycol dibenzoate is utilized in the formulation of personal care and cosmetic products such as creams, lotions, moisturizers, and sunscreens.
Dipropylene glycol dibenzoate helps improve the texture, spreadability, and emollient properties of these products.

Dipropylene glycol dibenzoate is used as a solvent and carrier for fragrances and essential oils in the fragrance and perfume industry.
Dipropylene glycol dibenzoate helps to stabilize and enhance the scent profile of the fragrance compositions.
Dipropylene glycol dibenzoate can be employed as a plasticizer in printing inks, including offset inks and specialty inks used in the printing and graphic arts industry. I

Dipropylene glycol dibenzoate is used as a modifier or additive in resin systems to enhance their performance and properties.
It can improve the flexibility, adhesion, and impact resistance of various resins, including epoxy resins and polyester resins.
Dipropylene glycol dibenzoate can be used as a solvent or co-solvent in various applications, including paint thinners, cleaning agents, and specialty solvent formulations.

Dipropylene glycol dibenzoate is sometimes used as a solvent and carrier for agricultural chemicals such as herbicides, insecticides, and fungicides.
Dipropylene glycol dibenzoate aids in the dispersion and application of these chemicals on crops and plants.
Dipropylene glycol dibenzoate can be found in industrial cleaning products, such as degreasers and specialty cleaners, where it acts as a solvent and aids in the removal of dirt, oils, and other contaminants.

Dipropylene glycol dibenzoate can be utilized as a plasticizer and solvent in textile printing inks.
Dipropylene glycol dibenzoate helps improve ink flow, adhesion, and color retention on textile substrates, contributing to vibrant and durable prints.
Dipropylene glycol dibenzoate is used as a plasticizer and softening agent in the finishing process of leather.

Dipropylene glycol dibenzoate is employed as a solvent and carrier in the formulation of pesticides and agricultural chemicals.
Dipropylene glycol dibenzoate helps dissolve active ingredients and improves the stability and effectiveness of the formulations.
Dipropylene glycol dibenzoate can be used as a plasticizer and processing aid in rubber manufacturing processes.

Dipropylene glycol dibenzoate is sometimes used in water treatment applications as a solvent and carrier for certain chemicals.
It aids in the dispersion and delivery of water treatment agents for purposes such as disinfection, pH adjustment, and corrosion control.
Dipropylene glycol dibenzoate can be used as a concrete additive to enhance workability and reduce water demand.

Dipropylene glycol dibenzoate is employed as a plasticizer and film-forming agent in metal coatings.
Dipropylene glycol dibenzoate helps improve the adhesion, flexibility, and corrosion resistance of the coatings applied to metal substrates.
Dipropylene glycol dibenzoate is used as a plasticizer and rheology modifier in the formulation of sealants and caulks.

Dipropylene glycol dibenzoate can be utilized as a plasticizer in polymer foam formulations, including polyurethane foam and expanded polystyrene (EPS).
Dipropylene glycol dibenzoate can be used as an additive in fuel and oil formulations to improve lubricity, reduce friction, and enhance performance.
Dipropylene glycol dibenzoate can be added to fuels, lubricating oils, and hydraulic fluids.

Dipropylene glycol dibenzoate can be used as a processing aid in polymer manufacturing processes, including extrusion and injection molding.
Dipropylene glycol dibenzoate helps improve the flow properties and processability of polymers during production.
Dipropylene glycol dibenzoate is employed in the formulation of metalworking fluids, such as cutting oils and lubricants, where it helps improve lubricity, cooling properties, and corrosion resistance.

Dipropylene glycol dibenzoate can be used as a fuel additive to improve the lubricity and flow properties of certain fuels, particularly in applications where low sulfur fuels are used.
Dipropylene glycol dibenzoate can be used as a plasticizer in industrial lubricants to improve their viscosity, reduce friction, and enhance their lubricating properties.
Dipropylene glycol dibenzoate may have applications in other industries, including textiles, printing and packaging, synthetic fibers, foam production, and specialty chemical formulations.

Dipropylene glycol dibenzoate can be employed in other industrial applications where plasticizers are required, such as in the production of films, sheets, profiles, molded parts, and synthetic fibers.
Dipropylene glycol dibenzoate finds application in numerous industries.
Dipropylene glycol dibenzoate is commonly used as a plasticizer in PVC-based products, such as vinyl flooring, wire and cable insulation, flexible hoses, and synthetic leather.

Dipropylene glycol dibenzoate is also utilized in coatings, adhesives, sealants, and elastomers to enhance their flexibility and workability.
Dipropylene glycol dibenzoate is mainly used as plasticizer, for example, used in resilient floors, plastisol, adhesives, binder, coatings and coated materials,screen printing ink, sealants, filler and caulking materials, dyes, nail polish, skin protect product, photoresist, liquid crystal film, polymer of disposable hygiene products and food packaging, etc., and it can be plasticized such as PVC, polyethylene/polypropylene, polyvinyl aceate£¬polystyrene, polyvinyl alcohol, polyvinyl butyral, polymethacrylate, polyisocyanate, polyurethane, phenolic resins, epoxy resins, polyether, ethylcellulose, cellulose butyrate, nitrocellulose, chloroethylene or ethylene-vinyl acetate copolymer, styrene-acrylate copolymer, ethylene-maleic anhydride copolymer, and so on.

Dipropylene glycol dibenzoate is also as processing aid of natural or synthetic rubber, solubilizer and dispersant of pigments or toner, and as extractive distillation agent for the organics that their boiling points is proximity.
Dipropylene glycol dibenzoate use as a solvent for many cosmetic actives, such as sunscreens and fragrances.
Dipropylene glycol dibenzoate use antiperspirants and deodorants where its humectant properties help to retain the natural moisture of hair as well as imparting considerable shine and body.

Dipropylene glycol dibenzoate may be used as a diluent for the preparation of polysulfone membranes by heat induced phase separation.
Dipropylene glycol dibenzoate finds potential applications in water treatment and food processing.
Dipropylene glycol dibenzoate may also be used as a plasticizer with poly(vinyl) chloride (PVC) for the fabrication of diamond coated PVC.

Dipropylene glycol dibenzoate use as a highly soluble benzoate plasticizer, because of its low toxicity and environmental protection, low solization temperature, high plasticizing efficiency, large filling volume, cold resistance, good pollution resistance and other characteristics.
Dipropylene glycol dibenzoate is recognized and recommended by the European Union to replace conventional o-benzene plasticizers and used as environmentally friendly plasticizers.
Dipropylene glycol dibenzoate is widely used in polyvinyl chloride synthetic plastics, water-based adhesives, polysulfide sealants, polyurethane sealants, and artificial leather And synthetic rubber and other fields, and reflect its superiority and plasticizing effect.

Dipropylene glycol dibenzoate uses can be used as a plasticizer for resins such as polyvinyl chloride, polyvinyl acetate and polyurethane.
Dipropylene glycol dibenzoate has strong solvent effect, good compatibility, low volatility, durability, oil resistance and pollution resistance.
Dipropylene glycol dibenzoate is often used for highly filled PVC flooring and extruded plastics, which can improve processability, reduce processing temperature and shorten processing cycle.

Dipropylene glycol dibenzoate may be used as a diluent for the preparation of polysulfone membranes by heat induced phase separation.
Dipropylene glycol dibenzoate finds potential applications in water treatment and food processing.
Dipropylene glycol dibenzoate may also be used as a plasticizer with poly(vinyl) chloride (PVC) for the fabrication of diamond coated PVC.

Dipropylene glycol dibenzoate used as a solvator for PVC, plasticizer in elastomers, in vinyl flooring, adhesives, latex caulks and sealants, color concentrates for PVC, and castable polyurethanes; Used to formulate adhesives, sealants, lubricants, plasticizers, coatings, and inks, to make fine and large scale chemicals, and as a plasticizer for PVC and carrier for agrochemicals; Permitted for use as an inert ingredient in non-food pesticide products;
Dipropylene glycol dibenzoate is most commonly used in the packaging industry for carton sealing, book binding and labelling purposes and in the textile industry for woven as well as non-woven fabrics.

Dipropylene glycol dibenzoate is used in the following products: coating products, adhesives and sealants and polymers.
Dipropylene glycol dibenzoate can occur from industrial use: formulation of mixtures and in the production of articles.
Dipropylene glycol dibenzoate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Dipropylene glycol dibenzoate can occur from industrial use: of articles where the substances are not intended to be released and where the conditions of use do not promote release and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).
Dipropylene glycol dibenzoate is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

Dipropylene glycol dibenzoate can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines), Vehicles (e.g. personal vehicles, delivery vans, boats, trains, metro or planes)) and machinery, mechanical appliances and electrical/electronic products e.g. refrigerators, washing machines, vacuum cleaners, computers, telephones, drills, saws, smoke detectors, thermostats, radiators, large-scale stationary industrial tools).
Dipropylene glycol dibenzoate can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material) and plastic (e.g. food packaging and storage, toys, mobile phones).This substance is used in the following products: adhesives and sealants, coating products and polymers.

Dipropylene glycol dibenzoate is used in the following areas: building & construction work and formulation of mixtures and/or re-packaging.
Dipropylene glycol dibenzoate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.This substance is used in the following products: adhesives and sealants, non-metal-surface treatment products, coating products, textile treatment products and dyes, polymers, pH regulators and water treatment products and leather treatment products.

Dipropylene glycol dibenzoate can occur from industrial use: formulation of mixtures, in the production of articles, formulation in materials, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and as processing aid.
Dipropylene glycol dibenzoate is used in the following products: coating products, non-metal-surface treatment products, textile treatment products and dyes, semiconductors, adhesives and sealants, laboratory chemicals, pH regulators and water treatment products and leather treatment products.

Dipropylene glycol dibenzoate has an industrial use resulting in manufacture of another substance (use of intermediates).
Dipropylene glycol dibenzoate is used in the following areas: formulation of mixtures and/or re-packaging.
Dipropylene glycol dibenzoate is used for the manufacture of: chemicals, machinery and vehicles, textile, leather or fur, electrical, electronic and optical equipment, mineral products (e.g. plasters, cement), plastic products and rubber products.

Dipropylene glycol dibenzoate may cause irritation to the eyes and skin upon direct contact.
Dipropylene glycol dibenzoate is important to avoid contact with the eyes and skin and use appropriate protective measures, such as gloves and safety goggles, when handling Dipropylene glycol dibenzoate.
Dipropylene glycol dibenzoate vapor or mist may cause irritation to the respiratory system.

Dipropylene glycol dibenzoate is considered to have low toxicity to aquatic organisms, however, like any chemical substance, it should be handled responsibly to prevent contamination of waterways or soil.
Spills or releases of Dipropylene glycol dibenzoate should be properly contained and reported according to applicable regulations.
Dipropylene glycol dibenzoate is combustible and may present a fire hazard if exposed to an ignition source.

Hazardous Decomposition Products:
During combustion or thermal decomposition, Dipropylene glycol dibenzoate may release hazardous decomposition products, including carbon monoxide, carbon dioxide, and various organic compounds.
Adequate ventilation and proper fire safety measures should be in place to minimize the risk of exposure to these decomposition products.

Health and Safety:
As with any chemical, Dipropylene glycol dibenzoate is important to follow appropriate safety measures when handling Dipropylene glycol dibenzoate.
This includes wearing protective equipment, such as gloves and goggles, and ensuring proper ventilation in the working area.

Packaging:
Dipropylene glycol dibenzoate is typically available in bulk containers, such as drums or intermediate bulk containers (IBCs).
Dipropylene glycol dibenzoate is important to store and transport the chemical in suitable containers that are compatible with the material.

Synonyms
27138-31-4
94-03-1
Oxydipropyl dibenzoate
1,1'-Oxybis-2-propanol dibenzoate
1,1'-Dimethyl-2,2'-oxydiethyl dibenzoate
9QQI0RSO3H
2-Propanol, 1,1'-oxybis-, dibenzoate
Oxybis(propane-1,2-diyl) dibenzoate
DTXCID507921
DTXSID6027921
CAS-27138-31-4
EINECS 202-296-9
UNII-9QQI0RSO3H
1,1'-OXYBIS(2-PROPANOL) DIBENZOATE
1-(2-benzoyloxypropoxy)propan-2-yl benzoate
SCHEMBL1255193
CHEMBL1877406
DTXSID401043495
1,1'-Oxybis(2-propanol)dibenzoate
Tox21_202280
Tox21_300147
NCGC00164208-01
NCGC00247908-01
NCGC00254168-01
NCGC00259829-01
1,1'-oxybis(propane-2,1-diyl) dibenzoate
2-Propanol,1,1'-oxybis-,dibenzoate(9ci)
FT-0698140
2-Propanol,1,1'-oxybis-, dibenzoate (9CI)
2-PROPANOL, 1,1'-OXYDI-, DIBENZOATE
Q27272899
DI(1,2-PROPYLENE GLYCOL) DIBENZOATE, TAIL TO TAIL-
Dipropylene Glycol Dibenzoate
1-(2-butoxy-1-methylethoxy)-2-propanol; 2-propanol, 1-(2-butoxy-1-methylethoxy)-; butyldipropasol solvent; DPnB; n-butoxy-methylethoxy-propanol; nbutoxy-propoxy-propanol; Solvenol DPnB) CAS NO:29911-28-2
Dipropylene Glycol n-Butyl Ether
Disodium cocoamphodiacetate; DSCADA; Disodium N-2-(N-(2-carboxymethoxyethyl)-N-carboxymethylamino)ethylcocamide cas no: 68650-39-5
DİSFLAMOLL TOF
Disflamoll TOF is a clear colorless to pale yellow liquid with a slight sharp odor.
Disflamoll TOF is a family of halogen free plasticizers with good flame retarding characteristics in many polymers.
Disflamoll TOF insoluble in water; Soluble in alcohol, acetone, and ether.

CAS Number: 78-42-2
Molecular Formula: C24H51O4P
Molecular Weight: 434.63
EINECS No: 201-116-6

Disflamoll TOF, a clear, viscous liquid, is used as a component of vinyl stabilizers, grease additives, and flame-proofing compositions; however, it is used primarily as a plasticizer for vinyl plastic and synthetic rubber compounds.
Disflamoll TOF has been employed as a specialty flameretardant plasticizer for vinyl compositions where low temperature flexibility is critical, eg, in military tarpaulins.

Disflamoll TOF can be included in blends with general purpose.
Disflamoll TOF has been employed as a specialty flameretardant plasticizer for vinyl compositions where low temperature flexibility is critical, eg, in military tarpaulins.
Disflamoll TOF can be included in blends with general purpose plasticizers such as phthalate esters to improve low temperature flexibility.

Disflamoll TOF finds application as a fire-retardant, plasticizer for polyvinyl chloride and cellulose nitrate.
Disflamoll TOF is used as a stimulant for the chemical warfare nerve agent VX. further, it used as an alkylation agent for nitrogen heterocyclic compounds and as a catalyst to produce phenolic and urea resins.

Disflamoll TOF is used as an antifoaming agent and a co-solvent in hydrogen peroxide production.
Disflamoll TOF has been employed as a specialty flameretardant plasticizer for vinyl compositions where low temperature flexibility is critical, eg, in military tarpaulins.
Disflamoll TOF can be included in blends with general purpose plasticizers such as phthalate esters to improve low temperature flexibility

Disflamoll TOF clear colorless to pale yellow liquid with a slight sharp odor.
Disflamoll TOF is widely used as a flame retardant, plasticizer, and extractant in the production of chemical enterprises.

Disflamoll TOFs most important use is the production of hydrogen peroxide.
As the solvent of hydrogen anthraquinone, Disflamoll TOF has the conditions of high solubility of hydrogen anthrone, high distribution coefficient of hydrogen peroxide between water and solvent, high boiling point and high ignition point.

Disflamoll TOF by Lanxess is Disflamoll TOF-based plasticizer for adhesives and sealants.
Disflamoll TOF offers very good resistance to low temperature and weathering.
Disflamoll TOF is a strong, moderately polar solvent.

Disflamoll TOF, commonly abbreviated as TEHP or TEOHP, is a chemical compound belonging to the class of compounds known as organophosphates.
It's an ester that is often used as a plasticizer and flame retardant in various industrial and consumer products.

Melting point: -70°C
Boiling point: 215 °C4 mm Hg(lit.)
Density: 0.92 g/mL at 20 °C(lit.)
vapor pressure: 2.1 mm Hg ( 20 °C)
refractive index: n20/D 1.444(lit.)
Flash point: >230 °F
storage temp.: Store below +30°C.
solubility: <0.001g/l
form: Liquid
Specific Gravity: 0.93
color: Colourless
PH: 7 (H2O, 20℃)
Water Solubility: BRN: 1715839
Indirect Additives used in Food Contact Substances TRI(2-ETHYLHEXYL) PHOSPHATE
FDA 21 CFR: 175.105
CAS DataBase Reference: 78-42-2(CAS DataBase Reference)
EWG's Food Scores: 1

Disflamoll TOF is a commercial chemical product that belongs to a class of chemicals known as flame retardants.
Disflamoll TOF flame retardants are additives that are used in various materials to reduce their flammability and slow down the spread of fire.
Disflamoll TOF is specifically used as a flame retardant in polymers, plastics, and other materials.

"Disflamoll" is a brand name used by LANXESS, a specialty chemicals company, and "TOF" likely refers to the specific formulation or variant of the flame retardant.
Different variants of flame retardants are developed to be suitable for use in various types of materials and applications.

Flame retardants like Disflamoll TOF work by interfering with the combustion process.
Disflamoll TOF can inhibit the formation of flammable gases, reduce heat release, and form a protective char layer on the material's surface.
This helps to slow down the ignition and spread of fire, providing additional time for people to evacuate a building and for firefighters to control the blaze.

It's important to note that the use of flame retardants, including Disflamoll TOF, has raised environmental and health concerns over the years.
Some flame retardants have been found to have adverse effects on human health and the environment.
Therefore, the selection and use of flame retardants in products are subject to regulations and guidelines to ensure their safety.

Disflamoll TOF is a specific flame retardant formulation that is designed for use in a variety of materials, primarily to enhance their fire resistance properties.
The exact chemical composition of Disflamoll TOF may vary based on the specific formulation used by LANXESS.
Flame retardant formulations often consist of several different chemical compounds that work together to achieve the desired fire-retardant effect.

Disflamoll TOF is typically used in the production of various polymers and plastics to improve their resistance to ignition and slow down the spread of flames.
Disflamoll TOF and other flame retardants work through various mechanisms to suppress or delay the combustion process.
This can involve the release of inert gases, the formation of a protective char layer, and the reduction of flammable gases that contribute to the propagation of flames.

Disflamoll TOF, have been subject to scrutiny due to potential environmental and health concerns.
Some flame retardants have been found to persist in the environment and accumulate in living organisms.
Some of these compounds are also associated with health risks, such as endocrine disruption and developmental effects.

Uses
Disflamoll TOF is used as a phosphorous flame retardant.
Disflamoll TOF used as a plasticizer in the preparation of a new potentiometric membrane sensor.
Disflamoll TOF finds application as a fire-retardant, plasticizer for polyvinyl chloride and cellulose nitrate.

Disflamoll TOF is used as a stimulant for the chemical warfare nerve agent VX.
Disflamoll TOF used as an alkylation agent for nitrogen heterocyclic compounds and as a catalyst to produce phenolic and urea.

In addition to this, Disflamoll TOF is used as an antifoaming agent and a co-solvent in hydrogen peroxide production.
Disflamoll TOF (TOF) is a plasticizer compatible with many types of polymers such as PVC, PUR, NBR, and SBR.
Disflamoll TOF shows very good resistance to low temperatures and has excellent weathering properties.

In the manufacturing of herbicides, pesticides, and flame retardants Disflamoll TOF is used.
Disflamoll TOF can also be used as a carrier for pigments.
Disflamoll TOF used to finds application as a fire-retardant, plasticizer for polyvinyl chloride and cellulose nitrate.

Disflamoll TOF is primarily used as a plasticizer, a type of additive that is mixed with polymers (such as plastics and rubbers) to increase their flexibility, durability, and processability.
Disflamoll TOF reduce the stiffness of materials and make them more suitable for molding, extrusion, and other manufacturing processes.
Disflamoll TOF is often used in applications where resistance to high temperatures and chemical stability are important.

Disflamoll TOF is also used as a flame retardant in various materials.
Flame retardants are added to products to reduce their flammability and slow down the spread of fire.
Disflamoll TOF can release non-flammable gases when exposed to heat, diluting the flammable gases released during combustion and reducing the overall fire hazard.

Disflamoll TOF can be found in industrial products such as paints, coatings, adhesives, and sealants.
It can provide fire resistance and improve the durability of these products.
Disflamoll TOF is used as a plasticizer in the insulation of wires and cables to enhance their flexibility and resistance to cracking, especially at low temperatures.

In the automotive industry, Disflamoll TOF may be used in the production of materials such as upholstery, dashboards, and interior components to provide flexibility and resistance to heat and chemicals.
Disflamoll TOF may also be present in consumer products like vinyl flooring, synthetic leather, toys, and some personal care items.

Disflamoll TOF is used as a phosphorous flame retardant.
Disflamoll TOF used as a plasticizer in the preparation of a new potentiometric membrane sensor.
Disflamoll TOF can replace hydrogenated terpene pine alcohol in hydrogen peroxide produced by anthraquinone method, so that the product has high concentration, good quality and low self-consumption, and can also be used as a cold-resistant plasticizer.

Disflamoll TOF (TEHP) is a non-flammable,colourless liquid with low water solubility and very low vapour pressure, which is used as a flame retardant and plasticizer for PVC and cellulose acetate and as a solvent.
Disflamoll TOF is produced from phosphorus oxychloride and 2-ethylhexanol.
Disflamoll TOF is a plasticizer for PVC, imparting good low-temperature flexibility, resistance to water extraction, flame and fungus resistance, and minimum change in flexibility over a wide temperature range.

Disflamoll TOF is primarily used as an additive in vinyls and synthetic rubbers to impart or enhance light stability, weather resistance and flame retardant properties.
Disflamoll TOF is also used as a solvent in the production of hydrogen peroxide, as a carrier in the manufacture of pigments for plastics and as an additive for mineral oils.

Disflamoll TOF is a kind of practical good fire-retardant, and one of cold resistant plasticizer is used for Vinylite, celluosic resin, resol, urethane, synthetic rubber, solvent, defoamer etc.
Disflamoll TOFs low-temperature performance is better than the adipic acid ester class, and has mildew-resistant and fire retardation, though thermostability and plasticizing capacity are slightly poor, can with phosphoric acid triphen first and usefulness.

With Disflamoll TOF and with obtaining the self-extinguishing goods, also can be used for polyvinyl chloride cable material, coating etc.
Disflamoll TOF is now chiefly used as a processing solvent,instead of hydroterpineol,for producing hydrogen peroxide by anthraquinone process.
It is an ideal solvent in this process,for its low volatility and good extraction distribution coefficient.

Disflamoll TOF is also a cold-resisting and fire-retarding plasticizer applied in ethylenic and cellulosic resins,synthetic rubbers.
The cold resisting property is superior to adipate esters.
Disflamoll TOF can be incorporated into coatings, adhesives, and sealants to improve their flexibility, durability, and resistance to heat.

These enhanced properties make Disflamoll TOF-containing coatings and adhesives suitable for various applications, including industrial and commercial settings.
Disflamoll TOFis utilized in the formulation of industrial products where its plasticizing and flame-retardant properties are advantageous.
This can include paints, varnishes, industrial coatings, and adhesives.

Disflamoll TOF can be added to textiles and upholstery materials to enhance their performance and fire resistance.
This is especially relevant in applications where safety standards require textiles to have reduced flammability.

Disflamoll TOF is used in the electronics industry to provide fire resistance to components and materials that may be exposed to heat or flames.
Disflamoll TOF might be present in various consumer products that require flexibility and fire resistance, such as vinyl or synthetic leather items, inflatable products, and certain toys.

Environmental and Health Concerns:
As with many chemicals, Disflamoll TOF has raised environmental and health concerns.
Some Disflamoll TOF, including certain plasticizers and flame retardants, have been associated with adverse effects on human health and the environment.
These concerns have prompted regulatory scrutiny and research into the potential risks of Disflamoll TOF exposure.

Regulation and Safety:
Regulatory agencies in different countries have established guidelines and regulations to control the use of chemicals like Disflamoll TOF in consumer products.
These regulations aim to ensure that products are safe for both human health and the environment.
Industries that use Disflamoll TOF are responsible for adhering to these regulations and ensuring the safe use of the compound in their products.

Synonyms
Disflamoll TOF
78-42-2
Disflamoll TOF
Disflamoll TOF
Kronitex TOF
Phosphoric acid, tris(2-ethylhexyl) ester
Flexol TOF
Flexol plasticizer TOF
Tri(2-ethylhexyl) phosphate
2-Ethyl-1-hexanol phosphate
Tris(ethylhexyl) phosphate
Tri(2-ethylhexyl)phosphate
1-Hexanol, 2-ethyl-, phosphate
NCI-C54751
TEHP
Triethylhexyl phosphate
Phosphoric acid, tris(ethylhexyl) ester
Tri(ethylhexyl) phosphate
2-Ethylhexanol, phosphate triester
Tris-(2-ethylhexyl)fosfat
Tris(2-ethylhexy)phosphate
CCRIS 615
NSC 407921
HSDB 2562
Tris-(2-ethylhexyl)fosfat [Czech]
EINECS 201-116-6
UNII-BQC0BKB72S
Tris-2(2-ethylhexyl)fosfat [Czech]
BQC0BKB72S
TOF
BRN 1715839
Tris-2(2-ethylhexyl)fosfat
AI3-07852
DTXSID0021414
NSC-407921
Phosphoric Acid Tris(2-ethylhexyl) Ester
Phosphoric acid, tris(2-ethylhexyl)ester
EC 201-116-6
DTXCID801414
CAS-78-42-2
Amgard TOF
MFCD00009491
'Trioctyl' phosphate
1-Hexanol, phosphate
Disflamoll TOF (TOP)
tris(2-ethylhexyl)phosphat
Tris(2-ethylhexl)phosphate
SCHEMBL35485
MLS002415769
Phosphoric Acid Trioctyl Ester
CHEMBL1562290
2-Ethylhexanol phosphate (3:1)
CHEBI:181994
GTVWRXDRKAHEAD-UHFFFAOYSA-N
HMS3039O17
Phosphoric acid tris(2-ethylhexyl)
Tox21_201369
Tox21_300321
NSC407921
Disflamoll TOF, 97%
AKOS015843194
CS-W009670
LS-1747
NCGC00091821-01
NCGC00091821-02
NCGC00091821-03
NCGC00254160-01
NCGC00258921-01
SMR001370923
P1022
Disflamoll TOF [HSDB]
WLN: 4Y2&1OPO&O1Y4&2&O1Y4&2
A865029
Q2454094
Tri(2-ethylhexyl) phosphate; (Disflamoll TOF)
Disflamoll TOF, Selectophore(TM), >=99.0%
InChI=1/C24H51O4P/c1-7-13-16-22(10-4)19-26-29(25,27-20-23(11-5)17-14-8-2)28-21-24(12-6)18-15-9-3/h22-24H,7-21H2,1-6H
Disodium Inosinate
Disodium Inosinate; GMP; 5'-Guanylate monophosphate; 5'-rGMP; Guanosine monophosphate; rGMP; Guanosine 5'-phosphate; Guanylic acid; Guanosine 5'-monophosphate; Guanosine monophosphate; Disodium inosinate; 5'-Inosinic acid, disodium salt; Inosine 5'-monophosphate, disodium salt hydrate; 5'-Inosinic acid hydrate; Inosine-5'-monophosphoric acid disodium salt; Disodium 5'-Inosinate; Inosine 5-monophosphate, disodium salt hydrate; IMP cas no: 4691-65-0
disodium laureth 3-sulfosuccinate
N° CAS : 39354-45-5 / 40754-59-4 / 42016-08-0 / 58450-52-5 / 68815-56-5 - DLS, Le Disodium Laureth Sulfosuccinate ou DLS est un tensioactif anionique faisant partie des plus doux de la gamme. Contrairement à ce que l'on pourrait penser, il ne fait pas partie des sulfates , il nettoie les cheveux et le corps plus en douceur que le SLES., Ses fonctions (INCI) Agent nettoyant : Aide à garder une surface propre Agent moussant : Capture des petites bulles d'air ou d'autres gaz dans un petit volume de liquide en modifiant la tension superficielle du liquide Sinergiste de mousse : Améliore la qualité de la mousse produite en augmentant une ou plusieurs des propriétés suivantes: volume, texture et / ou stabilité Hydrotrope : Augmente la solubilité d'une substance qui est peu soluble dans l'eau. Tensioactif : Réduit la tension superficielle des cosmétiques et contribue à la répartition uniforme du produit lors de son utilisation. Disodium Laureth Sulfosuccinate; Poly(oxy-1,2-ethanediyl), α-(3-carboxy-1-oxo-3-sulfopropyl)-ω-(dodecyloxy)-, sodium salt (1:2); disodium laureth (n=>3) sulfosuccinate; Disodium mono alkyl ether sulphosuccinate; disodium;4-(2-dodecoxyethoxy)-4-oxo-2-sulfonatobutanoate; Poly(oxy-1,2-ethanediyl), a-(3-carboxy-1-oxo-3-sulfopropyl)-w-(dodecyloxy)-, disodium salt; Poly(oxy-1,2-ethanediyl), alpha-(3-carboxy-1-oxo-3-sulfopropyl)-omega-(dodecyloxy)-, disodium salt; Sulfosuccinic acid 4-ester with PEG dodecyl ether, disodium salt, s; Aerosol A102; Di-Natrium-Laureth Sulfosuccinat; Dinatriumlaurylalkoholpolyglykolethersulfosuccinat; Disodium laureth sulfosuccinate (INCI); Disodium laureth-12 sulfosuccinate; Disodium laureth-12 sulfosuccinate (INCI); Disodium laureth-6 sulfosuccinate; Disodium laureth-6 sulfosuccinate (INCI); Disodium laureth-9 sulfosuccinate; Disodium laureth-9 sulfosuccinate (INCI); Disodium Laurethsulfosuccinate (INCI); Emcol 1484; Fettalkoholethersulfosuccinat Di-Na-Salz; Laurylethersulfosuccinat; Poly(oxy-1,2-ethandiyl), α-(3-carboxy-1-oxo-3-sulfopropyl)- ω-(dodecyloxy)-, di-Natriumsalz; Poly(oxy-1,2-ethanediyl), α-(3-carboxy-1-oxo-3-sulfopropyl)-ω-(dodecyloxy)-, disodium salt; Rewopol; Sulfobernsteinsäure(C10-12-alkyl-EO)halbester-di-Natrium-Salz; Sulfosuccinat-Na2, Lauryl-EO; 3-EO; Sulfosuccinic (C12 + 3EO)monoE, 2Na; 3-EO; Sulfosuccinic (C12 + nEO)monoE, 2Na; n-EO; Sulfosuccinic acid, ester with ethoxylated lauryl alcohol, disodium salt; Tego Sulfosuccinat F 30; 3-EO; 30-32% Active Matter; active substance; TEGO SULFOSUCCINATE F 30; 3-EO; 30% Active Matter; active substance; disodium 4-(2-dodecoxyethoxy)-4-oxo-2-sulfonato-butanoate; Poly(oxy-1,2-ethanediyl), .alpha.-(3-carboxy-1-oxo-3-sulfopropyl)- .omega.-(dodecyloxy)-, disodium salt (1EO); Poly(oxy-1,2-ethanediyl), .alpha.-(3-carboxy-1-oxo-3-sulfopropyl)- .omega.-(dodecyloxy)-, disodium salt (3EO)
disodium laureth sulfosuccinate
Disodium hydrogen orthophosphate; Sodium hydrogen phosphate; Sodium phosphate dibasic; disodium phosphate; Sodium Phosphate Dibasic Dodecahydrate; Disodium Phosphate Anhydrous; Disodium Phosphate dihydrate; Disodium Phosphate Heptahydrate; Disodium Phosphate Dodecahydrate CAS NO:7558-79-4 CAS NO:10028-24-7 (dihydrate) CAS NO:7782-85-6 (heptahydrate) CAS NO:10039-32-4 (dodecahydrate)
Disodium Phosphate Anhydorus
Sodium Phosphate Dibasic; Dsodium phosphoric acid; Disodium hydrogenphosphate; Disodium Hydrogenphosphate; Sodium monohydrogen phosphate; Disodium Hydrogen Orthophosphate; Disodium Phosphate; Phosphoric acid, disodium salt; sodium monohydrogen phosphate (2:1:1); dibasic sodium phosphate; disodium monohydrogen phosphate; disodium orthophosphate; DSP; soda phosphate; sodium hydrogen phosphate; Disodium Monophosphate; Disodium Monohydrogen Orthophoshate; CAS NO:7558-79-4
Distilled Coco Oil Acid
Kelco Crete200; S 657; V-MAR 3; S 657;D-Glucuronic acid polymer with 6-deoxy-L-mannose and D-glucose, acetate, calcium magnesium potassium sodium salt;S-657 Gum CAS NO:125005-87-0
Di-Trimethylolpropane
Methoxy Propoxy Propanol; DPG; Dipropylene Glycol Methyl Ether; Methoxypropoxypropanol; Mixture of Methyldipropylene glycol; Oxybispropanol, Methyl Ether; Bis-(2-Methoxypropyl) ether; cas no : 34590-94-8
DL MALIC ACID
DL Malic Acid is combination of biologically active L-malic acid and its optical isomer, D-malic acid.
DL Malic Acid is dicarboxylic acid found in fruits and vegetables, especially apples.
DL Malic Acid is an intermediate product of the Citric Acid Cycle, in its esterified form, malate.


CAS Number: 6915-15-7
EC Number: 230-022-8
MDL number: MFCD00064212
Molecular Formula: C4H6O5


DL Malic Acid is odourless and has a molecular weight of 134.09 g/mol.
Under high temperature, exceeding 140 °C, and under anaerobic conditions, acidum malicum converts into fumaric and maleic acids.
DL Malic Acid is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 tonnes per annum.


L-malic acid is naturally present in the bodys cells, and is involved in gluconeogenesis, the metabolic pathway that creates glucose for the brain.
DL Malic Acid is an organic compound with little to no odor, a dicarboxylic acid that is the active ingredient in many sour and tart foods.
DL Malic Acid is generated during fruit metabolism and occurs naturally in all fruits and many vegetables.


The pleasant, refreshing experience of biting into a juicy apple or cherry is partly caused by DL Malic Acid.
DL Malic Acid's mellow, smooth, persistent sourness can be blended with multiple food acids, sugars, high intensity sweeteners, flavors and seasonings to create distinctive taste experiences in foods, beverages and confections.


DL Malic Acid is formed in metabolic cycles in the cells of plants and animals, including humans.
DL Malic Acid provides cells with energy and carbon skeletons for the formation of amino acids.
The human body produces and breaks down relatively large amounts of DL Malic Acid every day.


DL Malic Acid contributes to the sourness of green apples.
DL Malic Acid is present in grapes and gives a tart taste to wine.
When added to food products, DL Malic Acid is the source of extreme tartness.


DL Malic Acid is combination of biologically active L-malic acid and its optical isomer, D-malic acid.
DL Malic Acid is dicarboxylic acid found in fruits and vegetables, especially apples.
DL Malic Acid is an intermediate product of the Citric Acid Cycle, in its esterified form, malate.


DL Malic Acid is an organic compound with the molecular formula C4H6O5.
DL Malic Acid is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive.
DL Malic Acid has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally.


The synthetic material produced commercially in Europe and the USA is a racemic mixture, whereas the naturally occurring material found in apples and many other fruits and plants is levorotatory.
The salts and esters of DL Malic Acidare known as malates.


The malate anion is an intermediate in the citric acid cycle.
DL Malic Acid plays an important role in biochemistry. In the C4 carbon fixation process, malate is a source of CO2 in the Calvin cycle.
In the citric acid cycle, (S)-malate is an intermediate, formed by the addition of an -OH group on the si face of fumarate.


DL Malic Acid can also be formed from pyruvate via anaplerotic reactions.
DL Malic Acid is also synthesized by the carboxylation of phosphoenolpyruvate in the guard cells of plant leaves.
DL Malic Acid, as a double anion, often accompanies potassium cations during the uptake of solutes into the guard cells in order to maintain electrical balance in the cell.


The accumulation of these solutes within the guard cell decreases the solute potential, allowing water to enter the cell and promote aperture of the stomata.
The process of malolactic fermentation converts DL Malic Acid to much milder lactic acid.


DL Malic Acid occurs naturally in all fruits and many vegetables, and is generated in fruit metabolism.
DL Malic Acid, when added to food products, is denoted by E number E296.
DL Malic Acid contains 10 kJ (2.39 kilocalories) of energy per gram.


DL Malic Acid is a 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
DL Malic Acid has a role as a food acidity regulator and a fundamental metabolite.
DL Malic Acid is a 2-hydroxydicarboxylic acid and a C4-dicarboxylic acid.


DL Malic Acid is functionally related to a succinic acid.
DL Malic Acid is a conjugate acid of a malate(2-) and a malate.
There are two types of DL-Malic Acid: granular type and powder type.


DL Malic Acid features pureness, gentleness, smoothness, tenderness, lasting acidic taste, high solubility and salt stability etc.
DL-Malic Acid is an organic acid with the ability to form complexes with metals, DL-Hydroxybutanedioic Acid.
An acid of natural origin contained in most fruit (L-malic acid) or synthetically made: DL Malic Acid.


Global consumption of DL-malic acid will grow by 4.7% during 2022–27, driven by developed markets in Western Europe and North America, as well as developing markets in Asia.
DL-malic acid is a major food acid used primarily in beverages, confections, and food.


Demand growth is dependent on the popularity of ready-todrink beverages and processed food.
Consumers’ desire for nutritional and healthful products such as nutraceutical and fruit-flavored beverages, low-calorie confections, and savory foods will also drive consumption growth.


Higher demand for DL-malic acid has resulted in continued investments in capacity expansion, which is set to speed up over the next five years as competition intensifies in the key growing markets.
DL Malic Acid, also known as 2 - hydroxy succinic acid, has two stereoisomers due to the presence of an asymmetric carbon atom in the molecule.


There are three forms in nature, namely D malic acid, L malic acid and its mixture DL malic acid.
DL Malic Acid is white crystalline or crystalline powder with strong moisture absorption, easily soluble in water and ethanol.
DL Malic Acid has a special pleasant sour taste.


DL Malic Acid is formed as a by-product of the metabolic processes of sugars and occurs under several names, such as:
*hydroxysuccinic acid,
*2-hydroxybutanedioic acid,
*acidum malicum,
*malic acid,
*acidity regulator E296.


DL Malic Acid belongs to the group of natural hydroxy acids.
This means that the molecule contains a hydroxyl group, consisting of oxygen (O) and hydrogen (H).

The structural formula of acidum malicum is as follows:
HOOC–CH(OH)–CH2–COOH.
The molecular formula for DL Malic Acid is: C4H6O5.


As an optically active compound, Malic Acid is classified into two forms:
L-malic acid (left-handed form, found in fruits),
D-malic acid (right-handed form, does not occur in nature).
As a result of industrial treatment of hydroxysuccinic acid, a mixture in the form of a racemate (DL-malic acid), which has no optical activity, is formed.



USES and APPLICATIONS of DL MALIC ACID:
DL Malic Acid is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
DL Malic Acid is used in the following products: cosmetics and personal care products, washing & cleaning products, coating products, water softeners, water treatment chemicals, adhesives and sealants, metal surface treatment products and pH regulators and water treatment products.


Other release to the environment of DL Malic Acid is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).


DL Malic Acid can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
DL Malic Acid is approved for use as a food additive in the EU, US and Australia and New Zealand (where it is listed by its INS number 296).


DL Malic Acid can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), plastic (e.g. food packaging and storage, toys, mobile phones), leather (e.g. gloves, shoes, purses, furniture) and rubber (e.g. tyres, shoes, toys).


DL Malic Acid is used in the following products: water softeners, washing & cleaning products, coating products, pH regulators and water treatment products, laboratory chemicals, inks and toners and water treatment chemicals.
DL Malic Acid is used in the following areas: mining, building & construction work, scientific research and development and health services.


DL Malic Acid is used for the manufacture of: food products and .
Other release to the environment of DL Malic Acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.


DL Malic Acid is used in the following products: non-metal-surface treatment products, cosmetics and personal care products, washing & cleaning products, metal surface treatment products, paper chemicals and dyes, pH regulators and water treatment products and pharmaceuticals.
Release to the environment of DL Malic Acid can occur from industrial use: formulation of mixtures.


DL Malic Acid is used in the following products: washing & cleaning products, non-metal-surface treatment products, metal surface treatment products, pH regulators and water treatment products, water treatment chemicals, coating products, welding & soldering products, cosmetics and personal care products, paper chemicals and dyes, textile treatment products and dyes and adhesives and sealants.


DL Malic Acid is used in the following areas: mining, building & construction work, scientific research and development and printing and recorded media reproduction.
DL Malic Acid is used for the manufacture of: pulp, paper and paper products, textile, leather or fur, , chemicals, plastic products, mineral products (e.g. plasters, cement) and fabricated metal products.



Release to the environment of DL Malic Acid can occur from industrial use: in the production of articles, in processing aids at industrial sites, of substances in closed systems with minimal release and as an intermediate step in further manufacturing of another substance (use of intermediates).
Release to the environment of DL Malic Acid can occur from industrial use: manufacturing of the substance.


Other release to the environment of DL Malic Acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
DL Malic Acid is sometimes used with or in place of the less sour citric acid in sour sweets.


DL Malic Acid, HOOCCH(OH).CH2COOH, also known as hydroxysuccinic acid, is used in medicine to do a good favour for patients.
DL Malic Acid is used to resolve α-phenylethylamine, a versatile resolving agent in its own right.
In food production, an ingredient called of DL Malic Acid E296 is used as one of the best citric acid substitutes.


DL Malic Acid makes the products stay fresh and attractive for longer.
DL Malic Acid is effective in impeding the appearance of clouding and the loss of colour of various substances.
In chemical industry, DL Malic Acid is also useful in the process of organic synthesis.


Thanks to this, DL Malic Acid is possible to obtain, among others, esters used in the production of cleaning agents and cosmetics.
Manufacturers in the pharmaceutical industry make good use of the beneficial properties of acidum malicum.
Organic acid is a healthy stimulant for the digestive system and improves the condition of the epidermis, and therefore DL Malic Acid is used as an ingredient in medicinal rinses, capsules and dietary supplements.


DL Malic Acid is used in cosmetics and the beauty industry
The antibacterial, stabilising, preserving and brightening properties of acidum malicum are appreciated especially by manufacturers from the cosmetic and beauty industries.


Treatments with DL Malic Acid are aimed at improving the condition of the epidermis, inhibiting bacterial growth and the ageing of cells.
Exposing the skin to intense acid action also helps to get rid of discolouration, blemishes and shrink unattractive-looking pores.
DL Malic Acid is used with or in place of the less sour citric acid in sour sweets.


DL Malic Acid is used as a flavor enhancer in food preparation for confectionaries, beverages, fruit preparations and preserves, desserts, and bakery products.
DL Malic Acid is also essential in the preparation of medical products such as throat lozenges, cough syrups, effervescent powdered preparations, toothpaste and mouthwash.


Additionally, DL Malic Acid is used in the manufacture of skin care products to rejuvenate and improve skin conditions.
DL Malic Acid is used in pharmaceutical formulations as a general purpose acidulant.
DL Malic Acid possesses a slight apple flavor and is used as a flavoring agent to mask bitter tastes and provide tartness.


DL Malic Acid is also used as an alternative to citric acid in effervescent powders, mouthwashes, and tooth-cleaning tablets.
DL-Malic Acid is used as acidulant, color retention agent, preservative and emulsion stabilizer in food industry, etc.
DL Malic Acid is mainly used in food and medicine industry.


DL Malic Acid is an alpha-hydroxy acid found in certain fruits and wines.
Some people take DL Malic acid supplements to treat fatigue and dry mouth.
DL Malic Acid is also used to make some medicines, add flavor to food, and serve as a natural exfoliating ingredient in many products used to improve skin tone.


Aside from adding tartness to foods and beverages, DL Malic Acid has been researched for a variety of health uses.
Malate, the ionized form of DL Malic Acid, plays a small role in the Krebs Cycle, the primary way our bodies generate energy.


-Plant defense
Soil supplementation with molasses increases microbial synthesis of DL Malic Acid.
This is thought to occur naturally as part of soil microbe suppression of disease, so soil amendment with molasses can be used as a crop treatment in horticulture


-Malic acid in food
DL Malic Acid was first isolated from apple juice by Carl Wilhelm Scheele in 1785.
Antoine Lavoisier in 1787 proposed the name acide malique which is derived from the Latin word for apple, mālum.
DL Malic Acid contributes to the sourness of green apples. Malic acid is present in grapes.
DL Malic Acid confers a tart taste to wine, although the amount decreases with increasing fruit ripeness.
The process of malolactic fermentation converts DL Malic Acid to much milder lactic acid.


-Skincare
DL Malic Acid is an alpha hydroxy acid, which is said to be a natural exfoliator.
DL Malic Acid may be used to smooth wrinkles and fine lines, improve skin texture, cleanse pores, and improve overall skin. Because of this, DL Malic Acid has been used in various skincare products.


-Kidney Stones
Kidney stones are painful and can affect many people.
DL Malic Acid has been researched for its potential role in preventing and treating kidney stones.
In one preliminary study set in a lab, DL Malic Acid was found to increase urine pH levels, making kidney stone formation less likely.
The researchers concluded that DL Malic Acid supplementation might help treat calcium kidney stones.
A 2016 review on the importance of a healthy diet to prevent kidney stones suggested pears could be a potential treatment option.
Per the review, the DL Malic Acid in pears may be used to prevent the formation of kidney stones.
This is because DL Malic Acid is a precursor for citrate, a compound that inhibits crystal growth in the kidneys.


-Fibromyalgia:
A pilot study from 1995 found that taking DL Malic Acid in combination with magnesium helped alleviate pain and tenderness in people with fibromyalgia.
In the small study, researchers assigned 24 people with fibromyalgia to treatment with either a placebo or a combination of DL Malic Acid and magnesium.
After six months, those treated with the DL Malic Acid/magnesium combination showed a significant improvement in pain and tenderness.
There remains a lack of more recent research on DL Malic Acid's effectiveness as a fibromyalgia treatment.


-Dry Mouth:
The use of a 1% oral DL Malic Acid spray has been explored as a treatment for dry mouth.
One study evaluated people with dry mouth caused by antidepressants.
Participants were randomized to receive either a 1% DL Malic Acidspray or a placebo.
After two weeks of using the sprays as needed, those using the DL Malic Acid spray had improved dry mouth symptoms and increased rates of saliva flow.
Similar results were seen in a different study looking at DL Malic Acid for dry mouth caused by blood pressure medications.
At the end of this two-week study, participants who used the 1% DL Malic Acid spray had less dry mouth and more saliva compared with the placebo group.


-DL Malic Acid is used as an ingredient in many cosmetics for everyday use, such as:
*moisturising and anti-wrinkle creams,
*brightening masks for face and hair,
*shampoos and hair rinses (including bleaches, colour fixers),
*regenerating and cleansing milks and tonics (soothing, brightening, anti-acne),
*natural rinses for hair and nails.


-In recent years, people associated with the beauty industry have also become interested in DL Malic Acid.
This antibacterial and antioxidant compound, DL Malic Acid, is more and more often used for specialised cosmetology treatments for skin and hair.
Among others, these are:
*brightening masks,
*exfoliating scrubs for the face and body,
*aesthetic anti-ageing treatments.


-Industrial application of DL Malic Acid:
Natural acids of organic origin have long been used in industry.
DL Malic Acid serves, among others, as a preservative and acidity regulator – such as the popular E296 – that’s added to:
*preserves,
*jams,
*marmalade,
*candy,
*jellies, etc.



BENEFITS OF DL MALIC ACID:
*Reduce muscle pain and muscle aches.
*Improve energy.
*Increased exercise tolerance.
*Is generally safe- DL Malic Acid is naturally occurring and safety every day



DL MALIC ACID – PROPERTIES AND ACTION:
How to recognise acidum malicum?
DL Malic Acid is a crystalline, white or yellowish substance with characteristic sour taste, well soluble in water and ethanol.
L-malic acid and D-malic acid melt at 100 °C and begin to boil at 140 °C.

DL Malic Acid has many valuable properties and actions:
*antibacterial,
*anti-inflammatory,
*exfoliating,
*preserving,
*brightening,
*regulating the acidity of other substances,
*supporting human metabolism.



CHARACTERISTICS OF DL MALIC ACID:
DL Malic Acid is white or off-white crystalline powder or granules with a clearly acid flavour.
Melting point of D,L-malic is 127°C-132°C
Melting point of L-malic is 100°C.



IN FOOD, DL MALIC ACID:
DL Malic Acid was first isolated from apple juice by Carl Wilhelm Scheele in 1785.
Antoine Lavoisier in 1787 proposed the name acide malique, which is derived from the Latin word for apple, mālum—as is its genus name Malus.
In German DL Malic Acid is named Äpfelsäure (or Apfelsäure) after plural or singular of a sour thing from the apple fruit, but the salt(s) are called Malat(e).

DL Malic Acid is the main acid in many fruits, including apricots, blackberries, blueberries, cherries, grapes, mirabelles, peaches, pears, plums, and quince and is present in lower concentrations in other fruits, such as citrus.
DL Malic Acid contributes to the sourness of unripe apples.

Sour apples contain high proportions of the acid.
DL Malic Acid is present in grapes and in most wines with concentrations sometimes as high as 5 g/L.
DL Malic Acid confers a tart taste to wine; the amount decreases with increasing fruit ripeness.

The taste of DL Malic Acid is very clear and pure in rhubarb, a plant for which it is the primary flavor.
DL Malic Acid is also the compound responsible for the tart flavor of sumac spice.
DL Malic Acid is also a component of some artificial vinegar flavors, such as "salt and vinegar" flavored potato chips.
In citrus, fruits produced in organic farming contain higher levels of DL Malic Acid than fruits produced in conventional agriculture.



RELATED CARBOXYLIC ACIDS:
*Succinic acid
*Tartaric acid
*Fumaric acid



RELATED COMPOUNDS OF DL MALIC ACID:
*Butanol
*Butyraldehyde
*Crotonaldehyde
*Sodium malate



PRODUCTION AND MAIN REACTIONS OF DL MALIC ACID:
Racemic DL Malic Acid is produced industrially by the double hydration of maleic anhydride.
In 2000, American production capacity was 5,000 tons per year.
The enantiomers may be separated by chiral resolution of the racemic mixture.
S-Malic acid is obtained by fermentation of fumaric acid.
Self-condensation of DL Malic Acid in the presence of fuming sulfuric acid gives the pyrone coumalic acid



FUNCTIONS AND APPLICATIONS OF DL MALIC ACID:
(1) In food industry:
DL Malic Acid can be used in the processing and concoction of beverage, liqueur, fruit juice and the manufacture of candy and jam etc.
DL Malic Acid also has effects of bacteria inhibition and antisepsis and can remove tartrate during wine brewing.

(2) In tobacco industry:
DL Malic Acidd derivative (such as esters) can improve the aroma of tobacco.

(3)In pharmaceutical industry:
The troches and syrup compounded with DL Malic Acid have fruit taste and can facilitate their absorption and diffusion in the body.

The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants.
Selective a-amino protecting reagent for amino acid derivatives.
Versatile synthon for the preparation of chiral compounds including ╬║-opioid receptor agonists, 1a,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.



ETYMOLOGY OF DL MALIC ACID:
The word 'malic' is derived from Latin 'mālum', meaning 'apple'.
The related Latin word mālus, meaning 'apple tree', is used as the name of the genus Malus, which includes all apples and crabapples; and the origin of other taxonomic classifications such as Maloideae, Malinae, and Maleae.



BIOCHEMISTRY OF DL MALIC ACID:
L-Malic acid is the naturally occurring form, whereas a mixture of L- and D-malic acid is produced synthetically.
DL Malic Acid is nearly odorless (sometimes a faint, acrid odor).
DL Malic Acid has a tart, acidic and non-pungent taste.



DOES DL MALIC ACID ONLY OCCUR IN UNRIPE APPLES?
Of course not!
This acidic compound, DL Malic Acid, is also found in many other fruits – rowan berries, cherries, gooseberries, pears, quinces, grapes. DL Malic Acid is present in some species of perennials, e.g., in rhubarb, which is very popular and valued in Poland.
On industrial scale, DL Malic Acid would be difficult to obtain the desired amounts of malic acid from fruit alone.
Therefore, producers often use acidum malicum obtained artificially by chemical method or fermentation method.



PHYSICAL and CHEMICAL PROPERTIES of DL MALIC ACID:
Molecular Weight: 134.09 g/mol
XLogP: -1.3
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 3
Exact Mass: 134.02152329 g/mol
Monoisotopic Mass: 134.02152329 g/mol
Topological Polar Surface Area: 94.8Ų
Heavy Atom Count: 9
Formal Charge: 0
Complexity: 129
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Solubility:
Water at 20°C: 55.8 g/100
Alcohol at 95% vol.: 45.5 g/100.
Ether: 0.84 g/ 100

Physical state: powder
Color: white
Odor: characteristic
Melting point/freezing point:
Melting point/range: 131 - 133 °C - lit.
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 203 °C
Autoignition temperature: 340 °C
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility 646,6 g/l at 20 °C completely soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: < 0,1 hPa at 20 °C
Density: 1,6 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available

Density: 1.6 g/cm3 (20 °C)
Flash point: 203 °C
Ignition temperature: 349 °C
Melting Point: 131 - 133 °C
pH value: 2.3 (10 g/l, H₂O, 20 °C)
Vapor pressure: Bulk density: 800 kg/m3
Solubility: 558 g/l
Chemical formula: C4H6O5
Molar mass: 134.09 g/mol
Appearance: Colorless
Density: 1.609 g⋅cm−3
Melting point: 130 °C (266 °F; 403 K)
Solubility in water: 558 g/L (at 20 °C)
Acidity (pKa): pKa1 = 3.40
pKa2 = 5.20[2]
Form: solid
Colour: colourless
Melting point: 128 - 132°C
Boiling point: 150°
Flash point: 203°C
Density: 1,60 g/cm3
Mol Weight: 134.08 g/mol
Storage temp: RT
Assay : 99 - 100.5%%
Identity : conforms
Appearance of the solution : conforms
Insoluble Matter (Non Solubles) : <0.1%
Melting Point : 128 - 132°C



FIRST AID MEASURES of DL MALIC ACID:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Rresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DL MALIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of DL MALIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DL MALIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DL MALIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of DL MALIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available



SYNONYMS:
hydroxysuccinic acid
hydroxybutanedioic acid
apple acid
H2mal
alpha-hydroxysuccinic acid
E296
2-hydroxybutanedioic acid
malic acid
2-hydroxyethane-1,2-dicarboxylic acid
2-hydroxysuccinic acid
DL-hydroxysuccinic acid
DL-2-hydroxybutanedioic acid
DL-apple acid
(±)-2-Hydroxysuccinic acid
DL-Hydroxybutanedioic acid
malic acid
DL-malic acid
6915-15-7
2-Hydroxybutanedioic acid
2-Hydroxysuccinic acid
617-48-1
malate
hydroxysuccinic acid
Butanedioic acid, hydroxy-
Malic acid, DL-
Kyselina jablecna
hydroxybutanedioic acid
Pomalus acid
Deoxytetraric acid
Hydroxybutandisaeure
Musashi-no-Ringosan
alpha-Hydroxysuccinic acid
dl-Hydroxybutanedioic acid
Caswell No. 537
Monohydroxybernsteinsaeure
Succinic acid, hydroxy-
FDA 2018
R,S(+-)-Malic acid
Malicum acidum
Pomalous acid
DL-2-hydroxybutanedioic acid
d,l-malic acid
FEMA Number 2655
2-Hydroxyethane-1,2-dicarboxylic acid
Kyselina jablecna [Czech]
Malic acid [NF]
(+-)-Malic acid
Aepfelsaeure
FEMA No. 2655
CCRIS 2950
CCRIS 6567
(+/-)-Malic acid
EPA Pesticide Chemical Code 051101
HSDB 1202
AI3-06292
H2mal
EINECS 210-514-9
EINECS 230-022-8
UNII-817L1N4CKP
NSC 25941
NSC-25941
817L1N4CKP
CHEBI:6650
INS NO.296
DTXSID0027640
E296
INS NO. 296
INS-296
Malic acid, L-
(+-)-Hydroxysuccinic acid
L-Malic acid-1-13C
MLS000084707
DTXCID107640
E-296
(+-)-1-Hydroxy-1,2-ethanedicarboxylic acid
Hydroxybutanedioic acid, (+-)-
EC 210-514-9
EC 230-022-8
NSC25941
Malic acid (NF)
(+/-)-HYDROXYSUCCINIC ACID
DL-MALIC-2,3,3-D3 ACID
SMR000019054
DL-Apple Acid
HYDROXYBUTANEDIOIC ACID, (+/-)-
MALIC ACID (II)
MALIC ACID [II]
(R)-Hydroxybutanedioic acid
(S)-Hydroxybutanedioic acid
MALIC ACID (USP-RS)
MALIC ACID [USP-RS]
BUTANEDIOIC ACID, HYDROXY-, (S)-
R-Malic acid
MALIC ACID (EP MONOGRAPH)
MALIC ACID (USP IMPURITY)
MALIC ACID [EP MONOGRAPH]
MALIC ACID [USP IMPURITY]
Butanedioic acid, 2-hydroxy-, (2S)-
CAS-6915-15-7
L-(-)-MalicAcid
DL-hydroxysuccinic acid
C4H6O5
Hydroxybutanedioic acid, (-)-
MFCD00064213
(+/-)-2-Hydroxysuccinic acid
Racemic malic acid
180991-05-3
MFCD00064212
.+-.-Malic acid
Opera_ID_805
2-hydroxyl-succinic acid
DL-Malic acid, 99%
MALIC ACID [MI]
MALIC ACID,(DL)
2-Hydroxydicarboxylic acid
MALIC ACID [FCC]
SCHEMBL856
2-hydroxy-butanedioic acid
bmse000046
bmse000904
D03WNI
MALIC ACID [INCI]
MALIC ACID [VANDF]
Malic acid-, (L-form)-
DL-Malic acid, >=99%
HYOSCYAMINEHYDROBROMIDE
Oprea1_130558
Oprea1_624131
MALIC ACID [WHO-DD]
butanedioic acid, 2-hydroxy-
DL-HYDROXYSUCOINIC ACID
Butanedioic acid, (.+-.)-
DL(+/-)-MALIC ACID
GTPL2480
2-HYDROXY-SUCCINIC ACID
DL-HYROXYBUTANEDIOIC ACID
CHEMBL1455497
BDBM92495
DL-Malic acid, FCC, >=99%
HMS2358H06
HMS3371C13
(C4-H6-O5)x-
DL-Malic acid, analytical standard
HY-Y1311
STR03457
Tox21_201536
Tox21_300372
s9001
STL283959
HYDROXYBUTANEDIOIC ACID [HSDB]
AKOS000120085
AKOS017278471
(+/-)-HYDROXYBUTANEDIOIC ACID
AM81418
Butanedioic acid, hydroxy-, (.+.)-
CCG-266122
DB12751
LS-2394
DL-Malic acid, ReagentPlus(R), 99%
NCGC00043225-02
NCGC00043225-03
NCGC00254259-01
NCGC00259086-01
78644-42-5
DL-Malic acid, >=98% (capillary GC)
LS-88709
SY003313
SY009804
DL-Malic acid, ReagentPlus(R), >=99%
DL-Malic acid 1000 microg/mL in Methanol
DL-Malic acid, USP, 99.0-100.5%
CS-0017784
E 296
EU-0067046
FT-0605225
FT-0625484
FT-0625485
FT-0625539
FT-0632189
M0020
DL-Malic acid, SAJ first grade, >=99.0%
EN300-19229
A19426
C00711
C03668
D04843
DL-Malic acid 1000 microg/mL in Acetonitrile
DL-Malic acid, Vetec(TM) reagent grade, 98%
M-0825
AB00443952-12
Malic acid, meets USP/NF testing specifications
4-ethoxyphenyltrans-4-propylcyclohexanecarboxylate
L023999
Q190143
Q-201028
0C9A2DC0-FEA2-4864-B98B-0597CDD0AD06
F0918-0088
Z104473230
MALIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION)
Malic acid, United States Pharmacopeia (USP) Reference Standard
MALIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
Malic acid, Pharmaceutical Secondary Standard; Certified Reference Material
DL-Malic acid, meets analytical specification of FCC, E296, 99-100.5% (alkalimetric)
2-Hydroxybutanedioic acid
Hydroxybutanedioic acid
2-Hydroxysuccinic acid
(L/D)-Malic acid
(±)-Malic acid
(S/R)-Hydroxybutanedioic acid
DL-Hydroxybutanedioic acid
Hydroxysuccinic acid
2-HYDROXYBUTANEDIOIC ACID


DL TARTARIC ACID
SYNONYMS DL-alpha-Tocopheryl Acetate; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-b- enzopyran-6-ol, acetate; Tocopheryl acetate; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate;VITAMIN E ACETATE CAS NO. 7695-91-2
DL-Alanine
dextro,laevo-alanine; 2-aminopropanoic acid; alanina; a- aminopropanoic acid; propanoic acid, 2-amino- cas no: 302-72-7
DL-ALPHA TOCOPHERYL ACETATE
DL-CAMPHOR N° CAS : 21368-68-3 Nom INCI : DL-CAMPHOR Nom chimique : DL-Bornan-2-one N° EINECS/ELINCS : 244-350-4 Ses fonctions (INCI) Agent parfumant : Utilisé pour le parfum et les matières premières aromatiques
D-LIMONENE
D-LIMONENE Abstract D-limonene is one of the most common terpenes in nature. It is a major constituent in several citrus oils (orange, lemon, mandarin, lime, and grapefruit). D-limonene is listed in the Code of Federal Regulations as generally recognized as safe (GRAS) for a flavoring agent and can be found in common food items such as fruit juices, soft drinks, baked goods, ice cream, and pudding. D-limonene is considered to have fairly low toxicity. It has been tested for carcinogenicity in mice and rats. Although initial results showed d-limonene increased the incidence of renal tubular tumors in male rats, female rats and mice in both genders showed no evidence of any tumor. Subsequent studies have determined how these tumors occur and established that d-limonene does not pose a mutagenic, carcinogenic, or nephrotoxic risk to humans. In humans, d-limonene has demonstrated low toxicity after single and repeated dosing for up to one year. Being a solvent of cholesterol, d-limonene has been used clinically to dissolve cholesterol-containing gallstones. Because of its gastric acid neutralizing effect and its support of normal peristalsis, it has also been used for relief of heartburn and gastroesophageal reflux (GERD). D-limonene has well-established chemopreventive activity against many types of cancer. Evidence from a phase I clinical trial demonstrated a partial response in a patient with breast cancer and stable disease for more than six months in three patients with colorectal cancer. D-Limonene Jump to navigationJump to search Not to be confused with Lemonene. D-Limonene Skeletal structure of the (R)-isomer Ball-and-stick model of the (R)-isomer D-Limonene extracted from orange peels. Names Preferred IUPAC name 1-Methyl-4-(prop-1-en-2-yl)cyclohex-1-ene Other names 1-Methyl-4-(1-methylethenyl)cyclohexene 4-Isopropenyl-1-methylcyclohexene p-Menth-1,8-diene Racemic: dl-D-Limonene; Dipentene Identifiers CAS Number 138-86-3 (R/S) ☒ 5989-27-5 (R) ☒ 5989-54-8 (S) ☒ 3D model (JSmol) Interactive image ChEBI CHEBI:15384 check ChEMBL ChEMBL449062 (R) ☒ ChemSpider 20939 (R/S) check 388386 (S) check 389747 (R) check ECHA InfoCard 100.028.848 Edit this at Wikidata KEGG D00194 check PubChem CID 22311 (R/S) 439250 (S) UNII 9MC3I34447 (R/S) ☒ GFD7C86Q1W (R) ☒ 47MAJ1Y2NE (S) ☒ CompTox Dashboard (EPA) DTXSID2029612 Edit this at Wikidata InChI[show] SMILES[show] Properties Chemical formula C10H16 Molar mass 136.238 g·mol−1 Appearance colorless to pale-yellow liquid Odor Orange Density 0.8411 g/cm3 Melting point −74.35 °C (−101.83 °F; 198.80 K) Boiling point 176 °C (349 °F; 449 K) Solubility in water Insoluble Solubility Miscible with benzene, chloroform, ether, CS2, and oils soluble in CCl4 Chiral rotation ([α]D) 87–102° Refractive index (nD) 1.4727 Thermochemistry Std enthalpy of combustion (ΔcH⦵298) −6.128 MJ mol−1 Hazards Main hazards Skin sensitizer / Contact dermatitis – After aspiration, pulmonary oedema, pneumonitis, and death[1] GHS pictograms GHS02: FlammableGHS07: HarmfulGHS08: Health hazardGHS09: Environmental hazard GHS Signal word Danger GHS hazard statements H226, H304, H315, H317, H400, H410 GHS precautionary statements P210, P233, P240, P241, P242, P243, P261, P264, P272, P273, P280, P301+330+331, P302+352, P303+361+353, P304+340, P312, P333+313, P362, P370+378, P391, P403+233, P235, P405, P501 NFPA 704 (fire diamond) NFPA 704 four-colored diamond 220 Flash point 50 °C (122 °F; 323 K) Autoignition temperature 237 °C (459 °F; 510 K) Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ☒ verify (what is check☒ ?) Infobox references D-Limonene is a colorless liquid aliphatic hydrocarbon classified as a cyclic monoterpene, and is the major component in the oil of citrus fruit peels.[1] The d-isomer, occurring more commonly in nature as the fragrance of oranges, is a flavoring agent in food manufacturing.[1][2] It is also used in chemical synthesis as a precursor to carvone and as a renewables-based solvent in cleaning products.[1] The less common l-isomer is found in mint oils and has a piny, turpentine-like odor.[1] The compound is one of the main volatile monoterpenes found in the resin of conifers, particularly in the Pinaceae, and of orange oil. D-Limonene takes its name from French limon ("lemon").[3] D-Limonene is a chiral molecule, and biological sources produce one enantiomer: the principal industrial source, citrus fruit, contains d-D-Limonene ((+)-D-Limonene), which is the (R)-enantiomer.[1] Racemic D-Limonene is known as dipentene.[4] d-D-Limonene is obtained commercially from citrus fruits through two primary methods: centrifugal separation or steam distillation. Contents 1 Chemical reactions 1.1 Biosynthesis 2 In plants 3 Safety and research 4 Uses 5 See also 6 References 7 External links Chemical reactions D-Limonene is a relatively stable monoterpene and can be distilled without decomposition, although at elevated temperatures it cracks to form isoprene.[5] It oxidizes easily in moist air to produce carveol, carvone, and D-Limonene oxide.[1][6] With sulfur, it undergoes dehydrogenation to p-cymene.[7] D-Limonene occurs commonly as the d- or (R)-enantiomer, but racemizes to dipentene at 300 °C. When warmed with mineral acid, D-Limonene isomerizes to the conjugated diene α-terpinene (which can also easily be converted to p-cymene). Evidence for this isomerization includes the formation of Diels–Alder adducts between α-terpinene adducts and maleic anhydride. It is possible to effect reaction at one of the double bonds selectively. Anhydrous hydrogen chloride reacts preferentially at the disubstituted alkene, whereas epoxidation with mCPBA occurs at the trisubstituted alkene. In another synthetic method Markovnikov addition of trifluoroacetic acid followed by hydrolysis of the acetate gives terpineol. Biosynthesis In nature, D-Limonene is formed from geranyl pyrophosphate, via cyclization of a neryl carbocation or its equivalent as shown.[8] The final step involves loss of a proton from the cation to form the alkene. center[Biosynthesis of D-Limonene from geranyl pyrophosphate The most widely practiced conversion of D-Limonene is to carvone. The three-step reaction begins with the regioselective addition of nitrosyl chloride across the trisubstituted double bond. This species is then converted to the oxime with a base, and the hydroxylamine is removed to give the ketone-containing carvone.[2] In plants d-D-Limonene is a major component of the aromatic scents and resins characteristic of numerous coniferous and broadleaved trees: red and silver maple (Acer rubrum, Acer saccharinum), cottonwoods (Populus angustifolia), aspens (Populus grandidentata, Populus tremuloides) sumac (Rhus glabra), spruce (Picea spp.), various pines (e.g., Pinus echinata, Pinus ponderosa), Douglas fir (Pseudotsuga menziesii), larches (Larix spp.), true firs (Abies spp.), hemlocks (Tsuga spp.), cannabis (Cannabis sativa spp.),[9] cedars (Cedrus spp.), various Cupressaceae, and juniper bush (Juniperus spp.).[1] It contributes to the characteristic odor of orange peel, orange juice and other citrus fruits.[1][10] To optimize recovery of valued components from citrus peel waste, d-D-Limonene is typically removed.[11] Safety and research d-D-Limonene applied to skin may cause irritation from contact dermatitis, but otherwise appears to be safe for human uses.[12][13] D-Limonene is flammable as a liquid or vapor and it is toxic to aquatic life.[1] Uses D-Limonene is common as a dietary supplement and as a fragrance ingredient for cosmetics products.[1] As the main fragrance of citrus peels, d-D-Limonene is used in food manufacturing and some medicines, such as a flavoring to mask the bitter taste of alkaloids, and as a fragrance in perfumery, aftershave lotions, bath products, and other personal care products.[1] d-D-Limonene is also used as a botanical insecticide.[1][14] d-D-Limonene is used in the organic herbicide "Avenger".[15] It is added to cleaning products, such as hand cleansers to give a lemon or orange fragrance (see orange oil) and for its ability to dissolve oils.[1] In contrast, l-D-Limonene has a piny, turpentine-like odor. D-Limonene is used as a solvent for cleaning purposes, such as adhesive remover, or the removal of oil from machine parts, as it is produced from a renewable source (citrus essential oil, as a byproduct of orange juice manufacture).[11] It is used as a paint stripper and is also useful as a fragrant alternative to turpentine. D-Limonene is also used as a solvent in some model airplane glues and as a constituent in some paints. Commercial air fresheners, with air propellants, containing D-Limonene are used by philatelists to remove self-adhesive postage stamps from envelope paper.[16] D-Limonene is also used as a solvent for fused filament fabrication based 3D printing.[17] Printers can print the plastic of choice for the model, but erect supports and binders from HIPS, a polystyrene plastic that is easily soluble in D-Limonene. As it is combustible, D-Limonene has also been considered as a biofuel.[18] In preparing tissues for histology or histopathology, d-D-Limonene is often used as a less toxic substitute for xylene when clearing dehydrated specimens. Clearing agents are liquids miscible with alcohols (such as ethanol or isopropanol) and with melted paraffin wax, in which specimens are embedded to facilitate cutting of thin sections for microscopy.[19][20][21] What Is D-Limonene? Everything You Need to Know What it is Uses Benefits Safety & side effects Dosage Bottom line We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here’s our process. D-Limonene is the oil extracted from the peels of oranges and other citrus fruits (1). People have been extracting essential oils like D-Limonene from citrus fruits for centuries. Today, D-Limonene is often used as a natural treatment for a variety of health issues and is a popular ingredient in household items. However, not all of D-Limonene’s benefits and uses are supported by science. This article examines D-Limonene’s uses, potential benefits, side effects, and dosage. What is D-Limonene? D-Limonene is a chemical found in the rind of citrus fruits, such as lemons, limes, and oranges. It is especially concentrated in orange peels, comprising around 97% of this rind’s essential oils (2Trusted Source). It’s often referred to as d-D-Limonene, which is its main chemical form. D-Limonene belongs to a group of compounds known as terpenes, whose strong aromas protect plants by deterring predators (3Trusted Source). D-Limonene is one of the most common terpenes found in nature and may offer several health benefits. It has been shown to possess anti-inflammatory, antioxidant, anti-stress, and possibly disease-preventing properties. SUMMARY D-Limonene is an essential oil found in citrus fruit peels. It belongs to a class of compounds called terpenes. ADVERTISEMENT Weight management options have evolved Take our quiz to learn more about techniques and tips that will help you achieve your goals. Common uses of D-Limonene D-Limonene is a popular additive in foods, cosmetics, cleaning products, and natural insect repellants. For example, it’s used in foods like sodas, desserts, and candies to provide a lemony flavor. D-Limonene is extracted through hydrodistillation, a process in which fruit peels are soaked in water and heated until the volatile molecules are released via steam, condensed, and separated (4). Due to its strong aroma, D-Limonene is utilized as a botanical insecticide. It’s an active ingredient in multiple pesticide products, such as eco-friendly insect repellents (5). Other household products containing this compound include soaps, shampoos, lotions, perfumes, laundry detergents, and air fresheners. Additionally, D-Limonene is available in concentrated supplements in capsule and liquid form. These are often marketed for their supposed health benefits. This citrus compound is also used as an aromatic oil for its calming and therapeutic properties. SUMMARY D-Limonene is used in a range of products, including food, cosmetics, and eco-friendly pesticides. It can also be found in supplement form, as it may boost health and fight certain diseases. Linked to several health benefits D-Limonene has been studied for its potential anti-inflammatory, antioxidant, anticancer, and heart-disease-fighting properties. However, most research has been conducted in test tubes or on animals, making it difficult to fully understand the role of D-Limonene in human health and disease prevention. Anti-inflammatory and antioxidant benefits D-Limonene has been shown to reduce inflammation in some studies (6Trusted Source, 7Trusted Source). While short-term inflammation is your body’s natural response to stress and is beneficial, chronic inflammation can harm your body and is a major cause of illness. It’s important to prevent or reduce this type of inflammation as much as possible (8Trusted Source). D-Limonene has been shown to reduce inflammatory markers that relate to osteoarthritis, a condition characterized by chronic inflammation. A test-tube study in human cartilage cells noted that D-Limonene reduced nitric oxide production. Nitric oxide is a signaling molecule that plays a key role in inflammatory pathways (9Trusted Source). In a study in rats with ulcerative colitis — another disease characterized by inflammation — treatment with D-Limonene significantly decreased inflammation and colon damage, as well as common inflammatory markers (10Trusted Source). D-Limonene has demonstrated antioxidant effects as well. Antioxidants help reduce cell damage caused by unstable molecules called free radicals. Free radical accumulation can lead to oxidative stress, which may trigger inflammation and disease (11Trusted Source). One test-tube study revealed that D-Limonene may inhibit free radicals in leukemia cells, suggesting a decrease in inflammation and cellular damage that would normally contribute to disease (12Trusted Source). Although promising, these effects need to be confirmed by human studies. May have anticancer effects D-Limonene may have anticancer effects. In a population study, those who consumed citrus fruit peel, the major source of dietary D-Limonene, had a reduced risk of developing skin cancer compared to those who only consumed citrus fruits or their juices (13Trusted Source). Another study in 43 women recently diagnosed with breast cancer experienced a significant 22% reduction in breast tumor cell expression after taking 2 grams of D-Limonene daily for 2–6 weeks (14Trusted Source). Additionally, research in rodents found that supplementing with D-Limonene inhibited the growth of skin tumors by preventing inflammation and oxidative stress (15Trusted Source). Other rodent studies indicate that D-Limonene may fight other types of cancer, including breast cancer (16Trusted Source). What’s more, when given to rats alongside the anticancer drug doxorubicin, D-Limonene helped prevent several common side effects of the medication, including oxidative damage, inflammation, and kidney damage (17Trusted Source). Although these results are promising, more human studies are needed. May boost heart health Heart disease remains the leading cause of death in the United States, accounting for nearly one in four deaths (18Trusted Source). D-Limonene may lower your risk of heart disease by reducing certain risk factors, such as elevated cholesterol, blood sugar, and triglyceride levels. In one study, mice given 0.27 grams of D-Limonene per pound of body weight (0.6 grams/kg) showed reduced triglycerides, LDL (bad) cholesterol, fasting blood sugar, and fat accumulation in the liver, compared to a control group (19Trusted Source). In another study, stroke-prone rats given 0.04 grams of D-Limonene per pound of body weight (20 mg/kg) exhibited significant reductions in blood pressure compared to rats of similar health status that did not receive the supplement (20Trusted Source). Keep in mind that human studies are needed before strong conclusions can be drawn. Other benefits Aside from the benefits listed above, D-Limonene may: Reduce appetite. The scent of D-Limonene has been shown to significantly reduce appetite in blowflies. However, this effect has not been studied in humans (21Trusted Source). Decrease stress and anxiety. Rodent studies suggest that D-Limonene could be used in aromatherapy as an anti-stress and anti-anxiety agent (22Trusted Source). Support healthy digestion. D-Limonene may protect against stomach ulcers. In a study in rats, citrus aurantium oil, which is 97% D-Limonene, protected nearly all of the rodents against ulcers caused by medication use (23Trusted Source). SUMMARY D-Limonene may offer antioxidant, anti-inflammatory, anticancer, and anti-heart-disease benefits, among others. However, more research in humans is needed. Safety and side effects D-Limonene is considered safe for humans with little risk of side effects. The Food and Drug Administration (FDA) recognizes D-Limonene as a safe food additive and flavoring (5). However, when applied directly to the skin, D-Limonene may cause irritation in some people, so caution should be used when handling its essential oil (24Trusted Source, 25). D-Limonene is sometimes taken as a concentrated supplement. Because of the way your body breaks it down, it’s likely safe consumed in this form. That said, human research on these supplements is lacking (26Trusted Source). Notably, high-dose supplements may cause side effects in some people. What’s more, insufficient evidence exists to determine whether D-Limonene supplements are acceptable for pregnant or breastfeeding women. It’s best to consult your healthcare practitioner before taking D-Limonene supplements, especially if you’re taking medications, are pregnant or breastfeeding, or have a medical condition. SUMMARY Aside from possible skin irritation associated with direct application, D-Limonene is likely safe for most people to use and consume in moderation. Potentially effective dosages Because few D-Limonene studies exist in humans, it’s difficult to provide a dosage recommendation. Nonetheless, dosages of up to 2 grams daily have been safely used in studies (9Trusted Source, 14Trusted Source). Capsule supplements that can be purchased online contain dosages of 250–1,000 mg. D-Limonene is also available in liquid form with typical dosages of 0.05 ml per serving. However, supplements aren’t always necessary. You can easily obtain this compound by eating citrus fruits and peels. For example, fresh orange, lime, or lemon zest can be used to add D-Limonene to baked goods, drinks, and other items. What’s more, pulpy citrus juices, such as lemon or orange juice, boast D-Limonene, too (27Trusted Source). SUMMARY While dosage recommendations don’t exist for D-Limonene, 2 grams daily has been safely used in studies. In addition to supplements, you can obtain D-Limonene from citrus fruits and zest. Other names of D-limonene: D-Limonene Orange peel oil Citrus peel oil Citrine p-mentha-1,8-diene (scientific name) What is D-limonene? What are the health effects of D-limonene? Terpene compounds, which are obtained from the peel of citrus fruits, mostly in lemon peel, and give these plants their scent, are called d-limonene. Intense citrus consumption is thought to be one of the reasons for less cancer and cardiovascular diseases in people eating a Mediterranean diet. Cancer of D-limonene with it has not been prevented or treated. Anti-inflammatory, wound-healing and tumor-shrinking therapy in laboratory studies. Again, in laboratory studies, it has been shown that D-limonene affects the growth signal pathways in cancer cells and can lead to apoptosis. In animal studies, D-limonene slowed the growth of pancreatic, stomach, colon, skin and lung cancers. It also slowed the formation and progress of animals exposed to cancer-causing substances. However, this has not been seen in anti-cancer patients. For which medicinal medicine is D-limonene tried? To prevent and treat cancer In laboratory studies, a combination of d-limonene and the chemotherapy drug called docetaxel increases the effectiveness against prostate cancer cells. A community study (epidemiological) study reported an inverse association between citrus consumption and squamous cell cancer of the skin. However, these results could not be supported by clinical studies. More research is needed to find that D-limonene is not the prevention or treatment of cancer. To treat heartburn and reflux Although it has been tried intensively to concentrate, the limits to support this use, even the d-limonene cause stomach complaints. More are needed in this area. Side effects of D-limonene Nausea Vomiting Diarrhea Allergic skin rash Trigger asthma Source 1. Vigushin DM, et al. Phase I and pharmacokinetic study of d-limonene in advanced cancer patients. Cancer Chemother Pharmacol 1998. 2. Judge IA, Harris RB, Ritenbaugh C. Citrus peel use is associated with a reduced risk of squamous cell carcinoma of the skin. Nutr Cancer. 2000 3. Topham EJ, Wakelin SH. D-Limonene contact dermatitis from hand cleaners. Contact dermatitis. 2003 4. Rabi T, Bishayee A. d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis. D-LEMONEN (D-LEMONEN) Lemon Peel; Scientific studies investigating the Mediterranean cuisine, which is widely used in cold beverages, have coincidentally found the reason why cancer and chronic diseases are rare. Liquid D-Limonene; Its homeland is India and the Far East, and it is a herbal medicine containing a special scented oil. Antioxidant substances are available in high amounts. D-Limonene Liquid active ingredient is found in the peel of other citrus fruits. In addition to cancer, it is beneficial in high blood pressure, lowering of bad cholesterol, increasing good cholesterol, and cardiovascular occlusion.
DL-LACTIC ACID
DL-Lactic Acid is an organic acid.
DL-Lactic Acid has the molecular formula CH3CH(OH)COOH.
DL-Lactic Acid is white in the solid state and it is miscible with water.

CAS: 50-21-5
MF: C3H6O3
MW: 90.08
EINECS: 200-018-0

Synonyms
FEMA 2611;DL-ALPHA-HYDROXYPROPIONIC ACID;DL-Lactic acid, ACS reagent, 85+%;LACTIC ACID, 85% REAGENT (ACS);Lactic;dl-lactic acid, acs;LACTICACID,RACEMIC,USP;2-Hydroxy-2-methylacetic acid
;lactic acid;2-hydroxypropanoic acid;DL-Lactic acid;50-21-5;2-hydroxypropionic acid;Milk acid;lactate;Tonsillosan;Racemic lactic acid;Ordinary lactic acid;Ethylidenelactic acid;26100-51-6;Lactovagan;Acidum lacticum;Milchsaeure;Lactic acid, dl-;Kyselina mlecna;Lacticum acidum;DL-Milchsaeure;Lactic acid USP;(+/-)-Lactic acid;Propanoic acid, 2-hydroxy-;Aethylidenmilchsaeure;598-82-3;1-Hydroxyethanecarboxylic acid;alpha-Hydroxypropionic acid;Lactic acid (natural);(RS)-2-Hydroxypropionsaeure;FEMA No. 2611;Milchsaure;Kyselina 2-hydroxypropanova;Lurex;Propionic acid, 2-hydroxy-;Purac FCC 80;Purac FCC 88;Cheongin samrakhan;DL- lactic acid;FEMA Number 2611;CCRIS 2951;HSDB 800;Cheongin Haewoohwan;Cheongin Haejanghwan;SY-83;2-Hydroxypropionicacid;(+-)-2-Hydroxypropanoic acid;Biolac;NSC 367919
;Lactic acid, tech grade;Chem-Cast;alpha-Hydroxypropanoic acid;AI3-03130;HIPURE 88;EINECS 200-018-0;EINECS 209-954-4;EPA Pesticide Chemical Code 128929;Lactic acid,buffered;NSC-367919;UNII-3B8D35Y7S4;2-Hydroxy-2-methylacetic acid;BRN 5238667;INS NO.270;DTXSID7023192;(+/-)-2-hydroxypropanoic acid;CHEBI:78320;INS-270;2 Hydroxypropanoic Acid;3B8D35Y7S4;E 270
;MFCD00004520;LACTIC ACID (+-);.alpha.-Hydroxypropanoic acid;.alpha.-Hydroxypropionic acid;DTXCID003192;E-270;EC 200-018-0;NCGC00090972-01;2-hydroxy-propionic acid;C01432;Milchsaure [German];Lactic acid [JAN];Kyselina mlecna [Czech];Propanoic acid, hydroxy-;CAS-50-21-5;(R)-2-Hydroxy-propionic acid;H-D-Lac-OH;2 Hydroxypropionic Acid;Kyselina 2-hydroxypropanova [Czech];Lactic acid [USP:JAN];lactasol;1-Hydroxyethane 1-carboxylic acid;acido lactico;DL-Milchsaure;MFCD00064266;(2RS)-2-Hydroxypropanoic acid;Lactate (TN);4b5w;Propanoic acid, (+-);DL-Lactic Acid, Racemic;LACTIC ACID (II);(.+/-.)-Lactic acid;Lactic acid (7CI,8CI);DL-Lactic Acid (90%);Lactic acid (JP17/USP);Lactic acid, 85%, FCC;Lactic Acid, Racemic, USP;NCIOpen2_000884;(+-)-LACTIC ACID;DL-LACTIC ACID [MI];LACTIC ACID [WHO-IP];(RS)-2-hydroxypropanoic acid;LACTIC ACID, DL-(II);LACTICUM ACIDUM [HPUS];1-hydroxyethane carboxylic acid;33X04XA5AT;DL-Lactic Acid (90per cent);L-(+)-Lactic acid, 98%;CHEMBL1200559;Lactic acid, natural, >=85%;BDBM23233;L-lactic acid or dl-lactic acid;Lactic Acid, 85 Percent, FCC;LACTIC ACID, DL- [II];DL-Lactic acid, ~90% (T);DL-Lactic acid, AR, >=88%;DL-Lactic acid, LR, >=88%;DL- LACTIC ACID [WHO-DD];LACTIC ACID (EP MONOGRAPH);Lactic Acid, 10 Percent Solution;HY-B2227;LACTIC ACID (USP MONOGRAPH);Propanoic acid, 2-hydroxy- (9CI);Tox21_111049;Tox21_202455;Tox21_303616;BBL027466;NSC367919;STL282744;AKOS000118855;AKOS17278364;Tox21_111049_1;ACIDUM LACTICUM [WHO-IP LATIN];AM87208;DB04398;SB44647;SB44652;Propanoic acid,2-hydroxy-,(.+/-.)-;2-Hydroxypropionic acid, DL-Lactic acid;NCGC00090972-02;NCGC00090972-03;NCGC00257515-01;NCGC00260004-01;849585-22-4;Lactic Acid, 85 Percent, Reagent, ACS;(R)-Lactate;(R)-2-Hydroxypropionic acid;;DB-071134;DB-347146;CS-0021601;L0226;EN300-19542;Lactic acid, meets USP testing specifications;D00111;F71201;A877374;DL-Lactic acid, SAJ first grade, 85.0-92.0%;Q161249;DL-Lactic acid, JIS special grade, 85.0-92.0%;Dl-alpha-hydroxypropionic acid;2-hydroxypropionic acid;F2191-0200;Z104474158;BC10F553-5D5D-4388-BB74-378ED4E24908;Lactic acid, United States Pharmacopeia (USP) Reference Standard;Lactic acid, Pharmaceutical Secondary Standard; Certified Reference Material;DL-Lactic acid 90%, synthetic, meets the analytical specifications of Ph. Eur.;152-36-3

When in the dissolved state, DL-Lactic Acid forms a colorless solution.
Production includes both artificial synthesis as well as natural sources.
DL-Lactic Acid is an alpha-hydroxy acid (AHA) due to the presence of a hydroxyl group adjacent to the carboxyl group.
DL-Lactic Acid is used as a synthetic intermediate in many organic synthesis industries and in various biochemical industries.
The conjugate base of DL-Lactic Acid is called lactate (or the lactate anion).
The name of the derived acyl group is lactoyl.
A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
In solution, DL-Lactic Acid can ionize by a loss of a proton to produce the lactate ion CH3CH(OH)CO−2.
Compared to acetic acid, its pKa is 1 unit less, meaning DL-Lactic Acid is ten times more acidic than acetic acid.
This higher acidity is the consequence of the intramolecular hydrogen bonding between the α-hydroxyl and the carboxylate group.

DL-Lactic Acid is chiral, consisting of two enantiomers.
One is known as DL-Lactic Acid, (S)-lactic acid, or (+)-lactic acid, and the other, its mirror image, is d-lactic acid, (R)-lactic acid, or (−)-lactic acid.
A mixture of the two in equal amounts is called DL-Lactic Acid, or racemic lactic acid.
Lactic acid is hygroscopic.
DL-Lactic Acid is miscible with water and with ethanol above its melting point, which is about 16 to 18 °C (61 to 64 °F).
DL-Lactic Acid and l-lactic acid have a higher melting point.
DL-Lactic Acid produced by fermentation of milk is often racemic, although certain species of bacteria produce solely d-lactic acid.
On the other hand, DL-Lactic Acid produced by anaerobic respiration in animal muscles has the enantiomer and is sometimes called "sarcolactic" acid, from the Greek sarx, meaning "flesh".

In animals, DL-Lactic Acid is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise.
DL-Lactic Acid does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal, which is governed by a number of factors, including monocarboxylate transporters, concentration and isoform of LDH, and oxidative capacity of tissues.
The concentration of blood lactate is usually 1–2 mMTooltip millimolar at rest, but can rise to over 20 mM during intense exertion and as high as 25 mM afterward.
In addition to other biological roles, DL-Lactic Acid is the primary endogenous agonist of hydroxycarboxylic acid receptor 1 (HCA1), which is a Gi/o-coupled G protein-coupled receptor (GPCR).

In industry, DL-Lactic Acid fermentation is performed by lactic acid bacteria, which convert simple carbohydrates such as glucose, sucrose, or galactose to lactic acid.
These bacteria can also grow in the mouth; the acid they produce is responsible for the tooth decay known as cavities.
In medicine, DL-Lactic Acid is one of the main components of lactated Ringer's solution and Hartmann's solution.
These intravenous fluids consist of sodium and potassium cations along with DL-Lactic Acid and chloride anions in solution with distilled water, generally in concentrations isotonic with human blood.
DL-Lactic Acid is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or burns.

DL-Lactic Acid is the most widely occurring organic acid in nature.
Due to its chiral a-carbon atom, DL-Lactic Acid has two enantiomeric forms.
Of these, DL-Lactic Acid is more important in food and pharmaceutical industries because humans have only L-lactate dehydrogenase.
The chemical behavior of DL-Lactic Acid is mostly determined by the two functional groups.
Besides the acidic character in aqueous medium, the bifunctionality (a terminal carboxylic acid and a hydroxyl group) allows lactic acid molecules to form ‘‘interesters’’ such as the cyclic dimers, the trimers, or longer lactic acid oligomers.
After its first isolation by the Swedish chemist Scheel in 1780 from sour milk, DL-Lactic Acid has been produced commercially since the 1880s in the United States and later in Europe.
Worldwide, DL-Lactic Acid production was approximately 250,000 metric tons per year in 2012 and is expected to reach 330,000 metric tons by the year 2015, with an average price of 1.25 US$ per kilogram in 2013 (food grade, 80–85 % purity).

Approximately 85 % of the demand for DL-Lactic Acid is from the food industry.
The primary use of DL-Lactic Acid is as a pH-adjusting agent in the beverage sector and as a preservative in the food industry.
DL-Lactic Acid is included in the Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration as a food ingredient and was deemed safe by the European Food Safety Authority as well.
The acceptable daily intake for DL-Lactic Acid was defined by the Joint FAO/WHO Expert Committee on Food Additives as ‘‘not limited,’’ and DL-Lactic Acid is also supported by the Scientific Committee of Food.
In recent decades, the consumption of DL-Lactic Acid due to its novel applications has grown quite rapidly, by 19 % per year.
Nonfood use of DL-Lactic Acid for polymer production contributes to this growth.

Biodegradable polylactic acid is considered to be an environmentally friendly alternative to other plastics from petroleum.
DL-Lactic Acid is used in various fields, including drug delivery systems, medical devices, fibers, and packaging materials.
DL-Lactic Acid can be produced via chemical synthesis or carbohydrate fermentation.
The chemical route has various issues, including toxic raw materials, low conversion rates, and especially the inability to produce the optically pure isomer.
Therefore, approximately 90 % of DL-Lactic Acid worldwide is produced by biotechnological processes, namely fermentations using renewable resources, which is relatively fast, economical, and able to supply selectively one or two stereoisomers of lactic acid.

DL-Lactic Acid is a metabolic intermediate that is produced in the muscle cells during anaerobic glycolysis.
DL-Lactic Acid is used to treat cancer and has been shown to be effective against squamous cell carcinoma.
DL-lactic acid also inhibits mitochondrial membrane potential, which may be one of the mechanisms by which it causes cell death.
DL-lactic acid has been found to have antibacterial efficacy against a number of bacteria, including Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, and Streptococcus pyogenes.
DL-lactic acid also inhibits enzyme activities that are necessary for bacterial growth such as phosphotransferase enzymes and urease.
DL-lactic acid is a metabolic intermediate that can be used to inhibit tumor growth and metastasis.
DL-lactic acid also inhibits transcriptional regulation in human serum.

History
Swedish chemist Carl Wilhelm Scheele was the first person to isolate DL-Lactic Acid in 1780 from sour milk.
The name reflects the lact- combining form derived from the Latin word lac, meaning "milk".
In 1808, Jöns Jacob Berzelius discovered that lactic acid (actually l-lactate) also is produced in muscles during exertion.
DL-Lactic Acid's structure was established by Johannes Wislicenus in 1873.
In 1856, the role of Lactobacillus in the synthesis of DL-Lactic Acid was discovered by Louis Pasteur.
This pathway was used commercially by the German pharmacy Boehringer Ingelheim in 1895.
In 2006, global production of DL-Lactic Acid reached 275,000 tonnes with an average annual growth of 10%.

DL-Lactic Acid Chemical Properties
Melting point: 18°C
Boiling point: 122 °C/15 mmHg (lit.)
Alpha: -0.05 º (c= neat 25 ºC)
Density: 1.209 g/mL at 25 °C (lit.)
Vapor density: 0.62 (vs air)
Vapor pressure: 19 mm of Hg (@ 20°C)
FEMA: 2611 | LACTIC ACID
Refractive index: n20/D 1.4262
Fp: >230 °F
Storage temp.: 2-8°C
Solubility: Miscible with water and with ethanol (96 per cent).
Form: syrup
pka: 3.08(at 100℃)
Color: Colorless to yellow
Specific Gravity: 1.209
PH: 3.51(1 mM solution);2.96(10 mM solution);2.44(100 mM solution);
Odor: at 100.00 %. odorless
Odor Type: odorless
Water Solubility: SOLUBLE
Merck: 14,5336
JECFA Number: 930
BRN: 1209341
Dielectric constant: 22.0(16℃)
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: JVTAAEKCZFNVCJ-UHFFFAOYSA-N
LogP: -0.72
CAS DataBase Reference: 50-21-5(CAS DataBase Reference)
NIST Chemistry Reference: DL-Lactic Acid (50-21-5)
EPA Substance Registry System: DL-Lactic Acid (50-21-5)

DL-Lactic Acid is odorless.
DL-Lactic Acid consists of a mixture of lactic acid (C3H6O3) and lactic acid lactate (C6H10O5).
DL-Lactic Acid is the racemic form.
DL-Lactic Acid is usually available in solutions containing 50 to 90% lactic acid.
DL-Lactic Acid, CH3CHOHCOOH, also known as 2-hydroxypropanoic acid, is a hygroscopic liquid that exists in three isometric forms.
DL-Lactic Acid is found in blood and animal tissue as a product of glucose and glycogen metabolism.
DL-Lactic Acid is obtained by fermentation of sucrose (corn refining), The racemic mixture is present in foods prepared by bacterial fermentation or prepared synthetically.
DL-Lactic Acid is soluble in water,alcohol,and ether.
DL-Lactic Acid is used as a solvent, in manufacturing confectionery, and in medicine.
DL-Lactic Acid consists of a mixture of 2-hydroxypropionic acid, its condensation products, such as lactoyllactic acid and other polylactic acids, and water.

DL-Lactic Acid is usually in the form of the racemate, (RS)-lactic acid, but in some cases the (S)-(+)-isomer is predominant.
DL-Lactic Acid is a practically odorless, colorless or slightly yellowcolored, viscous, hygroscopic, nonvolatile liquid.
A colorless or yellowish, nearly odorless, syrupy liquid consisting of a mixture of DL-Lactic Acid and lactic acid lactate (C6H10O5).
DL-Lactic Acid is obtained by the lactic fermentation of sugars or is prepared synthetically.
The commercial product is the racemic form.
DL-Lactic Acid is usually available in solutions containing the equivalent of from 50% to 90% lactic acid.
DL-Lactic Acid is hygroscopic, and when concentrated by boiling, the acid condenses to form lactic acid lactate, 2-(lactoyloxy)propanoic acid, which on dilution and heat ing hydrolyzes to lactic acid.
DL-Lactic Acid is miscible with water and with alcohol.

Uses
DL-Lactic Acid is a multi-purpose ingredient used as a preservative, exfoliant, moisturizer, and to provide acidity to a formulation.
In the body, DL-Lactic Acid is found in the blood and muscle tissue as a product of the metabolism of glucose and glycogen.
DL-Lactic Acid is also a component of the skin’s natural moisturizing factor.
DL-Lactic Acid has better water intake than glycerin.
Studies indicate an ability to increase the water-retention capacity of the stratum corneum.
They also show that the pliability of the stratum corneum layer is closely related to the absorption of DL-Lactic Acid; that is, the greater the amount of absorbed lactic acid, the more pliable the stratum corneum layer.
Researchers report that continuous use of preparations formulated with DL-Lactic Acid in concentrations ranging between 5 and 12 percent provided a mild to moderate improvement in fine wrinkling and promote softer, smoother skin.

DL-Lactic Acid's exfoliating properties can help in the process of removing excess pigment from the surface of the skin, as well as improving skin texture and feel.
DL-Lactic Acid is an alpha hydroxy acid occurring in sour milk and other lesser-known sources, such as beer, pickles, and foods made through a process of bacterial fermentation.
DL-Lactic Acid is caustic when applied to the skin in highly concentrated solutions.
DL-Lactic Acid is an acidulant that is a natural organic acid present in milk, meat, and beer, but is normally associated with milk.
DL-Lactic Acid is a syrupy liquid available as 50 and 88% aqueous solutions, and is mis- cible in water and alcohol.
DL-Lactic Acid is heat stable, nonvolatile, and has a smooth, milk acid taste.
DL-Lactic Acid functions as a flavor agent, preservative, and acidity adjuster in foods.
DL-Lactic Acid is used in spanish olives to prevent spoilage and provide flavor, in dry egg powder to improve disper- sion and whipping properties, in cheese spreads, and in salad dress- ing mixes.

Polymer precursor
Main article: polylactic acid
Two molecules of lactic acid can be dehydrated to the lactone lactide.
In the presence of catalysts lactide polymerize to either atactic or syndiotactic polylactide (PLA), which are biodegradable polyesters.
PLA is an example of a plastic that is not derived from petrochemicals.

Pharmaceutical and cosmetic applications
DL-Lactic Acid is also employed in pharmaceutical technology to produce water-soluble lactates from otherwise-insoluble active ingredients.
DL-Lactic Acid finds further use in topical preparations and cosmetics to adjust acidity and for its disinfectant and keratolytic properties.
DL-Lactic Acid containing bacteria have shown promise in reducing oxaluria with its descaling properties on calcium compounds.

Foods
Fermented food
DL-Lactic Acid is found primarily in sour milk products, such as kumis, laban, yogurt, kefir, and some cottage cheeses.
The casein in fermented milk is coagulated (curdled) by DL-Lactic Acid.
DL-Lactic Acid is also responsible for the sour flavor of sourdough bread.

In lists of nutritional information DL-Lactic Acid might be included under the term "carbohydrate" (or "carbohydrate by difference") because this often includes everything other than water, protein, fat, ash, and ethanol.
If this is the case then the calculated food energy may use the standard 4 kilocalories (17 kJ) per gram that is often used for all carbohydrates.
But in some cases DL-Lactic Acid is ignored in the calculation.
The energy density of DL-Lactic Acid is 362 kilocalories (1,510 kJ) per 100 g.

Some beers (sour beer) purposely contain DL-Lactic Acid, one such type being Belgian lambics.
Most commonly, this is produced naturally by various strains of bacteria.
These bacteria ferment sugars into acids, unlike the yeast that ferment sugar into ethanol.
After cooling the wort, yeast and bacteria are allowed to "fall" into the open fermenters.
Brewers of more common beer styles would ensure that no such bacteria are allowed to enter the fermenter.
Other sour styles of beer include Berliner weisse, Flanders red and American wild ale.

In winemaking, a bacterial process, natural or controlled, is often used to convert the naturally present malic acid to DL-Lactic Acid, to reduce the sharpness and for other flavor-related reasons.
This malolactic fermentation is undertaken by lactic acid bacteria.
While not normally found in significant quantities in fruit, lactic acid is the primary organic acid in akebia fruit, making up 2.12% of the juice.

Separately added
As a food additive DL-Lactic Acid is approved for use in the EU, United States and Australia and New Zealand; it is listed by its INS number 270 or as E number E270.
DL-Lactic Acid is used as a food preservative, curing agent, and flavoring agent.
DL-Lactic Acid is an ingredient in processed foods and is used as a decontaminant during meat processing.
DL-Lactic Acid is produced commercially by fermentation of carbohydrates such as glucose, sucrose, or lactose, or by chemical synthesis.
Carbohydrate sources include corn, beets, and cane sugar.

Forgery
DL-Lactic Acid has historically been used to assist with the erasure of inks from official papers to be modified during forgery.

Cleaning products
DL-Lactic Acid is used in some liquid cleaners as a descaling agent for removing hard water deposits such as calcium carbonate.

Production
DL-Lactic Acid is produced industrially by bacterial fermentation of carbohydrates, or by chemical synthesis from acetaldehyde.
As of 2009, DL-Lactic Acid was produced predominantly (70–90%) by fermentation.
Production of racemic lactic acid consisting of a 1:1 mixture of d and l stereoisomers, or of mixtures with up to 99.9% l-lactic acid, is possible by microbial fermentation.
Industrial scale production of DL-Lactic Acid by fermentation is possible, but much more challenging.

Fermentative production
Fermented milk products are obtained industrially by fermentation of milk or whey by Lactobacillus bacteria: Lactobacillus acidophilus, Lacticaseibacillus casei (Lactobacillus casei), Lactobacillus delbrueckii subsp. bulgaricus (Lactobacillus bulgaricus), Lactobacillus helveticus, Lactococcus lactis , Bacillus amyloliquefaciens, and Streptococcus salivarius subsp. thermophilus (Streptococcus thermophilus).

As a starting material for industrial production of DL-Lactic Acid, almost any carbohydrate source containing C5 (Pentose sugar) and C6 (Hexose sugar) can be used.
Pure sucrose, glucose from starch, raw sugar, and beet juice are frequently used.
DL-Lactic Acid producing bacteria can be divided in two classes: homofermentative bacteria like Lactobacillus casei and Lactococcus lactis, producing two moles of lactate from one mole of glucose, and heterofermentative species producing one mole of lactate from one mole of glucose as well as carbon dioxide and acetic acid/ethanol.

Chemical production
DL-Lactic Acid is synthesized industrially by reacting acetaldehyde with hydrogen cyanide and hydrolysing the resultant lactonitrile.
When hydrolysis is performed by hydrochloric acid, ammonium chloride forms as a by-product; the Japanese company Musashino is one of the last big manufacturers of DL-Lactic Acid by this route.
Synthesis of both racemic and enantiopure DL-Lactic Acid is also possible from other starting materials (vinyl acetate, glycerol, etc.) by application of catalytic procedures.

Production Methods
DL-Lactic Acid is prepared by the fermentation of carbohydrates, such as glucose, sucrose, and lactose, with Bacillus acidi lacti or related microorganisms.
On a commercial scale, whey, corn starch, potatoes, or molasses are used as a source of carbohydrate.
DL-Lactic Acid may also be prepared synthetically by the reaction between acetaldehyde and carbon monoxide at 130–200°C under high pressure, or by the hydrolysis of hexoses with sodium hydroxide.
DL-Lactic Acid prepared by the fermentation of sugars is levorotatory; lactic acid prepared synthetically is racemic.
However, DL-Lactic Acid prepared by fermentation becomes dextrorotatory on dilution with water owing to the hydrolysis of (R)-lactic acid lactate to (S)- lactic acid.

Biochem/physiol Actions
In animals, DL-Lactic Acid is a metabolic compound produced by proliferating cells and during anaerobic conditions such as strenuous exercise.
DL-Lactic Acid can be oxidized back to pyruvate or converted to glucose via gluconeogenesis.
DL-Lactic Acid is preferentially metabolized by neurons in several mammal species and during early brain development.
DL-MALIC ACID
CAS #: 6915-15-7
EC Number: 230-022-8
Moelcular Formula: C₄H₆O₅
Molar Mass: 134.09 g/mol
IUPAC Name: 2-hydroxybutanedioic acid


DESCRIPTION:
DL-Malic acid is an organic compound with the molecular formula C4H6O5.
DL-Malic acid is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive.

DL-Malic acid has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally.
The salts and esters of DL-Malic acid are known as malates.
The malate anion is an intermediate in the citric acid cycle.
DL-Malic acid is an organic acid that plays a role in the citric acid cycle.
DL-Malic acid is also used as an antimicrobial agent, and has been shown to be effective against fungi and bacteria.

DL-Malic acid binds to the active site of complex enzymes involved in energy metabolism and has been shown to inhibit transcriptional regulation of numerous genes.
DL-Malic acid has also shown to have a positive effect on metabolic disorders such as diabetes mellitus and hypoglycemia.

DL-Malic acid may be synthesized with sodium salts or sodium citrate, depending on the desired end product.
DL-Malic acid can also be produced by laser ablation of malonic acid or by enzymatic oxidation of tartaric acid, which is a natural source of this chemical.
DL-Malic acid is used as a food additive.
DL-Malic acid is a component of some artificial vinegar flavors.
Further, DL-Malic acid is used in the preparation of chiral compounds, including κ-opioid rece.
DL-Malic acid is utilized for chiral resolution by ligand-exchange capillary electrophoresis.


CAS #: 6915-15-7
EC Number: 230-022-8
Moelcular Formula: C₄H₆O₅
Molar Mass: 134.09 g/mol
IUPAC Name: 2-hydroxybutanedioic acid

Etymology:
The word 'malic' is derived from Latin 'mālum', meaning 'apple'.
The related Latin word mālus, meaning 'apple tree', is used as the name of the genus Malus, which includes all apples and crabapples; and the origin of other taxonomic classifications such as Maloideae, Malinae, and Maleae.

CHEMICAL AND PHYSICAL INFORMATION ABOUT DL-MALIC ACID:
Density: 1.6 g/cm3 (20 °C)
Flash point: 203 °C
Ignition temperature: 349 °C
Melting Point: 131 - 133 °C
pH value: 2.3 (10 g/l, H₂O, 20 °C)
Vapor pressure: Bulk density: 800 kg/m3
Solubility: 558 g/l
Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 128 °C
Melting range (upper value): ≤ 132 °C
Chemical formula C4H6O5
Molar mass 134.09 g/mol
Appearance Colorless
Acidity (pKa):
pKa1 = 3.40
pKa2 = 5.20
Arsenic (As) : <0.0003%
Lead (Pb) : <0.0002%
Copper (Cu) : <0.001%
Mercury (Hg) : <0.0001%
Zinc (Zn) : <0.001%
Sulfated Ash : <0.1%
Water : <2.0%
Heavy Metals : <0.002% Molecular Weight: 134.09
XLogP3: -1.3
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 3
Exact Mass: 134.02152329
Monoisotopic Mass: 134.02152329
Topological Polar Surface Area: 94.8 Ų
Heavy Atom Count: 9
Formal Charge: 0
Complexity: 129
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes



CAS #: 6915-15-7
EC Number: 230-022-8
Moelcular Formula: C₄H₆O₅
Molar Mass: 134.09 g/mol
IUPAC Name: 2-hydroxybutanedioic acid

BIOCHEMISTRY OF DL-MALIC ACID:
DL-Malic acid is the naturally occurring form, whereas a mixture of L- and D-malic acid is produced synthetically.

Malate plays an important role in biochemistry. In the C4 carbon fixation process, malate is a source of CO2 in the Calvin cycle.
In the citric acid cycle, (S)-malate is an intermediate, formed by the addition of an -OH group on the si face of fumarate.
It can also be formed from pyruvate via anaplerotic reactions.


Malate is also synthesized by the carboxylation of phosphoenolpyruvate in the guard cells of plant leaves.
Malate, as a double anion, often accompanies potassium cations during the uptake of solutes into the guard cells in order to maintain electrical balance in the cell.
The accumulation of these solutes within the guard cell decreases the solute potential, allowing water to enter the cell and promote aperture of the stomata.



DL-MALIC ACID IN FOOD:
DL-Malic acid was first isolated from apple juice by Carl Wilhelm Scheele in 1785.
Antoine Lavoisier in 1787 proposed the name acide malique, which is derived from the Latin word for apple, mālum—as is its genus name Malus.
In German it is named Äpfelsäure (or Apfelsäure) after plural or singular of a sour thing from the apple fruit, but the salt(s) are called Malat(e).

Malic acid is the main acid in many fruits, including apricots, blackberries, blueberries, cherries, grapes, mirabelles, peaches, pears, plums, and quince and is present in lower concentrations in other fruits, such as citrus.
DL-Malic acid contributes to the sourness of unripe apples.

Sour apples contain high proportions of the acid.
DL-Malic acid is present in grapes and in most wines with concentrations sometimes as high as 5 g/L.
DL-Malic acid confers a tart taste to wine; the amount decreases with increasing fruit ripeness.
The taste of malic acid is very clear and pure in rhubarb, a plant for which it is the primary flavor.

DL-Malic acid is also the compound responsible for the tart flavor of sumac spice.
DL-Malic acid is also a component of some artificial vinegar flavors, such as "salt and vinegar" flavored potato chips.

In citrus, fruits produced in organic farming contain higher levels of malic acid than fruits produced in conventional agriculture.
The process of malolactic fermentation converts malic acid to much milder lactic acid.
Malic acid occurs naturally in all fruits and many vegetables, and is generated in fruit metabolism.

Malic acid, when added to food products, is denoted by E number E296.
DL-Malic acid is sometimes used with or in place of the less sour citric acid in sour sweets.
These sweets are sometimes labeled with a warning stating that excessive consumption can cause irritation of the mouth.
DL-Malic acid is approved for use as a food additive in the EU, US and Australia and New Zealand (where it is listed by its INS number 296).

Malic acid contains 10 kJ (2.39 kilocalories) of energy per gram.

PRODUCTION AND MAIN REACTIONS OF DL-MALIC ACID:
Racemic malic acid is produced industrially by the double hydration of maleic anhydride.
In 2000, American production capacity was 5,000 tons per year.
The enantiomers may be separated by chiral resolution of the racemic mixture.
S-Malic acid is obtained by fermentation of fumaric acid.

Malic acid was important in the discovery of the Walden inversion and the Walden cycle, in which (−)-malic acid first is converted into (+)-chlorosuccinic acid by action of phosphorus pentachloride.
Wet silver oxide then converts the chlorine compound to (+)-malic acid, which then reacts with PCl5 to the (−)-chlorosuccinic acid.
The cycle is completed when silver oxide takes this compound back to (−)-malic acid.

USES OF DL- MALIC ACID:
l-malic acid is used to resolve α-phenylethylamine, a versatile resolving agent in its own right.

Plant defense:
Soil supplementation with molasses increases microbial synthesis of MA.
This is thought to occur naturally as part of soil microbe suppression of disease, so soil amendment with molasses can be used as a crop treatment in horticulture.

DL-Malic acid is used as a food additive.
DL-Malic acid is a component of some artificial vinegar flavors.
Further, DL-Malic acid is used in the preparation of chiral compounds, including κ-opioid rece.
DL-Malic acid is utilized for chiral resolution by ligand-exchange capillary electrophoresis.

CAS #: 6915-15-7
EC Number: 230-022-8
Moelcular Formula: C₄H₆O₅
Molar Mass: 134.09 g/mol
IUPAC Name: 2-hydroxybutanedioic acid





SAFETY INFORMATION ABOUT DL- MALIC ACID:
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.

If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.

Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.

Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.

Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials

Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.

Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.

Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.

If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.

Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.





CAS #: 6915-15-7
EC Number: 230-022-8
Moelcular Formula: C₄H₆O₅
Molar Mass: 134.09 g/mol
IUPAC Name: 2-hydroxybutanedioic acid






SYNONYMS OF DL- MALIC ACID:

2-Hydroxybutanedioic acid
Malic acid
(+/-)-Malic acid
2-hydroxysuccinic acid
malate
hydroxysuccinic acid
butanedioic acid
hydroxy
kyselina jablecna
pomalus acid
hydroxybutanedioic acid
deoxytetraric acid

MeSH Entry Terms:
calcium (hydroxy-1-malate) hexahydrate
malate
malic acid
malic acid, (R)-isomer
malic acid, calcium salt, (1:1), (S)-isomer
malic acid, disodium salt
malic acid, disodium salt, (R)-isomer
malic acid, disodium salt, (S)-isomer
malic acid, magnesium salt (2:1)
malic acid, monopotassium salt, (+-)-isomer
malic acid, potassium salt, (R)-isomer
malic acid, sodium salt, (+-)-isomer

Depositor-Supplied Synonyms:
malic acid
DL-malic acid
6915-15-7
2-Hydroxybutanedioic acid
2-Hydroxysuccinic acid
617-48-1
malate
Butanedioic acid, hydroxy-
hydroxysuccinic acid
Malic acid, DL-
Kyselina jablecna
hydroxybutanedioic acid
Pomalus acid
Deoxytetraric acid
dl-Hydroxybutanedioic acid
Hydroxybutandisaeure
alpha-Hydroxysuccinic acid
Musashi-no-Ringosan
Caswell No. 537
DL-2-hydroxybutanedioic acid
FDA 2018
Monohydroxybernsteinsaeure
Succinic acid, hydroxy-
R,S(+-)-Malic acid
Kyselina jablecna [Czech]
Malic acid [NF]
FEMA No. 2655
2-Hydroxyethane-1,2-dicarboxylic acid
Pomalous acid
Kyselina hydroxybutandiova [Czech]
d,l-malic acid
EPA Pesticide Chemical Code 051101
AI3-06292
(+/-)-Malic acid
Malic acid, L-
NSC-25941
E296
BUTANEDIOIC ACID, HYDROXY-, (S)-
MLS000084707
817L1N4CKP
CHEBI:6650
INS NO.296
(+-)-1-Hydroxy-1,2-ethanedicarboxylic acid
INS NO. 296
INS-296
NSC25941
Malic acid (NF)
SMR000019054
DL-Apple Acid
E-296
DSSTox_CID_7640
(R)-Hydroxybutanedioic acid
(S)-Hydroxybutanedioic acid
DSSTox_RID_78538
DSSTox_GSID_27640
(+-)-Malic acid
R-Malic acid
Malicum acidum
FEMA Number 2655
Butanedioic acid, 2-hydroxy-, (2S)-
CAS-6915-15-7
CCRIS 2950
CCRIS 6567
L-(-)-MalicAcid
HSDB 1202
DL-hydroxysuccinic acid
Kyselina hydroxybutandiova
EINECS 210-514-9
EINECS 230-022-8
NSC 25941
Hydroxybutanedioic acid, (-)-
(+-)-Hydroxysuccinic acid
UNII-817L1N4CKP
Aepfelsaeure
NSC 9232
MFCD00004245
MFCD00064213
(+/-)-2-Hydroxysuccinic acid
Hydroxybutanedioic acid, (+-)-
H2mal
Racemic malic acid
MFCD00064212
.+-.-Malic acid
143435-96-5
Opera_ID_805
2-hydroxyl-succinic acid
DL-Malic acid, 99%
MALIC ACID [II]
MALIC ACID [MI]
MALIC ACID,(DL)
2-Hydroxydicarboxylic acid
MALIC ACID [FCC]
SCHEMBL856
2-hydroxy-butanedioic acid
bmse000046
bmse000904
MALIC ACID [INCI]
EC 210-514-9
EC 230-022-8
MALIC ACID [VANDF]
Malic acid-, (L-form)-
DL-Malic acid, >=99%
HYOSCYAMINEHYDROBROMIDE
Oprea1_130558
Oprea1_624131
MALIC ACID [USP-RS]
MALIC ACID [WHO-DD]
butanedioic acid, 2-hydroxy-
DL-Malic acid-2-[13C]
DL-HYDROXYSUCOINIC ACID
Butanedioic acid, (.+-.)-
DL(+/-)-MALIC ACID
GTPL2480
2-HYDROXY-SUCCINIC ACID
DL-HYROXYBUTANEDIOIC ACID
CHEMBL1455497
DTXSID0027640
BDBM92495
MALIC ACID [EP MONOGRAPH]
MALIC ACID [USP IMPURITY]
DL-Malic acid, FCC, >=99%
HMS2358H06
HMS3371C13
DL-Malic acid, analytical standard
HY-Y1311
STR03457
(+/-)-HYDROXYSUCCINIC ACID
Tox21_201536
Tox21_300372
s9001
STL283959
HYDROXYBUTANEDIOIC ACID [HSDB]
AKOS000120085
AKOS017278471
(+/-)-HYDROXYBUTANEDIOIC ACID
AM81418
CCG-266122
DB12751
DL-Malic acid, ReagentPlus(R), 99%
NCGC00043225-02
NCGC00043225-03
NCGC00254259-01
NCGC00259086-01
DL-Malic acid, >=98% (capillary GC)
HYDROXYBUTANEDIOIC ACID, (+/-)-
SY003313
SY009804
DL-Malic acid, ReagentPlus(R), >=99%
DB-016133
DL-Malic acid 1000 microg/mL in Methanol
DL-Malic acid, USP, 99.0-100.5%
CS-0017784
E 296
EU-0067046
FT-0605225
FT-0625484
FT-0625485
FT-0625539
FT-0632189
M0020
DL-Malic acid, SAJ first grade, >=99.0%
EN300-19229
A19426
C00711
C03668
D04843
DL-Malic acid 1000 microg/mL in Acetonitrile
DL-Malic acid, Vetec(TM) reagent grade, 98%
M-0825
AB00443952-12
Malic acid, meets USP/NF testing specifications
4-ethoxyphenyltrans-4-propylcyclohexanecarboxylate
L023999
Q190143
Q-201028
0C9A2DC0-FEA2-4864-B98B-0597CDD0AD06
F0918-0088
Z104473230
Malic acid, United States Pharmacopeia (USP) Reference Standard
MALIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
Malic acid, Pharmaceutical Secondary Standard; Certified Reference Material
DL-Malic acid, meets analytical specification of FCC, E296, 99-100.5% (alkalimetric)

DL-MALIC ACID (CAS 6915-15-7)
DL-Malic acid (CAS 6915-15-7) is a white crystalline powder used in various laboratory applications, including organic synthesis and research.
DL-Malic acid (CAS 6915-15-7) is an organic compound with the molecular formula C4H6O5.


CAS Number: 6915-15-7
EC Number: 230-022-8
MDL number: MFCD00064212
Linear Formula: HO2CCH2CH(OH)CO2H
Molecular Formula: C4H6O5


DL-Malic acid (CAS 6915-15-7) is a white crystalline powder.
DL-Malic acid (CAS 6915-15-7) is an organic acid with the ability to form complexes with minerals.
DL-Malic acid (CAS 6915-15-7) is the most typical acid occurring in fruits, contributing to the sour taste.


DL-Malic acid (CAS 6915-15-7) is slight sour taste.
DL-Malic acid (CAS 6915-15-7) is soluble in water.
DL-Malic acid (CAS 6915-15-7) is an organic compound with the molecular formula C4H6O5.


DL-Malic acid (CAS 6915-15-7) is obtained as a white, or nearly white, crystalline powder or granules having a slight odour and a strongly acidic taste.
The product is DL-Malic acid (CAS 6915-15-7) in accordance with the standard of the Food Additive Specifications Compendium.
DL-Malic acid (CAS 6915-15-7) is almost odorless but does have a very slight peculiar odor and a peculiar acid taste.


DL-Malic acid (CAS 6915-15-7) is a white crystalline powder used in various laboratory applications, including organic synthesis and research.
Aside from adding tartness to foods and beverages, DL-Malic acid (CAS 6915-15-7) has been researched for a variety of health uses.
Malate, the ionized form of DL-Malic acid (CAS 6915-15-7), plays a small role in the Krebs Cycle, the primary way our bodies generate energy.


DL-Malic acid (CAS 6915-15-7) is the racemate of the metabolic intermediate L-malic acid.
DL-Malic acid (CAS 6915-15-7) reduces CCL2 and ICAM expression induced by IFN-gamma and TNF-alpha in HaCaT human keratinocytes when used at a concentration of 1 mM.


Topical administration of DL-Malic acid (CAS 6915-15-7) (10 mM) inhibits epidermis and dermis thickening, as well as mast cell and eosinophil dermal infiltration in a mouse model of atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNBC).
DL-Malic acid (CAS 6915-15-7) is soluble in water, ethanol, and acetone.


DL-Malic acid (CAS 6915-15-7) is a 2-hydroxydicarboxylic acid that is succinic acid in which one of the hydrogens attached to a carbon is replaced by a hydroxy group.
DL-Malic acid (CAS 6915-15-7) has a role as a food acidity regulator and a fundamental metabolite.


DL-Malic acid (CAS 6915-15-7) is a 2-hydroxydicarboxylic acid and a C4-dicarboxylic acid.
DL-Malic acid (CAS 6915-15-7) is functionally related to a succinic acid.
DL-Malic acid (CAS 6915-15-7) is a conjugate acid of a malate(2-) and a malate.


DL-Malic acid (CAS 6915-15-7) is an alpha hydroxy acid.
Don't confuse DL-Malic acid (CAS 6915-15-7) with other alpha hydroxy acids (AHAs).
DL-Malic acid (CAS 6915-15-7) is soluble in acetone, ether, water, methanol and ethanol.


DL-Malic acid (CAS 6915-15-7) is an organic compound.
DL-Malic acid (CAS 6915-15-7) is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive.


DL-Malic acid (CAS 6915-15-7) is not to be confused with Maleic Acid or Malonic Acid.
DL-Malic acid (CAS 6915-15-7) for Synthesis 6915-15-7 is a high-quality chemical reagent used in various laboratory applications, including organic synthesis and research.


DL-Malic acid (CAS 6915-15-7) is an organic acid with the ability to form complexes with metals, DL-Hydroxybutanedioic Acid.
DL-Malic acid (CAS 6915-15-7), CAS# 617-48-1, is a isomer of L-Malic Acid manufactured through chemical synthesis, available as White crystals or crystalline powder.


DL-Malic acid (CAS 6915-15-7) is widely used as acidity regulator.
DL-Malic acid (CAS 6915-15-7) is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E296.


DL-Malic acid (CAS 6915-15-7) is incompatible with bases, oxidizing agents, reducing agents and alkali metals.
DL-Malic acid (CAS 6915-15-7) is a dicarboxylic acid widely used as acidity regulator in food and beverage.
DL-Malic acid (CAS 6915-15-7) is soluble in methanol, ethanol, acetone and many other polar solvents.


Malic acid, also known as 2 - hydroxy succinic acid, has two stereoisomers due to the presence of an asymmetric carbon atom in the molecule.
There are three forms in nature, namely D malic acid, L malic acid and its mixture DL malic acid.
White crystalline or crystalline powder with strong moisture absorption, easily soluble in water and ethanol.


Have a special pleasant sour taste.
Malic acid is mainly used in food and medicine industry.
DL-Malic acid (CAS 6915-15-7) is a dicarboxylic acid with the chemical formula C4H6O5, which has two structures known as enantiomers.


L-malic acid occurs naturally in all organisms, while D-malic acid must be synthesized in the laboratory.
A mixture of D-malic acid and L-malic acid is called a racemic mixture, which is commonly known as DL-malic acid.
The Swedish chemist Carl Wilhelm Scheele first isolated malic acid from apple juice in 1785. Its name comes from “malum,” which is the Latin word for apple.


Malic acid is a major contributor to the sourness in apples, although its concentration decreases as the apple ripens.
DL-Malic acid (CAS 6915-15-7) is often formed in organisms as an intermediate product of metabolic reactions involving pyruvate.
DL-Malic acid (CAS 6915-15-7) also has many esters and salts known as malates that play critical biological roles.


Malates are a source of carbon dioxide in the Calvin cycle, and they are also an intermediate product in the citric acid cycle.
Malic Acid has two stereoisomeric forms (L- and D-enantiomers), although only the L-isomer exists naturally.
The salts and esters of Malic Acid are known as malates.


The malate anion is an intermediate in the citric acid cycle.
Malic acid has a clean, smooth taste and persistent sourness, allowing it to be blended with multiple food acids, sugars, high intensity sweeteners and flavours to create unique taste experiences.



USES and APPLICATIONS of DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) is used for biochemistry.
DL-Malic acid (CAS 6915-15-7) has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.
DL-Malic acid (CAS 6915-15-7) is an alpha hydroxy acid found in certain fruits and wines.


DL-Malic acid (CAS 6915-15-7)'s used in foods and cosmetics, and sometimes as medicine.
DL-Malic acid (CAS 6915-15-7) is sour and acidic.
This helps to clear away dead skin cells when applied to the skin.


DL-Malic acid (CAS 6915-15-7)'s source also helps to make more saliva in people with dry mouth.
DL-Malic acid (CAS 6915-15-7) is also involved in the Krebs cycle.
This is a process the body uses to make energy.


People commonly use DL-Malic acid (CAS 6915-15-7) for dry mouth.
DL-Malic acid (CAS 6915-15-7) is also used for acne, fibromyalgia, fatigue, wrinkled skin, and many other conditions, but there is no good scientific evidence to support these uses.


DL-Malic acid (CAS 6915-15-7) is used for the acidification of musts and wines in the conditions set by the regulation.
DL-Malic acid (CAS 6915-15-7) is used as a food additive.
DL-Malic acid (CAS 6915-15-7) is a component of some artificial vinegar flavors.


Further, DL-Malic acid (CAS 6915-15-7) is used in the preparation of chiral compounds, including κ-opioid residue.
DL-Malic acid (CAS 6915-15-7) is utilized for chiral resolution by ligand-exchange capillary electrophoresis.
DL-Malic acid (CAS 6915-15-7) is an alpha-hydroxy acid found in certain fruits and wines.


Some people take DL-Malic acid (CAS 6915-15-7) supplements to treat fatigue and dry mouth.
DL-Malic acid (CAS 6915-15-7) is also used to make some medicines, add flavor to food, and serve as a natural exfoliating ingredient in many products used to improve skin tone.


Crystallization grade DL-Malic acid (CAS 6915-15-7) is used for formulating screens or for optimization.
DL-Malic acid (CAS 6915-15-7) is used for general analytical applications: quantitative or qualitative work
DL-Malic acid (CAS 6915-15-7) is used in a wide variety of analytical techniques.


DL-Malic acid (CAS 6915-15-7) is also the primary flavor in rhubarb and is used to flavor “salt and vinegar” potato chips.
The uses of DL-malic acid generally relate to the role of malic acid in the production of chemical energy for both aerobic and anaerobic conditions. These uses include the management of discomfort, energy production, oral hygiene and general detoxification.


Oral hygiene support: DL-malic acid may have antiseptic properties that make it useful for maintaining oral hygiene.
Energy support: DL-malic acid may help to maintain normal energy levels, especially for chronic conditions characterized by fatigue.
Detoxification: DL-malic acid can bind metal ions such as aluminum and lead.


This effect can help to support general health, especially for the brain and liver.
Discomfort management: DL-malic acid may help to manage muscular discomfort due to chronic conditions.
This use is most applicable for conditions characterized by low oxygen levels.


D-malic acid is primarily used in health supplements, typically in the form of DL-malic acid.
DL-Malic acid (CAS 6915-15-7) is the synthesized form and is commonly used in beverages, confectionery, and personal care.
DL-Malic acid (CAS 6915-15-7) is used as an acidulant, an antioxidant flavouring agent, a buffering agent, and a chelating agent.


In pharmaceutical formulations, the substance is used as a general-purpose acidulant.
DL-Malic acid (CAS 6915-15-7) is also used as an alternative to citric acid in effervescent powders, mouthwashes, and tooth- cleaning tablets.
In addition, DL-Malic acid (CAS 6915-15-7) has chelating and antioxidant properties and may be used as a synergist, with butylated hydroxytoluene, to retard oxidation in vegetable oils.


DL-Malic acid (CAS 6915-15-7) is known as “best food acidity regulator” in biological and nutritional fields.
DL-Malic acid (CAS 6915-15-7) is widely used in foods such as wines, beverages, fruit juices and
chewing gums.


DL-Malic acid (CAS 6915-15-7) is not only the third food acidity regulator coming after citric acid and lactic acid, but also one of the biggest and most promising organic acids in food industry across the current world.
DL-Malic acid (CAS 6915-15-7) can be added in cool drinks, powder drinks, lactic acid drinks, milk drinks and fruit juice drinks to improve their tastes and flavors.


DL-Malic acid (CAS 6915-15-7) is capable of gelatinating pectin and therefore can be used for making fruitcakes, jelly fruit juice, puree, etc.
DL-Malic acid (CAS 6915-15-7) contains natural skin moisturizing elements.
DL-Malic acid (CAS 6915-15-7) is used as color-keeper and antiseptic of juice.


DL-Malic acid (CAS 6915-15-7) is a white crystals or crystalline powder, fairly hygroscopic, dissolving easily in water and alcohol.
This enables DL-Malic acid (CAS 6915-15-7) to dissolve “sticky matters” between dry scale- like dead cells easily, so as to smooth wrinkles on skin and make the skin tender, white, bright, clean and elastic.


For this reason, DL-Malic acid (CAS 6915-15-7) is very popular for its use in cosmetic formulae
DL-Malic Acid is used as acidulant, color retention agent, preservative and emulsion stabilizer in food industry, etc.
DL-Malic acid (CAS 6915-15-7) is commonly used as an acidulant, flavor enhancer, and pH regulator.


DL-Malic acid (CAS 6915-15-7) is used for research purposes only, not for human consumption.
Key applications of DL-Malic acid (CAS 6915-15-7): Buffer agent, Flavouring agent, Wine production, pH control, Acidifying agent, Personal care, and Anti-ageing products


DL-Malic acid (CAS 6915-15-7) is white crystal or crystalline powder with high water absorbability and easily soluble in water and ethanol.
DL-Malic acid can be used as an acidulant in cool drinks (including lactobacillus drinks, milk drinks, carbonated drinks, cola), frozen foods (including sherbet and ice cream),processed foods (including wine and mayonnaise).


DL-Malic acid (CAS 6915-15-7) is also used as emulsion stabilizer of egg yolk.
DL-Malic acid (CAS 6915-15-7) also can be used as intermediate, cosmetic,rinse, metal cleaner, buffering agent, retarder in textile industry, fluorescent whitening agent of polyester fibre.


As a acidulants, DL-Malic acid (CAS 6915-15-7) can be used in a wide variety of industries including: food production, beverage, pharmaceutical, cosmetics, agriculture/animal feed, and various other industries.
DL-Malic acid (CAS 6915-15-7) is widely used as acidity regulator.
DL-Malic acid (CAS 6915-15-7) is commonly used as an acidulant, flavor enhancer, and pH regulator in the food and beverage industry.


Formulations containing DL-Malic acid (CAS 6915-15-7) have been used as food and cosmetic preservatives and acidity regulators.
Food industry, DL-Malic acid (CAS 6915-15-7) is used as acidulants, color retention agents, preservatives and emulsion stabilizers such as egg yolk, also used in pharmaceutical.


-Organic synthesis:
DL-Malic acid (CAS 6915-15-7) is often used as a starting material or intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.

Its versatile nature and reactivity make DL-Malic acid (CAS 6915-15-7) a valuable compound in organic chemistry.
As a acidulants, DL-Malic acid (CAS 6915-15-7) can be used in a wide variety of industries including: food production, beverage, pharmaceutical, cosmetics, agriculture/animal feed, and various other industries.


-Food and beverage industry:
DL-Malic acid (CAS 6915-15-7) is commonly used as an acidulant, flavor enhancer, and pH regulator in the food and beverage industry.
DL-Malic acid (CAS 6915-15-7) provides a pleasant tart taste and helps preserve the freshness of many products, including fruit juices, carbonated beverages, and confectionery items.



SKINCARE USES OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) is an alpha hydroxy acid, which is said to be a natural exfoliator.
DL-Malic acid (CAS 6915-15-7) may be used to smooth wrinkles and fine lines, improve skin texture, cleanse pores, and improve overall skin.
Because of this, DL-Malic acid (CAS 6915-15-7) has been used in various skincare products.

A small study published in 2013 found DL-Malic acid (CAS 6915-15-7) to be beneficial in the treatment of melasma, a common disorder marked by patches of abnormally dark skin.
For the study, researchers assigned people with melasma to a skin-care regimen that included DL-Malic acid (CAS 6915-15-7), along with vitamin C.

At the end of the study, researchers concluded that using DL-Malic acid (CAS 6915-15-7) as a regular part of a skincare regimen could help improve the appearance of melasma.
It should be pointed out that this study used a combination of DL-Malic acid (CAS 6915-15-7) and vitamin C.

This means that even though the researchers concluded that DL-Malic acid (CAS 6915-15-7) was a beneficial component of the study, there is no way to know if the results were because of the DL-Malic acid (CAS 6915-15-7) alone, the vitamin C alone, or a combination of both.



INDUSTRIES OF DL-MALIC ACID (CAS 6915-15-7):
*Beauty & Personal Care
*Food & Nutrition



FUNCTIONAL CLASS OF DL-MALIC ACID (CAS 6915-15-7):
Flavouring Agent
FLAVOURING_AGENTFood Additives
ACIDITY_REGULATOR



FUNCTIONS OF APPLICATIONS OF DL-MALIC ACID (CAS 6915-15-7):
(1) In food industry:
DL-Malic acid (CAS 6915-15-7) can be used in the processing and concoction of beverage, liqueur, fruit juice and the manufacture of candy and jam etc.
DL-Malic acid (CAS 6915-15-7) also has effects of bacteria inhibition and antisepsis and can remove tartrate during wine brewing.

(2) In tobacco industry:
DL-Malic acid (CAS 6915-15-7) derivative (such as esters) can improve the aroma of tobacco.

(3)In pharmaceutical industry:
The troches and syrup compounded with DL-Malic acid (CAS 6915-15-7) have fruit taste and can facilitate their absorption and diffusion in the body.



RESEARCH AND DEVELOPMENT OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic Acid is extensively used in scientific research and development for its unique properties.
DL-Malic acid (CAS 6915-15-7) is often employed as a standard in analytical techniques, such as chromatography, to calibrate and validate analytical instruments.



PRECAUTIONS AND HANDLING OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) for Synthesis is intended for laboratory use only.
DL-Malic acid (CAS 6915-15-7) is not suitable for human consumption and should be handled with care.
When working with DL-Malic acid (CAS 6915-15-7), it is important to observe good laboratory practices, including wearing appropriate personal protective equipment, such as gloves and safety goggles.



STORAGE OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) should be stored in a cool, dry place away from direct sunlight and sources of heat.
When stored properly, DL-Malic acid (CAS 6915-15-7) has a long shelf life and can be used for an extended period of time.



PACKAGING OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) for Synthesis is available in various packaging options to suit different needs.
DL-Malic acid (CAS 6915-15-7) is commonly supplied in tightly sealed containers, such as glass bottles or plastic bags, to ensure its quality and integrity during transportation and storage.



FUNCTIONS OF DL-MALIC ACID (CAS 6915-15-7):
1.Pain release and reduce the feeling of tiredness or fibromyalgia.
This make it useful in medicine or some health product making.
2.Energy improvement.
3.Food Additive: In foods, DL-Malic acid (CAS 6915-15-7) is used as a flavoring additive to give food a tart taste.
4. Skin care or protection: DL-Malic acid (CAS 6915-15-7) is also a common additive to skin care products.
DL-Malic acid (CAS 6915-15-7) has been used in skin products for its exfoliating ability.



PURITY OF DL-MALIC ACID (CAS 6915-15-7):
The DL-Malic acid (CAS 6915-15-7) for Synthesis is guaranteed to have a minimum purity of 98%.
This high level of purity ensures accurate and reliable results in scientific experiments and research.



PROPERTIES OF DL-MALIC ACID (CAS 6915-15-7):
1. Compared with citric acid, malic acid has higher acidity (20 percent higher)
2. DL-Malic acid (CAS 6915-15-7) has lower quantity of heat, softer taste, higher buffering factor and more lasting time
3. DL-Malic acid (CAS 6915-15-7) contains natural skin moisturizing elements



CHEMICAL FORMULA AND MOLECULAR WEIGHT OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) has a chemical formula of C4H6O5 and a molecular weight of 134.09 g/mol.



SIGNS YOU MAY NEED DL-MALIC ACID (CAS 6915-15-7):
Chronic conditions characterized by discomfort and fatigue are some of the most common indications that you may need DL-Malic acid (CAS 6915-15-7), especially fibromyalgia and chronic fatigue syndrome.

DL-Malic acid (CAS 6915-15-7) may also help with other conditions that cause discomfort in the muscles, tendons and ligaments.
The presence of metal-based toxins is another condition that may mean you need DL-Malic acid (CAS 6915-15-7).
You may also benefit from DL-Malic acid (CAS 6915-15-7) if you have infections in the mouth due to low saliva production.


SOLUBILITY OF DL-MALIC ACID (CAS 6915-15-7):
DL-Malic acid (CAS 6915-15-7) is highly soluble in water, ethanol, and acetone.
This makes DL-Malic acid (CAS 6915-15-7) easy to incorporate into various solvents and solutions, allowing for versatile use in the laboratory.



KIDNEY STONES, DL-MALIC ACID (CAS 6915-15-7):
Kidney stones are painful and can affect many people.
DL-Malic acid (CAS 6915-15-7) has been researched for its potential role in preventing and treating kidney stones.

In one preliminary study set in a lab, DL-Malic acid (CAS 6915-15-7) was found to increase urine pH levels, making kidney stone formation less likely.
The researchers concluded that DL-Malic acid (CAS 6915-15-7) supplementation might help treat calcium kidney stones.

A 2016 review on the importance of a healthy diet to prevent kidney stones suggested pears could be a potential treatment option.
Per the review, the DL-Malic acid (CAS 6915-15-7) in pears may be used to prevent the formation of kidney stones.
This is because DL-Malic acid (CAS 6915-15-7) is a precursor for citrate, a compound that inhibits crystal growth in the kidneys.



FIBROMYALGIA, DL-MALIC ACID (CAS 6915-15-7):
A pilot study from 1995 found that taking DL-Malic acid (CAS 6915-15-7) in combination with magnesium helped alleviate pain and tenderness in people with fibromyalgia.

In the small study, researchers assigned 24 people with fibromyalgia to treatment with either a placebo or a combination of DL-Malic acid (CAS 6915-15-7) and magnesium.
After six months, those treated with the DL-Malic acid (CAS 6915-15-7)/magnesium combination showed a significant improvement in pain and tenderness.

However, because a combination of magnesium and DL-Malic acid (CAS 6915-15-7) was used in the study, we do not know which was responsible for the positive results.
There remains a lack of more recent research on DL-Malic acid (CAS 6915-15-7)'s effectiveness as a fibromyalgia treatment.



DRY MOUTH, DL-MALIC ACID (CAS 6915-15-7):
The use of a 1% oral DL-Malic acid (CAS 6915-15-7) spray has been explored as a treatment for dry mouth.
One study evaluated people with dry mouth caused by antidepressants.
Participants were randomized to receive either a 1% DL-Malic acid (CAS 6915-15-7) spray or a placebo.

After two weeks of using the sprays as needed, those using the DL-Malic acid (CAS 6915-15-7) spray had improved dry mouth symptoms and increased rates of saliva flow.
Similar results were seen in a different study looking at DL-Malic acid (CAS 6915-15-7) for dry mouth caused by blood pressure medications.
At the end of this two-week study, participants who used the 1% DL-Malic acid (CAS 6915-15-7) spray had less dry mouth and more saliva compared with the placebo group.



PHYSICAL and CHEMICAL PROPERTIES of DL-MALIC ACID (CAS 6915-15-7):
CAS Number: 6915-15-7
Molecular Weight: 134.09
FEMA Number: 2655
Beilstein: 1723539
EC Number: 230-022-8
MDL number: MFCD00064212
Physical state: powder
Color: white
Odor: characteristic
Melting point/freezing point:
Melting point/range: 131 - 133 °C - lit.
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: 203 °C
Autoignition temperature: 340 °C
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility 646,6 g/l at 20 °C - completely soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: < 0,1 hPa at 20 °C
Density: 1,6 g/cm3 at 20 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
CAS number: 6915-15-7
EC number: 230-022-8
Hill Formula: C₄H₆O₅
Molar Mass: 134.09 g/mol
HS Code: 2918 19 98
Density: 1.6 g/cm3 (20 °C)
Flash point: 203 °C

Ignition temperature: 349 °C
Melting Point: 131 - 133 °C
pH value: 2.3 (10 g/l, H₂O, 20 °C)
Vapor pressure: Bulk density: 800 kg/m3
Solubility: 558 g/l
Molecular Weight: 134.09 g/mol
XLogP3: -1.3
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 3
Exact Mass: 134.02152329 g/mol
Monoisotopic Mass: 134.02152329 g/mol
Topological Polar Surface Area: 94.8Ų
Heavy Atom Count: 9
Formal Charge: 0
Complexity: 129
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula / Molecular Weight: C4H6O5 = 134.09
Physical State (20 deg.C): Solid
CAS RN: 6915-15-7
Reaxys Registry Number: 1723539
PubChem Substance ID: 87572138
Merck Index (14): 5707
MDL Number: MFCD00064212
CAS: 6915-15-7
Molecular Formula: C4H6O5
Molecular Weight (g/mol): 134.087
MDL Number: MFCD00064212
InChI Key: BJEPYKJPYRNKOW-UHFFFAOYSA-N
PubChem CID: 525
ChEB: CHEBI:6650
IUPAC Name: 2-hydroxybutanedioic acid
SMILES: C(C(C(=O)O)O)C(=O)O

Melting Point: 128.0°C to 132.0°C
Assay Percent Range: 99+%
Linear Formula: HO2CCH2CH(OH)CO2H
Solubility Information: Solubility in water: 558g/L (20°C).
Other solubilities: 82.70 g/100 g methanol-17.75 g/100 g
acetone (20°C, 45.53 g/100 g ethanol-20.70 g/ 100 g)
dioxane (20°C, 0.84 g/100 g diethyl ether (20°C),
practically insoluble in benzene
Formula Weight: 134.09
Percent Purity: 99+%
Flash Point: 203°C
Chemical Name or Material: DL-Malic acid
CAS: 617-48-1
Molecular Formula: C4H6O5
Molecular Weight: 134.09
Storage Details: Ambient
Harmonised Tariff Code: 29181998 EXP 2918199890 IMP
Molecular Formula: C4H6O5
Molecular Weight: 134.08864
InChI: InChI=1/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m1/s1

CAS Registry Number: 617-48-1;6915-15-7
EINECS: 210-514-9
Melting point: 130-132℃
Boiling point: 306.4°C at 760 mmHg
Flash point: 153.4°C
Water solubility: 558 g/L (20℃)
Vapour Pressur: 7.19E-05mmHg at 25°C
CAS Number: 6915-15-7
Synonyms: DL-Malic acid, DL-Hydroxysuccinic acid, Hydroxybutanedioic acid
Chemical formula: C4H6O5
Molecular weight: 134.09 g/mol
Purity: ≥ 98%
Solubility: Soluble in water, ethanol, and acetone
Molecular Formula: C4H6O5
Molar Mass: 134.09
Density: 1,609 g/cm3
Melting Point: 131-133°C(lit.)
Boling Point: 150℃[at 101 325 Pa]
Specific Rotation(α): [α]D20 -0.5~+0.5° (c=5, H2O)
Flash Point: 203°C

Water Solubility: 500g/L at 25℃
Solubility: Soluble in water, alcohol, slightly soluble in ether, insoluble in benzene.
Vapor Presure: Vapor Density: 4.6 (vs air)
Appearance: White crystal or crystalline powder
Color: White to Off-White
pKa: pK1:3.458;pK2:5.097 (25°C)
Storage Condition: Refrigerator
Stability: Stable.
Incompatible with strong oxidizing agents, strong bases, amines, alkali metals, carbonates.
Sensitive: Sensitive to light
MDL: MFCD00064212
MDL:MFCD00064212
InChIKey:BJEPYKJPYRNKOW-UHFFFAOYSA-N
Inchi:1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)
SMILES:O([H])C([H])(C(=O)O[H])C([H])([H])C(=O)O[H]
BRN:1723539
Exact Mass: 134.02200
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 5

Rotatable Bond Count: 3
Monoisotopic Mass: 134.02152329 g/mol
Heavy Atom Count: 9
Complexity: 129
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
XLogP3: -1.3
Tautomer Count: nothing
Surface Charge: 0
Topological Polar Surface Area: 94.8
Molecular Weight: 134.09
LogP: -1.09340
PSA: 94.83000

Merck: 5707
Refractive Index: 1.3920 (estimate)
Water Partition Coefficient: 558G/L(20ºC)
Boiling Point: 306.4°C at 760 mmHg
Melting Point: 131-133 °C (lit.)
Vapor Pressure: Flash Point: 203ºC
Solubility: methanol: 0.1 g/mL, clear, colorless
Color/Form: Powder
PH: 2.3 (10g/l, H2O, 20℃)
Solubility: It is easily soluble in water and ethanol, but poorly soluble in ether and benzene.
It is easy to deliquesce, and the pH value of 1% aqueous solution is 2.34.
Sensitiveness: Sensitive to light
pka: 3.4(at 25℃)
Optical Activity: [α]/D −0.10 to +0.10°
Density: 1.609
Odor: Characteristic



FIRST AID MEASURES of DL-MALIC ACID (CAS 6915-15-7):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available



ACCIDENTAL RELEASE MEASURES of DL-MALIC ACID (CAS 6915-15-7):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.



FIRE FIGHTING MEASURES of DL-MALIC ACID (CAS 6915-15-7):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.



EXPOSURE CONTROLS/PERSONAL PROTECTION of DL-MALIC ACID (CAS 6915-15-7):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.



HANDLING and STORAGE of DL-MALIC ACID (CAS 6915-15-7):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.



STABILITY and REACTIVITY of DL-MALIC ACID (CAS 6915-15-7):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available



SYNONYMS:
DL-MALIC ACID
2-HYDROXYBUTANEDIOIC ACID
HYDROXYSUCCINIC ACID
2-HYDROXYBUTANEDIOIC ACID
(±)-2-Hydroxysuccinic acid
DL-Hydroxybutanedioic acid
DL-Hydroxysuccinic acid
Hydroxybutanedioic acid
DL-Hydroxysuccinic acid
malic acid
DL-malic acid
6915-15-7
2-Hydroxybutanedioic acid
2-Hydroxysuccinic acid
617-48-1
malate
hydroxysuccinic acid
Butanedioic acid, hydroxy-
Kyselina jablecna
hydroxybutanedioic acid
Pomalus acid
Malic acid, DL-
Deoxytetraric acid
Hydroxybutandisaeure
Musashi-no-Ringosan
Caswell No. 537
Monohydroxybernsteinsaeure
FDA 2018
R,S(+-)-Malic acid
alpha-Hydroxysuccinic acid
Malicum acidum
Pomalous acid
DL-2-hydroxybutanedioic acid
Succinic acid, hydroxy-
FEMA Number 2655
2-Hydroxyethane-1,2-dicarboxylic acid
Malic acid [NF]
Aepfelsaeure
FEMA No. 2655
CCRIS 2950
CCRIS 6567
(+/-)-Malic acid
EPA Pesticide Chemical Code 051101
HSDB 1202
d,l-malic acid
AI3-06292
H2mal
EINECS 210-514-9
EINECS 230-022-8
UNII-817L1N4CKP
NSC 25941
NSC-25941
Apple acid
817L1N4CKP
CHEBI:6650
INS NO.296
DTXSID0027640
E296
INS NO. 296
INS-296
Malic acid, L-
L-Malic acid-1-13C
BUTANEDIOIC ACID, HYDROXY-, (S)-
MLS000084707
DTXCID107640
E-296
(+-)-1-Hydroxy-1,2-ethanedicarboxylic acid
dl-Hydroxybutanedioic acid
EC 210-514-9
EC 230-022-8
NSC25941
Malic acid (NF)
DL-MALIC-2,3,3-D3 ACID
SMR000019054
DL-Apple Acid
HYDROXYBUTANEDIOIC ACID, (+/-)-
MALIC ACID (II)
MALIC ACID [II]
(R)-Hydroxybutanedioic acid
(S)-Hydroxybutanedioic acid
MALIC ACID (USP-RS)
MALIC ACID [USP-RS]
(+-)-Malic acid
R-Malic acid
MALIC ACID (EP MONOGRAPH)
MALIC ACID (USP IMPURITY)
MALIC ACID [EP MONOGRAPH]
MALIC ACID [USP IMPURITY]
Butanedioic acid, 2-hydroxy-, (2S)-
CAS-6915-15-7
L-(-)-MalicAcid
Hydroxybutanedioic acid, (-)-
(+-)-Hydroxysuccinic acid
NSC 9232
MFCD00064213
Hydroxybutanedioic acid, (+-)-
Racemic malic acid
180991-05-3
(+/-)-HYDROXYSUCCINIC ACID
MFCD00064212
Malic Acid1524
.+-.-Malic acid
Opera_ID_805
2-hydroxyl-succinic acid
DL-Malic acid, 99%
MALIC ACID [MI]
MALIC ACID,(DL)
2-Hydroxydicarboxylic acid
MALIC ACID [FCC]
SCHEMBL856
2-hydroxy-butanedioic acid
bmse000046
bmse000904
MALIC ACID [INCI]
MALIC ACID [VANDF]
Malic acid-, (L-form)-
DL-Malic acid, >=99%
HYOSCYAMINEHYDROBROMIDE
Oprea1_130558
Oprea1_624131
MALIC ACID [WHO-DD]
butanedioic acid, 2-hydroxy-
Butanedioic acid, (.+-.)-
GTPL2480
2-HYDROXY-SUCCINIC ACID
CHEMBL1455497
BDBM92495
DL-Malic acid, FCC, >=99%
HMS2358H06
HMS3371C13
DL-Malic acid, analytical standard
HY-Y1311
STR03457
Tox21_201536
Tox21_300372
s9001
HYDROXYBUTANEDIOIC ACID [HSDB]
AKOS000120085
AKOS017278471
AM81418
CCG-266122
DB12751
DL-Malic acid, ReagentPlus(R), 99%
NCGC00043225-02
NCGC00043225-03
NCGC00254259-01
NCGC00259086-01
DL-Malic acid, >=98% (capillary GC)
SY003313
SY009804
DL-Malic acid, ReagentPlus(R), >=99%
DL-Malic acid 1000 microg/mL in Methanol
DL-Malic acid, USP, 99.0-100.5%
CS-0017784
E 296
EU-0067046
FT-0605225
FT-0625484
FT-0625485
FT-0625539
FT-0632189
M0020
DL-Malic acid, SAJ first grade, >=99.0%
EN300-19229
A19426
C00711
C03668
D04843
DL-Malic acid, Vetec(TM) reagent grade, 98%
M-0825
AB00443952-12
Malic acid, meets USP/NF testing specifications
4-ethoxyphenyltrans-4-propylcyclohexanecarboxylate
L023999
Q190143
Q-201028
0C9A2DC0-FEA2-4864-B98B-0597CDD0AD06
F0918-0088
Z104473230
MALIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION)
Malic acid, United States Pharmacopeia (USP) Reference Standard
MALIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
Malic acid, Pharmaceutical Secondary Standard; Certified Reference Material
DL-Malic acid, meets analytical specification of FCC, E296, 99-100.5% (alkalimetric)
(±)-2-Hydroxysuccinic acid or DL-Hydroxybutanedioic acid
HO2CCH2CH(OH)CO2H
(+/-)-2-HYDROXYSUCCINIC ACID
DL-APPLE ACID
DL-HYDROXYBUTANEDIOIC ACID
DL-HYDROXYSUCCINIC ACID
DL-HYDROXYSUCOINIC ACID
DL-HYROXYBUTANEDIOIC ACID
DL-MALATE
DL(+/-)-MALIC ACID
DL-MALIC ACID
(+/-)-HYDROXYBUTANEDIOIC ACID
(+/-)-HYDROXYSUCCINIC ACID
(+/-)-MALIC ACID
MALIC ACID
MALIC ACID, DL-
alpha-Hydroxysuccinic acid
alpha-hydroxysuccinicacid
Butanedioic acid, hydroxy-
commonmalicacid
Deoxytetraric acid
deoxytetraricacid
DL-Hydroxysuccinic acid
Malicacidpfelsure
2-hydroxybutanedioic acid
(2R)-2-hydroxybutanedioate
Malic acid
Butanedioic acid, 2-hydroxy-
Malic acid
Butanedioic acid, hydroxy-
2-Hydroxybutanedioic acid
α-Hydroxysuccinic acid
Hydroxysuccinic acid
2-Hydroxyethane-1,2-dicarboxylic acid
Pomalus Acid
Deoxytetraric acid
2-Hydroxysuccinic acid
Musashi-no-Ringosan
Hydroxybutanedioic acid
dl-Malic acid
FDA 2018
(±)-Malic acid
DL-Malic acid
R,S(±)-Malic acid
E 296
NSC 25941
Nanoveson M
Xeros
Monohydroxybutanedioic acid
Purac Powder MA
Purac MA
Fuso M
DN 1992
MeSH ID: D008293
C00711
Malic acid
DL-Malic acid
MALIC ACID, DL-
Malicacidpfelsure
Musashi-no-Ringosan
DL-Hydroxysuccinic acid
2-hydroxybutanedioic acid
(2R)-2-hydroxybutanedioate



DL-Methionine
DL-2-Amino-4-(Methylthio)butyric Acid; Racemethionine; (±)-2-Amino-4-(methylmercapto)butyric acid; Methilonin; Acimetion; alpha-Amino-gamma-methylmercaptobutyric acid; Banthionine; Cynaron; cas no: 59-51-8
DL-TARTARIC ACID
DL-Tartaric acid is used as a synergist for antioxidants, emulsifier, sequestrant and flavoring agent.
It is also added with citric acid to prepare effervescent salts, thereby enhancing the taste of oral medications.
It is also utilized in pigments, processing aids, ink, toner and colorant products.

CAS: 133-37-9
MF: C4H6O6
MW: 150.09
EINECS: 205-105-7

Synonyms:
DL-Tartaric acid; 2,3-Dihydroxysuccinic acid; tartaric acid; 2,3-Dihydroxybutanedioic acid; 526-83-0; 133-37-9; Racemic acid; Uvic acid; Traubensaure; Racemic tartaric acid; DL-Tartrate; Paratartaric acid; Paratartaric aicd; BUTANEDIOIC ACID, 2,3-DIHYDROXY-; Resolvable tartaric acid; NSC62778; Tartaric acid D,L; Baros; CHEBI:15674; dl-2,3-dihydroxybutanedioic acid; (2RS,3RS)-Tartaric acid; tartrate; E-7050 (2S,3S)-2,3-dihydroxysuccinic acid; NSC 148314; Tartaric acid, L-(+)-; 2,3-dihydroxy-succinic acid; C4H6O6; 1007601-97-9; Butanedioic acid, 2,3-dihydroxy-(R*,R*)-(.+/-.)-; Butanedioic acid, 2,3-dihydroxy-, (R*,R*)-; Tartaric acid (VAN); Kyselina vinna [Czech]; NSC155080; Tartaric acid [USAN:JAN]; 2,3-Dihydrosuccinic acid; (.+-.)-Tartaric acid; DTXSID5046986; d-alpha,beta-Dihydroxysuccinic acid; MFCD00071626; NSC-148314; Kyselina 2,3-dihydroxybutandiova [Czech]; (+) tartaric acid; (-) tartaric acid; 1,2-dicarboxylic acid; WLN: QVYQYQVQ; (-) D-Tartaric acid; Sal tartar (Salt/Mix); Tartaric acid, (DL)-; Butanedioic acid, 2,3-dihydroxy- (R-(R*,R*))-; Butanedioic acid, 2,3-dihydroxy-, [S-(R*,R*)]-; Malic acid, 3-hydroxy-; 2,3-Dihydroxysuccinicacid; Succinic acid,3-dihydroxy; SCHEMBL848; bmse000167; Succinic acid,3-dihydroxy-; (.+/-.)-Tartaric acid; Oprea1_827092; TARTARIC ACID, (L); Tartaric acid, (.+-.)-; Butanedioic acid,3-dihydroxy-; CHEMBL333714; Dihydroxysuccinic acid, (DL)-; Tartaric acid, (.+/-.)-; DTXCID3026986; DTXSID501031477; HMS3370M15; (+)-2,3-dihydroxybutanedioic acid; BCP14303; Tox21_302052; MFCD00064206; NSC133735; NSC148314; NSC608773; s2997; 2,3-Dihydroxysuccinic acid, (DL)-; 3-carboxy-2,3-dihydroxypropanoic acid; AKOS000120086; AKOS016844048; NSC-133735; NSC-608773; SB44180; SB44181; SMP2_000051; d-.alpha.,.beta.-Dihydroxysuccinic acid; NCGC00256063-01; NCGC00347131-03; AS-10983; CAS-133-37-9; NCI60_001102; (+)-2,3-dihydroxy-1,4-butanedioic acid; AM20110247; CS-0022654; FT-0624346; FT-0625514; FT-0628018; FT-0628243; FT-0656080; FT-0772946; FT-0773804; NS00078822; NS00079339; NS00079739; T0001; (+/-)-2,3-dihydroxy-1,4-butanedioic acid; EN300-19175; A22866; Butanedioic acid,3-dihydroxy- [R-(R*,R*)]-; A829202; Q194322; Butanedioic acid,3-dihydroxy-, (R*,R*)-(.+-.)-; F2191-0230; Z104473036; 1,2-Dihydroxyethane-1,2-dicarboxylic acid; 2,3-Dihydrosuccinic acid; (2S,3S)-(-)-Tartaric acid; D(-)-Threaric acid; D(-)-Dihydroxysuccinic acid; Copper, mixt. with [R-(R*,R*)]-2,3-dihydroxybutanedioic acid monopotassium salt.

It acts as a chelating agent in metal and farming industries.
Further, it is used as lubricant and grease. It is mixed with sodium bicarbonate and used as a leavening agent in food preparation.
In the pharmaceutical industry, it is utilized in the preparation of tartar emetic, which is used in cough syrup as an expectorant.

DL-Tartaric acid is a calcium salt of tartaric acid.
It is used as a standard in the analysis of total calcium and tartaric acid content in beverages, wines, foodstuffs, and pharmaceuticals.
DL-Tartaric acid can be used to prepare standard solutions for the determination of benzalkonium chloride and other natural compounds by chromatographic methods.
The rate constants for the reaction between DL-tartaric acid and calcium pantothenate have been determined by electrochemical impedance spectroscopy.
The fluorescence intensity of chemiluminescent reactions with DL-tartaric acid has been found to be proportional to the concentration of tartrate ions in solution.
X-ray diffraction data confirm that DL-tartaric acid is an orthorhombic crystal system with space group P2/c.


DL-Tartaric acid Chemical Properties
Melting point: 210-212 °C(lit.)
Boiling point: 191.59°C (rough estimate)
Alpha: [α]D20 -0.2~+0.2° (c=20, H2O)
Density: 1.788
Vapor pressure: <0.1 hPa (20 °C)
FEMA: 3044 | TARTARIC ACID (D-, L-, DL-, MESO-)
Refractive index: 1.5860 (estimate)
Fp: 210 °C
Storage temp: Store below +30°C.
Solubility: H2O: 0.1 g/mL, clear
Form: Liquid
Pka: 3.03, 4.37(at 25℃)
Color: White
PH: 3.19(1 mM solution);2.58(10 mM solution);2.03(100 mM solution);
Odor: at 100.00 %. very mild caramellic
Odor Type: odorless
Water Solubility: soluble
Merck: 14,9069
JECFA Number: 621
BRN: 1725148
Dielectric constant: 35.9(-10℃)
Stability: Stable. Incompatible with bases, oxidizing agents, reducing agents, silver.
InChIKey: FEWJPZIEWOKRBE-UHFFFAOYSA-N
LogP: -1.43
CAS DataBase Reference: 133-37-9(CAS DataBase Reference)
NIST Chemistry Reference: DL-Tartaric(133-37-9)

Chemical Properties
DL-Tartaric acid is a water- and alcohol-soluble colorless crystalline solid with a characteristic acid taste and a melting temperature of 170°C(338°F).
Naturally occurring tartaric acid is generally of the L-configuration (based on the absolute configuration of D-glyceric acid).
The L-forms of tartrates are dextrorotatory in solution and thus are designated as L(+)-tartrates.
It is also known as dihydroxy succinic acid.
Tartaric acid is used as a chemical intermediate and a sequestrant,as well as in tanning, effervescent beverages, baking powder, ceramics, photography, textile processing,mirror silvering,and metal coloring.

Uses
DL-Tartaric acid is used as a synergist for antioxidants, emulsifier, sequestrant and flavoring agent.
It is also added with citric acid to prepare effervescent salts, thereby enhancing the taste of oral medications.
It is also utilized in pigments, processing aids, ink, toner and colorant products.
It acts as a chelating agent in metal and farming industries.
Further, it is used as lubricant and grease.
It is mixed with sodium bicarbonate and used as a leavening agent in food preparation.
In the pharmaceutical industry, it is utilized in the preparation of tartar emetic, which is used in cough syrup as an expectorant.

In the Debus–Radziszewski reaction as a weak acid for the synthesis of imidazolium ionic liquid.
As an additive in electrochemical deposition technique for the synthesis of bismuth thin films to be used as X-ray absorbers.
As a complexing agent for the synthesis of nano-crystalline indium tin oxide (ITO) powder.
As a dopant for the synthesis of polyaniline nanofibers and nanotubes by oxidation polymerization.

Preparation
The tartrates used in commerce are obtained as a by-product of wine manufacture and have the L(+) configuration. Produced from argols or wine lees, which are formed in the manufacture of wine by extracting the potassium acid tartrate, transforming this into the calcium salt and then acidifying with dilute sulfuric acid; also by oxidation of d-glucose with nitric acid.
The dl-tartaric acid is obtained by boiling the d-tartaric acid with an aqueous solution of NaOH or by oxidation of fumaric acid.
The l- and the meso-tartaric acid are also known, but are less important.
DL-TARTARIC ACID
CAS NUMBER: 133-37-9

EC NUMBER: 205-695-6

MOLECULAR FORMULA: COOH(CHOH)2COOH

MOLECULAR WEIGHT: 150.09 g/mol

IUPAC NAME: (2S,3S)-2,3-dihydroxybutanedioic acid



DL-Tartaric Acid is the D-enantiomer of tartaric acid.
DL-Tartaric Acid has a role as an Escherichia coli metabolite.

DL-Tartaric Acid is a conjugate acid of a D-tartrate(1-).
DL-Tartaric Acid is an enantiomer of a L-tartaric acid.

DL-Tartaric Acid is a metabolite found in or produced by Escherichia coli
DL-Tartaric Acid is a white crystalline dicarboxylic acid found in many plants, particularly tamarinds and grapes.
DL-Tartaric Acid is used to generate carbon dioxide through interaction with sodium bicarbonate following oral administration.

DL-Tartaric Acid has been used as food additives such as sour seasonings.
DL-Tartaric Acid can also widely be used as industrial chemicals such as starting materials for detergents.

DL-Tartaric Acid is used as an acidulant, pH control, and flavorant in wine.
DL-Tartaric Acid is also used as an anti-microbial agent

In the pharmaceutical industry, DL-Tartaric Acid is used as an excipient for drugs with poor solubility at higher pH levels.
DL-Tartaric Acid is used as an anti-set agent in cement formulations in the construction industry.

DL-Tartaric Acid is a white, crystalline powder.
DL-Tartaric Acid is mainly used in the food industry as an acidulant or ingredient producing emulsifier

DL-Tartaric Acid can be used as a starting material for pyruvate.
DL-Tartaric Acid is widely used as beverages and other food acidifier, similar to the use and citric acid.

DL-Tartaric Acid also used as split agent for pharmaceutical, food additives, chemical and biological reagents
DL-Tartaric Acid is a colorless and semi-transparent or white powder, with a sour taste.

DL-Tartaric Acid can be used as a beer vesicant, foodstuff sourness agent, and flavoring etc.
DL-Tartaric Acid is also very important for the tannage, photograph, glass, enamel and telecommunication equipment industries.

DL-Tartaric Acid can be used to produce a blueprint
DL-Tartaric Acid is used for chromatographic analysis of reagent and a masking agent.

DL-Tartaric Acid's usage also covers the construction industry as a retarder, metal complexing agent for electroplating industry.
DL-Tartaric Acid is a dicarboxylic acid available as a white crystalline powder.

DL-Tartaric Acid can be used in areas below:
-As an acidulant, or ingredient producing emulsifier in the food industry;
-As retarder in the construction industry;
-As an intermediate, resolving agent or salt-forming agent in the pharmaceutical industry;
-As a complexing agent, chelating agent or antiscaling agent in the electroplating and polishing industry;
-As fruit acid in the cosmetic industry.

USES:
DL-Tartaric Acid is a white, crystalline acid
DL-Tartaric Acid is widely used as an intermediate or resolving agent in the pharmaceutical industry.
DL-Tartaric Acid is white powder

DL-Tartaric Acid widely used in the food industry
DL-Tartaric Acid is used as a foaming agent of beer

DL-Tartaric Acid also used as an acid taste agent
DL-Tartaric Acid can be used as a taste modified agent

DL-Tartaric Acid is mainly used to make tartaric acid salts, like potassium sodium tartrate
DL-Tartaric Acid can also be served as a beer vesicant, foodstuff sourness agent and flavouring etc.

DL-Tartaric Acid's chemical formula is HOOC(CHOH)2COOH
DL-Tartaric Acid is a water- and alcohol-soluble colourless crystalline solid

DL-Tartaric Acid has an acid taste
DL-Tartaric Acid's melting point is 170°C
DL-Tartaric Acid is also known as dihydroxy succinic acid.

DL-Tartaric Acid is used as:
-a chemical intermediate
-a sequestrant, as well as in tanning
-effervescent beverages
-baking powder
-ceramics
-photography
-textile processing
-mirror silvering
-metal colouring

DL-Tartaric Acid is an alpha-hydroxy-carboxylic acid
DL-Tartaric Acid is diprotic and aldaric in acid characteristics


PHYSICAL PROPERTIES:

-Molecular Weight: 150.09 g/mol

-XLogP3-AA: -1.9

-Exact Mass: 150.01643791 g/mol

-Monoisotopic Mass: 150.01643791 g/mol

-Topological Polar Surface Area: 115Ų

-Physical Description: Colorless or white odorless solid

-Boiling Point: 399.26 °C

-Melting Point: 172.5°C

-Flash Point: 210 °C

-Solubility: 20.6 g/100ml

-Density: 1.79

-Autoignition Temperature: 425 °C


DL-Tartaric Acid is a dihydroxyl derivative of succinic acid.
DL-Tartaric Acid has been known to winemakers for centuries.

DL-Tartaric Acid is a white crystalline diprotic organic acid.
DL-Tartaric Acid occurs naturally in many plants, particularly in grapes, bananas, and tamarinds.


CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 4

-Hydrogen Bond Acceptor Count: 6

-Rotatable Bond Count: 3

-Heavy Atom Count: 10

-Formal Charge: 0

-Complexity: 134

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 2

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

-Chemical Classes: Other Classes -> Organic Acids


DL-Tartaric Acid is also one of the main acids found in wine.
DL-Tartaric Acid can be added to food when a sour taste is desired.

DL-Tartaric Acid is a white, crystalline organic acid with anti-inflammatory and anti-oxidant properties that occur naturally in many fruits.
These properties help to stimulate overall helps to boost an individual's immune systems.

DL-Tartaric Acid is a dicarboxylic acid, which is notably found in different fruits such as grapes, bananas, tamarind and citrus.
DL-Tartaric Acid is also obtained from wine fermentation by-products by salts, potassium bitartrate, also known as tartar cream.

DL-Tartaric Acid is an important ingredient in bakery items where, when mixed with baking powder, it acts as a leavening agent.
DL-Tartaric Acid also improves fruit flavours and in baked goods stabilizes batter structures and colour.
DL-Tartaric Acid extracts serve as buffers in the winemaking cycle to control antioxidant E334, acidity and preservatives; in other food items, they act as natural flavour enhancers and food emulsifiers.

DL-Tartaric Acid is freely soluble in water
DL-Tartaric Acid is sparingly soluble in ethanol

DL-Tartaric Acid is used to generate carbon dioxide through interaction with sodium bicarbonate following oral administration.
DL-Tartaric Acid is an organic acid naturally found in fruits including grapes and tamarind.

DL-Tartaric Acid is a principal ingredient in wine and provides it with the characteristic tart taste.
DL-Tartaric Acid is primarily manufactured from natural raw materials

However, DL-Tartaric Acid can also be manufactured synthetically from maleic anhydride.
DL-Tartaric Acid is found in cream of tartar, which is used in making candies and frostings for cakes.
DL-Tartaric Acid is also used in baking powder where it serves as the source of acid that reacts with sodium bicarbonate (baking soda).

DL-Tartaric Acid is used as a synergist for antioxidants, emulsifier, sequestrant and flavoring agent.
DL-Tartaric Acid is also added with citric acid to prepare effervescent salts, thereby enhancing the taste of oral medications.

DL-Tartaric Acid is also utilized in pigments, processing aids, ink, toner and colorant products.
DL-Tartaric Acid acts as a chelating agent in metal and farming industries.

Further, DL-Tartaric Acid is used as lubricant and grease.
DL-Tartaric Acid is mixed with sodium bicarbonate and used as a leavening agent in food preparation.
In the pharmaceutical industry, DL-Tartaric Acid is utilized in the preparation of tartar emetic, which is used in cough syrup as an expectorant.


SYNONYMS:

d-Tartaric acid
147-71-7
D-(-)-Tartaric acid
(2S,3S)-2,3-Dihydroxysuccinic acid
D(-)-TARTARIC ACID
(2S,3S)-2,3-dihydroxybutanedioic acid
(-)-Tartaric acid
D-threaric acid
(-)-D-Tartaric acid
DL-Tartaric acid
(2S,3S)-(-)-Tartaric acid
(S,S)-Tartaric acid
(-)-(S,S)-Tartaric acid
(S,S)-(-)-Tartaric acid
(2S,3S)-Tartaric acid
Butanedioic acid, 2,3-dihydroxy-, (2S,3S)-
S-Bacampicillin
levo-Tartaric acid
unusual tartaric acid
D-(-)-tartaricacid
UNII-RRX6A4PL3C
RRX6A4PL3C
tartaric acid
CHEBI:15672
EINECS 205-695-6
133-37-9
106449-07-4
tartrate
(+/-)-Tartaric Acid
DTXSID5046986
Linksweinsaeure
C4-H6-O6
Levotartaric Acid
1rpa
levo tartaric acid
(-)-Weinsaeure
MFCD00004238
D-()-Tartaric acid
E-7050 (2S,3S)-2,3-dihydroxysuccinic acid
(+)-D-tartaric acid
(- )- tartaric acid
NSC-155080
Butanedioic acid, 2,3-dihydroxy-, (S-(R*,R*))-
(2s, 3s)-tartaric acid
D0K2BZ
TARTARIC ACID, D-
Tartaric acid, D-(-)-
NCIStruc1_000172
NCIStruc2_000222
MLS001076664
D-TARTARIC ACID
DL-Tartaric acid, >=99%
SCHEMBL116846
UNNATURAL TARTARIC ACID
CHEMBL1200861
D-(-)-Tartaric acid, 99%
DTXSID4043775
(2S,3S) (-) tartaric acid
HMS2231C23
1007601-97-9
D-threo-2,3-dihydroxysuccinic acid
CCG-38066
MFCD00071626
NCGC00014424
NCI155080
s3134
AKOS005067832
DB01694
DS-3383
D-(-)-Tartaric acid
NCGC00014424-02
NCGC00097529-01
BP-13000
BP-31023
DL-Tartaric acid
E334
SMR000499572
AM20080237
CS-0017144
T0026
D-(-)-Tartaric acid
EN300-72270
(2R/S,3R/S)-dihydroxy-1,4-butanedioic acid
A22830
C02107
D78024
Butanedioic acid, 2,3-dihydroxy-, [S-(R,R)]-
DL-Tartaric acid
J-006363
J-501029
Q23034947
(S,S)-Tartaric acid;Tartaric acid;D-(-)-Tartaric acid
Butanedioic acid, 2,3-dihydroxy-, (S-(theta,theta))-
Z1147451575
D-(-)-Tartaric acid
DL-Tartaric acid, anhydrous
(-)-Tartaric acid
(-)-tartaric acid
(-)-tartaric acid
(-)-Weinsäure
(2R,3S)-2,3-dihydroxybutanedioic acid
(2S,3S)-2,3-dihydroxybutanedioate
(2S,3S)-2,3-dihydroxybutanedioic acid
(2S,3S)-2,3-dihydroxysuccinic acid
2,3-dihydroxybutanedioic acid
D-(-)-Tartaric Acid
tartaric acid
D-(−)-Tartaric acid
(-)-(S,S)-tartaric acid
(-)-D-tartaric acid
(-)-tartaric acid
(2S,3S)-(-)-Tartaric acid
(2S,3S)-(−)-Tartaric acid
(2S,3S)-2,3-dihydroxybutanedioic acid
(2S,3S)-2,3-Dihydroxysuccinic acid
(2S,3S)-tartaric acid
(S,S)-(-)-tartaric acid
(S,S)-tartaric acid
[S-(R*,R*)]-2,3-Dihydroxybutanedioic Acid
526-83-0 [RN]
Acide (2S,3S)-2,3-dihydroxysuccinique
Butanedioic acid, 2,3-dihydroxy-, (2S,3S)-
D-(-)-Tartaric Acid
D(-)-TARTARIC ACID
D-2,3-DIHYDROXYBUTANEDIOIC ACID
DL-Tartaric acid concentrate
D-Tartaric Acid
D-threaric acid
d-​(-​)​-​tartaric acid
D(-)-2,3-Dihydroxysuccinic Acid
D(-)TARTARIC ACID
D-(-)-Tartaric acid|(2S,3S)-(-)-Tartaric acid
D-(-)-Tartaricacid
D-(?)-Tartaric acid
d-2,3-dihydroxysuccinic acid