POLYAMINOPROPYL BIGUANIDE
POLYAMINOPROPYL BIGUANIDE
POLYAMINOPROPYL BIGUANIDE is classified as :
Preservative
CAS Number 32289-58-0 / 70170-61-5 / 133029-32-0 / 28757-47-3
Restriction (applies to EU only): VI/28
COSING REF No: 36692
Chem/IUPAC Name: Homopolymer of N-(3-Aminopropyl)-Imidodicarbonimidic Diamide
Polyaminopropyl biguanide
Polyaminopropyl biguanide
Polyaminopropyl biguanide.svg
Names
Other names
Polyamine-propyl-biguanidine
Identifiers
CAS Number 133029-32-0 check
Abbreviations Polyaminopropyl biguanide
ChemSpider none
ECHA InfoCard 100.118.649 UNII DT9D8Z79ET check
Properties
Chemical formula (C5H11N5)n
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Polyaminopropyl biguanide is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses. It is also an ingredient in many deodorant bodysprays.[citation needed] It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.[citation needed] Polyaminopropyl biguanide is specifically bactericidal at very low concentrations (10 mg/l) and is also fungicidal.[citation needed]
APBBiocidal activity
It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[1]
Disinfectant
Polyaminopropyl biguanide solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds.[2] It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).
Contact lens solution
A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented.[3] The solution is disinfecting and preservative and has a broad spectrum of bactericidal and fungicidal activity at low concentrations coupled with very low toxicity when used with soft-type contact lenses.
POLYAMINOPROPYL BIGUANIDE (Polyaminopropyl biguanide)
What is Polyaminopropyl biguanide?
“Polyaminopropyl biguanide (Polyaminopropyl biguanide), with the chemical formula (C5H11N5)n, is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.” What are the effects?
This ingredient belongs to the groups:
Organ system toxicants
Environmental hazards
Carcinogens
Irritants and allergens
Read the facts
Polyaminopropyl biguanide is a CMR substance, meaning it’s classified as carcinogenic, mutagenic or toxic for reproduction (CRM).
The European Chemicals Agency (ECHA) classifies polyaminopropyl biguanide (Polyaminopropyl biguanide) as
“fatal if inhaled, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, causes serious eye damage, is suspected of causing cancer and may cause an allergic skin reaction.”
How is it used?
Polyaminopropyl biguanide (Polyaminopropyl biguanide) is being used as a preservative to prevent the growth of harmful bacteria and mould in many cosmetic⋆ and household products. Polyaminopropyl biguanide can for example be found in sanitary napkins, creams, and after-shave balms.
Polyaminopropyl biguanide is banned for use in cosmetic products in the EU since January 2015 but the substance can still sometimes be found in products, even from major brands, according to the Danish Consumer Council THINK Chemicals.
This is because industry associations, led by Cosmetics Europe, lobbied that the current law should be re-interpreted to allow low doses of Polyaminopropyl biguanide in products.
Doses of 0.1 percent Polyaminopropyl biguanide is now allowed in certain products, but as the exact dose do not have to be written on the ingredients list, it is uncertain to know just how much is in a product.
When it comes to skin care and makeup, many of us probably have a list of ingredients we would never put on our faces — some lists longer than others. But one ingredient with some heavily skewed opinions is polyaminopropyl biguanide, also known as Polyaminopropyl biguanide or Polyaminopropyl biguanide. But what is Polyaminopropyl biguanide and is it bad for you? The ingredient is used in some pretty popular products in the USA but is actually banned from use in cosmetics in other countries. So what gives? To find out a little more about this controversial ingredient and whether you should avoid it, I emailed with a few experts.
Rachel Winard, founder of Soapwalla; Holly McWhorter, co-founder of PLANT Apothecary; and Dr. Clarissa Shetler and Christine Falsetti, PhD, founders of C2 California Clean, all let me in on what Polyaminopropyl biguanide is commonly used for along with some other useful information about the ingredient so you can make a more educated decision whether to use beauty products containing it. According to Winard, Polyaminopropyl biguanide is a "synthetic polymer that is used as a broad-spectrum preservative and antimicrobial agent in skin care." Drs. Shetler and Falsetti add that it can be found in many personal-care products "including skin care, cosmetics, eye-care solutions, wound care, and surgery care."
Even though Polyaminopropyl biguanide has proven antibacterial properties, it has also been shown to be harmful. McWhorter explains: "There's evidence based on results of studies on humans and animals that [Polyaminopropyl biguanide] is carcinogenic (causing cancer), mutagenic (causing gene mutation), and toxic. It's suspected primarily of affecting the reproductive system." Yikes.
The Scientific Committee on Consumer Safety (SCCS) has also concluded that Polyaminopropyl biguanide is not safe when used as a preservative in a concentration higher than 0.3-percent in cosmetic products, say Drs. Shetler and Falsetti. And according to McWhorter, in the EU, Polyaminopropyl biguanide was banned in personal-care products after being labeled a Category 2 Carcinogenic Agent in 2015.
Not everyone seems to agree on the dangers of this preservative though. Polyaminopropyl biguanide use in personal-care products is legal in the USA, and according to Drs. Shetler and Falsetti, "There are still many debates on the safety profile of the ingredient and some companies will still insist the ingredient is safe." So even though you can still find this ingredient on the shelves in US stores, if you're worried about using products with Polyaminopropyl biguanide, check out this list of products known to include the ingredient, and always read product labels to be sure whether Polyaminopropyl biguanide (although it may also be listed as polyaminopropyl biguanide or Polyaminopropyl biguanide) is included.
PAPB is an aqueous-based cationic preservative, active against spoilage bacteria and is compatible with a wide range of aqueous based cosmetics and personal care formulations. Its gentle nature makes it ideal for both rinse-off and leave-on applications like shampoo (with cationic, nonionic or amphoteric surfactants), hair care products, skin creams, skin lotions, baby products, and wet wipes. When mildness is an important feature for your product, PAPB's gentle and protective nature could make it your solution.
Molecular Formula of Polyaminopropyl biguanide (C8H17N5)n
Ph Level of Polyaminopropyl biguanide 4~5
Taste of Polyaminopropyl biguanide Bitter
Purity of Polyaminopropyl biguanide 20%
Ingredients of Polyaminopropyl biguanide PAPB
Properties of Polyaminopropyl biguanide PAPB (Polyaminopropyl biguanide) is a water-soluble cationic disinfectant with wide clinical, household, and industrial applications
Shelf Life of Polyaminopropyl biguanide 2 Years
Storage of Polyaminopropyl biguanide Room Temperature
Structural Formula of Polyaminopropyl biguanide (C8H17N5)n
Grade of Polyaminopropyl biguanide TECHNICAL
Product Type of Polyaminopropyl biguanide PAPB
Application of Polyaminopropyl biguanide Pharmaceutical
Physical Form of Polyaminopropyl biguanide Liquid
Appearance of Polyaminopropyl biguanide WATER WHITE
Polyaminopropyl biguanide,is Available in colorless to pale yellow form, Polyaminopropyl biguanide, PAPB is accessible in liquid form. Polyaminopropyl biguanide,tastes bitter and its purity level is 20%. Polyaminopropyl biguanide,can be stored for 24 months. Polyaminopropyl biguanide,disinfecting chemical is water soluble and it is cationic by nature. Polyaminopropyl biguanide,is suitable for household, industrial and clinical application purpose. Ph level of Polyaminopropyl biguanide, liquid substance ranges between 4 to 5. Polyaminopropyl biguanide, PAPB has been formulated under controlled temperature to preserve anti bacterial properties of Polyaminopropyl biguanide. Standard of Polyaminopropyl biguanide,liquid has been verified on the basis of composition of Polyaminopropyl biguanide,, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc. ppearance: white powder; colorless liquid; colorless translucent crystals
Assay of Polyaminopropyl biguanide,: 95%;98%;20%; 25%;50%
Polyaminopropyl biguanide can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.
Polyaminopropyl biguanide is widely used in health care, Polyaminopropyl biguanide is widely used in chemicals, Polyaminopropyl biguanide is widely used in textiles, Polyaminopropyl biguanide is widely used in paper, Polyaminopropyl biguanide is widely used in wipes,Polyaminopropyl biguanide is widely used in livestock, aquaculture, Polyaminopropyl biguanide is widely used in fisheries, plastics, Polyaminopropyl biguanide is widely used in agriculture, Polyaminopropyl biguanide is widely used in water treatment and Polyaminopropyl biguanide is widely used in other fields.
Polyaminopropyl biguanide containing Polyaminopropyl biguanide are used for inter-operative irrigation, Polyaminopropyl biguanide are used for pre- and Polyaminopropyl biguanide are used for post-surgery skin and Polyaminopropyl biguanide are used for mucous membrane Polyaminopropyl biguanide are used for disinfection, Polyaminopropyl biguanide are used for post-operative dressings, Polyaminopropyl biguanide are used for surgical and Polyaminopropyl biguanide are used for non-surgical wound dressings, Polyaminopropyl biguanide are used for surgical bath/hydrotherapy,Polyaminopropyl biguanide are used for chronic wounds like diabetic foot ulcer and burn wound management, Polyaminopropyl biguanide are used for routine antisepsis during minor incisions, Polyaminopropyl biguanide are used for catheterization, scopy, first aid, surface disinfection, and linen disinfection. Polyaminopropyl biguanide eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, Polyaminopropyl biguanide also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. Polyaminopropyl biguanide is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Polyaminopropyl biguanide Leisure Time Free system.Polyaminopropyl biguanide is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. Polyaminopropyl biguanide is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The Polyaminopropyl biguanide hydrochloride salt (solution) is used in the majority of formulations. Polyaminopropyl biguanide a related biguanide disinfectant. Polyaminopropyl biguanide (is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide is also known as polyhexanide and polyaminopropyl biguanide, polymeric biguanide hydrochloride; polyhexanide biguanide. Polyaminopropyl biguanide is a commonly applied antiseptic, Polyaminopropyl biguanide often used as a preservative in cosmetics and Polyaminopropyl biguanide often used as a in personal care products. The antimicrobial efficacy has been demonstrated on Acanthamoeba polyphaga, A castellanii, and A hatchetti (Hughes et al., 2003; Wright et al., 2003; Burgers et al., 1994; Hiti et al., 2002). In vivo studies have also demonstrated that a miltefosine–Polyaminopropyl biguanide combination is highly effective for the treatment of Acanthamoeba keratitis (Polat et al., 2013). Polyaminopropyl biguanide retains its activity in hard water and does not cause surface streaks or tackiness (Broxton et al., 1984b; Ikeda et al., 1984). Consistent with previous studies, a Polyaminopropyl biguanide mouthrinse was shown to inhibit plaque re-growth and reduced oral bacterial counts, indicating that Polyaminopropyl biguanide could be an alternative to established mouth rinses in preventive applications (Welk et al., 2005). Recreational water maintained and sanitized with Polyaminopropyl biguanide is however assumed to serve as a medium for transmission of ocular adenovirus infections, mainly because at a concentration of 50 ppm, Polyaminopropyl biguanide was not virucidal against adenovirus at temperatures consistent with swimming pools or hot tubs (Romanowski et al., 2013). Previous studies have shown increased frequency of sensitization to 0.5% and 0.4% PAPB in unselected dermatitis patients (Schnuch et al., 2007). Polyaminopropyl biguanide proved also toxic to keratocytes (Lee et al., 2007) and was shown to have acute toxic effects in human cells where it caused severe inflammation, atherogenesis, and aging. Moreover, Polyaminopropyl biguanide produced embryo toxicity and heart failure in zebrafish (Kim et al., 2013).
Two equivalent CAS number of Polyaminopropyl biguanide can be allocated depending on how the polymer is described. CAS-No 27083-27-8 expresses the Polyaminopropyl biguanide in terms of its starting monomers (N,N’’’-1,6- hexanediylbis(N’-cyanoguanidine) and 1,6-hexanediamine). CAS-No 32289-58-0 expresses the Polyaminopropyl biguanide as the resultant polymer.
Polyaminopropyl biguanide (PAPB) is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide (PAPB) is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe Polyaminopropyl biguanide use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories Polyaminopropyl biguanide hydrochloride (PAPB) (CAS 32289-58-0 / 27083-27-8 / 28757- 47-3 / 133029-32-0) with INCI name Polyaminopropyl Biguanide, is currently listed in Annex V (entry 28) of the Regulation (EC) No. 1223/20091 (Cosmetics Regulation) as preservative to be used in all cosmetic products up to a maximum concentration of 0.3%. Polyaminopropyl biguanide is classified as CMR 2 (Carc. 2) according to the Commission Regulation (EU) No. 944/20132 of 2 October 2013 amending for the purposes of Polyaminopropyl biguanide adaptation to technical and scientific progress the Regulation (EC) No. 1272/20083 . The classification applies from 1st January 2015 and according to Art. 15 (1) of the Cosmetics Regulation, Polyaminopropyl biguanide is considered prohibited as cosmetic ingredient from 1st January 2015. However, Polyaminopropyl biguanide Art. 15 (1) of the Cosmetics Regulation states that ‘a substance classified in category 2 may be used in cosmetic products where the substance has been evaluated by the SCCS and found safe for use in cosmetic products. To these ends the Commission shall adopt the necessary measures in accordance with the regulatory procedure with scrutiny referred to in Article 32(3) of this Regulation'. The SCCS published an opinion on the safety of Polyaminopropyl biguanide in June 2014 successively revised in July 2015 (SCCS/1535/14)4 in which they concluded that: " Polyaminopropyl biguanide is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe Polyaminopropyl biguanide use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories. Dermal absorption studies on additional representative cosmetic formulations are needed. On the basis of the data available, Polyaminopropyl biguanide the SCCS concludes that Polyaminopropyl biguanide is not safe for consumers when used as a preservative in cosmetic spray formulations up to concentration of 0.3%. Polyaminopropyl biguanide is used in a variety of applications other than cosmetics. General exposure data from sources others than cosmetics should be submitted for the assessment of the aggregate exposure of Polyaminopropyl biguanide.
The stability of Polyaminopropyl biguanide in deionised water has been established for at least 6 weeks. Polyaminopropyl biguanide was stated that nominal concentrations (expressed as Vantocil, i.e. 20 % Polyaminopropyl biguanide) of 0.1, 35 and 80 mg/ml would be stable for the duration of the test. Stability analysis revealed that Polyaminopropyl biguanide over a concentration range of 0.02 to 7.0 mg/l was stable in drinking water for a period of 7 days. PAPB is supported under the Biocides Regulation No 528/2012, which distinguishes 22 product types (PT) Directive 98/8/EC for uses as a disinfectant. Polyaminopropyl biguanide is used as a preservative and as an antimicrobial agent. As a preservative, PAPB is used in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyaminopropyl biguanide is used as a broad spectrum preservative. Polyaminopropyl biguanide is freely water soluble and therefore widely used in water-based products which are most susceptible to microorganism growth. Polyaminopropyl biguanide has an excellent activity against a wide range of Gram positive and Gram negative bacteria, fungi and yeasts and is particularly effective against microorganisms such as Pseudomanas species, which are difficult to control. Polyaminopropyl biguanide is also used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and SCCS/1581/16 Final Opinion on Polyaminopropyl biguanide Submission III 13 trays, farm equipment, animal drinking water, and hard surfaces for food handling institutions and hospitals; and to deodorize vacuums and toilets. Polyaminopropyl biguanide is used in antimicrobial hand washes and Polyaminopropyl biguanide is used in rubs and Polyaminopropyl biguanide is used in air filter treatments as an alternative to ozone. Polyaminopropyl biguanide is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms. Further reported uses of Polyaminopropyl biguanide are purification of swimming pool water, beer glass sanitisation, solid surface disinfection in breweries and short-term preservation of hides and skins. Polyaminopropyl biguanide also known as PAPB, polyhexanide or polihexanide, is a highly water soluble and hydrolytically stable polymeric material. The presence of multiple hydrogen bond and chelation sites within Polyaminopropyl biguanide renders Polyaminopropyl biguanide of potential interest in the field of supramolecular chemistry.Polyaminopropyl biguanide,is Available in colorless to pale yellow form, Polyaminopropyl biguanide, PAPB is accessible in liquid form. Polyaminopropyl biguanide,tastes bitter and its purity level is 20%. Polyaminopropyl biguanide,can be stored for 24 months. Polyaminopropyl biguanide,disinfecting chemical is water soluble and it is cationic by nature. Polyaminopropyl biguanide,is suitable for household, industrial and clinical application purpose. Ph level of Polyaminopropyl biguanide, liquid substance ranges between 4 to 5. Polyaminopropyl biguanide, PAPB has been formulated under controlled temperature to preserve anti bacterial properties of Polyaminopropyl biguanide. Standard of Polyaminopropyl biguanide,liquid has been verified on the basis of composition of Polyaminopropyl biguanide,, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc. ppearance: white powder; colorless liquid; colorless translucent crystals
Assay of Polyaminopropyl biguanide,: 95%;98%;20%; 25%;50%
Polyaminopropyl biguanide can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.
Polyaminopropyl biguanide is widely used in health care, Polyaminopropyl biguanide is widely used in chemicals, Polyaminopropyl biguanide is widely used in textiles, Polyaminopropyl biguanide is widely used in paper, Polyaminopropyl biguanide is widely used in wipes,Polyaminopropyl biguanide is widely used in livestock, aquaculture, Polyaminopropyl biguanide is widely used in fisheries, plastics, Polyaminopropyl biguanide is widely used in agriculture, Polyaminopropyl biguanide is widely used in water treatment and Polyaminopropyl biguanide is widely used in other fields.
Polyaminopropyl biguanide can be used directly after dilution with purified water or with other additive agent compound. Reference amount 1:125~1:1000 (w/w).
Since Polyaminopropyl biguanide in different areas of application, the product dosage are quite different, Polyaminopropyl biguanide is recommended to use under the guidance of our professional and technical persons.
Polyhexanide (Polyaminopropyl biguanide, PAPB) is a polymer used as a disinfectant and antiseptic. In dermatological use, Polyaminopropyl biguanide is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. Polyaminopropyl biguanide has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Polyaminopropyl biguanide containing Polyaminopropyl biguanide are used for inter-operative irrigation, Polyaminopropyl biguanide are used for pre- and Polyaminopropyl biguanide are used for post-surgery skin and Polyaminopropyl biguanide are used for mucous membrane Polyaminopropyl biguanide are used for disinfection, Polyaminopropyl biguanide are used for post-operative dressings, Polyaminopropyl biguanide are used for surgical and Polyaminopropyl biguanide are used for non-surgical wound dressings, Polyaminopropyl biguanide are used for surgical bath/hydrotherapy,Polyaminopropyl biguanide are used for chronic wounds like diabetic foot ulcer and burn wound management, Polyaminopropyl biguanide are used for routine antisepsis during minor incisions, Polyaminopropyl biguanide are used for catheterization, scopy, first aid, surface disinfection, and linen disinfection. Polyaminopropyl biguanide eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, Polyaminopropyl biguanide also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. Polyaminopropyl biguanide is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Polyaminopropyl biguanide Leisure Time Free system.Polyaminopropyl biguanide is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. Polyaminopropyl biguanide is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The Polyaminopropyl biguanide hydrochloride salt (solution) is used in the majority of formulations. Polyaminopropyl biguanide a related biguanide disinfectant. Polyaminopropyl biguanide (is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide is also known as polyhexanide and polyaminopropyl biguanide, polymeric biguanide hydrochloride; polyhexanide biguanide. Polyaminopropyl biguanide is a commonly applied antiseptic, Polyaminopropyl biguanide often used as a preservative in cosmetics and Polyaminopropyl biguanide often used as a in personal care products. Polyaminopropyl biguanide shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.Polyaminopropyl biguanide is available also as a solid. Polyaminopropyl biguanide hydrochloride (PAPB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications. This review provides a comprehensive literature of Polyaminopropyl biguanide features from synthesis methods,mode of action, antimicrobial effects and safety considerations to both humans and environments. Effectiveness against cellular organisms is due to the basic biguanide group attached to a flexible spacer, a hexamethylene group. Polyaminopropyl biguanide is a disinfectant with a broad spectrum of inducing cell death by disrupting cell membrane integrity. Polyaminopropyl biguanide is an environmentally friendly product noncorrosive and nontoxic to both humans and animals. Polyaminopropyl biguanide is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyaminopropyl biguanide the preservation of fruit and vegetables. Polyaminopropyl biguanide is also used to preserve wet wipes; Polyaminopropyl biguanide is also used to control odor in textiles;Polyaminopropyl biguanide is also used to prevent microbial contamination in wound irrigation and sterile dressings; to Polyaminopropyl biguanide is also used disinfect medical/dental utensil and trays, Polyaminopropyl biguanide is also used farm equipment, Polyaminopropyl biguanide is also used animal drinking water, and hard surfaces for food handling institutions and hospitals; and to Polyaminopropyl biguanide is also used deodorize vacuums and toilets. Polyaminopropyl biguanide can work at low concentrations with very fast action with a broad spectrum of action in addition of Polyaminopropyl biguanide wide acceptance and exploitation for potential multi-purpose functional use. Polyaminopropyl biguanide will be promising for advanced environmental treatments including food disinfection, Polyaminopropyl biguanide will be promising for water disinfection, Polyaminopropyl biguanide will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Disinfecting agent is a substances used to control, prevent, or destroy harmful microorganisms (i.e., bacteria, viruses, or fungi) on inanimate objects and surfaces. Polyaminopropyl biguanide destroys or irreversibly inactivates most pathogenic microorganisms (Ewart,2001; EPA, 2004; Quinn and Markey, 2001; Kennedy et al., 2000). Chemical disinfectants were used scientifically around 150 years ago, but empiric practices can be found in ancient times . Since then several new biocides have been introduced and a significant amount of research on their activity against microorganisms has been performed. Biguanidines are an interesting class of compounds with many known or potential applications. It is bacteriostatic at lower concentrations, inhibiting membrane enzymes and promoting leakage of cellular constituents. Polyaminopropyl biguanide hydrochloride is a chemical biocide and a member of the polymeric guanidine family is used as a disinfectant and antiseptic and general disinfecting agents in the food industry and, very successfully, for the disinfection of swimming pools. Polyaminopropyl biguanide used biocide has been reviewed by US Environmental Protection Agency (EPA) and noted, with the exception of occupational users, as having very low aggregate risk of adverse health effects to the public or environment(EPA, 2005). Polyaminopropyl biguanide binds to the negatively charged phosphate head groups of phospholipids at bacteria cell wall, causing increased rigidity, sinking nonpolar British Journal of Environmental Sciences Vol.4, No.1, pp.49-55, February 2016 ___Published by European Centre for Research Training and Development UK (www.eajournals.org) 50 ISSN 2055-0219(Print), ISSN 2055-0227(online) segments into hydrophobic domains, disrupting the membrane with subsequent cytoplas- mic shedding culminating in cell death (Kaehn, 2010). There have been no reported instances of bacteria acquiring resistance to Polyaminopropyl biguanide . Polyaminopropyl biguanide is well tolerated when used topically on skin, eyes, the ciliated epithelium of the nose, and wounds (Kaehn, 2010; Kramer et al., 2004; Dissemond et al., 2009; Kramer et al., 2008). The market for Polyaminopropyl biguanide -containing products, which now includes liquids, gels and antimicrobial dressings, is expanding rapidly. This article outlines the evidence on the antimicrobial properties of Polyaminopropyl biguanide. PAPB was firstly synthesized by Rose and Swain (1954). Polyaminopropyl biguanide is a cationic biguanide polymer which is utilized in a wide variety of antibacterial applications (O’Malley et al., 2007). Several methods have been devised in order to prepare Polyaminopropyl biguanide. For instance, one of the current methods is to obtain Polyaminopropyl biguanide by polycondensation of sodium dicyanamide and hexamethylenediamine in two steps (de Paula et al., 2011). Preparations of Polyaminopropyl biguanide are polydisperse mixtures of polymeric biguanides, with a weighted average number (n) of 12 repeating hexamethylene biguanide units. The heterogeneity of the molecule is increased further by the presence of either amine, or cyanoguanidine or guanidine end-groups in any combination at the terminal positions of each chain. Equal amounts (in molar) of hexamethylenediamine and guanidine hydrochloride to be mixed in a round-bottomed three-necked flask, which is equipped with a mechanical stirrer and vacuum system. The mixture reacts at 100 °C for 60 min, and then at 170 °C for a certain time. During the reaction, by-product ammonia is neutralized by bubbling through aqueous HCl. At the end of reaction, the slightly yellow, viscous liquid solidifies upon cooling giving Polyaminopropyl biguanide samples (Wei et al., 2009). PHMG is a new generation of disinfectant with a wide scope of applications in agriculture and food processing plants, logistics, kitchens, transport vehicles.